Natural organophosphate inhibitor of Acetylcholinesterase isolated from cultures of Streptomyces antibioticus strain DSM 1951. Compound very close to Cyclophostin described by Kurokawa 1993 J.Antibiot.(Tokyo) 46 1315. IC50 for AChE of 500 nM
Out of three most important classes of synthetic insecticides only the carbamates and pyrethroids were known to have ancestors in nature. Now two organophosphates (which are quite good insecticides and very potent acetylcholinesterase inhibitors, e.g. comparable to carbofuran) have been isolated from Streptomyces antibiotices antibioticus strain DSM 1951.
