human-NOTUM

Homo sapiens (Human) Protein notum homolog

Comment

In animals Notum acts to modify heparan sulfate proteoglycans and thereby alters the extracellular gradient of Wg\/Wnt protein. Kinetic and mass spectrometric analyses of human proteins show that Notum is a carboxylesterase that removes an essential palmitoleate moiety from Wnt proteins and thus constitutes the first known extracellular protein deacylase (Kakugawa et al.). Notum also deacylates octanoylated Ghrelin

Relationship

Family : Pectinacetylesterase-Notum

Block : X

Position in NCBI Life Tree : Homo sapiens

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N E

Molecular evidence

No mutation

8BT7 - Structure of the human Wnt deacylase Notum in complex with ARUK3004903 8BT8 - Structure of the human Wnt deacylase Notum in complex with ARUK3004048 8BTA - Structure of the human Wnt deacylase Notum in complex with ARUK3004308 8BTC - Structure of the human Wnt deacylase Notum in complex with ARUK3004558 8BTE - Structure of the human Wnt deacylase Notum in complex with ARUK3004470 8BTH - Structure of the human Wnt deacylase Notum in complex with ARUK3004552 8BTI - Structure of the human Wnt deacylase Notum in complex with ARUK3004556 8BSZ - Structure of the human Wnt deacylase Notum in complex with ARUK3005522 8BT0 - Structure of the human Wnt deacylase Notum in complex with ARUK3005518 8BT2 - Structure of the human Wnt deacylase Notum in complex with ARUK3004876 8BT5 - Structure of the human Wnt deacylase Notum in complex with ARUK3004877 8BSP - Structure of the human Wnt deacylase Notum in complex with ARUK3006560 8BSQ - Structure of the human Wnt deacylase Notum in complex with ARUK3006561 8BSR - Structure of the human Wnt deacylase Notum in complex with ARUK3006562 7PJR - Structure of the human Wnt deacylase Notum in complex with ARUK3000438 7QVZ - Structure of the human Wnt deacylase Notum in complex with ARUK3001043 7PK3 - Structure of the human Wnt deacylase Notum in complex with ARUK3001185 7PKV - Structure of the human Wnt deacylase Notum in complex with ARUK3000223 Compound 7b 7BLS - Human Notum-maybridge_18 7BLT - Human Notum-maybridge_4 7BLU - Human Notum-maybridge_56 7BLW - Human Notum_Piperine complex 7BNL - Human Notum ARUK3003710 6ZYF - Human Notum (S232A) inactive mutant Ghrelin complex 7BM1 - Human Notum_Valsartan complex 7BM3 - Human Notum Rosmarinic acid complex 7BO1 - Human Notum complexed with Fragment_274 [(4-fluorophenyl)amino]thiourea ((4-fluoroanilino)thiourea) 7BO5 - Human Notum complexed with Fragment_130_methyEster (methyl 4H-thieno[3,2-c]chromene-2-carboxylate) 7BO2 - Human Notum complexed with Fragment_130 (4H-thieno[3,2-c]chromene-2-carboxylic acid) 7BM7 - Human Notum complexed with fragment 5e, 1-Naphthalenepentanoic acid 7BLI - Notum-Bepridil complex 7BMD - Human Notum TDZD8 complex 7BMB - Human Notum PPOH complex 7BNB - Human Notum comlexed with fragment_50 (3-(quinazolin-4-ylsulfanyl)propanoic acid) 7BN5 - Human Notum comlexed with fragment_1 (2-(isoquinolin-1-ylsulfanyl)acetic acid) 7BN8 - Human Notum complexed with fragment_3 (4H,5H-naphtho[1,2-b]thiophene-2-carboxylic acid) 7BNE - Human Notum complexed with Nicotine 7BNF - Human Notum comlexed with Cotinine 7BNC - Human Notum complexed with fragment_126 (2-(1,2-dihydroacenaphthylen-5-ylsulfanyl)acetic acid) 7BND - Human Notum complexed with Fragment41 (N-methyl-4,5-dihydronaphtho,2-bthiophene-2-carboxamide) 7BNJ - Human Notum complexed with Riluzole 7B3G - Human Notum in complex with ARUK3003902 7ARG - Human Notum in complex with ARUK3002704 compound 1 Methyl- 7B2Z - Human Notum in complex with ARUK3003907 compound 6\; iso-propanol 7B2Y - Human Notum in complex with ARUK3003910 compound 4\; 2,2 difluoroethyl- 7B2V - Human Notum in complex with ARUK3003906 compound 3\; ethyl- 7B37 - Human Notum in complex with ARUK3003718 compound 2 acid 7B3X - Human Notum in complex with ARUK3003748 7B3P - Human Notum in complex with ARUK3003775 7B3I - Human Notum in complex with ARUK3003776 7B3H - Human Notum in complex with ARUK3003909 7B3F - Human Notum S232A in complex with ARUK3003718 compound 2 acid 7B50 - Human Notum in complex with ARUK3003778 7B4X - Human Notum in complex with ARUK3002697 7B45 - Human Notum in complex with ARUK3003934 7BAP - Structure of the human Wnt deacylase Notum in complex with fragment 648 7BD3 - Structure of the human Wnt deacylase Notum in complex with fragment 823 7BD4 - Structure of the human Wnt deacylase Notum in complex with fragment 828 7BD2 - Structure of the human Wnt deacylase Notum in complex with fragment 810 7BD8 - Structure of the human Wnt deacylase Notum in complex with fragment 872 7BD5 - Structure of the human Wnt deacylase Notum in complex with fragment 830 7BD6 - Structure of the human Wnt deacylase Notum in complex with fragment 863 7BCK - Structure of the human Wnt deacylase Notum in complex with fragment 791 7BCH - Structure of the human Wnt deacylase Notum in complex with fragment 772 7BCI - Structure of the human Wnt deacylase Notum in complex with fragment 784 7BCL - Structure of the human Wnt deacylase Notum in complex with fragment 792 7BCC - Structure of the human Wnt deacylase Notum in complex with fragment 705 7BCF - Structure of the human Wnt deacylase Notum in complex with fragment 722 7BCD - Structure of the human Wnt deacylase Notum in complex with fragment 714 7BCE - Structure of the human Wnt deacylase Notum in complex with fragment 718 7BC8 - Structure of the human Wnt deacylase Notum in complex with fragment 658 7BC9 - Structure of the human Wnt deacylase Notum in complex with fragment 690 7BDC - Structure of the human Wnt deacylase Notum in complex with fragment 923 7BDD - Structure of the human Wnt deacylase Notum in complex with fragment 924 7BDA - Structure of the human Wnt deacylase Notum in complex with fragment 900 7BDB - Structure of the human Wnt deacylase Notum in complex with fragment 916 7BDG - Structure of the human Wnt deacylase Notum in complex with fragment 934 7BDH - Structure of the human Wnt deacylase Notum in complex with fragment 955 7BDF - Structure of the human Wnt deacylase Notum in complex with fragment 927 7BD9 - Structure of the human Wnt deacylase Notum in complex with fragment 886 7B86 - Structure of the human Wnt deacylase Notum in complex with fragment 067 7B7W - Structure of the human Wnt deacylase Notum in complex with fragment 049 7B87 - Structure of the human Wnt deacylase Notum in complex with fragment 074 7B7Y - Structure of the human Wnt deacylase Notum in complex with fragment 064 7B7X - Structure of the human Wnt deacylase Notum in complex with fragment 063 7B89 - Structure of the human Wnt deacylase Notum in complex with fragment 077 7B84 - Structure of the human Wnt deacylase Notum in complex with fragment 065 7B8F - Structure of the human Wnt deacylase Notum in complex with fragment 154 7B8G - Structure of the human Wnt deacylase Notum in complex with fragment 159 7B8J - Structure of the human Wnt deacylase Notum in complex with fragment 163 Felbinac 7B8L - Structure of the human Wnt deacylase Notum in complex with fragment 174 7B8K - Structure of the human Wnt deacylase Notum in complex with fragment 173 7B8A - Structure of the human Wnt deacylase Notum in complex with fragment 110 7B8D - Structure of the human Wnt deacylase Notum in complex with (fragment 151) Sulfapyridine 7B8C - Structure of the human Wnt deacylase Notum in complex with fragment 147 7B9I - Structure of the human Wnt deacylase Notum in complex with fragment 297 7B9D - Structure of the human Wnt deacylase Notum in complex with fragment 290 7B8U - Structure of the human Wnt deacylase Notum in complex with fragment 201 7B8X - Structure of the human Wnt deacylase Notum in complex with fragment 210 7B99 - Structure of the human Wnt deacylase Notum in complex with fragment 283 7B98 - Structure of the human Wnt deacylase Notum in complex with fragment 282 7B8Z - Structure of the human Wnt deacylase Notum in complex with fragment 277 7B8Y - Structure of the human Wnt deacylase Notum in complex with fragment 276 7B8N - Structure of the human Wnt deacylase Notum in complex with fragment 197 7B8M - Structure of the human Wnt deacylase Notum in complex with fragment 193 7B8O - Structure of the human Wnt deacylase Notum in complex with fragment 199 7B9N - Structure of the human Wnt deacylase Notum in complex with fragment 588 7B9U - Structure of the human Wnt deacylase Notum in complex with fragment 609 7BA1 - Structure of the human Wnt deacylase Notum in complex with fragment 634 7BAC - Structure of the human Wnt deacylase Notum in complex with fragment 646 6ZUV - Structure of the human Wnt deacylase Notum in complex with fragment 286 (Compound 7, 4F-329S) 6ZVL - Structure of the human Wnt deacylase Notum in complex with SCHEMBL21776992 (ARUK3000263 Compound23dd 7a) 6YV0 - Structure of the human Wnt deacylase Notum in complex with a pyrrolidine-3-carboxylic acid fragment 587 6YV2 - Structure of the human Wnt deacylase Notum in complex with a pyrrolidine-3-carboxylic acid fragment 598 6YV4 - Structure of the human Wnt deacylase Notum in complex with a pyrrole-3-carboxylic acid fragment 454 6YUW - Structure of the human Wnt deacylase Notum in complex with a pyrrole-3-carboxylic acid fragment 454 6YUY - Structure of the human Wnt deacylase Notum in complex with a pyrrole-3-carboxylic acid fragment 471 6YXI - Structure of human Notum in complex with a 1-(3-Chlorophenyl)-2,5-dimethyl-1H-pyrrole-3-carboxylic acid inhibitor 6YSK - 1-phenylpyrroles and 1-enylpyrrolidines as inhibitors of human Notum 6TV4 - Caffeine- human Notum complex 6TUZ - Theophylline- human Notum complex 6TR5 - Melatonin-human Notum complex 6TR6 - N-acetylserotonin- humanNotum complex 6TR7 - Structure of the human Wnt deacylase Notum in complex with N-[2-(5-fluoro-1H-indol-3-yl)ethyl]acetamide (6QCQ withdrawn) 6T2H - Furano[2,3-d]prymidine amides as human Notum inhibitors 1 (M9N) 6T2K - Furano[2,3-d]prymidine amides as human Notum inhibitors 2 (LP-922056) 6R8P - Structure of the human Wnt deacetylase notum with inhibitor fragment 723 JVB Pyridine 6R8Q - Structure of the human Wnt deacylase Notum in complex with a benzotriazole fragment JV5 6R8R - Structure of the human Wnt deacylase Notum in complex with isoquinoline 45 JV8 4UYU - Structure of the human wnt deacetylase notum - Crystal form I iodide complex - 2.3A 4UYW - Structure of the human wnt deacetylase notum - Crystal form I heparin complex - 1.7A 4UYZ - Structure of the human wnt deacetylase notum - Crystal form II - 2.8A 4UZ1 - Structure of the wnt deacetylase notum - Crystal form III - 1.4A 4UZ5 - Structure of the human wnt deacetylase notum - Crystal form IV - 2.1A 4UZ6 - Structure of the human wnt deacetylase notum - Crystal form V SOS complex - 1.9A 4UZ7 - Structure of the human wnt deacetylase notum - Crystal form VI - 2.2A 4UZA - Structure of the human wnt deacetylase notum - Crystal form VIII - Phosphate complex 2.4A 4UZQ - Structure of th humane wnt deacetylase notum in complex with O-Palmitoleoyl serine- Crystal form IX - 1.5A 4UZL - Structure of the wnt deacetylase notum - Crystal form I myristoleate complex 2.1A 4UZ9 - Structure of the human wnt deacetylase notum - Crystal form VII SOS complex - 2.2A 4WBH - Structure of the human wnt deacetylase notum - Crystal form I Apo - 2.2A

No kinetic

No disease

(4-fluoroanilino)thiourea (Isoquinolin-1-ylsulfanyl)-acetic-acid 1-Naphthalenepentanoic-acid 2-(1,2-Dihydroacenaphthylen-5-ylsulfanyl)acetic-acid 2-N-pyridin-2-ylbenzene-1,2-diamine 3-(Quinazolin-4-ylthio)propanoic-acid 4,5-Dihydronaphtho[1,2-b]thiophene-2-carboxylic-acid 4F-329S 4H-thieno[3,2-c]chromene-2-carboxylic-acid ABC99 ARUK3000223 ARUK3000438 ARUK3001043 ARUK3001185 ARUK3002697 ARUK3002704 ARUK3003710 ARUK3003718 ARUK3003748 ARUK3003775 ARUK3003776 ARUK3003778 ARUK3003902 ARUK3003906 ARUK3003907 ARUK3003909 ARUK3003910 ARUK3003934 ARUK3004048 ARUK3004308 ARUK3004470 ARUK3004552 ARUK3004556 ARUK3004558 ARUK3004876 ARUK3004877 ARUK3004903 ARUK3005518 ARUK3005522 ARUK3006560 ARUK3006561 ARUK3006562 Benzotriazole-39-JV5 Bepridil CHEMBL4539054 CHEMBL57478 Caffeine Cotinine Decanoate Felbinac Fragment-049-notum-screen Fragment-063-notum-screen Fragment-064-notum-screen Fragment-065 Fragment-067 Fragment-074 Fragment-077 Fragment-110 Fragment-147 Fragment-154 Fragment-159 Fragment-173 Fragment-174 Fragment-193 Fragment-197 Fragment-199 Fragment-201 Fragment-210 Fragment-276 Fragment-277 Fragment-282 Fragment-283 Fragment-290 Fragment-297 Fragment-588 Fragment-609 Fragment-634 Fragment-646 Fragment-658 Fragment-690 Fragment-705 Fragment-714 Fragment-722 Fragment-772 Fragment-784 Fragment-791 Fragment-792 Fragment-810 Fragment-828 Fragment-830 Fragment-863 Fragment-872 Fragment-886 Fragment-900 Fragment-916 Fragment-923 Fragment-924 Fragment-927 Fragment-934 Fragment-955 Heparin-disaccharide Isoquinoline-45-JV8 JVB LP-914822 LP-922056 LP-935001 Laurate M9N Maybridge_18 Maybridge_4 Maybridge_56 Melatonin Methyl-4H-thieno[3,2-c]chromene-2-carboxylic-acid Myristic-acid Myristoleic-acid N-[2-(5-fluoro-1H-indol-3-yl)ethyl]acetamide N-acetylserotonin N-methyl-4,5-dihydronaphtho[1,2-b]thiophene-2-carboxamide Nicotine Octanoate PMSF PPOH Palmitoleic-acid Piperine Pyrrole-20i-6YXI Pyrrole-26-6YSK Pyrrole-5-6YUY Pyrrole-6-6YV4 Pyrrole-7-6YUW Pyrrolidine-10-6YV0 Pyrrolidine-8-6YV2 Riluzole SCHEMBL21776992 Sucrose-octasulfate Sulfapyridine TDZD8 Theophylline

Database

Sequence

Peptide

MGRGVRVLLL LSLLHCAGGS EGRKTWRRRG QQPPPPPRTE AAPAAGQPVE SFPLDFTAVE GNMDSFMAQV KSLAQSLYPC SAQQLNEDLR LHLLLNTSVT CNDGSPAGYY LKESRGSRRW LLFLEGGWYC FNRENCDSRY DTMRRLMSSR DWPRTRTGTG ILSSQPEENP YWWNANMVFI PYCSSDVWSG ASSKSEKNEY AFMGALIIQE VVRELLGRGL SGAKVLLLAG SSAGGTGVLL NVDRVAEQLE KLGYPAIQVR GLADSGWFLD NKQYRHTDCV DTITCAPTEA IRRGIRYWNG VVPERCRRQF QEGEEWNCFF GYKVYPTLRC PVFVVQWLFD EAQLTVDNVH LTGQPVQEGL RLYIQNLGRE LRHTLKDVPA SFAPACLSHE IIIRSHWTDV QVKGTSLPRA LHCWDRSLHD SHKASKTPLK GCPVHLVDSC PWPHCNPSCP TVRDQFTGQE MNVAQFLMHM GFDMQTVAQP QGLEPSELLG MLSNGS

References (32)

Title : Designed switch from covalent to non-covalent inhibitors of carboxylesterase Notum activity - Atkinson_2023_Eur.J.Med.Chem_251_115132
Author(s) : Atkinson BN , Willis NJ , Zhao Y , Patel C , Frew S , Costelloe K , Magno L , Svensson F , Jones EY , Fish PV
Ref : Eur Journal of Medicinal Chemistry , 251 :115132 , 2023
PubMedID: 36934521
Gene_locus related to this paper: human-NOTUM

Title : Structural Analysis and Development of Notum Fragment Screening Hits - Zhao_2022_ACS.Chem.Neurosci_13_2060
Author(s) : Zhao Y , Mahy W , Willis NJ , Woodward HL , Steadman D , Bayle ED , Atkinson BN , Sipthorp J , Vecchia L , Ruza RR , Harlos K , Jeganathan F , Constantinou S , Costa A , Kjaer S , Bictash M , Salinas PC , Whiting P , Vincent JP , Fish PV , Jones EY
Ref : ACS Chem Neurosci , 13 :2060 , 2022
PubMedID: 35731924
Gene_locus related to this paper: human-NOTUM

Title : Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity - Steadman_2022_J.Med.Chem_65_562
Author(s) : Steadman D , Atkinson BN , Zhao Y , Willis NJ , Frew S , Monaghan A , Patel C , Armstrong E , Costelloe K , Magno L , Bictash M , Jones EY , Fish PV , Svensson F
Ref : Journal of Medicinal Chemistry , 65 :562 , 2022
PubMedID: 34939789
Gene_locus related to this paper: human-NOTUM

Title : Design of a potent, selective and brain penetrant inhibitor of Wnt-deactivating enzyme Notum by optimization of a crystallographic fragment hit - Willis_2022_J.Med.Chem_65_7212
Author(s) : Willis NJ , Mahy W , Sipthorp J , Zhao Y , Woodward HL , Atkinson BN , Bayle ED , Svensson F , Frew S , Jeganathan F , Monaghan A , Benvegnu S , Jolly S , Vecchia L , Ruza RR , Kjaer S , Howell SA , Snidjers AP , Bictash M , Salinas PC , Vincent JP , Jones EY , Whiting P , Fish PV
Ref : Journal of Medicinal Chemistry , 65 :7212 , 2022
PubMedID: 35536179
Gene_locus related to this paper: human-NOTUM

Title : Structural Insights into Notum Covalent Inhibition - Zhao_2021_J.Med.Chem_64_11354
Author(s) : Zhao Y , Svensson F , Steadman D , Frew S , Monaghan A , Bictash M , Moreira T , Chalk R , Lu W , Fish PV , Jones EY
Ref : Journal of Medicinal Chemistry , 64 :11354 , 2021
PubMedID: 34292747
Gene_locus related to this paper: human-NOTUM

Title : Notum deletion from late-stage skeletal cells increases cortical bone formation and potentiates skeletal effects of sclerostin inhibition - Choi_2021_J.Bone.Miner.Res__
Author(s) : Choi RB , Bullock WA , Hoggatt AM , Horan DJ , Pemberton EZ , Hong JM , Zhang X , He X , Robling AG
Ref : J Bone Miner Res , : , 2021
PubMedID: 34223673
Gene_locus related to this paper: human-NOTUM , mouse-notum

Title : NOTUM from Apc-mutant cells biases clonal competition to initiate cancer - Flanagan_2021_Nature__
Author(s) : Flanagan DJ , Pentinmikko N , Luopajarvi K , Willis NJ , Gilroy K , Raven AP , McGarry L , Englund JI , Webb AT , Scharaw S , Nasreddin N , Hodder MC , Ridgway RA , Minnee E , Sphyris N , Gilchrist E , Najumudeen AK , Romagnolo B , Perret C , Williams AC , Clevers H , Nummela P , Lahde M , Alitalo K , Hietakangas V , Hedley A , Clark W , Nixon C , Kirschner K , Jones EY , Ristimaki A , Leedham SJ , Fish PV , Vincent JP , Katajisto P , Sansom OJ
Ref : Nature , : , 2021
PubMedID: 34079124
Gene_locus related to this paper: human-NOTUM

Title : Small-molecule inhibitors of carboxylesterase Notum - Zhao_2021_Future.Med.Chem__
Author(s) : Zhao Y , Jolly S , Benvegnu S , Jones EY , Fish PV
Ref : Future Med Chem , : , 2021
PubMedID: 33882714
Gene_locus related to this paper: human-NOTUM

Title : Notum Deacylates Octanoylated Ghrelin - Zhao_2021_Mol.Metab__101201
Author(s) : Zhao Y , Schuhmacher LN , Roberts M , Kakugawa S , Bineva-Todd G , Howell S , O'Reilly N , Perret C , Snijders AP , Vincent JP , Jones EY
Ref : Mol Metab , :101201 , 2021
PubMedID: 33647468
Gene_locus related to this paper: human-NOTUM

Title : Carboxylesterase Notum Is a Druggable Target to Modulate Wnt Signaling - Bayle_2021_J.Med.Chem__
Author(s) : Bayle ED , Svensson F , Atkinson BN , Steadman D , Willis NJ , Woodward HL , Whiting P , Vincent JP , Fish PV
Ref : Journal of Medicinal Chemistry , : , 2021
PubMedID: 33783220
Gene_locus related to this paper: human-NOTUM

Title : Osteocyte- and late Osteoblast-derived NOTUM Reduces Cortical Bone Mass in Mice - Nilsson_2021_Am.J.Physiol.Endocrinol.Metab__
Author(s) : Nilsson KH , Henning P , El Shahawy M , Wu J , Koskela A , Tuukkanen J , Perret C , Lerner UH , Ohlsson C , Moverare-Skrtic S
Ref : American Journal of Physiology Endocrinol Metab , : , 2021
PubMedID: 33749332
Gene_locus related to this paper: human-NOTUM , mouse-notum

Title : 5-Phenyl-1,3,4-oxadiazol-2(3H)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit - Mahy_2020_J.Med.Chem_63_12942
Author(s) : Mahy W , Willis NJ , Zhao Y , Woodward HL , Svensson F , Sipthorp J , Vecchia L , Ruza RR , Hillier J , Kjr S , Frew S , Monaghan A , Bictash M , Salinas PC , Whiting P , Vincent JP , Jones EY , Fish PV
Ref : Journal of Medicinal Chemistry , 63 :12942 , 2020
PubMedID: 33124429
Gene_locus related to this paper: human-NOTUM

Title : Caffeine inhibits Notum activity by binding at the catalytic pocket - Zhao_2020_Commun.Biol_3_555
Author(s) : Zhao Y , Ren J , Hillier J , Lu W , Jones EY
Ref : Commun Biol , 3 :555 , 2020
PubMedID: 33033363
Gene_locus related to this paper: human-NOTUM

Title : Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity - Mahy_2020_J.Med.Chem_63_9464
Author(s) : Mahy W , Patel M , Steadman D , Woodward HL , Atkinson BN , Svensson F , Willis NJ , Flint A , Papatheodorou D , Zhao Y , Vecchia L , Ruza RR , Hillier J , Frew S , Monaghan A , Costa A , Bictash M , Walter MW , Jones EY , Fish PV
Ref : Journal of Medicinal Chemistry , 63 :9464 , 2020
PubMedID: 32787107
Gene_locus related to this paper: human-NOTUM

Title : Single-Cell Profiling and SCOPE-Seq Reveal Lineage Dynamics of Adult Ventricular-Subventricular Zone Neurogenesis and NOTUM as a Key Regulator - Mizrak_2020_Cell.Rep_31_107805
Author(s) : Mizrak D , Bayin NS , Yuan J , Liu Z , Suciu RM , Niphakis MJ , Ngo N , Lum KM , Cravatt BF , Joyner AL , Sims PA
Ref : Cell Rep , 31 :107805 , 2020
PubMedID: 32579931
Gene_locus related to this paper: human-NOTUM

Title : Structural characterisation of melatonin as an inhibitor of the Wnt deacylase Notum - Zhao_2019_J.Pineal.Res__e12630
Author(s) : Zhao Y , Ren J , Hillier J , Jones M , Lu W , Jones EY
Ref : J Pineal Res , :e12630 , 2019
PubMedID: 31876313
Gene_locus related to this paper: human-NOTUM

Title : Notum attenuates HBV-related liver fibrosis through inhibiting Wnt 5a mediated non-canonical pathways - Li_2019_Biol.Res_52_10
Author(s) : Li W , Yu X , Zhu C , Wang Z , Zhao Z , Li Y , Zhang Y
Ref : Biol Res , 52 :10 , 2019
PubMedID: 30871618
Gene_locus related to this paper: human-NOTUM

Title : NOTUM inhibition increases endocortical bone formation and bone strength - Brommage_2019_Bone.Res_7_2
Author(s) : Brommage R , Liu J , Vogel P , Mseeh F , Thompson AY , Potter DG , Shadoan MK , Hansen GM , Jeter-Jones S , Cui J , Bright D , Bardenhagen JP , Doree DD , Moverare-Skrtic S , Nilsson KH , Henning P , Lerner UH , Ohlsson C , Sands AT , Tarver JE , Powell DR , Zambrowicz B , Liu Q
Ref : Bone Res , 7 :2 , 2019
PubMedID: 30622831
Gene_locus related to this paper: human-NOTUM

Title : An improved, scalable synthesis of Notum inhibitor LP-922056 using 1-chloro-1,2-benziodoxol-3-one as a superior electrophilic chlorinating agent - Willis_2019_Beilstein.J.Org.Chem_15_2790
Author(s) : Willis NJ , Bayle ED , Papageorgiou G , Steadman D , Atkinson BN , Mahy W , Fish PV
Ref : Beilstein J Org Chem , 15 :2790 , 2019
PubMedID: 31807213
Gene_locus related to this paper: human-NOTUM

Title : Scaffold-hopping identifies furano[2,3-d]pyrimidine amides as potent Notum inhibitors - Atkinson_2019_Bioorg.Med.Chem.Lett__126751
Author(s) : Atkinson BN , Steadman D , Mahy W , Zhao Y , Sipthorp J , Bayle ED , Svensson F , Papageorgiou G , Jeganathan F , Frew S , Monaghan A , Bictash M , Jones EY , Fish PV
Ref : Bioorganic & Medicinal Chemistry Lett , :126751 , 2019
PubMedID: 31862412
Gene_locus related to this paper: human-NOTUM

Title : Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium - Pentinmikko_2019_Nature_571_398
Author(s) : Pentinmikko N , Iqbal S , Mana M , Andersson S , Cognetta AB, 3rd , Suciu RM , Roper J , Luopajarvi K , Markelin E , Gopalakrishnan S , Smolander OP , Naranjo S , Saarinen T , Juuti A , Pietilainen K , Auvinen P , Ristimaki A , Gupta N , Tammela T , Jacks T , Sabatini DM , Cravatt BF , Yilmaz OH , Katajisto P
Ref : Nature , 571 :398 , 2019
PubMedID: 31292548
Gene_locus related to this paper: human-NOTUM , mouse-notum

Title : Osteoblast-derived NOTUM reduces cortical bone mass in mice and the NOTUM locus is associated with bone mineral density in humans - Moverare-Skrtic_2019_FASEB.J__fj201900707R
Author(s) : Moverare-Skrtic S , Nilsson KH , Henning P , Funck-Brentano T , Nethander M , Rivadeneira F , Coletto Nunes G , Koskela A , Tuukkanen J , Tuckermann J , Perret C , Souza PPC , Lerner UH , Ohlsson C
Ref : FASEB Journal , :fj201900707R , 2019
PubMedID: 31307226
Gene_locus related to this paper: human-NOTUM

Title : Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen - Atkinson_2019_Medchemcomm_10_1361
Author(s) : Atkinson BN , Steadman D , Zhao YG , Sipthorp J , Vecchia L , Ruza RR , Jeganathan F , Lines G , Frew S , Monaghan A , Kjaer S , Bictash M , Jones Y , Fish PV , Zhao Y , Jones EY
Ref : Medchemcomm , 10 :1361 , 2019
PubMedID: 31534655
Gene_locus related to this paper: human-NOTUM

Title : Selective Irreversible Inhibitors of the Wnt-Deacylating Enzyme NOTUM Developed by Activity-Based Protein Profiling - Suciu_2018_ACS.Med.Chem.Lett_9_563
Author(s) : Suciu RM , Cognetta AB, 3rd , Potter ZE , Cravatt BF
Ref : ACS Med Chem Lett , 9 :563 , 2018
PubMedID: 29937983
Gene_locus related to this paper: human-NOTUM

Title : NOTUM is a potential pharmacodynamic biomarker of Wnt pathway inhibition - Madan_2016_Oncotarget_7_12386
Author(s) : Madan B , Ke Z , Lei ZD , Oliver FA , Oshima M , Lee MA , Rozen S , Virshup DM
Ref : Oncotarget , 7 :12386 , 2016
PubMedID: 26848981
Gene_locus related to this paper: human-NOTUM

Title : Stimulation of cortical bone formation with thienopyrimidine based inhibitors of Notum Pectinacetylesterase - Tarver_2016_Bioorg.Med.Chem.Lett_26_1525
Author(s) : Tarver JE, Jr. , Pabba PK , Barbosa J , Han Q , Gardyan MW , Brommage R , Thompson AY , Schmidt JM , Wilson AG , He W , Lombardo VK , Carson KG , Wilson AGE
Ref : Bioorganic & Medicinal Chemistry Lett , 26 :1525 , 2016
PubMedID: 26897593
Gene_locus related to this paper: human-NOTUM

Title : Notum deacylates Wnt proteins to suppress signalling activity - Kakugawa_2015_Nature_519_187
Author(s) : Kakugawa S , Langton PF , Zebisch M , Howell SA , Chang TH , Liu Y , Feizi T , Bineva G , O'Reilly N , Snijders AP , Jones EY , Vincent JP
Ref : Nature , 519 :187 , 2015
PubMedID: 25731175
Gene_locus related to this paper: drome-q9vux3 , human-NOTUM

Title : Novel insights into Notum and glypicans regulation in colorectal cancer - De Robertis_2015_Oncotarget_6_41237
Author(s) : De Robertis M , Arigoni M , Loiacono L , Riccardo F , Calogero RA , Feodorova Y , Tashkova D , Belovejdov V , Sarafian V , Cavallo F , Signori E
Ref : Oncotarget , 6 :41237 , 2015
PubMedID: 26517809
Gene_locus related to this paper: human-NOTUM

Title : Genetic Approaches To Identifying Novel Osteoporosis Drug Targets - Brommage_2015_J.Cell.Biochem_116_2139
Author(s) : Brommage R
Ref : Journal of Cellular Biochemistry , 116 :2139 , 2015
PubMedID: 25833316
Gene_locus related to this paper: human-NOTUM

Title : The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) - Gerhard_2004_Genome.Res_14_2121
Author(s) : Gerhard DS , Wagner L , Feingold EA , Shenmen CM , Grouse LH , Schuler G , Klein SL , Old S , Rasooly R , Good P , Guyer M , Peck AM , Derge JG , Lipman D , Collins FS , Jang W , Sherry S , Feolo M , Misquitta L , Lee E , Rotmistrovsky K , Greenhut SF , Schaefer CF , Buetow K , Bonner TI , Haussler D , Kent J , Kiekhaus M , Furey T , Brent M , Prange C , Schreiber K , Shapiro N , Bhat NK , Hopkins RF , Hsie F , Driscoll T , Soares MB , Casavant TL , Scheetz TE , Brown-stein MJ , Usdin TB , Toshiyuki S , Carninci P , Piao Y , Dudekula DB , Ko MS , Kawakami K , Suzuki Y , Sugano S , Gruber CE , Smith MR , Simmons B , Moore T , Waterman R , Johnson SL , Ruan Y , Wei CL , Mathavan S , Gunaratne PH , Wu J , Garcia AM , Hulyk SW , Fuh E , Yuan Y , Sneed A , Kowis C , Hodgson A , Muzny DM , McPherson J , Gibbs RA , Fahey J , Helton E , Ketteman M , Madan A , Rodrigues S , Sanchez A , Whiting M , Madari A , Young AC , Wetherby KD , Granite SJ , Kwong PN , Brinkley CP , Pearson RL , Bouffard GG , Blakesly RW , Green ED , Dickson MC , Rodriguez AC , Grimwood J , Schmutz J , Myers RM , Butterfield YS , Griffith M , Griffith OL , Krzywinski MI , Liao N , Morin R , Palmquist D , Petrescu AS , Skalska U , Smailus DE , Stott JM , Schnerch A , Schein JE , Jones SJ , Holt RA , Baross A , Marra MA , Clifton S , Makowski KA , Bosak S , Malek J
Ref : Genome Res , 14 :2121 , 2004
PubMedID: 15489334
Gene_locus related to this paper: human-AFMID , human-CES4A , human-CES5A , human-NOTUM , human-SERAC1 , human-SERHL2 , human-TMEM53 , mouse-acot1 , mouse-adcl4 , mouse-Ces2f , mouse-Ces4a , mouse-notum , mouse-q6wqj1 , mouse-Q9DAI6 , mouse-rbbp9 , mouse-SERHL , mouse-srac1 , mouse-tmm53 , rat-abhd6 , rat-abhda , rat-abhea , rat-abheb , rat-Ldah , rat-cd029 , rat-estd , rat-Kansl3 , rat-nceh1 , ratno-acph , ratno-CMBL , mouse-b2rwd2 , rat-b5den3 , rat-ab17c

Title : HSPG modification by the secreted enzyme Notum shapes the Wingless morphogen gradient - Giraldez_2002_Dev.Cell_2_667
Author(s) : Giraldez AJ , Copley RR , Cohen SM
Ref : Dev Cell , 2 :667 , 2002
PubMedID: 12015973
Gene_locus related to this paper: drome-q9vux3 , human-NOTUM