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Mahanimbine

Mahanimbine is a natural product found in Murraya euchrestifolia, Murraya siamensis. Found together with Galanthamine

General

Type : Natural,Alkaloid

Chemical_Nomenclature : 3,5-dimethyl-3-(4-methylpent-3-enyl)-11H-pyrano[3,2-a]carbazole

Canonical SMILES : CC1=CC2=C(C3=C1OC(C=C3)(C)CCC=C(C)C)NC4=CC=CC=C42

InChI : InChI=1S\/C23H25NO\/c1-15(2)8-7-12-23(4)13-11-18-21-19(14-16(3)22(18)25-23)17-9-5-6-10-20(17)24-21\/h5-6,8-11,13-14,24H,7,12H2,1-4H3

InChIKey : HTNVFUBCWIYPJN-UHFFFAOYSA-N

Other name(s) : (+)-Mahanimbine,CHEBI:6646,Rel-(+)-Mahanimbine,CHEMBL495873

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MW : 331.4

Formula : C23H25NO

CAS_number : 21104-28-9

PubChem : 167963

UniChem : HTNVFUBCWIYPJN-UHFFFAOYSA-N

Target

References (3)

1. Mahanimbine Improved Aging-Related Memory Deficits in Mice through Enhanced Cholinergic Transmission and Suppressed Oxidative Stress, Amyloid Levels, and Neuroinflammation

Title : Mahanimbine Improved Aging-Related Memory Deficits in Mice through Enhanced Cholinergic Transmission and Suppressed Oxidative Stress, Amyloid Levels, and Neuroinflammation - Mani_2021_Brain.Sci_12_12

Author(s) : Mani V , Mohd Azahan NS , Ramasamy K , Lim SM , Abdul Majeed AB

Ref : Brain Sci , 12 :12 , 2021

Abstract : Mani_2021_Brain.Sci_12_12

ESTHER : Mani_2021_Brain.Sci_12_12

PubMedSearch : Mani_2021_Brain.Sci_12_12

PubMedID: 35053756

2. Acetylcholinesterase inhibitory potential of a carbazole alkaloid, mahanimbine, from Murraya koenigii

Title : Acetylcholinesterase inhibitory potential of a carbazole alkaloid, mahanimbine, from Murraya koenigii - Kumar_2010_Phytother.Res_24_629

Author(s) : Kumar NS , Mukherjee PK , Bhadra S , Saha BP , Pal BC

Ref : Phytother Res , 24 :629 , 2010

Abstract : Kumar_2010_Phytother.Res_24_629

ESTHER : Kumar_2010_Phytother.Res_24_629

PubMedSearch : Kumar_2010_Phytother.Res_24_629

PubMedID: 19943242

3. Pancreatic lipase inhibitory alkaloids of Murraya koenigii leaves

Title : Pancreatic lipase inhibitory alkaloids of Murraya koenigii leaves - Birari_2009_Nat.Prod.Commun_4_1089

Author(s) : Birari R , Roy SK , Singh A , Bhutani KK

Ref : Nat Prod Commun , 4 :1089 , 2009

Abstract : Birari_2009_Nat.Prod.Commun_4_1089

ESTHER : Birari_2009_Nat.Prod.Commun_4_1089

PubMedSearch : Birari_2009_Nat.Prod.Commun_4_1089

PubMedID: 19768989

Array
(
    [id] => 5187
    [inhibitor] => Mahanimbine
    [type] => Array
        (
            [0] => Natural
            [1] => Alkaloid
        )

    [other_name] => Array
        (
            [0] => (+)-Mahanimbine
            [1] => CHEBI:6646
            [2] => Rel-(+)-Mahanimbine
            [3] => CHEMBL495873
        )

    [chemical_nomenclature] => 3,5-dimethyl-3-(4-methylpent-3-enyl)-11H-pyrano[3,2-a]carbazole
    [formula] => C23H25NO
    [cas_number] => 21104-28-9
    [mw] => 331.4
    [pick_me_to_call] => display_script
    [kinetic_parameter] => 
    [paper] => Kumar_2010_Phytother.Res_24_629 || Birari_2009_Nat.Prod.Commun_4_1089 || Mani_2021_Brain.Sci_12_12
    [comment] => Mahanimbine is a natural product found in Murraya euchrestifolia, Murraya siamensis. Found together with Galanthamine
    [gene_locus] => 
    [kin_inhibitor] => 
    [cid] => 167963
    [family] => 
    [inchikey] => HTNVFUBCWIYPJN-UHFFFAOYSA-N
    [canonicalsmiles] => CC1=CC2=C(C3=C1OC(C=C3)(C)CCC=C(C)C)NC4=CC=CC=C42
    [inchi] => InChI=1S\/C23H25NO\/c1-15(2)8-7-12-23(4)13-11-18-21-19(14-16(3)22(18)25-23)17-9-5-6-10-20(17)24-21\/h5-6,8-11,13-14,24H,7,12H2,1-4H3
    [wikipedia] => 
    [iupharlig] => 
    [structure] => 
    [substrate] => 
    [interact_gene_locus] => 
    [mutation] => 
    [comment2] => 
    [extoxnet] => 
    [news] => 
    [theoretical_model] => 
)