| Title : Designed switch from covalent to non-covalent inhibitors of carboxylesterase Notum activity - Atkinson_2023_Eur.J.Med.Chem_251_115132 |
| Author(s) : Atkinson BN , Willis NJ , Zhao Y , Patel C , Frew S , Costelloe K , Magno L , Svensson F , Jones EY , Fish PV |
| Ref : Eur Journal of Medicinal Chemistry , 251 :115132 , 2023 |
| Abstract : |
| PubMedSearch : Atkinson_2023_Eur.J.Med.Chem_251_115132 |
| PubMedID: 36934521 |
| Gene_locus related to this paper: human-NOTUM |
| Title : Structural Analysis and Development of Notum Fragment Screening Hits - Zhao_2022_ACS.Chem.Neurosci_13_2060 |
| Author(s) : Zhao Y , Mahy W , Willis NJ , Woodward HL , Steadman D , Bayle ED , Atkinson BN , Sipthorp J , Vecchia L , Ruza RR , Harlos K , Jeganathan F , Constantinou S , Costa A , Kjaer S , Bictash M , Salinas PC , Whiting P , Vincent JP , Fish PV , Jones EY |
| Ref : ACS Chem Neurosci , 13 :2060 , 2022 |
| Abstract : |
| PubMedSearch : Zhao_2022_ACS.Chem.Neurosci_13_2060 |
| PubMedID: 35731924 |
| Gene_locus related to this paper: human-NOTUM |
| Title : Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity - Steadman_2022_J.Med.Chem_65_562 |
| Author(s) : Steadman D , Atkinson BN , Zhao Y , Willis NJ , Frew S , Monaghan A , Patel C , Armstrong E , Costelloe K , Magno L , Bictash M , Jones EY , Fish PV , Svensson F |
| Ref : Journal of Medicinal Chemistry , 65 :562 , 2022 |
| Abstract : |
| PubMedSearch : Steadman_2022_J.Med.Chem_65_562 |
| PubMedID: 34939789 |
| Gene_locus related to this paper: human-NOTUM |
| Title : Design of a potent, selective and brain penetrant inhibitor of Wnt-deactivating enzyme Notum by optimization of a crystallographic fragment hit - Willis_2022_J.Med.Chem_65_7212 |
| Author(s) : Willis NJ , Mahy W , Sipthorp J , Zhao Y , Woodward HL , Atkinson BN , Bayle ED , Svensson F , Frew S , Jeganathan F , Monaghan A , Benvegnu S , Jolly S , Vecchia L , Ruza RR , Kjaer S , Howell SA , Snidjers AP , Bictash M , Salinas PC , Vincent JP , Jones EY , Whiting P , Fish PV |
| Ref : Journal of Medicinal Chemistry , 65 :7212 , 2022 |
| Abstract : |
| PubMedSearch : Willis_2022_J.Med.Chem_65_7212 |
| PubMedID: 35536179 |
| Gene_locus related to this paper: human-NOTUM |
| Title : Structural Insights into Notum Covalent Inhibition - Zhao_2021_J.Med.Chem_64_11354 |
| Author(s) : Zhao Y , Svensson F , Steadman D , Frew S , Monaghan A , Bictash M , Moreira T , Chalk R , Lu W , Fish PV , Jones EY |
| Ref : Journal of Medicinal Chemistry , 64 :11354 , 2021 |
| Abstract : |
| PubMedSearch : Zhao_2021_J.Med.Chem_64_11354 |
| PubMedID: 34292747 |
| Gene_locus related to this paper: human-NOTUM |
| Title : NOTUM from Apc-mutant cells biases clonal competition to initiate cancer - Flanagan_2021_Nature__ |
| Author(s) : Flanagan DJ , Pentinmikko N , Luopajarvi K , Willis NJ , Gilroy K , Raven AP , McGarry L , Englund JI , Webb AT , Scharaw S , Nasreddin N , Hodder MC , Ridgway RA , Minnee E , Sphyris N , Gilchrist E , Najumudeen AK , Romagnolo B , Perret C , Williams AC , Clevers H , Nummela P , Lahde M , Alitalo K , Hietakangas V , Hedley A , Clark W , Nixon C , Kirschner K , Jones EY , Ristimaki A , Leedham SJ , Fish PV , Vincent JP , Katajisto P , Sansom OJ |
| Ref : Nature , : , 2021 |
| Abstract : |
| PubMedSearch : Flanagan_2021_Nature__ |
| PubMedID: 34079124 |
| Gene_locus related to this paper: human-NOTUM |
| Title : Small-molecule inhibitors of carboxylesterase Notum - Zhao_2021_Future.Med.Chem__ |
| Author(s) : Zhao Y , Jolly S , Benvegnu S , Jones EY , Fish PV |
| Ref : Future Med Chem , : , 2021 |
| Abstract : |
| PubMedSearch : Zhao_2021_Future.Med.Chem__ |
| PubMedID: 33882714 |
| Gene_locus related to this paper: human-NOTUM |
| Title : Notum Deacylates Octanoylated Ghrelin - Zhao_2021_Mol.Metab__101201 |
| Author(s) : Zhao Y , Schuhmacher LN , Roberts M , Kakugawa S , Bineva-Todd G , Howell S , O'Reilly N , Perret C , Snijders AP , Vincent JP , Jones EY |
| Ref : Mol Metab , :101201 , 2021 |
| Abstract : |
| PubMedSearch : Zhao_2021_Mol.Metab__101201 |
| PubMedID: 33647468 |
| Gene_locus related to this paper: human-NOTUM |
| Title : 5-Phenyl-1,3,4-oxadiazol-2(3H)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit - Mahy_2020_J.Med.Chem_63_12942 |
| Author(s) : Mahy W , Willis NJ , Zhao Y , Woodward HL , Svensson F , Sipthorp J , Vecchia L , Ruza RR , Hillier J , Kjr S , Frew S , Monaghan A , Bictash M , Salinas PC , Whiting P , Vincent JP , Jones EY , Fish PV |
| Ref : Journal of Medicinal Chemistry , 63 :12942 , 2020 |
| Abstract : |
| PubMedSearch : Mahy_2020_J.Med.Chem_63_12942 |
| PubMedID: 33124429 |
| Gene_locus related to this paper: human-NOTUM |
| Title : Caffeine inhibits Notum activity by binding at the catalytic pocket - Zhao_2020_Commun.Biol_3_555 |
| Author(s) : Zhao Y , Ren J , Hillier J , Lu W , Jones EY |
| Ref : Commun Biol , 3 :555 , 2020 |
| Abstract : |
| PubMedSearch : Zhao_2020_Commun.Biol_3_555 |
| PubMedID: 33033363 |
| Gene_locus related to this paper: human-NOTUM |
| Title : Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity - Mahy_2020_J.Med.Chem_63_9464 |
| Author(s) : Mahy W , Patel M , Steadman D , Woodward HL , Atkinson BN , Svensson F , Willis NJ , Flint A , Papatheodorou D , Zhao Y , Vecchia L , Ruza RR , Hillier J , Frew S , Monaghan A , Costa A , Bictash M , Walter MW , Jones EY , Fish PV |
| Ref : Journal of Medicinal Chemistry , 63 :9464 , 2020 |
| Abstract : |
| PubMedSearch : Mahy_2020_J.Med.Chem_63_9464 |
| PubMedID: 32787107 |
| Gene_locus related to this paper: human-NOTUM |
| Title : Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen - Atkinson_2019_Medchemcomm_10_1361 |
| Author(s) : Atkinson BN , Steadman D , Zhao YG , Sipthorp J , Vecchia L , Ruza RR , Jeganathan F , Lines G , Frew S , Monaghan A , Kjaer S , Bictash M , Jones Y , Fish PV , Zhao Y , Jones EY |
| Ref : Medchemcomm , 10 :1361 , 2019 |
| Abstract : |
| PubMedSearch : Atkinson_2019_Medchemcomm_10_1361 |
| PubMedID: 31534655 |
| Gene_locus related to this paper: human-NOTUM |
| Title : Structural characterisation of melatonin as an inhibitor of the Wnt deacylase Notum - Zhao_2019_J.Pineal.Res__e12630 |
| Author(s) : Zhao Y , Ren J , Hillier J , Jones M , Lu W , Jones EY |
| Ref : J Pineal Res , :e12630 , 2019 |
| Abstract : |
| PubMedSearch : Zhao_2019_J.Pineal.Res__e12630 |
| PubMedID: 31876313 |
| Gene_locus related to this paper: human-NOTUM |
| Title : Scaffold-hopping identifies furano[2,3-d]pyrimidine amides as potent Notum inhibitors - Atkinson_2019_Bioorg.Med.Chem.Lett__126751 |
| Author(s) : Atkinson BN , Steadman D , Mahy W , Zhao Y , Sipthorp J , Bayle ED , Svensson F , Papageorgiou G , Jeganathan F , Frew S , Monaghan A , Bictash M , Jones EY , Fish PV |
| Ref : Bioorganic & Medicinal Chemistry Lett , :126751 , 2019 |
| Abstract : |
| PubMedSearch : Atkinson_2019_Bioorg.Med.Chem.Lett__126751 |
| PubMedID: 31862412 |
| Gene_locus related to this paper: human-NOTUM |
| Title : Notum Is Required for Neural and Head Induction via Wnt Deacylation, Oxidation, and Inactivation - Zhang_2015_Dev.Cell_32_719 |
| Author(s) : Zhang X , Cheong SM , Amado NG , Reis AH , MacDonald BT , Zebisch M , Jones EY , Abreu JG , He X |
| Ref : Dev Cell , 32 :719 , 2015 |
| Abstract : |
| PubMedSearch : Zhang_2015_Dev.Cell_32_719 |
| PubMedID: 25771893 |
| Title : Notum deacylates Wnt proteins to suppress signalling activity - Kakugawa_2015_Nature_519_187 |
| Author(s) : Kakugawa S , Langton PF , Zebisch M , Howell SA , Chang TH , Liu Y , Feizi T , Bineva G , O'Reilly N , Snijders AP , Jones EY , Vincent JP |
| Ref : Nature , 519 :187 , 2015 |
| Abstract : |
| PubMedSearch : Kakugawa_2015_Nature_519_187 |
| PubMedID: 25731175 |
| Gene_locus related to this paper: drome-q9vux3 , human-NOTUM |
| Title : Structural basis for cell surface patterning through NetrinG-NGL interactions - Seiradake_2011_EMBO.J_30_4479 |
| Author(s) : Seiradake E , Coles CH , Perestenko PV , Harlos K , McIlhinney RA , Aricescu AR , Jones EY |
| Ref : EMBO Journal , 30 :4479 , 2011 |
| Abstract : |
| PubMedSearch : Seiradake_2011_EMBO.J_30_4479 |
| PubMedID: 21946559 |
| Title : Crystal structure of the GluR2 amino-terminal domain provides insights into the architecture and assembly of ionotropic glutamate receptors - Clayton_2009_J.Mol.Biol_392_1125 |
| Author(s) : Clayton A , Siebold C , Gilbert RJ , Sutton GC , Harlos K , McIlhinney RA , Jones EY , Aricescu AR |
| Ref : Journal of Molecular Biology , 392 :1125 , 2009 |
| Abstract : |
| PubMedSearch : Clayton_2009_J.Mol.Biol_392_1125 |
| PubMedID: 19651138 |
| Title : Positional cloning of a novel gene influencing asthma from chromosome 2q14. - Allen_2003_Nat.Genet_35_258 |
| Author(s) : Allen M , Heinzmann A , Noguchi E , Abecasis G , Broxholme J , Ponting CP , Bhattacharyya S , Tinsley J , Zhang Y , Holt R , Jones EY , Lench N , Carey A , Jones H , Dickens NJ , Dimon C , Nicholls R , Baker C , Xue L , Townsend E , Kabesch M , Weiland SK , Carr D , von Mutius E , Adcock IM , Barnes PJ , Lathrop GM , Edwards M , Moffatt MF , Cookson WO |
| Ref : Nat Genet , 35 :258\ , 2003 |
| Abstract : |
| PubMedSearch : Allen_2003_Nat.Genet_35_258 |
| PubMedID: 14566338 |
| Gene_locus related to this paper: human-DPP10 |