Pyridine

General

Pyridine is a basic heterocyclic organic compound with the chemical formula C5H5N. It is structurally related to benzene, with one methine group (=CH-) replaced by a nitrogen atom. Pyridine is not abundant in nature, except for the leaves and roots of belladonna (Atropa belladonna) and in marshmallow (Althaea officinalis, Guimauve officinale). Pyridine derivatives, however, are often part of biomolecules such as alkaloids. Building block for many inhibitors of enzymes
Inhibitor Main targeted enzyme familyes Type Structure
Phenyl-phenylpyridin-oxadiazol-cpd5a Oxadiazol Multitarget Pyridine
X20403 Thioesterase Pyridine Triazol Cyclopropyl
X20404 Thioesterase Pyridine Triazol
PyrTac-5f Derivative of Tacrine Multitarget Protein Phosphatase activator Pyridine
Tacrine-Sibiriline-Cpd7 BCHE ACHE Multitarget Acridine Derivative of Tacrine Alkyl linked bis-ligand Pyridine Carbamate Pyrrolidine
Pyrazolopyridine-Cpd37 Monoglyceridelipase_lysophospholip Pyridine Pyrazole
CHEMBL5206601 ACHE anti-Abeta-aggregation Multitarget Pyridine
8AEV-LWU ACHE Pyridine Pyrimidine
8AM2-N0C BCHE Trimethylammonium Pyridine
6RKY-K7K-phosphodiester Hormone-sensitive_lipase_like Organophosphate Pyridine Metal ion chelator
ZK8 Hormone-sensitive_lipase_like Organophosphate Pyridine Metal ion chelator
6RKY-K7K Hormone-sensitive_lipase_like Organophosphate Pyridine Metal ion chelator
CHEMBL4289712 ABHD6-Lip Triazol Pyridine
3-aminocoumarin-N-benzylpyridinium-9h ACHE Coumarin Pyridine Chromen
8AM1-5a BCHE Trimethylammonium Pyridine
LF-14 ACHE Pyridine Urea derivative
Bivalent-4-Aminopyridine-12i ACHE Pyridine Alkyl linked bis-ligand
JM-20 Benzodiazepin Not A\/B H target Pyridine Multitarget 2-nitrophenyl Azepine
Coumarin-Pyridine-3f ACHE BCHE Coumarin Pyridine Chromen
Difluorophenyl-pyridin-piperazin-1,3,4-oxadiazole-49 ACHE BCHE Oxadiazol Pyridine Piperazine
4-aminopyridine-1,3,4-oxadiazole-9 ACHE Oxadiazol Pyridine
N-dodecyl-pyridinyl-1,3,4-thiadiazol-amine-3t ACHE Sulfur Compound Pyridine Thiadiazol
5-pyrid-3-yl-1,3,4-oxadiazole-5e ACHE BCHE Oxadiazol Pyridine
Fragment-810 Pectinacetylesterase-Notum Pyridine Carboxamide
Fragment-872 Pectinacetylesterase-Notum Fragment inhibitor of Notum Pyridine
Fragment-110 Pectinacetylesterase-Notum Fragment inhibitor of Notum Urea derivative Pyridine
Sulfapyridine Pectinacetylesterase-Notum Fragment inhibitor of Notum Sulfonamide Sulfur Compound Antibiotic Pyridine Not A\/B H target Benzenesulfonamide
Fragment-147 Pectinacetylesterase-Notum Fragment inhibitor of Notum Carboxamide Pyridine Not A\/B H target
Fragment-297 Pectinacetylesterase-Notum Fragment inhibitor of Notum Benzodioxo Pyridine
Fragment-197 Pectinacetylesterase-Notum Fragment inhibitor of Notum Pyridine Benzoate
2-N-pyridin-2-ylbenzene-1,2-diamine Pectinacetylesterase-Notum Fragment inhibitor of Notum Pyridine
Maybridge_18 Pectinacetylesterase-Notum Fragment inhibitor of Notum Pyridine Sulfur Compound
CHEMBL45663-49N-4Y2Q Epoxide_hydrolase Piperazine Pyridine Trifluoro
CHEMBL48137-49O-4Y2R Epoxide_hydrolase Piperazine Pyridine Cyanide Not A\/B H target Adrenergic-Receptor-ligand
VF2-Styrylpyridine-Dye Haloalkane_dehalogenase-HLD2 Pyridine Dye Fluorescent Probe Polymethine
thio-NAD PlaB Sulfur Compound Nicotinamide Organophosphate Pyridine Purine
LIPG-inhib-Compound32 Lipoprotein_Lipase Pyridine Benzothiazol Sulfur Compound Sulfonyl Cyclopropyl
XEN445 Lipoprotein_Lipase Pyridine Trifluoro
JVB Pectinacetylesterase-Notum Pyridine
FG1912 GSK-3 kinase inhibitor Multitarget Pyridine Piperidine Cyclopropyl Carboxamide Derivative of Donepezil
GD29 ACHE GSK-3 kinase inhibitor Multitarget Thiazole Pyridine Piperidine Cyclopropyl Carboxamide Derivative of Donepezil
GT15 ACHE Derivative of Tacrine GSK-3 kinase inhibitor Multitarget Carboxamide Pyridine Thiazole Cyclopropyl
BIA-10-2474 Carb_B_Chordata ABHD6-Lip Pyridine Imidazole FAAH inhibitor Multitarget Carboxamide
CHEMBL3402235 Epoxide_hydrolase Pyridine
BMS-744891 DPP4N_Peptidase_S9 Pyrrolidine Pyridine
CHEMBL2441952 DPP4N_Peptidase_S9 Pyrrolidine Pyridine
CHEMBL1910114 DPP4N_Peptidase_S9 Pyrrolidine Pyridine
CHEMBL1909991 DPP4N_Peptidase_S9 Pyrrolidine Pyridine
CHEMBL1910111 DPP4N_Peptidase_S9 Pyrrolidine Pyridine Pyrimidine
CHEMBL1234565 Epoxide_hydrolase Pyridine Nicotinamide Carboxamide Pyrazole
TAK-100 DPP4N_Peptidase_S9 Pyridine
TAK-986 DPP4N_Peptidase_S9 Pyridine
33N Epoxide_hydrolase Pyridine Nicotinamide Carboxamide
SCHEMBL7329991 Epoxide_hydrolase Pyridine
CHEMBL4451596 Epoxide_hydrolase Sulfonamide Pyridine Trifluoro Sulfur Compound
3-amino-4-phenyl-pyrrolidine-15B DPP4N_Peptidase_S9 Trifluoro Pyrrolidine Pyridine Pyrimidine
MK0626 DPP4N_Peptidase_S9 Pyridine Pyrrolidine Triazol
ABC99 Pectinacetylesterase-Notum Pyridine Carbamate
SMR000042088 S9N_PREPL_Peptidase_S9 Pyridine Cyanide
ARI-3531 S9N_PPCE_Peptidase_S9 Pyridine Pyrrolidine Boron compound
CHEMBL1684295 Prolylcarboxypeptidase Pyrrolidine Imidazole Pyridine Oxadiazol Piperidine Benzimidazole
CHEMBL3086040 Prolylcarboxypeptidase Pyridine Carboxamide Morpholine
ARI-3099 DPP4N_Peptidase_S9 ACPH_Peptidase_S9 Pyridine Pyrrolidine Boron compound
LEI105 Lipase_3 Pyridine
E2030 ACHE BCHE Pyridine Boron compound
P-10358 ACHE BCHE Carbamate Indole Pyridine
4,4'-bipyridine ACHE BCHE Pyridine
7-MEOTA-4-pyridinealdoxime ACHE Derivative of Tacrine Acridine Pyridine Pyridine-aldoxime
Dehydroevodiamine ACHE Natural Pyridine Indole beta-carboline Natural_modified Derivative of Evodiamine
Diethylparaquat ACHE Pyridinium Pyridine Herbicide
BChE-IN-21 BCHE Pyridine Quinoline Carboxamide
SB-1436 Pyridine Naphthalen Pyridinium
hAChE-IN-6 Pyridine Pyrazole GSK-3 kinase inhibitor Multitarget
Monoquat ACHE Pyridine
Morfamquat ACHE Pyridine Herbicide Morpholine
Distigmine BCHE Carbamate Drug Pyridine
Pyridostigmine BCHE ACHE Carbamate Drug Pyridine
RU-47213 ACHE Pyridine
N-Benzylpyridinium ACHE Pyridine
LEI104 Lipase_3 Pyridine
Amiloride ACHE BCHE Carboxamide Drug Pyridine Not A\/B H target