1. Home
  2. Inhibitor
  3. Fluoropezil

Fluoropezil

AChe IC50 = 2.4 nM. 24r is a mixed-type inhibitor against AChE Ki value equal to 0.4 nM. 24r reduced tau phosphorylation at S396 and Abeta aggregation in the presence of AChE

General

Type : Multitarget,Derivative of Donepezil,Sulfur Compound,Antioxidant

Chemical_Nomenclature : 2-Fluoro-2-((1-(3-fluorobenzyl)piperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydrobenzo[b]thiophene 1,1-dioxide || 2-fluoro-2-[[1-[(3-fluorophenyl)methyl]piperidin-4-yl]methyl]-5,6-dimethoxy-3H-1-benzothiophene 1,1-dioxide

Canonical SMILES : C1=CC(=CC(=C1)CN2CCC(CC2)CC4(CC3=CC(=C(C=C3[S]4(=O)=O)OC)OC)F)F || COC1=C(C=C2C(=C1)CC(S2(=O)=O)(CC3CCN(CC3)CC4=CC(=CC=C4)F)F)OC

InChI : InChI=1S\/C23H27F2NO4S\/c1-29-20-11-18-14-23(25,31(27,28)22(18)12-21(20)30-2)13-16-6-8-26(9-7-16)15-17-4-3-5-19(24)10-17\/h3-5,10-12,16H,6-9,13-15H2,1-2H3

InChIKey : IVJYMZOWJKEUNR-UHFFFAOYSA-N

Other name(s) : Donepezil-sulfone-analogue-24r,AChE-IN-10,24r,Donepezil sulfone analogue 24r,DC20,DC511020,HY-144775,CS-0434465

MW : 451.52

Formula : C23H27F2NO4S

CAS_number :

PubChem : 163409065

UniChem : IVJYMZOWJKEUNR-UHFFFAOYSA-N

Target

Families : Fluoropezil ligand of proteins in family
ACHE

Protein :
human-ACHE

References (4)

Title : Novel inhibitors of AChE and Abeta aggregation with neuroprotective properties as lead compounds for the treatment of Alzheimer's disease - Liu_2022_Eur.J.Med.Chem_235_114305
Author(s) : Liu Y , Uras G , Onuwaje I , Li W , Yao H , Xu S , Li X , Phillips J , Allen S , Gong Q , Zhang H , Zhu Z , Liu J , Xu J
Ref : Eur Journal of Medicinal Chemistry , 235 :114305 , 2022
Abstract : Liu_2022_Eur.J.Med.Chem_235_114305
ESTHER : Liu_2022_Eur.J.Med.Chem_235_114305
PubMedSearch : Liu_2022_Eur.J.Med.Chem_235_114305
PubMedID: 35339839

Title : LC-MS\/MS assay of fluoropezil and its two major metabolites in human plasma: an application to pharmacokinetic studies - Guo_2022_Bioanalysis_14_817
Author(s) : Guo R , Hu J , Jing J , Liu Y , Li J , Zhou Y , Liu H , Zhou L , Chen X
Ref : Bioanalysis , 14 :817 , 2022
Abstract : Guo_2022_Bioanalysis_14_817
ESTHER : Guo_2022_Bioanalysis_14_817
PubMedSearch : Guo_2022_Bioanalysis_14_817
PubMedID: 35735138

Title : Safety, tolerability, and pharmacokinetics of fluoropezil (DC20), a novel AChE inhibitor: a singlecenter, phase I study in healthy young and elderly Chinese subjects - Qian_2022_ResearchSquare__
Author(s) : Qian H , Yu C , Zhu H , Ding Q , Cai Y , Jing J , Xu X , Guo R , Zhang H , Liu H , Chen X , Liu Y
Ref : ResearchSquare , : , 2022
Abstract : Qian_2022_ResearchSquare__
ESTHER : Qian_2022_ResearchSquare__
PubMedSearch : Qian_2022_ResearchSquare__
PubMedID:

Title : Desorption electrospray ionization (DESI) source coupling ion mobility mass spectrometry for imaging fluoropezil (DC20) distribution in rat brain - Guo_2021_Anal.Bioanal.Chem_413_5835
Author(s) : Guo R , Zhou L , Chen X
Ref : Anal Bioanal Chem , 413 :5835 , 2021
Abstract : Guo_2021_Anal.Bioanal.Chem_413_5835
ESTHER : Guo_2021_Anal.Bioanal.Chem_413_5835
PubMedSearch : Guo_2021_Anal.Bioanal.Chem_413_5835
PubMedID: 34405263 
Array
(
    [id] => 1224
    [inhibitor] => Fluoropezil
    [type] => Array
        (
            [0] => Multitarget
            [1] => Derivative of Donepezil
            [2] => Sulfur Compound
            [3] => Antioxidant
        )

    [other_name] => Array
        (
            [0] => Donepezil-sulfone-analogue-24r
            [1] => AChE-IN-10
            [2] => 24r
            [3] => Donepezil sulfone analogue 24r
            [4] => DC20
            [5] => DC511020
            [6] => HY-144775
            [7] => CS-0434465
        )

    [chemical_nomenclature] => 2-Fluoro-2-((1-(3-fluorobenzyl)piperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydrobenzo[b]thiophene 1,1-dioxide || 2-fluoro-2-[[1-[(3-fluorophenyl)methyl]piperidin-4-yl]methyl]-5,6-dimethoxy-3H-1-benzothiophene 1,1-dioxide
    [formula] => C23H27F2NO4S
    [cas_number] => 
    [mw] => 451.52
    [pick_me_to_call] => display_script
    [kinetic_parameter] => 
    [paper] => Liu_2022_Eur.J.Med.Chem_235_114305 || Guo_2022_Bioanalysis_14_817 || Guo_2021_Anal.Bioanal.Chem_413_5835 || Qian_2022_ResearchSquare__
    [comment] => AChe  IC50 = 2.4 nM.  24r is a mixed-type inhibitor against AChE Ki value equal to 0.4 nM. 24r reduced tau phosphorylation at S396 and Abeta aggregation in the presence of AChE
    [gene_locus] => human-ACHE
    [kin_inhibitor] => 
    [cid] => 163409065
    [family] => ACHE
    [inchikey] => IVJYMZOWJKEUNR-UHFFFAOYSA-N
    [canonicalsmiles] => C1=CC(=CC(=C1)CN2CCC(CC2)CC4(CC3=CC(=C(C=C3[S]4(=O)=O)OC)OC)F)F || COC1=C(C=C2C(=C1)CC(S2(=O)=O)(CC3CCN(CC3)CC4=CC(=CC=C4)F)F)OC
    [inchi] => InChI=1S\/C23H27F2NO4S\/c1-29-20-11-18-14-23(25,31(27,28)22(18)12-21(20)30-2)13-16-6-8-26(9-7-16)15-17-4-3-5-19(24)10-17\/h3-5,10-12,16H,6-9,13-15H2,1-2H3
    [wikipedia] => 
    [iupharlig] => 
    [structure] => 
    [substrate] => 
    [interact_gene_locus] => 
    [mutation] => 
    [comment2] => 
    [extoxnet] => 
    [news] => 
    [theoretical_model] => 
)