Glimepiride
Glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Sulfonylureas are one of the insulin secretagogues widely used for the management of type 2 diabetes to lower blood glucose levels. . Glimepiride blocks ATP-sensitive potassium channels (KATP channels) and causing depolarization of the beta cells. It is also an inhibitor of epoxide hydrolase
General
Type : Sulfonamide,Sulfur Compound,Carboxamide,Urea derivative
Chemical_Nomenclature : 4-ethyl-3-methyl-N-[2-[4-[(4-methylcyclohexyl)carbamoylsulfamoyl]phenyl]ethyl]-5-oxo-2H-pyrrole-1-carboxamide
Canonical SMILES : CCC1=C(CN(C1=O)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCC(CC3)C)C
InChI : InChI=1S\/C24H34N4O5S\/c1-4-21-17(3)15-28(22(21)29)24(31)25-14-13-18-7-11-20(12-8-18)34(32,33)27-23(30)26-19-9-5-16(2)6-10-19\/h7-8,11-12,16,19H,4-6,9-10,13-15H2,1-3H3,(H,25,31)(H2,26,27,30)
InChIKey : WIGIZIANZCJQQY-UHFFFAOYSA-N
Other name(s) : Amaryl,Amarel,Glimepirid,CHEMBL1481,SCHEMBL8738802,SCHEMBL14371714,SCHEMBL14965363,CHEBI:92609
MW : 490.6
Formula : C24H34N4O5S
CAS_number : 93479-97-1
PubChem : 3476
UniChem : WIGIZIANZCJQQY-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families : Glimepiride ligand of proteins in family: Epoxide_hydrolase
Stucture :
Protein : human-EPHX2
References (1)
| Title : Glimepiride, a novel soluble epoxide hydrolase inhibitor, protects against heart failure via increasing epoxyeicosatrienoic acids - Zhao_2023_J.Mol.Cell.Cardiol_185_13 |
| Author(s) : Zhao C , Jiang X , Peng L , Zhang Y , Li H , Zhang Q , Wang Y , Yang F , Wu J , Wen Z , He Z , Shen J , Chen C , Wang DW |
| Ref : Journal of Molecular & Cellular Cardiology , 185 :13 , 2023 |
| Abstract : Zhao_2023_J.Mol.Cell.Cardiol_185_13 |
| ESTHER : Zhao_2023_J.Mol.Cell.Cardiol_185_13 |
| PubMedSearch : Zhao_2023_J.Mol.Cell.Cardiol_185_13 |
| PubMedID: 37871528 |