Physostigmine Eserine analogue
Type : Derivative of physostigmine-eserine,Carbamate,Isoquinoline,Indole
Chemical_Nomenclature : (3aS,8aR)-1,2,3,3a,8,8a-Hexahydro-1,3a,8-trimethylpyrrolo(2,3-b)indol-5-yl 3,4-dihydro-2(1H)-isoquinolinecarboxylate
Canonical SMILES : CC12CCN(C1N(C3=C2C=C(C=C3)OC(=O)N4CCC5=CC=CC=C5C4)C)C
InChI : InChI=1S\/C23H27N3O2\/c1-23-11-13-24(2)21(23)25(3)20-9-8-18(14-19(20)23)28-22(27)26-12-10-16-6-4-5-7-17(16)15-26\/h4-9,14,21H,10-13,15H2,1-3H3\/t21-,23+\/m1\/s1
InChIKey : IIFRKALDATVOJE-GGAORHGYSA-N
Other name(s) : NXX 066,HP 290,NXX-066
MW : 377.480
Formula : C23H27N3O2
CAS_number : 139314-01-5
PubChem : 132228
UniChem : IIFRKALDATVOJE-GGAORHGYSA-N
Families : Quilostigmine ligand of proteins in family
ACHE
Title : A comparative study in rats of the in vitro and in vivo pharmacology of the acetylcholinesterase inhibitors tacrine, donepezil and NXX-066 - Snape_1999_Neuropharmacol_38_181 |
Author(s) : Snape MF , Misra A , Murray TK , De Souza RJ , Williams JL , Cross AJ , Green AR |
Ref : Neuropharmacology , 38 :181 , 1999 |
Abstract : Snape_1999_Neuropharmacol_38_181 |
ESTHER : Snape_1999_Neuropharmacol_38_181 |
PubMedSearch : Snape_1999_Neuropharmacol_38_181 |
PubMedID: 10193909 |
Title : NXX-066 in patients with Alzheimer's disease: a bridging study - Sramek_1999_Life.Sci_64_1215 |
Author(s) : Sramek JJ , Hourani J , Jhee SS , Cutler NR |
Ref : Life Sciences , 64 :1215 , 1999 |
Abstract : Sramek_1999_Life.Sci_64_1215 |
ESTHER : Sramek_1999_Life.Sci_64_1215 |
PubMedSearch : Sramek_1999_Life.Sci_64_1215 |
PubMedID: 10210264 |
Title : Detectability improvements in capillary zone electrophoresis by combining single capillary isotachophoretic preconcentration and frequency doubled argon ion laser-induced fluorescence detection - Enlund_1998_Electrophoresis_19_707 |
Author(s) : Enlund AM , Schmidt S , Westerlund D |
Ref : Electrophoresis , 19 :707 , 1998 |
Abstract : Enlund_1998_Electrophoresis_19_707 |
ESTHER : Enlund_1998_Electrophoresis_19_707 |
PubMedSearch : Enlund_1998_Electrophoresis_19_707 |
PubMedID: 9629903 |
Array ( [id] => 5610 [inhibitor] => Quilostigmine [type] => Array ( [0] => Derivative of physostigmine-eserine [1] => Carbamate [2] => Isoquinoline [3] => Indole ) [other_name] => Array ( [0] => NXX 066 [1] => HP 290 [2] => NXX-066 ) [chemical_nomenclature] => (3aS,8aR)-1,2,3,3a,8,8a-Hexahydro-1,3a,8-trimethylpyrrolo(2,3-b)indol-5-yl 3,4-dihydro-2(1H)-isoquinolinecarboxylate [formula] => C23H27N3O2 [cas_number] => 139314-01-5 [mw] => 377.480 [pick_me_to_call] => display_script [kinetic_parameter] => [paper] => Snape_1999_Neuropharmacol_38_181 || Sramek_1999_Life.Sci_64_1215 || Enlund_1998_Electrophoresis_19_707 [comment] => Physostigmine Eserine analogue [gene_locus] => [kin_inhibitor] => [cid] => 132228 [family] => ACHE [inchikey] => IIFRKALDATVOJE-GGAORHGYSA-N [canonicalsmiles] => CC12CCN(C1N(C3=C2C=C(C=C3)OC(=O)N4CCC5=CC=CC=C5C4)C)C [inchi] => InChI=1S\/C23H27N3O2\/c1-23-11-13-24(2)21(23)25(3)20-9-8-18(14-19(20)23)28-22(27)26-12-10-16-6-4-5-7-17(16)15-26\/h4-9,14,21H,10-13,15H2,1-3H3\/t21-,23+\/m1\/s1 [wikipedia] => [iupharlig] => [structure] => [substrate] => [interact_gene_locus] => [mutation] => [comment2] => [extoxnet] => [news] => [theoretical_model] => )