3-(Dimethylamino)-N-propanamide-Tryptanthrin
Inhibition : IC50 hACHE 12.17 +/- 1.50 nM hBCHE 6293 +/- 488 nM
General
Type : Derivative of Deoxyvasicinone,Quinazoline,Indole
Chemical_Nomenclature : 3-(Dimethylamino)-N-[6,12-dioxo-6,12-dihydroindolo(2,1-b)quinazolin-2-yl]propanamide
Canonical SMILES : C12=CC(=CC=C1N=C3N(C2=O)C4=C(C3=O)C=CC=C4)NC(=O)CCN(C)C
InChI : InChI=1S\/C20H18N4O3\/c1-23(2)10-9-17(25)21-12-7-8-15-14(11-12)20(27)24-16-6-4-3-5-13(16)18(26)19(24)22-15\/h3-8,11H,9-10H2,1-2H3,(H,21,25)
InChIKey : RBQDDGRIOJVGRE-UHFFFAOYSA-N
Other name(s) :
MW : 362.38
Formula : C20H18N4O3
CAS_number :
PubChem :
UniChem : RBQDDGRIOJVGRE-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
-N-propanamide-Tryptanthrin.gif)
Target
Families : 3-(Dimethylamino)-N-propanamide-Tryptanthrin ligand of proteins in family: ACHE
Stucture :
Protein : human-ACHE
References (1)
| Title : Design, synthesis, and biological evaluation of novel tryptanthrin derivatives as selective acetylcholinesterase inhibitors for the treatment of Alzheimer's disease - Xia_2023_Bioorg.Chem_143_106980 |
| Author(s) : Xia J , Dong S , Yang L , Wang F , Xing S , Du J , Li Z |
| Ref : Bioorg Chem , 143 :106980 , 2023 |
| Abstract : Xia_2023_Bioorg.Chem_143_106980 |
| ESTHER : Xia_2023_Bioorg.Chem_143_106980 |
| PubMedSearch : Xia_2023_Bioorg.Chem_143_106980 |
| PubMedID: 38006789 |