H327
N-salicyloyl tryptamine-carbamate eqBChE IC50 = 0.057 +/- 0.005 microM
General
Type : Carbamate,Derivative of Tryptamine,Indole
Chemical_Nomenclature : 2-((2-(5-chloro-1H-indol-3-yl)ethyl)carbamoyl)-5-methylphenyl methoxy (methyl) carbamate
Canonical SMILES : C1(=CC=C2C(=C1)C(=C[N]2)CCNC(=O)C3=C(C=C(C=C3)C)OC(=O)N(OC)C)Cl
InChI : InChI=1S\/C21H22ClN3O4\/c1-13-4-6-16(19(10-13)29-21(27)25(2)28-3)20(26)23-9-8-14-12-24-18-7-5-15(22)11-17(14)18\/h4-7,10-12,24H,8-9H2,1-3H3,(H,23,26)
InChIKey : YYACRVSEYDEYHN-UHFFFAOYSA-N
Other name(s) :
MW : 415.87
Formula : C21H22ClN3O4
CAS_number :
PubChem :
UniChem : YYACRVSEYDEYHN-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
References (2)
| Title : Discovery of carbamate-based N-salicyloyl tryptamine derivatives as novel pleiotropic agents for the treatment of Alzheimer's disease - Wang_2022_Bioorg.Chem_127_105993 |
| Author(s) : Wang Y , Zhang H , Liu D , Li X , Long L , Peng Y , Qi F , Jiang W , Wang Z |
| Ref : Bioorg Chem , 127 :105993 , 2022 |
| Abstract : Wang_2022_Bioorg.Chem_127_105993 |
| ESTHER : Wang_2022_Bioorg.Chem_127_105993 |
| PubMedSearch : Wang_2022_Bioorg.Chem_127_105993 |
| PubMedID: 35834980 |
| Title : Design, synthesis, and biological evaluation of carbamate derivatives of N-salicyloyl tryptamine as multifunctional agents for the treatment of Alzheimer's disease - Liu_2022_Eur.J.Med.Chem_229_114044 |
| Author(s) : Liu D , Zhang H , Wang Y , Liu W , Yin G , Wang D , Li J , Shi T , Wang Z |
| Ref : Eur Journal of Medicinal Chemistry , 229 :114044 , 2022 |
| Abstract : Liu_2022_Eur.J.Med.Chem_229_114044 |
| ESTHER : Liu_2022_Eur.J.Med.Chem_229_114044 |
| PubMedSearch : Liu_2022_Eur.J.Med.Chem_229_114044 |
| PubMedID: 34923430 |