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Derivative of Donepezil

General

Donepezil used in treatment of Alzheimer Disease, trademark is Aricept Reversible inhibitor of AChE but not of BChE. Used as a building block of new inhibitors and also multi-target drug candidates
Inhibitor Main targeted enzyme families Type Structure
Donepezil-chromone-melatonin-hybrid-Cpd14n BCHE Derivative of Tryptamine Indole Alkyl linked bis-ligand Multitarget Antioxidant Benzylpiperidine Derivative of Donepezil Chromen Carboxamide Monoamine-oxidase-inhibitor
Donepezil-Melatonin-hybrid-Cpd9 BCHE Derivative of Tryptamine Indole Alkyl linked bis-ligand Multitarget Antioxidant Benzylpiperidine Derivative of Donepezil
L1R1-6 ACHE Quinoline Piperidine Derivative of Donepezil
LY36 BCHE Fluorescent Probe Phenalen Piperidine Indole Benzylpiperidine Derivative of Donepezil
KS07 ACHE Multitarget Piperidine Dimethoxyphenyl Benzylpiperidine Derivative of Donepezil Hydroxycinnamic-ester Cinnamate Acrylate
KS12 ACHE Multitarget Piperidine Dimethoxyphenyl Benzylpiperidine Derivative of Donepezil Hydroxycinnamic-ester Sinapyl Cinnamate Acrylate
Indazol-methoxybenzyl-piperazin-acetamide-Cpd13f BCHE ACHE Derivative of Donepezil Piperazine Indazole Multitarget BACE1-inhibitor
Bipiperidyl-oxoethyl-phenyl-tetraaza-dihydro-indenone-Cpd9a ACHE Derivative of Donepezil Multitarget Piperidine Inden anti-tau-aggregation Indole Pyrazole Pyrimidine
Cinnamic-acid-N-benzyl-pyridinium-Cpd7b ACHE BCHE Hydroxycinnamic-ester Pyridine Pyridinium Derivative of Donepezil Cinnamate
Sigma1R-BCHE-Cpd18c BCHE Multitarget Sigma1R ligand Azetidin Carbamate Benzylpiperidine Derivative of Donepezil
Fluorobenzyl-dimethoxy-oxobenzofuran-pyridinium-Cpd5b ACHE Flavonoid Benzofuran Multitarget Derivative of Donepezil Pyridine Pyridinium
Benzylpiperidin-dimethylamino-hydroxyphenyl-pyridazin-one-Cpd7a ACHE Pyridazine Piperidine anti-Abeta-aggregation Multitarget Benzylpiperidine Derivative of Donepezil
Compound-D1f BCHE ACHE Derivative of Donepezil Sulfur Compound Thiazole Hydrazide cyanide Piperidine
Phenothiazin-piperidin-inden-one-CpdC11 ACHE Derivative of Donepezil Phenothiazine Multitarget Sulfur Compound Piperidine Inden anti-tau-aggregation Indole
SCHEMBL27820343-CpdA3 Carb_B_Chordata Derivative of Donepezil Indole Inden
Phenolidene-dimethoxy-inden-CpdB7 Carb_B_Chordata Derivative of Donepezil Indole Inden
Ethyl-methyl-phenolidene-dimethoxy-inden-benzenecarbamate-cpdC3 Carb_B_Chordata Derivative of Donepezil Indole Inden Carbamate
CD05692 BCHE Piperidine cyanide Benzylpiperidine Derivative of Donepezil
CHEMBL5647316-11a ACHE Pyrimidine Phosphodiesterase-IN Multitarget Piperidine Pyrazole Benzylpiperidine Derivative of Donepezil
Chalcone-VitaminE-donepezil-Cpd17f ACHE Chalcone Monoamine-oxidase-inhibitor Multitarget Dimethoxyphenyl Derivative of Donepezil
AChE-Nrf2modulator-Cpd32 ACHE Chromen Nrf2 modulator Derivative of Donepezil Multitarget Flavonoid
AChE-Nrf2modulator-1 ACHE Pyridine Oxadiazol Nrf2 modulator Derivative of Donepezil Multitarget
CHEMBL4085222 BCHE Derivative of Donepezil Piperidine Quinoline Feruloyl Isoquinoline Benzylpiperidine
Deriv-CHEMBL4085222-Cpd8e BCHE Feruloyl Derivative of Donepezil Piperidine Quinoline Benzylpiperidine
TA8Amino ACHE Derivative of Tacrine Derivative of Donepezil Quinoline Piperidine Inden
TAHB3 ACHE Derivative of Tacrine Derivative of Donepezil Piperidine Inden Quinoline
Benzylpiperidine-isatin-Cpd15 ACHE Monoamine-oxidase-inhibitor Multitarget Piperidine Isatin Alkyne Benzylpiperidine Derivative of Donepezil Organochlorine
CHEMBL4595876 ACHE Multitarget Pyridine Sigma1R ligand cyanide Alkyne Benzylpiperidine Derivative of Donepezil
DNP-BIM-PP ACHE Derivative of Donepezil Multitarget Benzimidazole Metal ion chelator
SCHEMBL21061872 Monoglyceridelipase_lysophospholip Benzoxazine Oxazine Piperidine Benzylpiperidine Derivative of Donepezil
Benzylpiperidin-methylene-methoxy-dihydro-inden-one ACHE Inden BACE1-inhibitor Derivative of Donepezil Multitarget Piperidine Benzylpiperidine
lipoicacid-donepezil-cpd5 ACHE BCHE Multitarget Sulfur Compound Alkyl linked bis-ligand Benzylpiperidine Derivative of Donepezil
Colchicine-donepezil-SBN-284-3x ACHE BCHE Multitarget Benzylpiperidine Derivative of Donepezil Piperidine NLRP3 inflammasome activation
ADS031 ACHE Histamine-Receptor3-H3-Antagonist Multitarget Piperidine Naphthalen Benzylpiperidine Derivative of Donepezil
Aurone-Donepezil-Cpd5g ACHE Flavonoid Benzofuran Multitarget Derivative of Donepezil
Aurone-Donepezil-Cpd6b ACHE Flavonoid Benzofuran Multitarget Derivative of Donepezil Pyridine Pyridinium
Rivastigmine-Donepezil-COR783 ACHE BCHE Cannabinoid-Receptor-ligand Derivative of Rivastigmine Stigmine Multitarget Sulfur Compound Derivative of Donepezil Carbamate Adamantyl
Coumarin-dimethoxyphenyl-methylpiperidine-carboxamise-cpd3b ACHE Coumarin Piperidine Carboxamide Derivative of Donepezil Chromen Dimethoxyphenyl
Benzylpiperidin-methylsulfonyl-indol-acryloyl-phenyl-acetamide-cpd6b BCHE ACHE Multitarget Indole Carboxamide Piperidine Sulfur Compound Benzylpiperidine Derivative of Donepezil
Benzylpiperidin-oxoindolin-acetamide-Cpd23 ACHE Piperidine Indole Benzylpiperidine Derivative of Donepezil
Indole-piperidine-amide-cpd23a ACHE Multitarget Indole Carboxamide Derivative of Donepezil BACE1-inhibitor Piperidine Benzylpiperidine
SB-1448 BCHE ACHE Multitarget Derivative of Donepezil BACE1-inhibitor Piperidine
J8-A34 ACHE Piperidine Sulfur Compound Sulfonamide Quinoline Isoquinoline Cyclobutyl Benzylpiperidine Derivative of Donepezil Organochlorine
Compound5d-Benzylpiperidine-Phenyl-oxadiazol-thiol ACHE anti-Abeta-aggregation Sulfur Compound BACE1-inhibitor Piperidine Multitarget Carboxamide Oxadiazol Derivative of Donepezil cyanide Benzylpiperidine
Compound19n-quinolinol ACHE Trifluoro anti-Abeta-aggregation Metal ion chelator Quinoline Multitarget Derivative of Donepezil
ZINC22029744 ACHE BCHE Multitarget Sulfur Compound Derivative of Donepezil BACE1-inhibitor Piperazine Oxadiazol
WMY90-5f ACHE Quinoline Multitarget Monoamine-oxidase-inhibitor Alkyne cyanide Benzylpiperidine Derivative of Donepezil
DPH6 BCHE ACHE Quinoline Multitarget Monoamine-oxidase-inhibitor Alkyne cyanide Benzylpiperidine Derivative of Donepezil
SCHEMBL1532301 ACHE Indole Isoindole Acridine Alkyl linked bis-ligand Derivative of Tacrine Derivative of Donepezil Organochlorine
C4I-7QHE BCHE Acridine Alkyl linked bis-ligand Derivative of Tacrine Carboxamide Derivative of Donepezil Naphthalen Piperidine
C0I-7QHD BCHE Acridine Alkyl linked bis-ligand Derivative of Tacrine Carboxamide Derivative of Donepezil Indole Piperidine
DFAH-12 BCHE ACHE Piperidine Hydroxycinnamic-ester Multitarget Antioxidant Benzylpiperidine Derivative of Donepezil Organochlorine Cinnamate
Donepezil-idebenone-cpd9 BCHE Multitarget Antioxidant anti-Abeta-aggregation Derivative of Donepezil
m-Amino-donepezil ACHE Derivative of Donepezil Piperidine Inden
Benzyl-piperidine-4-ethyl-phthalimide-6c ACHE Isoindole Piperidine Indole Benzylpiperidine Derivative of Donepezil
Fluoropezil ACHE Multitarget Derivative of Donepezil Sulfur Compound anti-tau-aggregation Antioxidant Thiophen
7QB4-Cpd2 ACHE Monoamine-oxidase-inhibitor Multitarget Coumarin Chromen Benzylpiperidine Derivative of Donepezil
H0L-7D9O ACHE Inden Piperidine Derivative of Donepezil
H1R-7D9Q ACHE Inden Piperidine Derivative of Donepezil
H0R-7D9P ACHE Inden Piperidine Derivative of Donepezil
ABC44 Palmitoyl-protein_thioesterase Carbamate Piperidine N-hydroxyhydantoin Benzylpiperidine Derivative of Donepezil
KT203 ABHD6-Lip Piperidine Triazol Benzylpiperidine Derivative of Donepezil
ZINC11996936 ACHE Trifluoro Derivative of Donepezil
ZINC11709541 ACHE Trifluoro Derivative of Donepezil
SCHEMBL24135488 ACHE BCHE Multitarget Calcium Channel Antagonist anti-Abeta-aggregation Derivative of Donepezil Histamine-Receptor3-H3-Antagonist Benzylpiperidine
BIGI-3h ACHE BCHE Multitarget Monoamine-oxidase-inhibitor GSK-3 kinase inhibitor Calcium Channel Antagonist anti-Abeta-aggregation Benzylpiperidine Derivative of Donepezil Organochlorine
MC1420 ACHE Derivative of Donepezil Carboxamide Chromen
6RUA-3a BCHE Sulfur Compound Sulfonamide Coumarin Piperidine Carboxamide Naphthalen Chromen Benzylpiperidine Derivative of Donepezil
JUB BCHE Piperidine Piperazine NBD-nitro-benzoxadiazol-fluorescent Benzoxadiazole Sulfur Compound Sulfonamide Naphthalen Benzylpiperidine Derivative of Donepezil
BYYT-25 ACHE BCHE Cholinesterase Derivative of Donepezil Inden Pyrrolidine
FG1912 ACHE GSK-3 kinase inhibitor Multitarget Pyridine Piperidine Cyclopropyl Carboxamide Derivative of Donepezil
GD29 ACHE GSK-3 kinase inhibitor Multitarget Thiazole Pyridine Piperidine Cyclopropyl Carboxamide Sulfur Compound Derivative of Donepezil
Donecopride ACHE Multitarget 5-HT-receptor-ligand Derivative of Donepezil Piperidine Organochlorine
Phenolic-deriv-Donecopride-4 ACHE Multitarget 5-HT-receptor-ligand Derivative of Donepezil Piperidine Organochlorine
Phenolic-deriv-Donecopride-20 ACHE Carbamate Multitarget 5-HT-receptor-ligand Derivative of Donepezil Piperidine Organochlorine
Salicylic-donepezil-rivastigmine-5a BCHE Carbamate Derivative of Donepezil Salicylic Derivative of Rivastigmine Stigmine Benzylpiperidine
Sigma1R-ACHE-6a ACHE Multitarget 5-HT-receptor-ligand Piperidine Sigma1R ligand Indole Derivative of Donepezil Organochlorine
Sigma1R-ACHE-6b ACHE Multitarget 5-HT-receptor-ligand Piperidine Sigma1R ligand Indole Derivative of Donepezil Organochlorine
Donepezil-derivative-DZ7 ACHE Piperidine Derivative of Donepezil Inden
Donepezil-derivative-DZ0 ACHE Piperidine Derivative of Donepezil Inden
5DYT-5hb BCHE Piperidine Benzylpiperidine Derivative of Donepezil Sulfonamide Sulfur Compound Naphthalen
5DYY-5hh BCHE Piperidine Sulfonamide Sulfur Compound Naphthalen Benzylpiperidine Derivative of Donepezil
CHEMBL4293015 BCHE Indole Piperidine Alkyl linked bis-ligand Benzylpiperidine Derivative of Donepezil
Donepezil-8-Hydroxyquinoline-2b BCHE Quinoline Multitarget Antioxidant Derivative of Donepezil
ASS234 ACHE Multitarget Monoamine-oxidase-inhibitor Alkyl linked bis-ligand Piperidine Indole Alkyne Benzylpiperidine Derivative of Donepezil
CHEMBL4105611 BCHE Piperidine Sulfur Compound Sulfonamide PET probe Naphthalen Benzylpiperidine Derivative of Donepezil
5DYW-5hf-F BCHE Piperidine Derivative of Donepezil Sulfur Compound Sulfonamide PET probe
Benzylpyrrolidin-methyl-N-methylnaphthalene-2-sulfonamide-(R)-(-)-3 Pyrrolidine Derivative of Donepezil Sulfur Compound Sulfonamide Naphthalen
Benzylpyrrolidin-methyl-N-methylnaphthalene-2-sulfonamide-(S)-(+)-3 Pyrrolidine Derivative of Donepezil Sulfur Compound Sulfonamide Naphthalen
Tacrine-Donepezil-hybrid3 ACHE Derivative of Tacrine Acridine Benzylpiperidine Derivative of Donepezil
Mebbpp ACHE Multitarget Sulfur Compound Piperidine Benzylpiperidine Derivative of Donepezil
Donepezil-Melatonin-4u ACHE Derivative of Tryptamine Indole Alkyl linked bis-ligand Multitarget Antioxidant Benzylpiperidine Derivative of Donepezil
Selenepezil ACHE Organoselenium Thiol-reactive Piperidine Benzylpiperidine Derivative of Donepezil
MGL-Inhibitor-26 Monoglyceridelipase_lysophospholip Piperidine Carboxamide Pyrazole Benzylpiperidine Derivative of Donepezil
KT172 Lipase_3 Carb_B_Chordata ABHD6-Lip Piperidine Biphenyl Triazol Benzylpiperidine Derivative of Donepezil
KT109 Lipase_3 Carb_B_Chordata ABHD6-Lip abh_upf0017 Piperidine Biphenyl Triazol Benzylpiperidine Derivative of Donepezil
C7653 ACHE Piperidine Derivative of Donepezil Organochlorine
T-82(1) ACHE Piperidine Quinoline Benzylpiperidine Derivative of Donepezil
Aricept~Donepezil~E2020 ACHE Derivative of Donepezil Piperidine Drug Benzylpiperidine Inden Organochlorine
N-benzylpiperidine-carbazol-9c BCHE Piperidine Carbazol beta-carboline Derivative of Donepezil Multitarget Benzylpiperidine
TAK-147 ACHE Piperidine Transition state analogue Benzazepin Benzylpiperidine Derivative of Donepezil
Icopezil ACHE Piperidine Benzoxazol Benzylpiperidine Derivative of Donepezil