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217-AO

Tertiary analogue of Echothiophate

General

Type : Organophosphate,Sulfur Compound,Organothiophosphate

Chemical_Nomenclature : 2-diethoxyphosphorylsulfanyl-N,N-dimethylethanamine

Canonical SMILES : CCOP(=O)(OCC)SCCN(C)C

InChI : InChI=1S\/C8H20NO3PS\/c1-5-11-13(10,12-6-2)14-8-7-9(3)4\/h5-8H2,1-4H3

InChIKey : GRPHSFSJUDRMKP-UHFFFAOYSA-N || PXPPTYPWWLDKPW-UHFFFAOYSA-N

Other name(s) : O,O'-diethyl S-ethyldimethylaminephosphorothiolate acidoxalate,(2-mercaptoethyl)dimethylamine acidoxalate O,O'-diethylphosphorothioate,217AO,CHEMBL3277096,BRN 1780326,S-[2-(dimethylamino)ethyl] o,o-diethyl phosphorothioate,S-(2-(N,N-Dimethylamino)ethyl)O,O-diethyl phosphorothiolate,Diethoxy-(2-dimethylaminoethylthio)phosphine oxide oxalate,Phosphorothioic acid, O,O-diethyl-S-(2-(dimethylamino)ethyl)ester, oxalate,Phosphorothioic acid, O,O-diethyl ester, S-ester with 2-dimethylaminoethanol, oxalate

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MW : 241.28

Formula : C8H20NO3PS

CAS_number : 3147-20-4 || 470-94-0

PubChem : 68053, 68052

UniChem : GRPHSFSJUDRMKP-UHFFFAOYSA-N || PXPPTYPWWLDKPW-UHFFFAOYSA-N

Target

Families : 217-AO ligand of proteins in family
ACHE

References (3)

1. On the origin and fate of external acetylcholinesterase in peripheral nerve

Title : On the origin and fate of external acetylcholinesterase in peripheral nerve - Brimijoin_1978_J.Physiol_285_143

Author(s) : Brimijoin S , Skau KA , Wiermaa MJ

Ref : The Journal of Physiology , 285 :143 , 1978

Abstract : Brimijoin_1978_J.Physiol_285_143

ESTHER : Brimijoin_1978_J.Physiol_285_143

PubMedSearch : Brimijoin_1978_J.Physiol_285_143

PubMedID: 84869

2. Sodium transport by the acetylcholine receptor of cultured muscle cells

Title : Sodium transport by the acetylcholine receptor of cultured muscle cells - Catterall_1975_J.Biol.Chem_250_1776

Author(s) : Catterall WA

Ref : Journal of Biological Chemistry , 250 :1776 , 1975

Abstract : Catterall_1975_J.Biol.Chem_250_1776

ESTHER : Catterall_1975_J.Biol.Chem_250_1776

PubMedSearch : Catterall_1975_J.Biol.Chem_250_1776

PubMedID: 1167546

3. Differential effects of quaternary cholinesterase inhibitor, phospholine, and its tertiary analogue, compound 217-AO, on central control of respiration and on neuromuscular transmission. The antagonism by 217-AO of the respiratory arrest caused by morphine

Title : Differential effects of quaternary cholinesterase inhibitor, phospholine, and its tertiary analogue, compound 217-AO, on central control of respiration and on neuromuscular transmission. The antagonism by 217-AO of the respiratory arrest caused by morphine -

Author(s) : Schaumann W , Job C

Ref : Journal of Pharmacology & Experimental Therapeutics , 123 :114 , 1958

PubMedID: 13550065

Array
(
    [id] => 4653
    [inhibitor] => 217-AO
    [type] => Array
        (
            [0] => Organophosphate
            [1] => Sulfur Compound
            [2] => Organothiophosphate
        )

    [other_name] => Array
        (
            [0] => O,O'-diethyl S-ethyldimethylaminephosphorothiolate acidoxalate
            [1] => (2-mercaptoethyl)dimethylamine acidoxalate O,O'-diethylphosphorothioate
            [2] => 217AO
            [3] => CHEMBL3277096
            [4] => BRN 1780326
            [5] => S-[2-(dimethylamino)ethyl] o,o-diethyl phosphorothioate
            [6] => S-(2-(N,N-Dimethylamino)ethyl)O,O-diethyl phosphorothiolate
            [7] => Diethoxy-(2-dimethylaminoethylthio)phosphine oxide oxalate
            [8] => Phosphorothioic acid, O,O-diethyl-S-(2-(dimethylamino)ethyl)ester, oxalate
            [9] => Phosphorothioic acid, O,O-diethyl ester, S-ester with 2-dimethylaminoethanol, oxalate
        )

    [chemical_nomenclature] => 2-diethoxyphosphorylsulfanyl-N,N-dimethylethanamine
    [formula] => C8H20NO3PS
    [cas_number] => 3147-20-4 || 470-94-0
    [mw] => 241.28
    [pick_me_to_call] => display_script
    [kinetic_parameter] => 
    [paper] => Brimijoin_1978_J.Physiol_285_143 || Catterall_1975_J.Biol.Chem_250_1776 || Schaumann_1958_J.Pharmacol.Exp.Therap_123_114
    [comment] => Tertiary analogue of Echothiophate
    [gene_locus] => 
    [kin_inhibitor] => 
    [cid] => 68053 || 68052
    [family] => ACHE
    [inchikey] => GRPHSFSJUDRMKP-UHFFFAOYSA-N || PXPPTYPWWLDKPW-UHFFFAOYSA-N
    [canonicalsmiles] => CCOP(=O)(OCC)SCCN(C)C
    [inchi] => InChI=1S\/C8H20NO3PS\/c1-5-11-13(10,12-6-2)14-8-7-9(3)4\/h5-8H2,1-4H3
    [wikipedia] => 
    [iupharlig] => 
    [structure] => 
    [substrate] => 
    [interact_gene_locus] => 
    [mutation] => 
    [comment2] => 
    [extoxnet] => 
    [news] => 
    [theoretical_model] => 
)