ZGR
Hydrolysis product of zearalenone by the lactonase ZHD. The mycotoxin zearalenone has been contaminating maize and other grains. It can be hydrolyzed and inactivated by the lactonase ZHD. Zearalenone differs from other quorum-sensing lactones. Macrolides are organic compounds containing a lactone ring of at least twelve members.
General
Type : Natural, Toxin, Mycotoxin-metabolite
Chemical_Nomenclature : 2,4-dihydroxy-6-[(E,10S)-10-hydroxy-6-oxoundec-1-enyl]benzoic acid
Canonical SMILES : CC(CCCC(=O)CCCC=CC1=CC(=CC(=C1C(=O)O)O)O)O
InChI : InChI=1S\/C18H24O6\/c1-12(19)6-5-9-14(20)8-4-2-3-7-13-10-15(21)11-16(22)17(13)18(23)24\/h3,7,10-12,19,21-22H,2,4-6,8-9H2,1H3,(H,23,24)\/b7-3+\/t12-\/m0\/s1
InChIKey : KZABMNZGZHPCFB-QBODLPLBSA-N
Other name(s) : ZENY || ZHD-product || SCHEMBL18194413 || 2,4-Dihydroxy-6-[(1e,10s)-10-Hydroxy-6-Oxoundec-1-En-1-Yl]benzoic Acid || 2,4-Dihydroxy-6-[(1E,10S)-6-oxo-10-hydroxy-1-undecenyl]benzoic acid || HZEN
MW : 336.38
Formula : C18H24O6
CAS_number :
PubChem : 101750128
UniChem : KZABMNZGZHPCFB-QBODLPLBSA-N
Target
Families : ZGR ligand of proteins in family
Zearalenone-hydrolase
Zearalenone-hydrolase-fam2
Protein :
biooc-ZHD101
9actn-ZenA
9noca-a0aa46n777
References (4)
| Title : Characterization, Structural Analysis, and Thermal Stability Mutation of a New Zearalenone-Degrading Enzyme Mined from Bacillus subtilis - Shi_2024_J.Agric.Food.Chem__ |
| Author(s) : Shi J , Mwabulili F , Xie Y , Yang Y , Sun S , Li Q , Ma W , Jia H |
| Ref : Journal of Agricultural and Food Chemistry , : , 2024 |
| Abstract : |
| PubMedSearch : Shi_2024_J.Agric.Food.Chem__ |
| PubMedID: 38300990 |
| Gene_locus related to this paper: bacsu-YRAK |
| Title : Bacterial Lactonases ZenA with Noncanonical Structural Features Hydrolyse the Mycotoxin Zearalenone - Fruhauf_2024_ACS.Catal_14_3392 |
| Author(s) : Fruhauf S , Puhringer D , Thamhesl M , Fajtl P , Kunz-Vekiru E , Hobartner-Gussl A , Schatzmayr G , Adam G , Damborsky J , Djinovic-Carugo K , Prokop Z , Moll WD |
| Ref : ACS Catal , 14 :3392 , 2024 |
| Abstract : |
| PubMedSearch : Fruhauf_2024_ACS.Catal_14_3392 |
| PubMedID: 38449531 |
| Gene_locus related to this paper: 9actn-ZenA , 9noca-a0aa46n777 |
| Title : Metabolism of Zearalenone in the Rumen of Dairy Cows with and without Application of a Zearalenone-Degrading Enzyme - Gruber-Dorninger_2021_Toxins.(Basel)_13_ |
| Author(s) : Gruber-Dorninger C , Faas J , Doupovec B , Aleschko M , Stoiber C , Hobartner-Gussl A , Schondorfer K , Killinger M , Zebeli Q , Schatzmayr D |
| Ref : Toxins (Basel) , 13 : , 2021 |
| Abstract : |
| PubMedSearch : Gruber-Dorninger_2021_Toxins.(Basel)_13_ |
| PubMedID: 33499402 |
| Gene_locus related to this paper: biooc-ZHD101 |
| Title : Isolation and characterisation of enzymatic zearalenone hydrolysis reaction products - Vekiru_2016_World.Mycotoxin.J_9_353 |
| Author(s) : Vekiru E , Fruhauf S , Hametner C , Schatzmayr G , Krska R , Moll WD , Schuhmacher R |
| Ref : World Mycotoxin Journal , 9 :353 , 2016 |
| Abstract : |
| PubMedSearch : Vekiru_2016_World.Mycotoxin.J_9_353 |
| PubMedID: |
| Gene_locus related to this paper: biooc-ZHD101 |