Pyridine

General

Pyridine is a basic heterocyclic organic compound with the chemical formula C5H5N. It is structurally related to benzene, with one methine group (=CH-) replaced by a nitrogen atom. Pyridine is not abundant in nature, except for the leaves and roots of belladonna (Atropa belladonna) and in marshmallow (Althaea officinalis, Guimauve officinale). Pyridine derivatives, however, are often part of biomolecules such as alkaloids. Building block for many inhibitors of enzymes

Inhibitor	Main targeted enzyme families	Type
Phenyl-phenylpyridin-oxadiazol-cpd5a	ACHE BCHE	Oxadiazol Multitarget Pyridine
X20403	Thioesterase	Pyridine Triazol Cyclopropyl
X20404	Thioesterase	Pyridine Triazol
PyrTac-5f	ACHE	Derivative of Tacrine Multitarget Protein Phosphatase activator Pyridine
Tacrine-Sibiriline-Cpd7	BCHE ACHE	Multitarget Acridine Derivative of Tacrine Alkyl linked bis-ligand Pyridine Carbamate Pyrrolidine
Pyrazolopyridine-Cpd37	Monoglyceridelipase_lysophospholip	Pyridine Pyrazole
(S)Aporphine-N-benzylpyridinium	ACHE	Isoquinoline Pyridine Alkaloid
CHEMBL5206601	ACHE	anti-Abeta-aggregation Multitarget Pyridine
8AEV-LWU	ACHE	Pyridine Pyrimidine
8AM2-N0C	BCHE	Trimethylammonium Pyridine
6RKY-K7K-phosphodiester	Hormone-sensitive_lipase_like	Organophosphate Pyridine Metal ion chelator
ZK8	Hormone-sensitive_lipase_like	Organophosphate Pyridine Metal ion chelator
6RKY-K7K	Hormone-sensitive_lipase_like	Organophosphate Pyridine Metal ion chelator
CHEMBL4289712	ABHD6-Lip	Triazol Pyridine
3-aminocoumarin-N-benzylpyridinium-9h	ACHE	Coumarin Pyridine Chromen
8AM1-5a	BCHE	Trimethylammonium Pyridine
LF-14	ACHE	Pyridine Urea derivative
Bivalent-4-Aminopyridine-12i	ACHE	Pyridine Alkyl linked bis-ligand
JM-20	ACHE	Benzodiazepin Not A\/B H target Pyridine Multitarget 2-nitrophenyl Azepane
Coumarin-Pyridine-3f	ACHE BCHE	Coumarin Pyridine Chromen
Difluorophenyl-pyridin-piperazin-1,3,4-oxadiazole-49	ACHE BCHE	Oxadiazol Pyridine Piperazine
4-aminopyridine-1,3,4-oxadiazole-9	ACHE	Oxadiazol Pyridine
N-dodecyl-pyridinyl-1,3,4-thiadiazol-amine-3t	ACHE	Sulfur Compound Pyridine Thiadiazol
5-pyrid-3-yl-1,3,4-oxadiazole-5e	ACHE BCHE	Oxadiazol Pyridine
Fragment-810	Pectinacetylesterase-Notum	Pyridine Carboxamide
Fragment-872	Pectinacetylesterase-Notum	Fragment inhibitor of Notum Pyridine
Fragment-110	Pectinacetylesterase-Notum	Fragment inhibitor of Notum Urea derivative Pyridine
Sulfapyridine	Pectinacetylesterase-Notum	Fragment inhibitor of Notum Sulfonamide Sulfur Compound Antibiotic Pyridine Not A\/B H target Benzenesulfonamide
Fragment-147	Pectinacetylesterase-Notum	Fragment inhibitor of Notum Carboxamide Pyridine Not A\/B H target
Fragment-297	Pectinacetylesterase-Notum	Fragment inhibitor of Notum Benzodioxo Pyridine
Fragment-197	Pectinacetylesterase-Notum	Fragment inhibitor of Notum Pyridine Benzoate
2-N-pyridin-2-ylbenzene-1,2-diamine	Pectinacetylesterase-Notum	Fragment inhibitor of Notum Pyridine
Maybridge_18	Pectinacetylesterase-Notum	Fragment inhibitor of Notum Pyridine Sulfur Compound
CHEMBL45663-49N-4Y2Q	Epoxide_hydrolase	Piperazine Pyridine Trifluoro
CHEMBL48137-49O-4Y2R	Epoxide_hydrolase	Piperazine Pyridine Cyanide Not A\/B H target Adrenergic-Receptor-ligand
VF2-Styrylpyridine-Dye	Haloalkane_dehalogenase-HLD2	Pyridine Dye Fluorescent Probe Polymethine
thio-NAD	PlaB	Sulfur Compound Nicotinamide Organophosphate Pyridine Purine
LIPG-inhib-Compound32	Lipoprotein_Lipase	Pyridine Benzothiazol Sulfur Compound Sulfonyl Cyclopropyl
XEN445	Lipoprotein_Lipase	Pyridine Trifluoro
JVB	Pectinacetylesterase-Notum	Pyridine
FG1912	ACHE	GSK-3 kinase inhibitor Multitarget Pyridine Piperidine Cyclopropyl Carboxamide Derivative of Donepezil
GD29	ACHE	GSK-3 kinase inhibitor Multitarget Thiazole Pyridine Piperidine Cyclopropyl Carboxamide Derivative of Donepezil
GT15	ACHE	Derivative of Tacrine GSK-3 kinase inhibitor Multitarget Carboxamide Pyridine Thiazole Cyclopropyl
BIA-10-2474	Carb_B_Chordata ABHD6-Lip	Pyridine Imidazole FAAH inhibitor Multitarget Carboxamide
CHEMBL3402235	Epoxide_hydrolase	Pyridine
BMS-744891	DPP4N_Peptidase_S9	Pyrrolidine Pyridine
CHEMBL2441952	DPP4N_Peptidase_S9	Pyrrolidine Pyridine
CHEMBL1910114	DPP4N_Peptidase_S9	Pyrrolidine Pyridine
CHEMBL1909991	DPP4N_Peptidase_S9	Pyrrolidine Pyridine
CHEMBL1910111	DPP4N_Peptidase_S9	Pyrrolidine Pyridine Pyrimidine
CHEMBL1234565	Epoxide_hydrolase	Pyridine Nicotinamide Carboxamide Pyrazole
TAK-100	DPP4N_Peptidase_S9	Pyridine
TAK-986	DPP4N_Peptidase_S9	Pyridine
33N	Epoxide_hydrolase	Pyridine Nicotinamide Carboxamide
SCHEMBL7329991	Epoxide_hydrolase	Pyridine
CHEMBL4451596	Epoxide_hydrolase	Sulfonamide Pyridine Trifluoro Sulfur Compound
3-amino-4-phenyl-pyrrolidine-15B	DPP4N_Peptidase_S9	Trifluoro Pyrrolidine Pyridine Pyrimidine
MK0626	DPP4N_Peptidase_S9	Pyridine Pyrrolidine Triazol
ABC99	Pectinacetylesterase-Notum	Pyridine Carbamate
SMR000042088	S9N_PREPL_Peptidase_S9	Pyridine Cyanide
ARI-3531	S9N_PPCE_Peptidase_S9	Pyridine Pyrrolidine Boron Compound
CHEMBL1684295	Prolylcarboxypeptidase	Pyrrolidine Imidazole Pyridine Oxadiazol Piperidine Benzimidazole
CHEMBL3086040	Prolylcarboxypeptidase	Pyridine Carboxamide Morpholine
ARI-3099	DPP4N_Peptidase_S9 ACPH_Peptidase_S9	Pyridine Pyrrolidine Boron Compound
LEI105	Lipase_3	Pyridine
E2030	ACHE BCHE	Pyridine Boron Compound
P-10358	ACHE BCHE	Carbamate Indole Pyridine
4,4'-bipyridine	ACHE BCHE	Pyridine
7-MEOTA-4-pyridinealdoxime	ACHE	Derivative of Tacrine Acridine Pyridine Pyridine-aldoxime
Dehydroevodiamine	ACHE	Natural Pyridine Indole beta-carboline Natural_modified Derivative of Evodiamine
Diethylparaquat	ACHE	Pyridinium Pyridine Herbicide
BChE-IN-21	BCHE	Pyridine Quinoline Carboxamide
SB-1436	BCHE ACHE	Pyridine Naphthalen Pyridinium anti-Abeta-aggregation
hAChE-IN-6	BCHE ACHE	Pyridine Pyrazole GSK-3 kinase inhibitor Multitarget
Monoquat	ACHE	Pyridine
Morfamquat	ACHE	Pyridine Herbicide Morpholine
Distigmine	BCHE	Carbamate Drug Pyridine
Pyridostigmine	BCHE ACHE	Carbamate Drug Pyridine
RU-47213	ACHE	Pyridine
N-Benzylpyridinium	ACHE	Pyridine
LEI104	Lipase_3	Pyridine
Amiloride	ACHE BCHE	Carboxamide Drug Pyridine Not A\/B H target