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MF217

General

Type : Derivative of physostigmine-eserine,Carbamate,Morpholine,Indole

Chemical_Nomenclature : [(3aR,8bS)-3,4,8b-trimethyl-2,3a-dihydro-1H-pyrrolo[2,3-b]indol-7-yl] N-(8-morpholin-4-yloctyl)carbamate

Canonical SMILES : CC12CCN(C1N(C3=C2C=C(C=C3)OC(=O)NCCCCCCCCN4CCOCC4)C)C

InChI : InChI=1S\/C26H42N4O3\/c1-26-12-15-28(2)24(26)29(3)23-11-10-21(20-22(23)26)33-25(31)27-13-8-6-4-5-7-9-14-30-16-18-32-19-17-30\/h10-11,20,24H,4-9,12-19H2,1-3H3,(H,27,31)\/t24-,26+\/m1\/s1

InChIKey : PLDHPJSOABLSHM-RSXGOPAZSA-N

Other name(s) : MF 217,CHEMBL65018,Morphlinyloctylcarbamoyleseroline,Carbamic acid, (8-(4-morpholinyl)octyl)-, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo(2,3-b)indol-5-yl ester, (3aS-cis)-,AC1MINCM,8-Morpholinoctylphysostigmine,Morpholinoctylcarbamoyleseroline,MF-217

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MW : 458.637

Formula : C26H42N4O3

CAS_number : 154619-56-4

PubChem : 3074014

UniChem : PLDHPJSOABLSHM-RSXGOPAZSA-N

Target

Families : MF217 ligand of proteins in family
ACHE

References (1)

1. Long chain analogs of physostigmine as potential drugs for Alzheimer's disease: new insights into the mechanism of action in the inhibition of acetylcholinesterase.

Title : Long chain analogs of physostigmine as potential drugs for Alzheimer's disease: new insights into the mechanism of action in the inhibition of acetylcholinesterase. - Perola_1997_Biochim.Biophys.Acta_1343_41

Author(s) : Perola E , Cellai L , Lamba D , Filocamo L , Brufani M

Ref : Biochimica & Biophysica Acta , 1343 :41 , 1997

Abstract : Perola_1997_Biochim.Biophys.Acta_1343_41

ESTHER : Perola_1997_Biochim.Biophys.Acta_1343_41

PubMedSearch : Perola_1997_Biochim.Biophys.Acta_1343_41

PubMedID: 9428657

Array
(
    [id] => 5349
    [inhibitor] => MF217
    [type] => Array
        (
            [0] => Derivative of physostigmine-eserine
            [1] => Carbamate
            [2] => Morpholine
            [3] => Indole
        )

    [other_name] => Array
        (
            [0] => MF 217
            [1] => CHEMBL65018
            [2] => Morphlinyloctylcarbamoyleseroline
            [3] => Carbamic acid, (8-(4-morpholinyl)octyl)-, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo(2,3-b)indol-5-yl ester, (3aS-cis)-
            [4] => AC1MINCM
            [5] => 8-Morpholinoctylphysostigmine
            [6] => Morpholinoctylcarbamoyleseroline
            [7] => MF-217
        )

    [chemical_nomenclature] => [(3aR,8bS)-3,4,8b-trimethyl-2,3a-dihydro-1H-pyrrolo[2,3-b]indol-7-yl] N-(8-morpholin-4-yloctyl)carbamate
    [formula] => C26H42N4O3
    [cas_number] => 154619-56-4
    [mw] => 458.637
    [pick_me_to_call] => display_script
    [kinetic_parameter] => 
    [paper] => Perola_1997_Biochim.Biophys.Acta_1343_41
    [comment] => 
    [gene_locus] => 
    [kin_inhibitor] => 
    [cid] => 3074014
    [family] => ACHE
    [inchikey] => PLDHPJSOABLSHM-RSXGOPAZSA-N
    [canonicalsmiles] => CC12CCN(C1N(C3=C2C=C(C=C3)OC(=O)NCCCCCCCCN4CCOCC4)C)C
    [inchi] => InChI=1S\/C26H42N4O3\/c1-26-12-15-28(2)24(26)29(3)23-11-10-21(20-22(23)26)33-25(31)27-13-8-6-4-5-7-9-14-30-16-18-32-19-17-30\/h10-11,20,24H,4-9,12-19H2,1-3H3,(H,27,31)\/t24-,26+\/m1\/s1
    [wikipedia] => 
    [iupharlig] => 
    [structure] => 
    [substrate] => 
    [interact_gene_locus] => 
    [mutation] => 
    [comment2] => 
    [extoxnet] => 
    [news] => 
    [theoretical_model] => 
)