Z-321
General
Type : Pyrrolidine, Thiazolidine, Inden, Sulfure Compound
Chemical_Nomenclature : 2-(2,3-dihydro-1H-inden-2-yl)-1-[(4R)-4-(pyrrolidine-1-carbonyl)-1,3-thiazolidin-3-yl]ethanone
Canonical SMILES : C1CCN(C1)C(=O)[C@@H]2CSCN2C(=O)CC3CC4=CC=CC=C4C3
InChI : InChI=1S\/C19H24N2O2S\/c22-18(11-14-9-15-5-1-2-6-16(15)10-14)21-13-24-12-17(21)19(23)20-7-3-4-8-20\/h1-2,5-6,14,17H,3-4,7-13H2\/t17-\/m0\/s1
InChIKey : GDOVFSONSLOIAK-KRWDZBQOSA-N
Other name(s) : Z 321 || (4R)-3-(2-Indanacetyl)-4-(1-pyrrolidinecarbonyl)thiazolidine || M2V0Y789FK || UNII-M2V0Y789FK || CHEMBL62960 || SCHEMBL2048453
MW : 344.5
Formula : C19H24N2O2S
CAS_number : 130849-58-0
PubChem : 9798234
UniChem : GDOVFSONSLOIAK-KRWDZBQOSA-N
Target
Families : Z-321 ligand of proteins in family
S9N_PPCE_Peptidase_S9
Protein :
human-PREP
References (3)
| Title : Computer-Aided Drug Discovery Identifies Alkaloid Inhibitors of Parkinson's Disease Associated Protein, Prolyl Oligopeptidase - Kulkarni_2021_Evid.Based.Complement.Alternat.Med_2021_6687572 |
| Author(s) : Kulkarni AM , Rampogu S , Lee KW |
| Ref : Evid Based Complement Alternat Med , 2021 :6687572 , 2021 |
| Abstract : |
| PubMedSearch : Kulkarni_2021_Evid.Based.Complement.Alternat.Med_2021_6687572 |
| PubMedID: 33897801 |
| Gene_locus related to this paper: human-PREP |
| Title : Pharmacokinetics and safety of Z-321, a novel specific orally active prolyl endopeptidase inhibitor, in healthy male volunteers - Umemura_1999_J.Clin.Pharmacol_39_462 |
| Author(s) : Umemura K , Kondo K , Ikeda Y , Nishimoto M , Hiraga Y , Yoshida Y , Nakashima M |
| Ref : Journal of Clinical Pharmacology , 39 :462 , 1999 |
| Abstract : |
| PubMedSearch : Umemura_1999_J.Clin.Pharmacol_39_462 |
| PubMedID: 10234593 |
| Title : Increase in the septal vasopressin content by prolyl endopeptidase inhibitors in rats - Miura_1995_Neurosci.Lett_196_128 |
| Author(s) : Miura N , Shibata S , Watanabe S |
| Ref : Neuroscience Letters , 196 :128 , 1995 |
| Abstract : |
| PubMedSearch : Miura_1995_Neurosci.Lett_196_128 |
| PubMedID: 7501240 |