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Derivative of Donepezil

General

Donepezil used in treatment of Alzheimer Disease, trademark is Aricept Reversible inhibitor of AChE but not of BChE. Used as a building block of new inhibitors and also multi-target drug candidates
Inhibitor Main targeted enzyme families Type Structure
CHEMBL4085222 BCHE Derivative of Donepezil Piperidine Benzylpiperidine Quinoline Feruloyl Isoquinoline
Deriv-CHEMBL4085222-Cpd8e BCHE Feruloyl Derivative of Donepezil Piperidine Benzylpiperidine Quinoline
TA8Amino ACHE Derivative of Tacrine Derivative of Donepezil Quinoline Piperidine Inden
TAHB3 ACHE Derivative of Tacrine Derivative of Donepezil Piperidine Inden Quinoline
DNP-BIM-PP ACHE Derivative of Donepezil Multitarget Benzimidazole Metal ion chelator
Benzylpiperidin-methylene-methoxy-dihydro-inden-one ACHE Inden BACE1-inhibitor Derivative of Donepezil Multitarget Piperidine
lipoicacid-donepezil-cpd5 ACHE BCHE Multitarget Sulfur Compound Alkyl linked bis-ligand Derivative of Donepezil
Colchicine-donepezil-SBN-284-3x ACHE BCHE Multitarget Derivative of Donepezil Piperidine NLRP3 inflammasome activation
Aurone-Donepezil-Cpd5g ACHE Flavonoid Benzofuran Multitarget Derivative of Donepezil
Aurone-Donepezil-Cpd6b ACHE Flavonoid Benzofuran Multitarget Derivative of Donepezil
Rivastigmine-Donepezil-COR783 ACHE BCHE Cannabinoid-Receptor-ligand Derivative of Rivastigmine Multitarget Sulfur Compound Derivative of Donepezil Carbamate Adamantyl
Coumarin-dimethoxyphenyl-methylpiperidine-carboxamise-cpd3b ACHE Coumarin Piperidine Carboxamide Derivative of Donepezil Chromen
Benzylpiperidin-methylsulfonyl-indol-acryloyl-phenyl-acetamide-cpd6b BCHE ACHE Multitarget Indole Carboxamide Piperidine Derivative of Donepezil Sulfur Compound
Benzylpiperidin-oxoindolin-acetamide-Cpd23 ACHE Derivative of Donepezil Piperidine Indole
Indole-piperidine-amide-cpd23a ACHE Multitarget Indole Carboxamide Derivative of Donepezil BACE1-inhibitor Piperidine Benzylpiperidine
SB-1448 BCHE ACHE Multitarget Derivative of Donepezil BACE1-inhibitor Piperidine
J8-A34 ACHE Piperidine Sulfur Compound Sulfonamide Quinoline Isoquinoline Derivative of Donepezil
Compound5d-Benzylpiperidine-Phenyl-oxadiazol-thiol ACHE anti-Abeta-aggregation Sulfur Compound BACE1-inhibitor Piperidine Multitarget Carboxamide Oxadiazol Derivative of Donepezil Cyanide Benzylpiperidine
Compound19n-quinolinol ACHE Trifluoro anti-Abeta-aggregation Metal ion chelator Quinoline Multitarget Derivative of Donepezil
ZINC22029744 ACHE BCHE Multitarget Sulfur Compound Derivative of Donepezil BACE1-inhibitor Piperazine Oxadiazol
WMY90-5f ACHE Quinoline Multitarget Monoamine-oxidase-inhibitor Derivative of Donepezil Alkyne Cyanide
DPH6 BCHE ACHE Quinoline Multitarget Monoamine-oxidase-inhibitor Derivative of Donepezil Alkyne Cyanide
SCHEMBL1532301 ACHE Indole Isoindole Acridine Alkyl linked bis-ligand Derivative of Tacrine Derivative of Donepezil
C4I-7QHE BCHE Acridine Alkyl linked bis-ligand Derivative of Tacrine Carboxamide Derivative of Donepezil Naphthalen Piperidine
C0I-7QHD BCHE Acridine Alkyl linked bis-ligand Derivative of Tacrine Carboxamide Derivative of Donepezil Indole Piperidine
DFAH-12 BCHE ACHE Piperidine Hydroxycinnamic-ester Multitarget Antioxidant Derivative of Donepezil
Donepezil-idebenone-cpd9 BCHE Multitarget Antioxidant anti-Abeta-aggregation Derivative of Donepezil
m-Amino-donepezil ACHE Derivative of Donepezil Piperidine Inden
Benzyl-piperidine-4-ethyl-phthalimide-6c ACHE Isoindole Piperidine Derivative of Donepezil
Fluoropezil ACHE Multitarget Derivative of Donepezil Sulfur Compound Antioxidant Thiophen
7QB4-Cpd2 ACHE Monoamine-oxidase-inhibitor Multitarget Coumarin Chromen Derivative of Donepezil
H0L-7D9O ACHE Inden Piperidine Derivative of Donepezil
H1R-7D9Q ACHE Inden Piperidine Derivative of Donepezil
H0R-7D9P ACHE Inden Piperidine Derivative of Donepezil
ZINC11996936 ACHE Trifluoro Derivative of Donepezil
ZINC11709541 ACHE Trifluoro Derivative of Donepezil
SCHEMBL24135488 ACHE BCHE Multitarget Calcium Channel Antagonist anti-Abeta-aggregation Derivative of Donepezil Histamine-Receptor3-H3-Antagonist
BIGI-3h ACHE BCHE Multitarget Monoamine-oxidase-inhibitor GSK-3 kinase inhibitor Calcium Channel Antagonist anti-Abeta-aggregation Derivative of Donepezil
MC1420 ACHE Derivative of Donepezil Carboxamide Chromen
BYYT-25 ACHE BCHE Cholinesterase Derivative of Donepezil Inden Pyrrolidine
FG1912 ACHE GSK-3 kinase inhibitor Multitarget Pyridine Piperidine Cyclopropyl Carboxamide Derivative of Donepezil
GD29 ACHE GSK-3 kinase inhibitor Multitarget Thiazole Pyridine Piperidine Cyclopropyl Carboxamide Sulfur Compound Derivative of Donepezil
Donecopride ACHE Multitarget 5-HT-receptor-ligand Derivative of Donepezil Piperidine
Phenolic-deriv-Donecopride-4 ACHE Multitarget 5-HT-receptor-ligand Derivative of Donepezil Piperidine
Phenolic-deriv-Donecopride-20 ACHE Carbamate Multitarget 5-HT-receptor-ligand Derivative of Donepezil Piperidine
Salicylic-donepezil-rivastigmine-5a BCHE Carbamate Derivative of Donepezil Salicylic Derivative of Rivastigmine Benzylpiperidine
Sigma1R-ACHE-6a ACHE Multitarget 5-HT-receptor-ligand Piperidine Sigma1R ligand Indole Derivative of Donepezil
Sigma1R-ACHE-6b ACHE Multitarget 5-HT-receptor-ligand Piperidine Sigma1R ligand Indole Derivative of Donepezil
Donepezil-derivative-DZ7 ACHE Piperidine Derivative of Donepezil Inden
Donepezil-derivative-DZ0 ACHE Piperidine Derivative of Donepezil Inden
5DYT-5hb BCHE Piperidine Derivative of Donepezil Sulfonamide Sulfur Compound Naphthalen
5DYY-5hh BCHE Piperidine Derivative of Donepezil Sulfonamide Sulfur Compound Naphthalen
CHEMBL4293015 BCHE Indole Piperidine Derivative of Donepezil Alkyl linked bis-ligand
Donepezil-8-Hydroxyquinoline-2b BCHE Quinoline Multitarget Antioxidant Derivative of Donepezil
5DYW-5hf-C11 BCHE Piperidine Derivative of Donepezil Sulfur Compound Sulfonamide PET probe Naphthalen
5DYW-5hf-F BCHE Piperidine Derivative of Donepezil Sulfur Compound Sulfonamide PET probe
Benzylpyrrolidin-methyl-N-methylnaphthalene-2-sulfonamide-(R)-(-)-3 Pyrrolidine Derivative of Donepezil Sulfur Compound Sulfonamide Naphthalen
Benzylpyrrolidin-methyl-N-methylnaphthalene-2-sulfonamide-(S)-(+)-3 Pyrrolidine Derivative of Donepezil Sulfur Compound Sulfonamide Naphthalen
5DYW-5hf BCHE Piperidine Derivative of Donepezil Sulfur Compound Sulfonamide Naphthalen
Tacrine-Donepezil-hybrid3 ACHE Derivative of Tacrine Derivative of Donepezil
Mebbpp ACHE Derivative of Donepezil Multitarget Sulfur Compound Piperidine
Donepezil-Melatonin-4u ACHE Derivative of Donepezil Derivative of Tryptamine Indole Alkyl linked bis-ligand Multitarget Antioxidant
Selenepezil ACHE Organoselenium Thiol-reactive Derivative of Donepezil Piperidine
C7653 ACHE Piperidine Derivative of Donepezil
Aricept~Donepezil~E2020 ACHE Derivative of Donepezil Piperidine Drug Inden
N-benzylpiperidine-carbazol-9c BCHE Piperidine Carbazol beta-carboline Derivative of Donepezil Multitarget Benzylpiperidine
TAK-147 ACHE Piperidine Derivative of Donepezil Transition state analogue Benzazepin
Icopezil ACHE Piperidine Derivative of Donepezil Benzoxazol