Markowitz JS

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Title : Prediction of Carboxylesterase 1 (CES1)-mediated In Vivo Drug Interaction between Methylphenidate and Cannabinoids using Static and Physiologically Based Pharmacokinetic Models - Qian_2022_Drug.Metab.Dispos__
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Title : Involvement of esterases in the pulmonary metabolism of beclomethasone dipropionate and the potential influence of cannabis use - Qian_2022_Chem.Biol.Interact__110228
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Title : In vitro inhibition of carboxylesterase 1 by Kava (Piper methysticum) Kavalactones - Melchert_2022_Chem.Biol.Interact__109883
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Title : In vitro evaluation of the impact of Covid-19 therapeutic agents on the hydrolysis of the antiviral prodrug remdesivir - Zhang_2022_Chem.Biol.Interact_365_110097
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Title : The Influence of Cannabidiol on the Pharmacokinetics of Methylphenidate in Healthy Subjects - Markowitz_2022_Med.Cannabis.Cannabinoids_5_199
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Title : Plasma carboxylesterase 1 predicts methylphenidate exposure: a proof-of-concept study using plasma protein biomarker for hepatic drug metabolism - Shi_2021_Clin.Pharmacol.Ther__
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Title : Natural Products as Modulators of CES1 Activity - Qian_2020_Drug.Metab.Dispos_48_993
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Title : The influence of carboxylesterase 1 polymorphism and cannabidiol on the hepatic metabolism of heroin - Qian_2019_Chem.Biol.Interact__108914
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Title : The Potential for Pharmacokinetic Interactions Between Cannabis Products and Conventional Medications - Qian_2019_J.Clin.Psychopharmacol_39_462
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Title : In Vitro Inhibition of Carboxylesterase 1 by Major Cannabinoids and Selected Metabolites - Qian_2019_Drug.Metab.Dispos_47_465
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Gene_locus related to this paper: human-CES1

Title : Ethanol Interactions With Dexmethylphenidate and dl-Methylphenidate Spheroidal Oral Drug Absorption Systems in Healthy Volunteers - Zhu_2017_J.Clin.Psychopharmacol_37_419
Author(s) : Zhu HJ , Patrick KS , Straughn AB , Reeves OT, 3rd , Bernstein H , Shi J , Johnson HJ , Knight JM , Smith AT , Malcolm RJ , Markowitz JS
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Title : CES1P1 variant -816A>C is not associated with hepatic carboxylesterase 1 expression and activity or antihypertensive effect of trandolapril - Zhu_2016_Eur.J.Clin.Pharmacol_72_681
Author(s) : Zhu HJ , Langaee TY , Gong Y , Wang X , Pepine CJ , Cooper-DeHoff RM , Johnson JA , Markowitz JS
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Gene_locus related to this paper: human-CES1

Title : Carboxylesterase 1-Mediated Drug-Drug Interactions between Clopidogrel and Simvastatin - Wang_2015_Biol.Pharm.Bull_38_292
Author(s) : Wang X , Zhu HJ , Markowitz JS
Ref : Biol Pharm Bull , 38 :292 , 2015
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Title : Clopidogrel Bioactivation and Risk of Bleeding in Patients Cotreated With Angiotensin-Converting Enzyme Inhibitors After Myocardial Infarction: A Proof-of-Concept Study - Kristensen_2014_Clin.Pharmacol.Ther_96_713
Author(s) : Kristensen KE , Zhu HJ , Wang X , Gislason GH , Torp-Pedersen C , Rasmussen HB , Markowitz JS , Hansen PR
Ref : Clinical Pharmacology & Therapeutics , 96 :713 , 2014
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Title : Carboxylesterase 1 as a determinant of clopidogrel metabolism and activation - Zhu_2013_J.Pharmacol.Exp.Ther_344_665
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Gene_locus related to this paper: human-CES1

Title : Isopropylphenidate: an ester homolog of methylphenidate with sustained and selective dopaminergic activity and reduced drug interaction liability - Markowitz_2013_J.Child.Adolesc.Psychopharmacol_23_648
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Ref : J Child Adolesc Psychopharmacol , 23 :648 , 2013
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Title : A discriminative analytical method for detection of CES1A1 and CES1A2\/CES1A3 genetic variants - Zhu_2012_Pharmacogenet.Genomics_22_215
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PubMedID: 22237548
Gene_locus related to this paper: human-CES1

Title : Enantiospecific determination of dl-methylphenidate and dl-ethylphenidate in plasma by liquid chromatography-tandem mass spectrometry: Application to human ethanol interactions - Zhu_2011_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_879_783
Author(s) : Zhu HJ , Patrick KS , Markowitz JS
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Title : Age- and sex-related expression and activity of carboxylesterase 1 and 2 in mouse and human liver - Zhu_2009_Drug.Metab.Dispos_37_1819
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Title : Activation of the antiviral prodrug oseltamivir is impaired by two newly identified carboxylesterase 1 variants - Zhu_2009_Drug.Metab.Dispos_37_264
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Gene_locus related to this paper: human-CES1

Title : Role of carboxylesterase 1 and impact of natural genetic variants on the hydrolysis of trandolapril - Zhu_2009_Biochem.Pharmacol_77_1266
Author(s) : Zhu HJ , Appel DI , Johnson JA , Chavin KD , Markowitz JS
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Gene_locus related to this paper: human-CES1

Title : Enantiospecific gas chromatographic-mass spectrometric analysis of urinary methylphenidate: implications for phenotyping - LeVasseur_2008_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_862_140
Author(s) : LeVasseur NL , Zhu HJ , Markowitz JS , DeVane CL , Patrick KS
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Title : Two CES1 gene mutations lead to dysfunctional carboxylesterase 1 activity in man: clinical significance and molecular basis - Zhu_2008_Am.J.Hum.Genet_82_1241
Author(s) : Zhu HJ , Patrick KS , Yuan HJ , Wang JS , Donovan JL , DeVane CL , Malcolm R , Johnson JA , Youngblood GL , Sweet DH , Langaee TY , Markowitz JS
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PubMedID: 18485328
Gene_locus related to this paper: human-CES1

Title : Double-blind donepezil-placebo crossover augmentation study of atypical antipsychotics in chronic, stable schizophrenia: a pilot study - Risch_2007_Schizophr.Res_93_131
Author(s) : Risch SC , Horner MD , McGurk SR , Palecko S , Markowitz JS , Nahas Z , DeVane CL
Ref : Schizophr Res , 93 :131 , 2007
PubMedID: 17391930

Title : Donepezil effects on mood in patients with schizophrenia and schizoaffective disorder - Risch_2006_Int.J.Neuropsychopharmacol_9_603
Author(s) : Risch SC , Horner MD , McGurk SR , Palecko S , Markowitz JS , Nahas Z , DeVane CL
Ref : Int J Neuropsychopharmacol , 9 :603 , 2006
PubMedID: 16202177

Title : Examination of nighttime sleep-related problems during double-blind, placebo-controlled trials of galantamine in patients with Alzheimer's disease - Stahl_2004_Curr.Med.Res.Opin_20_517
Author(s) : Stahl SM , Markowitz JS , Papadopoulos G , Sadik K
Ref : Curr Med Res Opin , 20 :517 , 2004
PubMedID: 15119989

Title : Co-use of donepezil and hypnotics among Alzheimer's disease patients living in the community - Stahl_2003_J.Clin.Psychiatry_64_466
Author(s) : Stahl SM , Markowitz JS , Gutterman EM , Papadopoulos G
Ref : J Clin Psychiatry , 64 :466 , 2003
PubMedID: 12716251

Title : Augmenting atypical antipsychotics with a cognitive enhancer (donepezil) improves regional brain activity in schizophrenia patients: a pilot double-blind placebo controlled BOLD fMRI study - Nahas_2003_Neurocase_9_274
Author(s) : Nahas Z , George MS , Horner MD , Markowitz JS , Li X , Lorberbaum JP , Owens SD , McGurk S , DeVane L , Risch SC
Ref : Neurocase , 9 :274 , 2003
PubMedID: 12925933

Title : Sleep-related outcomes in persons with mild to moderate Alzheimer disease in a placebo-controlled trial of galantamine - Markowitz_2003_Sleep_26_602
Author(s) : Markowitz JS , Gutterman EM , Lilienfeld S , Papadopoulos G
Ref : Sleep , 26 :602 , 2003
PubMedID: 12938815

Title : A double-blind placebo-controlled case study of the use of donepezil to improve cognition in a schizoaffective disorder patient: functional MRI correlates - Risch_2001_Neurocase_7_105
Author(s) : Risch SC , McGurk S , Horner MD , Nahas Z , Owens SD , Molloy M , Gilliard C , Christie S , Markowitz JS , DeVane CL , Mintzer J , George MS
Ref : Neurocase , 7 :105 , 2001
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