tacrine-isatin-Cpd7d
IC50 value of 0.11 nM for BuChE
General
Type : anti-Abeta-aggregation,Derivative of Tacrine,Multitarget,Alkyl linked bis-ligand,Indole
Chemical_Nomenclature : 1-(5-((1,2,3,4-tetrahydroacridin-9-yl)amino)pentyl)-3-(m-tolylimino)indolin-2-one
Canonical SMILES : C3CCC2=NC1=CC=CC=C1C(=C2C3)NCCCCCN5C4=CC=CC=C4C(C5=O)=NC6=CC=CC(=C6)C
InChI : InChI=1S\/C33H34N4O\/c1-23-12-11-13-24(22-23)35-32-27-16-5-8-19-30(27)37(33(32)38)21-10-2-9-20-34-31-25-14-3-6-17-28(25)36-29-18-7-4-15-26(29)31\/h3,5-6,8,11-14,16-17,19,22H,2,4,7,9-10,15,18,20-21H2,1H3,(H,34,36)
InChIKey : SMDJBDAOYZEEEM-UHFFFAOYSA-N
Other name(s) :
MW : 502.65
Formula : C33H34N4O
CAS_number :
PubChem :
UniChem : SMDJBDAOYZEEEM-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
References (1)
| Title : Design, synthesis and biological activity of novel tacrine-isatin Schiff base hybrid derivatives - Riazimontazer_2019_Bioorg.Chem_89_103006 |
| Author(s) : Riazimontazer E , Sadeghpour H , Nadri H , Sakhteman A , Tuylu Kucukkilinc T , Miri R , Edraki N |
| Ref : Bioorg Chem , 89 :103006 , 2019 |
| Abstract : Riazimontazer_2019_Bioorg.Chem_89_103006 |
| ESTHER : Riazimontazer_2019_Bioorg.Chem_89_103006 |
| PubMedSearch : Riazimontazer_2019_Bioorg.Chem_89_103006 |
| PubMedID: 31158577 |