Derivative of Donepezil

General

Donepezil used in treatment of Alzheimer Disease, trademark is Aricept Reversible inhibitor of AChE but not of BChE. Used as a building block of new inhibitors and also multi-target drug candidates
Inhibitor Main targeted enzyme familyes Type Structure
Aurone-Donepezil-Cpd5g ACHE Flavonoid Benzofuran Multitarget Derivative of Donepezil
Aurone-Donepezil-Cpd6b Flavonoid Benzofuran Multitarget Derivative of Donepezil
Rivastigmine-Donepezil-COR783 Cannabinoid-Receptor-ligand Derivative of Rivastigmine Multitarget Sulfur Compound Derivative of Donepezil Carbamate Adamantyl
Coumarin-dimethoxyphenyl-methylpiperidine-carboxamise-cpd3b ACHE Coumarin Piperidine Carboxamide Derivative of Donepezil Chromen
Benzylpiperidin-methylsulfonyl-indol-acryloyl-phenyl-acetamide-cpd6b BCHE ACHE Multitarget Indole Carboxamide Piperidin Derivative of Donepezil Sulfur Compound
Benzylpiperidin-oxoindolin-acetamide-Cpd23 Derivative of Donepezil Piperidine Indole
Indole-piperidine-amide-cpd23a ACHE Multitarget Indole Carboxamide Derivative of Donepezil BACE1-inhibitor Piperidine
SB-1448 BCHE ACHE Multitarget Derivative of Donepezil BACE1-inhibitor Piperidine
J8-A34 ACHE Piperidine Sulfur Compound Sulfonamide Quinoline Derivative of Donepezil
Compound5d-Benzylpiperidine-Phenyl-oxadiazol-thiol ACHE anti-Abeta-aggregation Sulfur Compound BACE1-inhibitor Piperidine Multitarget Carboxamide Oxadiazol Derivative of Donepezil Cyanide
Compound19n-quinolinol ACHE Trifluoro anti-Abeta-aggregation Metal ion chelator Quinoline Multitarget Derivative of Donepezil
ZINC22029744 ACHE BCHE Multitarget Sulfur Compound Derivative of Donepezil BACE1-inhibitor Piperazine Oxadiazol
WMY90-5f ACHE Quinoline Multitarget Monoamine-oxidase-inhibitor Derivative of Donepezil
DPH6 BCHE ACHE Quinoline Multitarget Monoamine-oxidase-inhibitor Derivative of Donepezil
SCHEMBL1532301 ACHE Indole Isoindole Acridine Alkyl linked bis-ligand Derivative of Tacrine Derivative of Donepezil
C4I-7QHE BCHE Acridine Alkyl linked bis-ligand Derivative of Tacrine Carboxamide Derivative of Donepezil Naphthalen Piperidine
C0I-7QHD BCHE Acridine Alkyl linked bis-ligand Derivative of Tacrine Carboxamide Derivative of Donepezil Indole Piperidine
DFAH-12 BCHE ACHE Piperidine Hydroxycinnamic-ester Multitarget Antioxidant Derivative of Donepezil
Donepezil-idebenone-cpd9 BCHE Multitarget Antioxidant anti-Abeta-aggregation Derivative of Donepezil
Fluoropezil ACHE Multitarget Derivative of Donepezil Sulfur Compound Antioxidant
7QB4-Cpd2 ACHE Monoamine-oxidase-inhibitor Multitarget Coumarin Chromen Derivative of Donepezil
ZINC11996936 ACHE Trifluoro Derivative of Donepezil
ZINC11709541 ACHE Trifluoro Derivative of Donepezil
BIGI-3h ACHE BCHE Multitarget Monoamine-oxidase-inhibitor GSK-3 kinase inhibitor Calcium Channel Antagonist anti-Abeta-aggregation Derivative of Donepezil
MC1420 ACHE Derivative of Donepezil Carboxamide Chromen
BYYT-25 ACHE BCHE Cholinesterase Derivative of Donepezil Inden Pyrrolidine
FG1912 GSK-3 kinase inhibitor Multitarget Pyridine Piperidine Cyclopropyl Carboxamide Derivative of Donepezil
GD29 ACHE GSK-3 kinase inhibitor Multitarget Thiazole Pyridine Piperidine Cyclopropyl Carboxamide Derivative of Donepezil
Donecopride ACHE Multitarget 5-HT-receptor-ligand Derivative of Donepezil Piperidine
Phenolic-deriv-Donecopride-4 Multitarget 5-HT-receptor-ligand Derivative of Donepezil Piperidine
Phenolic-deriv-Donecopride-20 Carbamate Multitarget 5-HT-receptor-ligand Derivative of Donepezil Piperidine
Salicylicdonepezilrivastigmine-5a Carbamate Derivative of Donepezil Salicylic Derivative of Rivastigmine
Sigma1R-ACHE-6a ACHE Multitarget 5-HT-receptor-ligand Piperidine Sigma1R Indole Derivative of Donepezil
Sigma1R-ACHE-6b ACHE Multitarget 5-HT-receptor-ligand Piperidine Sigma1R Indole Derivative of Donepezil
Donepezil-derivative-DZ7 ACHE Piperidine Derivative of Donepezil Inden
Donepezil-derivative-DZ0 ACHE Piperidine Derivative of Donepezil Inden
5DYT-5hb BCHE Piperidine Derivative of Donepezil Sulfonamide Sulfur Compound Naphthalen
5DYY-5hh BCHE Piperidine Derivative of Donepezil Sulfonamide Sulfur Compound Naphthalen
CHEMBL4293015 BCHE Indole Piperidine Derivative of Donepezil Alkyl linked bis-ligand
Donepezil-8-Hydroxyquinoline-2b BCHE Quinoline Multitarget Antioxidant Derivative of Donepezil
5DYW-5hf-C11 BCHE Piperidine Derivative of Donepezil Sulfur Compound Sulfonamide PET probe Naphthalen
5DYW-5hf-F BCHE Piperidine Derivative of Donepezil Sulfur Compound Sulfonamide PET probe
5DYW-5hf BCHE Piperidine Derivative of Donepezil Sulfur Compound Sulfonamide Naphthalen
Tacrine-Donepezil-hybrid3 ACHE Derivative of Tacrine Derivative of Donepezil
Mebbpp ACHE Derivative of Donepezil Multitarget Sulfur Compound Piperidine
Donepezil-Melatonin-4u ACHE Derivative of Donepezil Derivative of Tryptamine Indole Alkyl linked bis-ligand Multitarget Antioxidant
Selenepezil ACHE Organoselenium Thiol-reactive Derivative of Donepezil Piperidine
C7653 ACHE Piperidine Derivative of Donepezil
Aricept~Donepezil~E2020 ACHE Derivative of Donepezil Piperidine Drug Inden
TAK-147 ACHE Piperidine Derivative of Donepezil Transition state analogue Benzazepin
Icopezil ACHE Piperidine Derivative of Donepezil