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Inhibitor Report for: N-acetylserotonin

N-Acetylserotonin is an intermediate in the metabolic pathway of melatonin and indoleamine in the pineal gland of mammalians. In most mammalian species the content of NAS (and melatonin) in the pineal gland shows clear circadian changes with the highest level occurring during the dark period. Experimental studies show that N-acetylserotonin possess free radical scavenging activity.


General
Type Derivative of Tryptamine, Not A/B H target, Natural
Chemical_Nomenclature N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]acetamide
Canonical SMILES CC(=O)NCCC1=CNC2=C1C=C(C=C2)O
InChI InChI=1S/C12H14N2O2/c1-8(15)13-5-4-9-7-14-12-3-2-10(16)6-11(9)12/h2-3,6-7,14,16H,4-5H2,1H3,(H,13,15)
InChIKey MVAWJSIDNICKHF-UHFFFAOYSA-N
Other name(s) N-Acetyl-5-hydroxytryptamine ; N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]acetamide ; Normelatonin ; CHEMBL33103 ; CHEBI:17697 ; ZINC66104 ; DB04275 ; Desmethylmelatonin
________________________________________________________________________________________________
MW|218.25
Formula|C12H14N2O2
CAS_number|1210-83-9
PubChem|903
UniChem|MVAWJSIDNICKHF-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | N-acetylserotonin ligand of proteins in family: Pectinacetylesterase-Notum
Stucture | 1 structure: 6TR6: N-acetylserotonin-Notum complex
Protein | human-NOTUM

References:
Search PubMed for references concerning: N-acetylserotonin
    Title: Structural characterisation of melatonin as an inhibitor of the Wnt deacylase Notum
    Zhao Y, Ren J, Hillier J, Jones M, Lu W, Jones EY
    Ref: J Pineal Res, :e12630, 2019 : PubMed