Gene Locus : human-BCHE
Mode of mutation : Site directed mutagenesis
Disease :
Summary : Cocaine hydrolysis hydrolyzed cocaine 15-fold faster compared with wild-type BChE Duysen_2002_J.Pharmacol.Exp.Ther_302_751
AAA Change :
Allelic Variant :
Risk Factor :
Inhibitor :
Structure :
Disease by interaction :
Interact Gene Locus :
Xenobiotic sensitivity :
Modification : Acyl specificity || Cocaine hydrolysis
Torpedo_number : 330
Kinetic Parameter : No kinetic parameter
News : No news
Comment :
p.A328W Ala328Trp (p.A356W Ala356Trp in primary sequence with 28 amino-acids signal peptide) Cocaine hydrolysis\; hydrolyzed cocaine 15-fold faster compared with wild-type BChE
| Title : Wild-type and A328W mutant human butyrylcholinesterase tetramers expressed in Chinese hamster ovary cells have a 16-hour half-life in the circulation and protect mice from cocaine toxicity - Duysen_2002_J.Pharmacol.Exp.Ther_302_751 |
| Author(s) : Duysen EG , Bartels CF , Lockridge O |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 302 :751 , 2002 |
| Abstract : |
| PubMedSearch : Duysen_2002_J.Pharmacol.Exp.Ther_302_751 |
| PubMedID: 12130740 |