Gene Locus : human-CES1
Mode of mutation : Natural mutant
Disease :
Summary : Expression No activity or expression Zhu_2008_Am.J.Hum.Genet_82_1241 || Expression activation of the antiviral prodrug oseltamivir is impaired Zhu_2009_Drug.Metab.Dispos_37_264
AAA Change :
Allelic Variant :
Risk Factor :
Inhibitor :
Structure :
Disease by interaction :
Interact Gene Locus :
Xenobiotic sensitivity :
Modification : Expression
Torpedo_number : 241
Kinetic Parameter : No kinetic parameter
News : No news
Comment :
P.D260EfsX39 Asp260GlufsX39 c.888delT rs778068631 activation of the antiviral prodrug oseltamivir is impaired
| Title : Carboxylesterase 1 as a determinant of clopidogrel metabolism and activation - Zhu_2013_J.Pharmacol.Exp.Ther_344_665 |
| Author(s) : Zhu HJ , Wang X , Gawronski BE , Brinda BJ , Angiolillo DJ , Markowitz JS |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 344 :665 , 2013 |
| Abstract : |
| PubMedSearch : Zhu_2013_J.Pharmacol.Exp.Ther_344_665 |
| PubMedID: 23275066 |
| Gene_locus related to this paper: human-CES1 |
| Title : Activation of the antiviral prodrug oseltamivir is impaired by two newly identified carboxylesterase 1 variants - Zhu_2009_Drug.Metab.Dispos_37_264 |
| Author(s) : Zhu HJ , Markowitz JS |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 37 :264 , 2009 |
| Abstract : |
| PubMedSearch : Zhu_2009_Drug.Metab.Dispos_37_264 |
| PubMedID: 19022936 |
| Gene_locus related to this paper: human-CES1 |
| Title : Two CES1 gene mutations lead to dysfunctional carboxylesterase 1 activity in man: clinical significance and molecular basis - Zhu_2008_Am.J.Hum.Genet_82_1241 |
| Author(s) : Zhu HJ , Patrick KS , Yuan HJ , Wang JS , Donovan JL , DeVane CL , Malcolm R , Johnson JA , Youngblood GL , Sweet DH , Langaee TY , Markowitz JS |
| Ref : American Journal of Human Genetics , 82 :1241 , 2008 |
| Abstract : |
| PubMedSearch : Zhu_2008_Am.J.Hum.Genet_82_1241 |
| PubMedID: 18485328 |
| Gene_locus related to this paper: human-CES1 |