F295Y_mouse-ACHE

General

Gene Locus : mouse-ACHE

Mode of mutation : Site directed mutagenesis

Disease :

Summary : Acyl specificity Acyl pocket decreases km and kcat for ACT Radic_1993_Biochemistry_32_12074 Pickering_1995_5th.ChE.Meeting.Madras__227

AAA Change :

Allelic Variant :

Risk Factor :

Inhibitor :

Structure :

Disease by interaction :

Interact Gene Locus :

Xenobiotic sensitivity :

Modification : Acyl specificity

Torpedo_number : 288

Kinetic Parameter : Acetylthiocholine_F295Y_mouse-ACHE, Butyrylthiocholine_F295Y_mouse-ACHE, Benzoylthiocholine_F295Y_mouse-ACHE

News : No news

Comment :
p.Phe295Tyr

References (3)

Title : Organophosphate Specificity of Acyl Pocket Cholinesterase Mutants -
Author(s) : Pickering NA , Taylor P , Berman HA
Ref : In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases , (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp. :227 , 1995
PubMedID:

Title : Specificity and orientation of trigonal carboxyl esters and tetrahedral alkylphosphonyl esters in cholinesterases - Hosea_1995_Biochemistry_34_11528
Author(s) : Hosea NA , Berman HA , Taylor P
Ref : Biochemistry , 34 :11528 , 1995
Abstract :
PubMedSearch : Hosea_1995_Biochemistry_34_11528
PubMedID: 7547883

Title : Three distinct domains in the cholinesterase molecule confer selectivity for acetyl- and butyrylcholinesterase inhibitors - Radic_1993_Biochemistry_32_12074
Author(s) : Radic Z , Pickering NA , Vellom DC , Camp S , Taylor P
Ref : Biochemistry , 32 :12074 , 1993
Abstract :
PubMedSearch : Radic_1993_Biochemistry_32_12074
PubMedID: 8218285