m-Amino-donepezil
IC50 47.3 nM
General
Type : Derivative of Donepezil, Piperidine, Inden
Chemical_Nomenclature : 2-((1-(3-aminobenzyl)piperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
Canonical SMILES : C1(=C(C=C2C(=C1)C(C(C2)CC3CCN(CC3)CC4=CC=CC(=C4)N)=O)OC)OC
InChI : InChI=1S\/C24H30N2O3\/c1-28-22-13-18-12-19(24(27)21(18)14-23(22)29-2)10-16-6-8-26(9-7-16)15-17-4-3-5-20(25)11-17\/h3-5,11,13-14,16,19H,6-10,12,15,25H2,1-2H3
InChIKey : BMPUHMYLKLRNDH-UHFFFAOYSA-N
Other name(s) : Compound 2g
Target
Families : m-Amino-donepezil ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : Amine-containing donepezil analogues as potent acetylcholinesterase inhibitors with increased polarity - Kaltbeitzel_2024_RSC.Med.Chem_15_2037 |
| Author(s) : Kaltbeitzel J , Kersten C , Wich PR |
| Ref : RSC Med Chem , 15 :2037 , 2024 |
| Abstract : |
| PubMedSearch : Kaltbeitzel_2024_RSC.Med.Chem_15_2037 |
| PubMedID: 38911155 |