Full name : Radic Zoran
First name : Zoran
Mail : Skaggs School of Pharmacy and Pharmaceutical Sciences\; University of California at San Diego\; 9500 Gilman Drive\; La Jolla\; CA 92093-0650
Zip Code : CA 92093
City : San Diego
Country : USA
Email : zradic@ucsd.edu
Phone : +18588224834
Fax :
Website : \/\/pharmacy.ucsd.edu\/faculty\/bios\/radic.shtml
Directory :
Comment
| Title : Connectivity between surface and interior in catalytic subunits of acetylcholinesterases inferred from their X-ray structures - Radic_2023_J.Neurochem_17thISCM_ |
| Author(s) : Radic Z |
| Ref : Journal of Neurochemistry , : , 2023 |
| Abstract : |
| PubMedSearch : Radic_2023_J.Neurochem_17thISCM_ |
| PubMedID: 36892323 |
| Title : Structural and dynamic effects of paraoxon binding to human acetylcholinesterase by X-ray crystallography and inelastic neutron scattering - Gerlits_2022_Structure_30_1538 |
| Author(s) : Gerlits O , Fajer M , Cheng X , Blumenthal DK , Radic Z , Kovalevsky A |
| Ref : Structure , 30 :1538 , 2022 |
| Abstract : |
| PubMedSearch : Gerlits_2022_Structure_30_1538 |
| PubMedID: 36265484 |
| Gene_locus related to this paper: human-ACHE |
| Title : Enhancing target tissue levels and diminishing plasma clearance of ionizing zwitterionic antidotes in organophosphate exposures - Shyong_2021_J.Pharmacol.Exp.Ther__ |
| Author(s) : Shyong YJ , Sepulveda Y , Garcia A , Samskey NM , Radic Z , Sit R , Sharpless KB , Momper JD , Taylor P |
| Ref : Journal of Pharmacology & Experimental Therapeutics , : , 2021 |
| Abstract : |
| PubMedSearch : Shyong_2021_J.Pharmacol.Exp.Ther__ |
| PubMedID: 34145064 |
| Title : Shifts in backbone conformation of acetylcholinesterases upon binding of covalent inhibitors, reversible ligands and substrates - Radic_2021_Crystals_11_1557 |
| Author(s) : Radic Z |
| Ref : Crystals , 11 :1557 , 2021 |
| Abstract : |
| PubMedSearch : Radic_2021_Crystals_11_1557 |
| PubMedID: |
| Title : Backbone Conformation Shifts in X-ray Structures of Human Acetylcholinesterase upon Covalent Organophosphate Inhibition - Luedtke_2021_Crystals_11_1270 |
| Author(s) : Luedtke S , Bojo C , Li Y , Luna E , Bianca Pomar , Radic Z |
| Ref : Crystals , 11 :1270 , 2021 |
| Abstract : |
| PubMedSearch : Luedtke_2021_Crystals_11_1270 |
| PubMedID: |
| Title : Ligand design for human acetylcholinesterase and nicotinic acetylcholine receptors, extending beyond the conventional and canonical - Taylor_2021_J.Neurochem__ |
| Author(s) : Taylor P , Shong YJ , Samskey N , Ho KY , Radic Z , Fenical W , Sharpless KB , Kovarik Z , Andrea Camacho-Hernandez G |
| Ref : Journal of Neurochemistry , : , 2021 |
| Abstract : |
| PubMedSearch : Taylor_2021_J.Neurochem__ |
| PubMedID: 33638151 |
| Title : Covalent inhibition of hAChE by organophosphates causes homodimer dissociation through long-range allosteric effects - Blumenthal_2021_J.Biol.Chem__ |
| Author(s) : Blumenthal DK , Cheng X , Fajer M , Ho KY , Rohrer J , Gerlits O , Taylor P , Juneja P , Kovalevsky A , Radic Z |
| Ref : Journal of Biological Chemistry , :101007 , 2021 |
| Abstract : |
| PubMedSearch : Blumenthal_2021_J.Biol.Chem__ |
| PubMedID: 34324828 |
| Gene_locus related to this paper: human-ACHE |
| Title : Room temperature crystallography of human acetylcholinesterase bound to a substrate analogue 4K-TMA: Towards a neutron structure - Gerlits_2021_Curr.Res.Struct.Biol_3_206 |
| Author(s) : Gerlits O , Blakeley MP , Keen DA , Radic Z , Kovalevsky A |
| Ref : Current Research in Structural Biology , 3 :206 , 2021 |
| Abstract : |
| PubMedSearch : Gerlits_2021_Curr.Res.Struct.Biol_3_206 |
| PubMedID: 34541552 |
| Gene_locus related to this paper: human-ACHE |
| Title : Rational design, synthesis and evaluation of uncharged, smart bis-oxime antidotes of organophosphate-inhibited human acetylcholinesterase - Gorecki_2020_J.Biol.Chem_295_4079 |
| Author(s) : Gorecki L , Gerlits O , Kong X , Cheng X , Blumenthal DK , Taylor P , Ballatore C , Kovalevsky A , Radic Z |
| Ref : Journal of Biological Chemistry , 295 :4079 , 2020 |
| Abstract : |
| PubMedSearch : Gorecki_2020_J.Biol.Chem_295_4079 |
| PubMedID: 32019865 |
| Gene_locus related to this paper: human-ACHE |
| Title : Evaluation of high-affinity phenyltetrahydroisoquinoline aldoximes, linked through anti-triazoles, as reactivators of phosphylated cholinesterases - Macek Hrvat_2019_Toxicol.Lett_321_83 |
| Author(s) : Macek Hrvat N , Kalisiak J , Sinko G , Radic Z , Sharpless KB , Taylor P , Kovarik Z |
| Ref : Toxicol Lett , 321 :83 , 2019 |
| Abstract : |
| PubMedSearch : Macek Hrvat_2019_Toxicol.Lett_321_83 |
| PubMedID: 31863869 |
| Title : Assessment of ionizable, zwitterionic oximes as reactivating antidotal agents for organophosphate exposure - Taylor_2019_Chem.Biol.Interact_13ChEPon_308_194 |
| Author(s) : Taylor P , Yan-Jye S , Momper J , Hou W , Camacho-Hernandez GA , Radic Z , Rosenberg YJ , Kovarik Z , Sit R , Sharpless KB |
| Ref : Chemico-Biological Interactions , 308 :194 , 2019 |
| Abstract : |
| PubMedSearch : Taylor_2019_Chem.Biol.Interact_13ChEPon_308_194 |
| PubMedID: 31100277 |
| Title : Reversal of Tabun Toxicity Enabled by a Triazole-Annulated Oxime Library-Reactivators of Acetylcholinesterase - Kovarik_2019_Chemistry_25_4100 |
| Author(s) : Kovarik Z , Kalisiak J , Macek Hrvat N , Katalinic M , Zorbaz T , Zunec S , Green C , Radic Z , Fokin VV , Sharpless KB , Taylor P |
| Ref : Chemistry , 25 :4100 , 2019 |
| Abstract : |
| PubMedSearch : Kovarik_2019_Chemistry_25_4100 |
| PubMedID: 30458057 |
| Title : A new crystal form of human acetylcholinesterase for exploratory room-temperature crystallography studies - Gerlits_2019_Chem.Biol.Interact_13ChEPon_ |
| Author(s) : Gerlits O , Ho KY , Cheng X , Blumenthal D , Taylor P , Kovalevsky A , Radic Z |
| Ref : Chemico-Biological Interactions , : , 2019 |
| Abstract : |
| PubMedSearch : Gerlits_2019_Chem.Biol.Interact_13ChEPon_ |
| PubMedID: 31176713 |
| Gene_locus related to this paper: human-ACHE |
| Title : Productive reorientation of a bound oxime reactivator revealed in room temperature X-ray structures of native and VX-inhibited human acetylcholinesterase - Gerlits_2019_J.Biol.Chem_294_10607 |
| Author(s) : Gerlits O , Kong X , Cheng X , Wymore T , Blumenthal DK , Taylor P , Radic Z , Kovalevsky A |
| Ref : Journal of Biological Chemistry , 294 :10607 , 2019 |
| Abstract : |
| PubMedSearch : Gerlits_2019_J.Biol.Chem_294_10607 |
| PubMedID: 31138650 |
| Gene_locus related to this paper: human-ACHE |
| Title : Counteracting tabun inhibition by reactivation by pyridinium aldoximes that interact with active center gorge mutants of acetylcholinesterase - Kovarik_2019_Toxicol.Appl.Pharmacol_372_40 |
| Author(s) : Kovarik Z , Macek Hrvat N , Kalisiak J , Katalinic M , Sit RK , Zorbaz T , Radic Z , Fokin VV , Sharpless KB , Taylor P |
| Ref : Toxicol Appl Pharmacol , 372 :40 , 2019 |
| Abstract : |
| PubMedSearch : Kovarik_2019_Toxicol.Appl.Pharmacol_372_40 |
| PubMedID: 30978400 |
| Gene_locus related to this paper: human-ACHE |
| Title : Pharmacology, Pharmacokinetics, and Tissue Disposition of Zwitterionic Hydroxyiminoacetamido Alkylamines as Reactivating Antidotes for Organophosphate Exposure - Sit_2018_J.Pharmacol.Exp.Ther_367_363 |
| Author(s) : Sit RK , Kovarik Z , Macek Hrvat N , Zunec S , Green C , Fokin VV , Sharpless KB , Radic Z , Taylor P |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 367 :363 , 2018 |
| Abstract : |
| PubMedSearch : Sit_2018_J.Pharmacol.Exp.Ther_367_363 |
| PubMedID: 30190337 |
| Title : The JAVA Based Computational Tool for Pairwise Comparison of Protein Backbone Folds in Liganded and Apo 3D Structures of the alpha\/beta Hydrolase Fold Proteins - Zheng_2018_FaASEB.J_32_527 |
| Author(s) : Zheng Z , Rohrer J , Radic Z |
| Ref : FASEB Journal , 32 :527 , 2018 |
| Abstract : |
| PubMedSearch : Zheng_2018_FaASEB.J_32_527 |
| PubMedID: |
| Title : Planarian cholinesterase: molecular and functional characterization of an evolutionarily ancient enzyme to study organophosphorus pesticide toxicity - Hagstrom_2018_Arch.Toxicol_92_1161 |
| Author(s) : Hagstrom D , Zhang S , Ho A , Tsai ES , Radic Z , Jahromi A , Kaj KJ , He Y , Taylor P , Collins ES |
| Ref : Archives of Toxicology , 92 :1161 , 2018 |
| Abstract : |
| PubMedSearch : Hagstrom_2018_Arch.Toxicol_92_1161 |
| PubMedID: 29167930 |
| Gene_locus related to this paper: dugja-CHE1 , dugja-CHE2 |
| Title : Post-exposure treatment with the oxime RS194B rapidly reverses early and advanced symptoms in macaques exposed to sarin vapor - Rosenberg_2017_Chem.Biol.Interact_274_50 |
| Author(s) : Rosenberg YJ , Mao L , Jiang X , Lees J , Zhang L , Radic Z , Taylor P |
| Ref : Chemico-Biological Interactions , 274 :50 , 2017 |
| Abstract : |
| PubMedSearch : Rosenberg_2017_Chem.Biol.Interact_274_50 |
| PubMedID: 28693885 |
| Title : Butyrylcholinesterase identification in a phenylvalerate esterase-enriched fraction sensitive to low mipafox concentrations in chicken brain - Mangas_2017_Arch.Toxicol_91_909 |
| Author(s) : Mangas I , Radic Z , Taylor P , Ghassemian M , Candela H , Vilanova E , Estevez J |
| Ref : Archives of Toxicology , 91 :909 , 2017 |
| Abstract : |
| PubMedSearch : Mangas_2017_Arch.Toxicol_91_909 |
| PubMedID: 26838044 |
| Title : Limitations in current acetylcholinesterase structure-based design of oxime antidotes for organophosphate poisoning - Kovalevsky_2016_Ann.N.Y.Acad.Sci_1378_41 |
| Author(s) : Kovalevsky A , Blumenthal DK , Cheng X , Taylor P , Radic Z |
| Ref : Annals of the New York Academy of Sciences , 1378 :41 , 2016 |
| Abstract : |
| PubMedSearch : Kovalevsky_2016_Ann.N.Y.Acad.Sci_1378_41 |
| PubMedID: 27371941 |
| Title : Resolving pathways of interaction of mipafox and a sarin analog with human acetylcholinesterase by kinetics, mass spectrometry and molecular modeling approaches - Mangas_2016_Arch.Toxicol_90_603 |
| Author(s) : Mangas I , Taylor P , Vilanova E , Estevez J , Franca TCC , Komives E , Radic Z |
| Ref : Archives of Toxicology , 90 :603 , 2016 |
| Abstract : |
| PubMedSearch : Mangas_2016_Arch.Toxicol_90_603 |
| PubMedID: 25743373 |
| Title : Mechanistic studies of new oximes reactivators of human butyrylcholinesterase inhibited by cyclosarin and sarin - de Lima_2016_J.Biomol.Struct.Dyn__1 |
| Author(s) : de Lima WE , Francisco A , da Cunha EFF , Radic Z , Taylor P , Franca TCC , Ramalho TC |
| Ref : J Biomol Struct Dyn , :1 , 2016 |
| Abstract : |
| PubMedSearch : de Lima_2016_J.Biomol.Struct.Dyn__1 |
| PubMedID: 27125569 |
| Title : HI-6 assisted catalytic scavenging of VX by acetylcholinesterase choline binding site mutants - Macek Hrvat_2016_Chem.Biol.Interact_259_148 |
| Author(s) : Macek Hrvat N , Zunec S , Taylor P , Radic Z , Kovarik Z |
| Ref : Chemico-Biological Interactions , 259 :148 , 2016 |
| Abstract : |
| PubMedSearch : Macek Hrvat_2016_Chem.Biol.Interact_259_148 |
| PubMedID: 27083141 |
| Gene_locus related to this paper: human-ACHE |
| Title : Planarian cholinesterase: in vitro characterization of an evolutionarily ancient enzyme to study organophosphorus pesticide toxicity and reactivation - Hagstrom_2017_Arch.Toxicol_91_2837 |
| Author(s) : Hagstrom D , Hirokawa H , Zhang L , Radic Z , Taylor P , Collins ES |
| Ref : Archives of Toxicology , 91 :2837 , 2016 |
| Abstract : |
| PubMedSearch : Hagstrom_2017_Arch.Toxicol_91_2837 |
| PubMedID: 27990564 |
| Gene_locus related to this paper: dugja-CHE1 , dugja-CHE2 |
| Title : Catalytic Soman Scavenging by the Y337A\/F338A Acetylcholinesterase Mutant Assisted with Novel Site-Directed Aldoximes - Kovarik_2015_Chem.Res.Toxicol_28_1036 |
| Author(s) : Kovarik Z , Macek Hrvat N , Katalinic M , Sit RK , Paradyse A , Zunec S , Musilek K , Fokin VV , Taylor P , Radic Z |
| Ref : Chemical Research in Toxicology , 28 :1036 , 2015 |
| Abstract : |
| PubMedSearch : Kovarik_2015_Chem.Res.Toxicol_28_1036 |
| PubMedID: 25835984 |
| Title : Quaternary and tertiary aldoxime antidotes for organophosphate exposure in a zebrafish model system - Schmidt_2015_Toxicol.Appl.Pharmacol_284_197 |
| Author(s) : Schmidt HR , Radic Z , Taylor P , Fradinger EA |
| Ref : Toxicol Appl Pharmacol , 284 :197 , 2015 |
| Abstract : |
| PubMedSearch : Schmidt_2015_Toxicol.Appl.Pharmacol_284_197 |
| PubMedID: 25701203 |
| Title : Marine Macrocyclic Imines, Pinnatoxins A and G: Structural Determinants and Functional Properties to Distinguish Neuronal alpha7 from Muscle alpha1(2)betagammadelta nAChRs - Bourne_2015_Structure_23_1106 |
| Author(s) : Bourne Y , Sulzenbacher G , Radic Z , Araoz R , Reynaud M , Benoit E , Zakarian A , Servent D , Molgo J , Taylor P , Marchot P |
| Ref : Structure , 23 :1106 , 2015 |
| Abstract : |
| PubMedSearch : Bourne_2015_Structure_23_1106 |
| PubMedID: 26004441 |
| Title : Imidazole aldoximes effective in assisting butyrylcholinesterase catalysis of organophosphate detoxification - Sit_2014_J.Med.Chem_57_1378 |
| Author(s) : Sit RK , Fokin VV , Amitai G , Sharpless KB , Taylor P , Radic Z |
| Ref : Journal of Medicinal Chemistry , 57 :1378 , 2014 |
| Abstract : |
| PubMedSearch : Sit_2014_J.Med.Chem_57_1378 |
| PubMedID: 24571195 |
| Title : Centrally acting oximes in reactivation of tabun-phosphoramidated AChE - Kovarik_2013_Chem.Biol.Interact_203_77 |
| Author(s) : Kovarik Z , Macek Hrvat N , Sit RK , Radic Z , Fokin VV , Sharpless KB , Taylor P |
| Ref : Chemico-Biological Interactions , 203 :77 , 2013 |
| Abstract : |
| PubMedSearch : Kovarik_2013_Chem.Biol.Interact_203_77 |
| PubMedID: 22960624 |
| Title : Mechanism of interaction of novel uncharged, centrally active reactivators with OP-hAChE conjugates - Radic_2013_Chem.Biol.Interact_203_67 |
| Author(s) : Radic Z , Sit RK , Garcia E , Zhang LM , Zunec S , Kovarik Z , Amitai G , Fokin VV , Sharpless KB , Taylor P |
| Ref : Chemico-Biological Interactions , 203 :67 , 2013 |
| Abstract : |
| PubMedSearch : Radic_2013_Chem.Biol.Interact_203_67 |
| PubMedID: 22975155 |
| Title : Catalytic detoxification of nerve agent and pesticide organophosphates by butyrylcholinesterase assisted with non-pyridinium oximes - Radic_2013_Biochem.J_450_231 |
| Author(s) : Radic Z , Dale T , Kovarik Z , Zunec S , Garcia E , Zhang LM , Amitai G , Green C , Radic B , Duggan BM , Ajami D , Rebek J , Taylor P |
| Ref : Biochemical Journal , 450 :231 , 2013 |
| Abstract : |
| PubMedSearch : Radic_2013_Biochem.J_450_231 |
| PubMedID: 23216060 |
| Title : Automated docking with protein flexibility in the design of femtomolar click chemistry inhibitors of acetylcholinesterase - Morris_2013_J.Chem.Inf.Model_53_898 |
| Author(s) : Morris GM , Green LG , Radic Z , Taylor P , Sharpless KB , Olson AJ , Grynszpan F |
| Ref : J Chem Inf Model , 53 :898 , 2013 |
| Abstract : |
| PubMedSearch : Morris_2013_J.Chem.Inf.Model_53_898 |
| PubMedID: 23451944 |
| Title : Refinement of structural leads for centrally acting oxime reactivators of phosphylated cholinesterases - Radic_2012_J.Biol.Chem_287_11798 |
| Author(s) : Radic Z , Sit RK , Kovarik Z , Zunec S , Garcia E , Zhang L , Amitai G , Green C , Radic B , Fokin VV , Sharpless KB , Taylor P |
| Ref : Journal of Biological Chemistry , 287 :11798 , 2012 |
| Abstract : |
| PubMedSearch : Radic_2012_J.Biol.Chem_287_11798 |
| PubMedID: 22343626 |
| Title : New structural scaffolds for centrally acting oxime reactivators of phosphylated cholinesterases - Sit_2011_J.Biol.Chem_286_19422 |
| Author(s) : Sit RK , Radic Z , Gerardi V , Zhang L , Garcia E , Katalinic M , Amitai G , Kovarik Z , Fokin VV , Sharpless KB , Taylor P |
| Ref : Journal of Biological Chemistry , 286 :19422 , 2011 |
| Abstract : |
| PubMedSearch : Sit_2011_J.Biol.Chem_286_19422 |
| PubMedID: 21464125 |
| Title : Oxime-assisted acetylcholinesterase catalytic scavengers of organophosphates that resist aging - Cochran_2011_J.Biol.Chem_286_29718 |
| Author(s) : Cochran R , Kalisiak J , Tuylu Kucukkilinc T , Radic Z , Garcia E , Zhang L , Ho KY , Amitai G , Kovarik Z , Fokin VV , Sharpless KB , Taylor P |
| Ref : Journal of Biological Chemistry , 286 :29718 , 2011 |
| Abstract : |
| PubMedSearch : Cochran_2011_J.Biol.Chem_286_29718 |
| PubMedID: 21730071 |
| Title : Naturally occurring variations in the human cholinesterase genes: heritability and association with cardiovascular and metabolic traits - Valle_2011_J.Pharmacol.Exp.Ther_338_125 |
| Author(s) : Valle AM , Radic Z , Rana BK , Mahboubi V , Wessel J , Shih PA , Rao F , O'Connor DT , Taylor P |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 338 :125 , 2011 |
| Abstract : |
| PubMedSearch : Valle_2011_J.Pharmacol.Exp.Ther_338_125 |
| PubMedID: 21493754 |
| Title : Conformational remodeling of femtomolar inhibitor-acetylcholinesterase complexes in the crystalline state - Bourne_2010_J.Am.Chem.Soc_132_18292 |
| Author(s) : Bourne Y , Radic Z , Taylor P , Marchot P |
| Ref : Journal of the American Chemical Society , 132 :18292 , 2010 |
| Abstract : |
| PubMedSearch : Bourne_2010_J.Am.Chem.Soc_132_18292 |
| PubMedID: 21090615 |
| Gene_locus related to this paper: mouse-ACHE |
| Title : Interaction kinetics of oximes with native, phosphylated and aged human acetylcholinesterase - Radic_2010_Chem.Biol.Interact_187_163 |
| Author(s) : Radic Z , Kalisiak J , Fokin VV , Sharpless KB , Taylor P |
| Ref : Chemico-Biological Interactions , 187 :163 , 2010 |
| Abstract : |
| PubMedSearch : Radic_2010_Chem.Biol.Interact_187_163 |
| PubMedID: 20412789 |
| Title : Investigating the structural influence of surface mutations on acetylcholinesterase inhibition by organophosphorus compounds and oxime reactivation - Kucukkilinc_2010_Chem.Biol.Interact_187_238 |
| Author(s) : Tuylu Kucukkilinc T , Cochran R , Kalisiak J , Garcia E , Valle A , Amitai G , Radic Z , Taylor P |
| Ref : Chemico-Biological Interactions , 187 :238 , 2010 |
| Abstract : |
| PubMedSearch : Kucukkilinc_2010_Chem.Biol.Interact_187_238 |
| PubMedID: 20382137 |
| Title : Structural determinants in phycotoxins and AChBP conferring high affinity binding and nicotinic AChR antagonism - Bourne_2010_Proc.Natl.Acad.Sci.U.S.A_107_6076 |
| Author(s) : Bourne Y , Radic Z , Araoz R , Talley TT , Benoit E , Servent D , Taylor P , Molgo J , Marchot P |
| Ref : Proc Natl Acad Sci U S A , 107 :6076 , 2010 |
| Abstract : |
| PubMedSearch : Bourne_2010_Proc.Natl.Acad.Sci.U.S.A_107_6076 |
| PubMedID: 20224036 |
| Title : Probing gorge dimensions of cholinesterases by freeze-frame click chemistry - Radic_2008_Chem.Biol.Interact_175_161 |
| Author(s) : Radic Z , Manetsch R , Fournier D , Sharpless KB , Taylor P |
| Ref : Chemico-Biological Interactions , 175 :161 , 2008 |
| Abstract : |
| PubMedSearch : Radic_2008_Chem.Biol.Interact_175_161 |
| PubMedID: 18555981 |
| Title : Acetylcholinesterase: mechanisms of covalent inhibition of H447I mutant determined by computational analyses - Cheng_2008_Chem.Biol.Interact_175_196 |
| Author(s) : Cheng YH , Cheng XL , Radic Z , McCammon JA |
| Ref : Chemico-Biological Interactions , 175 :196 , 2008 |
| Abstract : |
| PubMedSearch : Cheng_2008_Chem.Biol.Interact_175_196 |
| PubMedID: 18657802 |
| Title : The cholinesterases: analysis by pharmacogenomics in man - Valle_2008_Chem.Biol.Interact_175_343 |
| Author(s) : Valle AM , Radic Z , Rana BK , Whitfield JB , O'Connor DT , Martin NG , Taylor P |
| Ref : Chemico-Biological Interactions , 175 :343 , 2008 |
| Abstract : |
| PubMedSearch : Valle_2008_Chem.Biol.Interact_175_343 |
| PubMedID: 18541229 |
| Title : Atomic interactions of neonicotinoid agonists with AChBP: molecular recognition of the distinctive electronegative pharmacophore - Talley_2008_Proc.Natl.Acad.Sci.U.S.A_105_7606 |
| Author(s) : Talley TT , Harel M , Hibbs RE , Radic Z , Tomizawa M , Casida JE , Taylor P |
| Ref : Proc Natl Acad Sci U S A , 105 :7606 , 2008 |
| Abstract : |
| PubMedSearch : Talley_2008_Proc.Natl.Acad.Sci.U.S.A_105_7606 |
| PubMedID: 18477694 |
| Title : Mechanisms of organophosphate toxicity and detoxication with emphasis on studies in Croatia - Reiner_2007_Arh.Hig.Rada.Toksikol_58_329 |
| Author(s) : Reiner E , Radic Z , Simeon-Rudolf V |
| Ref : Arh Hig Rada Toksikol , 58 :329 , 2007 |
| Abstract : |
| PubMedSearch : Reiner_2007_Arh.Hig.Rada.Toksikol_58_329 |
| PubMedID: 17913688 |
| Title : Acetylcholinesterase: converting a vulnerable target to a template for antidotes and detection of inhibitor exposure - Taylor_2007_Toxicology_233_70 |
| Author(s) : Taylor P , Kovarik Z , Reiner E , Radic Z |
| Ref : Toxicology , 233 :70 , 2007 |
| Abstract : |
| PubMedSearch : Taylor_2007_Toxicology_233_70 |
| PubMedID: 17196318 |
| Title : Application of recombinant DNA methods for production of cholinesterases as organophosphate antidotes and detectors - Taylor_2007_Arh.Hig.Rada.Toksikol_58_339 |
| Author(s) : Taylor P , Reiner E , Kovarik Z , Radic Z |
| Ref : Arh Hig Rada Toksikol , 58 :339 , 2007 |
| Abstract : |
| PubMedSearch : Taylor_2007_Arh.Hig.Rada.Toksikol_58_339 |
| PubMedID: 17913689 |
| Title : Acetylcholinesterase: mechanisms of covalent inhibition of wild-type and H447I mutant determined by computational analyses - Cheng_2007_J.Am.Chem.Soc_129_6562 |
| Author(s) : Cheng Y , Cheng X , Radic Z , McCammon JA |
| Ref : Journal of the American Chemical Society , 129 :6562 , 2007 |
| Abstract : |
| PubMedSearch : Cheng_2007_J.Am.Chem.Soc_129_6562 |
| PubMedID: 17461584 |
| Title : Mutation of acetylcholinesterase to enhance oxime-assisted catalytic turnover of methylphosphonates - Kovarik_2007_Toxicology_233_79 |
| Author(s) : Kovarik Z , Radic Z , Berman HA , Taylor P |
| Ref : Toxicology , 233 :79 , 2007 |
| Abstract : |
| PubMedSearch : Kovarik_2007_Toxicology_233_79 |
| PubMedID: 17046138 |
| Title : Structure-guided drug design: conferring selectivity among neuronal nicotinic receptor and acetylcholine-binding protein subtypes - Taylor_2007_Biochem.Pharmacol_74(8)_1164 |
| Author(s) : Taylor P , Talley TT , Radic Z , Hansen SB , Hibbs RE , Shi J |
| Ref : Biochemical Pharmacology , 74 :1164 , 2007 |
| Abstract : |
| PubMedSearch : Taylor_2007_Biochem.Pharmacol_74(8)_1164 |
| PubMedID: 17826748 |
| Title : Substrate and product trafficking through the active center gorge of acetylcholinesterase analyzed by crystallography and equilibrium binding - Bourne_2006_J.Biol.Chem_281_29256 |
| Author(s) : Bourne Y , Radic Z , Sulzenbacher G , Kim E , Taylor P , Marchot P |
| Ref : Journal of Biological Chemistry , 281 :29256 , 2006 |
| Abstract : |
| PubMedSearch : Bourne_2006_J.Biol.Chem_281_29256 |
| PubMedID: 16837465 |
| Gene_locus related to this paper: mouse-ACHE |
| Title : Active site mutant acetylcholinesterase interactions with 2-PAM, HI-6, and DDVP - Kovarik_2006_Biochem.Biophys.Res.Commun_342_973 |
| Author(s) : Kovarik Z , Ciban N , Radic Z , Simeon-Rudolf V , Taylor P |
| Ref : Biochemical & Biophysical Research Communications , 342 :973 , 2006 |
| Abstract : |
| PubMedSearch : Kovarik_2006_Biochem.Biophys.Res.Commun_342_973 |
| PubMedID: 16598855 |
| Title : A mutation linked with autism reveals a common mechanism of endoplasmic reticulum retention for the alpha,beta-hydrolase fold protein family - De Jaco_2006_J.Biol.Chem_281_9667 |
| Author(s) : De Jaco A , Comoletti D , Kovarik Z , Gaietta G , Radic Z , Lockridge O , Ellisman MH , Taylor P |
| Ref : Journal of Biological Chemistry , 281 :9667 , 2006 |
| Abstract : |
| PubMedSearch : De Jaco_2006_J.Biol.Chem_281_9667 |
| PubMedID: 16434405 |
| Title : Conformational transitions in protein-protein association: binding of fasciculin-2 to acetylcholinesterase - Bui_2006_Biophys.J_90_3280 |
| Author(s) : Bui JM , Radic Z , Taylor P , McCammon JA |
| Ref : Biophysical Journal , 90 :3280 , 2006 |
| Abstract : |
| PubMedSearch : Bui_2006_Biophys.J_90_3280 |
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| Title : Influence of agonists and antagonists on the segmental motion of residues near the agonist binding pocket of the acetylcholine-binding protein - Hibbs_2006_J.Biol.Chem_281_39708 |
| Author(s) : Hibbs RE , Radic Z , Taylor P , Johnson DA |
| Ref : Journal of Biological Chemistry , 281 :39708 , 2006 |
| Abstract : |
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| PubMedID: 17068341 |
| Title : In situ selection of lead compounds by click chemistry: target-guided optimization of acetylcholinesterase inhibitors - Krasinski_2005_J.Am.Chem.Soc_127_6686 |
| Author(s) : Krasinski A , Radic Z , Manetsch R , Raushel J , Taylor P , Sharpless KB , Kolb HC |
| Ref : Journal of the American Chemical Society , 127 :6686 , 2005 |
| Abstract : |
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| PubMedID: 15869290 |
| Title : Molecular basis of interactions of cholinesterases with tight binding inhibitors - Radic_2005_Chem.Biol.Interact_157-158_133 |
| Author(s) : Radic Z , Manetsch R , Krasinski A , Raushel J , Yamauchi J , Garcia C , Kolb HC , Sharpless KB , Taylor P |
| Ref : Chemico-Biological Interactions , 157-158 :133 , 2005 |
| Abstract : |
| PubMedSearch : Radic_2005_Chem.Biol.Interact_157-158_133 |
| PubMedID: 16289416 |
| Title : Structural insights into conformational flexibility at the peripheral site and within the active center gorge of AChE - Bourne_2005_Chem.Biol.Interact_157-158_159 |
| Author(s) : Bourne Y , Radic Z , Kolb HC , Sharpless KB , Taylor P , Marchot P |
| Ref : Chemico-Biological Interactions , 157-158 :159 , 2005 |
| Abstract : |
| PubMedSearch : Bourne_2005_Chem.Biol.Interact_157-158_159 |
| PubMedID: 16259971 |
| Title : Tetrameric mouse acetylcholinesterase: continuum diffusion rate calculations by solving the steady-state Smoluchowski equation using finite element methods - Zhang_2005_Biophys.J_88_1659 |
| Author(s) : Zhang D , Suen J , Zhang Y , Song Y , Radic Z , Taylor P , Holst MJ , Bajaj C , Baker NA , McCammon JA |
| Ref : Biophysical Journal , 88 :1659 , 2005 |
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| PubMedID: 15626705 |
| Title : Species-related differences in the oxime-induced reactivation of organophosphate-inhibited acetylcholinesterases - |
| Author(s) : Luo C , Dawson M , Chambers C , Chilukuri N , Radic Z , Taylor P , Doctor BP , Saxena A |
| Ref : Chemico-Biological Interactions , 157-158 :393 , 2005 |
| PubMedID: 16429528 |
| Title : Ligand-induced conformational changes in residues flanking the active site gorge of acetylcholinesterase - |
| Author(s) : Pezzementi L , Shi J , Johnson DA , Radic Z , Boyd A , Taylor P |
| Ref : Chemico-Biological Interactions , 157-158 :413 , 2005 |
| PubMedID: 16429560 |
| Title : Poster (50) Insights into the interactions at the acetylcholinesterase peripheral anionic site. - |
| Author(s) : Bourne Y , Taylor P , Radic Z , Berman HA , Marchot P |
| Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :347 , 2004 |
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| Title : Poster (51) Novel compounds with distinctive interactions at the acetylcholinesterase peripheral anionic site - |
| Author(s) : Bourne Y , Taylor P , Radic Z , Lewis WG , Grynszpan F , Finn MG , Sharpless KB , Marchot P |
| Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :348 , 2004 |
| PubMedID: |
| Title : Freeze-frame inhibitor captures acetylcholinesterase in a unique conformation - Bourne_2004_Proc.Natl.Acad.Sci.U.S.A_101_1449 |
| Author(s) : Bourne Y , Kolb HC , Radic Z , Sharpless KB , Taylor P , Marchot P |
| Ref : Proc Natl Acad Sci U S A , 101 :1449 , 2004 |
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| Gene_locus related to this paper: mouse-ACHE |
| Title : Mutant cholinesterases possessing enhanced capacity for reactivation of their phosphonylated conjugates - Kovarik_2004_Biochemistry_43_3222 |
| Author(s) : Kovarik Z , Radic Z , Berman HA , Simeon-Rudolf V , Reiner E , Taylor P |
| Ref : Biochemistry , 43 :3222 , 2004 |
| Abstract : |
| PubMedSearch : Kovarik_2004_Biochemistry_43_3222 |
| PubMedID: 15023072 |
| Title : In situ click chemistry: enzyme inhibitors made to their own specifications - Manetsch_2004_J.Am.Chem.Soc_126_12809 |
| Author(s) : Manetsch R , Krasinski A , Radic Z , Raushel J , Taylor P , Sharpless KB , Kolb HC |
| Ref : Journal of the American Chemical Society , 126 :12809 , 2004 |
| Abstract : |
| PubMedSearch : Manetsch_2004_J.Am.Chem.Soc_126_12809 |
| PubMedID: 15469276 |
| Title : Kinetics of interaction of ethopropazine enantiomers with butyrylcholinesterase and acetylcholinesterase. - |
| Author(s) : Reiner E , Sinko G , Radic Z , Taylor P , Simeon-Rudolf V |
| Ref : Cholinergic Mechanisms, CRC Press :705 , 2004 |
| PubMedID: |
| Title : Poster (89) Phosphorylation of mouse cholinesterases and mutants by ddvp and reactivation of conjugates by Hi-6 and 2-PAM - |
| Author(s) : Kovarik Z , Wong L , Radic Z , Taylor P |
| Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :367 , 2004 |
| PubMedID: |
| Title : Nanosecond dynamics of acetylcholinesterase near the active center gorge - Boyd_2004_J.Biol.Chem_279_26612 |
| Author(s) : Boyd AE , Dunlop CS , Wong L , Radic Z , Taylor P , Johnson DA |
| Ref : Journal of Biological Chemistry , 279 :26612 , 2004 |
| Abstract : |
| PubMedSearch : Boyd_2004_J.Biol.Chem_279_26612 |
| PubMedID: 15078872 |
| Title : Poster (13) Conformational dynamics accompanying substrate and inhibitor binding to acetylcholinesterase. - |
| Author(s) : Taylor P , Shi J , Johnson DA , Boyd AE , Radic Z |
| Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :327 , 2004 |
| PubMedID: |
| Title : Spectroscopic approaches to the study of acetylcholinesterase structure and function - |
| Author(s) : Taylor P , Shi J , Radic Z , Boyd AE , Johnson DA |
| Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :177 , 2004 |
| PubMedID: |
| Title : Kinetics of ethopropazine binding to butyrylcholinesterase in the absence and presence of acetylthiocholine - |
| Author(s) : Reiner E , Sinko G , Bosak A , Simeon-Rudolf V , Radic Z , Taylor P , Stojan J , Golicnik M |
| Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :187 , 2004 |
| PubMedID: |
| Title : Poster (105) Analysis of acetylcholinesterase structure and dynamics by steady state and time-resolved fluorescence - |
| Author(s) : Shi J , Radic Z , Johnson DA , Taylor P |
| Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :375 , 2004 |
| PubMedID: |
| Title : Poster (19) Kinetics of ethopropazine binding to butyrylcholinesterase in the absence and presence of acetylthiocholine. - |
| Author(s) : Reiner E , Sinko G , Stuglin A , Simeon-Rudolf V , Radic Z , Taylor P , Stojan J , Golicnik M |
| Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :330 , 2004 |
| PubMedID: |
| Title : Ligand-induced conformational changes in the omega loop of acetylcholinesterase revealed by fluorescence spectroscopy. - |
| Author(s) : Shi J , Radic Z , Boyd AE , Johnson DA , Taylor P |
| Ref : Cholinergic Mechanisms, CRC Press :695 , 2004 |
| PubMedID: |
| Title : Phosphorylation of mouse cholinesterases and mutants by DDVP and reactivation of conjugates by HI-6 and 2-PAM - |
| Author(s) : Kovarik Z , Wong L , Radic Z , Taylor P |
| Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :219 , 2004 |
| PubMedID: |
| Title : Analysis of acetylcholinesterase structure and dynamics by steady state and time-resolved fluorescence - |
| Author(s) : Shi J , Radic Z , Johnson DA , Taylor P |
| Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :225 , 2004 |
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| Title : Contemporary paradigms for cholinergic ligand design guided by biological structure - Taylor_2004_Bioorg.Med.Chem.Lett_14_1875 |
| Author(s) : Taylor P , Hansen SB , Talley TT , Hibbs RE , Radic Z |
| Ref : Bioorganic & Medicinal Chemistry Lett , 14 :1875 , 2004 |
| Abstract : |
| PubMedSearch : Taylor_2004_Bioorg.Med.Chem.Lett_14_1875 |
| PubMedID: 15050619 |
| Title : Two possible orientations of the HI-6 molecule in the reactivation of organophosphate-inhibited acetylcholinesterase - Luo_2003_Biochem.Pharmacol_66_387 |
| Author(s) : Luo C , Leader H , Radic Z , Maxwell DM , Taylor P , Doctor BP , Saxena A |
| Ref : Biochemical Pharmacology , 66 :387 , 2003 |
| Abstract : |
| PubMedSearch : Luo_2003_Biochem.Pharmacol_66_387 |
| PubMedID: 12907237 |
| Title : Structural insights into ligand interactions at the acetylcholinesterase peripheral anionic site - Bourne_2003_Embo.J_22_1 |
| Author(s) : Bourne Y , Taylor P , Radic Z , Marchot P |
| Ref : EMBO Journal , 22 :1 , 2003 |
| Abstract : |
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| PubMedID: 12505979 |
| Gene_locus related to this paper: mouse-ACHE |
| Title : Aromatic amino-acid residues at the active and peripheral anionic sites control the binding of E2020 (Aricept) to cholinesterases - Saxena_2003_Eur.J.Biochem_270_4447 |
| Author(s) : Saxena A , Fedorko JM , Vinayaka CR , Medhekar R , Radic Z , Taylor P , Lockridge O , Doctor BP |
| Ref : European Journal of Biochemistry , 270 :4447 , 2003 |
| Abstract : |
| PubMedSearch : Saxena_2003_Eur.J.Biochem_270_4447 |
| PubMedID: 14622273 |
| Title : Acetylcholinesterase active centre and gorge conformations analyzed by combinatorial mutations and enantiomeric phosphonates - Kovarik_2003_Biochem.J_373_33 |
| Author(s) : Kovarik Z , Radic Z , Berman HA , Simeon-Rudolf V , Reiner E , Taylor P |
| Ref : Biochemical Journal , 31 :33 , 2003 |
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| PubMedSearch : Kovarik_2003_Biochem.J_373_33 |
| PubMedID: 12665427 |
| Title : Cover picture: angew. Chem. Int. Ed. 6\/2002 - Lewis_2002_Angew.Chem.Int.Ed.Engl_41_875 |
| Author(s) : Lewis WG , Green LG , Grynszpan F , Radic Z , Carlier PR , Taylor P , Finn MG , Sharpless KB |
| Ref : Angew Chem Int Ed Engl , 41 :875 , 2002 |
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| PubMedID: |
| Title : Click chemistry in situ: acetylcholinesterase as a reaction vessel for the selective assembly of a femtomolar inhibitor from an array of building blocks - |
| Author(s) : Lewis WG , Green LG , Grynszpan F , Radic Z , Carlier PR , Taylor P , Finn MG , Sharpless KB |
| Ref : Angew Chem Int Ed Engl , 41 :1053 , 2002 |
| PubMedID: 12491310 |
| Title : Inhibitors of different structure induce distinguishing conformations in the omega loop, Cys 69- Cys 96, of mouse acetylcholinesterase - Shi_2002_J.Biol.Chem_277_43301 |
| Author(s) : Shi J , Radic Z , Taylor P |
| Ref : Journal of Biological Chemistry , 277 :43301 , 2002 |
| Abstract : |
| PubMedSearch : Shi_2002_J.Biol.Chem_277_43301 |
| PubMedID: 12196517 |
| Title : Tryptophan fluorescence reveals conformational changes in the acetylcholine binding protein - Hansen_2002_J.Biol.Chem_277_41299 |
| Author(s) : Hansen SB , Radic Z , Talley TT , Molles BE , Deerinck TJ , Tsigelny I , Taylor P |
| Ref : Journal of Biological Chemistry , 277 :41299 , 2002 |
| Abstract : |
| PubMedSearch : Hansen_2002_J.Biol.Chem_277_41299 |
| PubMedID: 12235129 |
| Title : Reversibly bound and covalently attached ligands induce conformational changes in the Omega loop, Cys 69-Cys 96, of mouse acetylcholinesterase - Shi_2001_J.Biol.Chem_276_42196 |
| Author(s) : Shi J , Boyd AE , Radic Z , Taylor P |
| Ref : Journal of Biological Chemistry , 276 :42196 , 2001 |
| Abstract : |
| PubMedSearch : Shi_2001_J.Biol.Chem_276_42196 |
| PubMedID: 11517229 |
| Title : Peripheral site ligands accelerate inhibition of acetylcholinesterase by neutral organophosphates - Radic_2001_J.Appl.Toxicol_21 Suppl 1_S13 |
| Author(s) : Radic Z , Taylor P |
| Ref : J Appl Toxicol , 21 Suppl 1 :S13 , 2001 |
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| PubMedSearch : Radic_2001_J.Appl.Toxicol_21 Suppl 1_S13 |
| PubMedID: 11920914 |
| Title : Mechanism of oxime reactivation of acetylcholinesterase analyzed by chirality and mutagenesis - Wong_2000_Biochemistry_39_5750 |
| Author(s) : Wong L , Radic Z , Bruggemann RJ , Hosea NA , Berman HA , Taylor P |
| Ref : Biochemistry , 39 :5750 , 2000 |
| Abstract : |
| PubMedSearch : Wong_2000_Biochemistry_39_5750 |
| PubMedID: 10801325 |
| Title : Synthesis of fluorescent probes directed to the active site gorge of acetylcholinesterase - Saltmarsh_2000_Bioorg.Med.Chem.Lett_10_1523 |
| Author(s) : Saltmarsh JR , Boyd AE , Rodriguez OP , Radic Z , Taylor P , Thompson CM |
| Ref : Bioorganic & Medicinal Chemistry Lett , 10 :1523 , 2000 |
| Abstract : |
| PubMedSearch : Saltmarsh_2000_Bioorg.Med.Chem.Lett_10_1523 |
| PubMedID: 10915041 |
| Title : Atypical effect of some spin trapping agents: reversible inhibition of acetylcholinesterase - Milatovic_2000_Free.Radic.Biol.Med_28_597 |
| Author(s) : Milatovic D , Radic Z , Zivin M , Dettbarn W |
| Ref : Free Radic Biol Med , 28 :597 , 2000 |
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| PubMedSearch : Milatovic_2000_Free.Radic.Biol.Med_28_597 |
| PubMedID: 10719241 |
| Title : Reversible inhibition of acetylcholinesterase and butyrylcholinesterase by 4,4'-bipyridine and by a coumarin derivative - Simeon-Rudolf_1999_Chem.Biol.Interact_119-120_119 |
| Author(s) : Simeon-Rudolf V , Kovarik Z , Radic Z , Reiner E |
| Ref : Chemico-Biological Interactions , 119-120 :119 , 1999 |
| Abstract : |
| PubMedSearch : Simeon-Rudolf_1999_Chem.Biol.Interact_119-120_119 |
| PubMedID: 10421445 |
| Title : Amino acid residues involved in the interaction of acetylcholinesterase and butyrylcholinesterase with the carbamates Ro 02-0683 and bambuterol, and with terbutaline - Kovarik_1999_Biochim.Biophys.Acta_1433_261 |
| Author(s) : Kovarik Z , Radic Z , Grgas B , Skrinjaric-Spoljar M , Reiner E , Simeon-Rudolf V |
| Ref : Biochimica & Biophysica Acta , 1433 :261 , 1999 |
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| PubMedSearch : Kovarik_1999_Biochim.Biophys.Acta_1433_261 |
| PubMedID: 10446376 |
| Title : The influence of peripheral site ligands on the reaction of symmetric and chiral organophosphates with wildtype and mutant acetylcholinesterases - Radic_1999_Chem.Biol.Interact_119-120_111 |
| Author(s) : Radic Z , Taylor P |
| Ref : Chemico-Biological Interactions , 119-120 :111 , 1999 |
| Abstract : |
| PubMedSearch : Radic_1999_Chem.Biol.Interact_119-120_111 |
| PubMedID: 10421444 |
| Title : Role of edrophonium in prevention of the re-inhibition of acetylcholinesterase by phosphorylated oxime - Luo_1999_Chem.Biol.Interact_119-120_129 |
| Author(s) : Luo C , Saxena A , Ashani Y , Leader H , Radic Z , Taylor P , Doctor BP |
| Ref : Chemico-Biological Interactions , 119-120 :129 , 1999 |
| Abstract : |
| PubMedSearch : Luo_1999_Chem.Biol.Interact_119-120_129 |
| PubMedID: 10421446 |
| Title : Phosphoryl oxime inhibition of acetylcholinesterase during oxime reactivation is prevented by edrophonium - Luo_1999_Biochemistry_38_9937 |
| Author(s) : Luo C , Saxena A , Smith M , Garcia GE , Radic Z , Taylor P , Doctor BP |
| Ref : Biochemistry , 38 :9937 , 1999 |
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| PubMedSearch : Luo_1999_Biochemistry_38_9937 |
| PubMedID: 10433700 |
| Title : Analysis of cholinesterase inactivation and reactivation by systematic structural modification and enantiomeric selectivity - Taylor_1999_Chem.Biol.Interact_119-120_3 |
| Author(s) : Taylor P , Wong L , Radic Z , Tsigelny I , Bruggemann R , Hosea NA , Berman HA |
| Ref : Chemico-Biological Interactions , 119-120 :3 , 1999 |
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| PubMedSearch : Taylor_1999_Chem.Biol.Interact_119-120_3 |
| PubMedID: 10421434 |
| Title : Electron paramagnetic resonance reveals altered topography of the active center gorge of acetylcholinesterase after binding of fasciculin to the peripheral site - Sentjurc_1999_Biochim.Biophys.Acta_1430_349 |
| Author(s) : Sentjurc M , Pecar S , Stojan J , Marchot P , Radic Z , Grubic Z |
| Ref : Biochimica & Biophysica Acta , 1430 :349 , 1999 |
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| PubMedSearch : Sentjurc_1999_Biochim.Biophys.Acta_1430_349 |
| PubMedID: 10082962 |
| Title : Oxime Reactivation of Acetylcholinesterase Inhibited by Enantiomeric Organophosphates - |
| Author(s) : Bruggemann RJ , Radic Z , Tsigelny I , Taylor P |
| Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :377 , 1998 |
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| Title : Rapid binding of a cationic active site inhibitor to wild type and mutant mouse acetylcholinesterase: Brownian dynamics simulation including diffusion in the active site gorge - Tara_1998_Biopolymers_46_465 |
| Author(s) : Tara S , Elcock AH , Kirchhoff PD , Briggs JM , Radic Z , Taylor P , McCammon JA |
| Ref : Biopolymers , 46 :465 , 1998 |
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| Title : Isomalathion Stereoisomers - |
| Author(s) : Talley TT , Jianmongkol S , Richardson RJ , Radic Z , Thompson CM |
| Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :531 , 1998 |
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| Title : The Effect of Peripheral Site Ligands on the Reaction Kinetics of Phosphyl and Carboxyl Esters with Acetylcholinesterase - |
| Author(s) : Radic Z , Taylor P |
| Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :211 , 1998 |
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| Title : Reactivation of Enantiomeric Organophosphonyl Conjugates of Acetylcholinesterase Mutants, F295L and F297I by Mono- and Bis-Quarternary Oximes - |
| Author(s) : Wong L , Radic Z , Hosea NA , Berman HA , Taylor P |
| Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :250 , 1998 |
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| Title : Inhibition of Acetylcholinesterase (ACHE\; E.C. 3.1.1.7) and Butyrylcholinesterase (BCHE\; E.C. 3.1.1.8) by Terbutaline - |
| Author(s) : Kovarik Z , Radic Z , Skrinjaric-Spoljar M , Reiner E , Simeon-Rudolf V |
| Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :243 , 1998 |
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| Title : Determining ligand orientation and transphosphonylation mechanisms on acetylcholinesterase by Rp, Sp enantiomer selectivity and site-specific mutagenesis - Taylor_1997_Enantiomer_2_249 |
| Author(s) : Taylor P , Hosea NA , Tsigelny I , Radic Z , Berman HA |
| Ref : Enantiomer , 2 :249 , 1997 |
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| Title : Electrostatic influence on the kinetics of ligand binding to acetylcholinesterase. Distinctions between active center ligands and fasciculin - Radic_1997_J.Biol.Chem_272_23265 |
| Author(s) : Radic Z , Kirchhoff PD , Quinn DM , McCammon JA , Taylor P |
| Ref : Journal of Biological Chemistry , 272 :23265 , 1997 |
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| PubMedSearch : Radic_1997_J.Biol.Chem_272_23265 |
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| Title : Mutant acetylcholinesterases as potential detoxification agents for organophosphate poisoning - Saxena_1997_Biochem.Pharmacol_54_269 |
| Author(s) : Saxena A , Maxwell DM , Quinn DM , Radic Z , Taylor P , Doctor BP |
| Ref : Biochemical Pharmacology , 54 :269 , 1997 |
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| PubMedID: 9271331 |
| Title : Expression and activity of mutants of fasciculin, a peptidic acetylcholinesterase inhibitor from mamba venom - Marchot_1997_J.Biol.Chem_272_3502 |
| Author(s) : Marchot P , Prowse CN , Kanter J , Camp S , Ackermann EJ , Radic Z , Bougis PE , Taylor P |
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| Title : Aspartate 74 as a primary determinant in acetylcholinesterase governing specificity to cationic organophosphonates - Hosea_1996_Biochemistry_35_10995 |
| Author(s) : Hosea NA , Radic Z , Tsigelny I , Berman HA , Quinn DM , Taylor P |
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| Title : Amino acid residues controlling reactivation of organophosphonyl conjugates of acetylcholinesterase by mono- and bisquaternary oximes - Ashani_1995_J.Biol.Chem_270_6370 |
| Author(s) : Ashani Y , Radic Z , Tsigelny I , Vellom DC , Pickering NA , Quinn DM , Doctor BP , Taylor P |
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| Title : Amino Acid Residues in Acetylcholinesterase which Influence Fasciculin Inhibition - |
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| Ref : In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases , (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp. :183 , 1995 |
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| Title : Structural Determinants of Fasciculin Specificity for Acetylcholinesterase - |
| Author(s) : Marchot P , Camp S , Radic Z , Bougis PE , Taylor P |
| Ref : In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases , (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp. :197 , 1995 |
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| Title : Theoretical analysis of the structure of the peptide fasciculin and its docking to acetylcholinesterase - van den Born_1995_Prot.Sci_4_703 |
| Author(s) : van den Born HK , Radic Z , Marchot P , Taylor P , Tsigelny I |
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| PubMedID: 7613468 |
| Title : Structural bases for the specificity of cholinesterase catalysis and inhibition. - Taylor_1995_Toxicol.Lett_83_453 |
| Author(s) : Taylor P , Radic Z , Hosea NA , Camp S , Marchot P , Berman HA |
| Ref : Toxicology Letters , 83 :453 , 1995 |
| Abstract : |
| PubMedSearch : Taylor_1995_Toxicol.Lett_83_453 |
| PubMedID: 8597093 |
| Title : Amino Acid Residues that Control Mono- and Bisquaternary Oxime-Induced Reactivation of O-Ethyl Methylphosphonylated Cholinesterases - |
| Author(s) : Ashani Y , Radic Z , Tsigelny I , Vellom DC , Pickering NA , Quinn DM , Doctor BP , Taylor P |
| Ref : In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases , (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp. :133 , 1995 |
| PubMedID: |
| Title : Allosteric control of acetylcholinesterase catalysis by fasciculin - Radic_1995_J.Biol.Chem_270_20391 |
| Author(s) : Radic Z , Quinn DM , Vellom DC , Camp S , Taylor P |
| Ref : Journal of Biological Chemistry , 270 :20391 , 1995 |
| Abstract : |
| PubMedSearch : Radic_1995_J.Biol.Chem_270_20391 |
| PubMedID: 7657613 |
| Title : The Function of Electrostatics in Acetylcholinesterase Catalysis - |
| Author(s) : Quinn DM , Seravalli J , Nair HK , Medhekar R , Husseini B , Radic Z , Vellom DC , Pickering NA , Taylor P |
| Ref : In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases , (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp. :203 , 1995 |
| PubMedID: |
| Title : Ligand Specificity and Gene Expression in the Cholinergic Synapse - |
| Author(s) : Taylor P , Radic Z , Kreienkamp HJ , Luo ZD , Pickering NA , Camp S |
| Ref : In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases , (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp. :15 , 1995 |
| PubMedID: |
| Title : Residues important for folding and dimerisation of recombinant Torpedo californica acetylcholinesterase - Bucht_1994_Biochim.Biophys.Acta_1209_265 |
| Author(s) : Bucht G , Haggstrom B , Radic Z , Osterman A , Hjalmarsson K |
| Ref : Biochimica & Biophysica Acta , 1209 :265 , 1994 |
| Abstract : |
| PubMedSearch : Bucht_1994_Biochim.Biophys.Acta_1209_265 |
| PubMedID: 7811701 |
| Title : Site of fasciculin interaction with acetylcholinesterase - Radic_1994_J.Biol.Chem_269_11233 |
| Author(s) : Radic Z , Duran R , Vellom DC , Li Y , Cervenansky C , Taylor P |
| Ref : Journal of Biological Chemistry , 269 :11233 , 1994 |
| Abstract : |
| PubMedSearch : Radic_1994_J.Biol.Chem_269_11233 |
| PubMedID: 8157652 |
| Title : Expression and ligand specificity of acetylcholinesterase and the nicotinic receptor: a tale of two cholinergic sites - Taylor_1994_Biochem.Soc.Trans_22_740 |
| Author(s) : Taylor P , Radic Z , Kreienkamp HJ , Maeda RK , Luo ZD , Fuentes ME , Vellom DC , Pickering NA |
| Ref : Biochemical Society Transactions , 22 :740 , 1994 |
| Abstract : |
| PubMedSearch : Taylor_1994_Biochem.Soc.Trans_22_740 |
| PubMedID: 7821676 |
| Title : Identification of amino acid residues involved in the binding of Huperzine A to cholinesterases - Saxena_1994_Protein.Sci_3_1770 |
| Author(s) : Saxena A , Qian N , Kovach IM , Kozikowski AP , Pang YP , Vellom DC , Radic Z , Quinn DM , Taylor P , Doctor BP |
| Ref : Protein Science , 3 :1770 , 1994 |
| Abstract : |
| PubMedSearch : Saxena_1994_Protein.Sci_3_1770 |
| PubMedID: 7849595 |
| Title : The cholinesterases: from genes to proteins - Taylor_1994_Annu.Rev.Pharmacol.Toxicol_34_281 |
| Author(s) : Taylor P , Radic Z |
| Ref : Annual Review of Pharmacology & Toxicology , 34 :281 , 1994 |
| Abstract : |
| PubMedSearch : Taylor_1994_Annu.Rev.Pharmacol.Toxicol_34_281 |
| PubMedID: 8042853 |
| Title : Differentiation of esterases reacting with organophosphorus compounds - Reiner_1993_Chem.Biol.Interact_87_77 |
| Author(s) : Reiner E , Pavkovic E , Radic Z , Simeon-Rudolf V |
| Ref : Chemico-Biological Interactions , 87 :77 , 1993 |
| Abstract : |
| PubMedSearch : Reiner_1993_Chem.Biol.Interact_87_77 |
| PubMedID: 8393750 |
| Title : Amino acid residues controlling acetylcholinesterase and butyrylcholinesterase specificity - Vellom_1993_Biochemistry_32_12 |
| Author(s) : Vellom DC , Radic Z , Li Y , Pickering NA , Camp S , Taylor P |
| Ref : Biochemistry , 32 :12 , 1993 |
| Abstract : |
| PubMedSearch : Vellom_1993_Biochemistry_32_12 |
| PubMedID: 8418833 |
| Title : Three distinct domains in the cholinesterase molecule confer selectivity for acetyl- and butyrylcholinesterase inhibitors - Radic_1993_Biochemistry_32_12074 |
| Author(s) : Radic Z , Pickering NA , Vellom DC , Camp S , Taylor P |
| Ref : Biochemistry , 32 :12074 , 1993 |
| Abstract : |
| PubMedSearch : Radic_1993_Biochemistry_32_12074 |
| PubMedID: 8218285 |
| Title : The role of glutamate-199 in the aging of cholinesterase - Saxena_1993_Biochem.Biophys.Res.Commun_197_343 |
| Author(s) : Saxena A , Doctor BP , Maxwell DM , Lenz DE , Radic Z , Taylor P |
| Ref : Biochemical & Biophysical Research Communications , 197 :343 , 1993 |
| Abstract : |
| PubMedSearch : Saxena_1993_Biochem.Biophys.Res.Commun_197_343 |
| PubMedID: 7902714 |
| Title : Structure and regulation of expression of the acetylcholinesterase gene - Taylor_1993_Chem.Biol.Interact_87_199 |
| Author(s) : Taylor P , Li Y , Camp S , Rachinsky TL , Ekstrom TJ , Getman DK , Fuentes ME , Vellom DC , Radic Z |
| Ref : Chemico-Biological Interactions , 87 :199 , 1993 |
| Abstract : |
| PubMedSearch : Taylor_1993_Chem.Biol.Interact_87_199 |
| PubMedID: 8343976 |
| Title : Expression of recombinant acetylcholinesterase in a baculovirus system: kinetic properties of glutamate 199 mutants - Radic_1992_Biochemistry_31_9760 |
| Author(s) : Radic Z , Gibney G , Kawamoto S , MacPhee-Quigley K , Bongiorno C , Taylor P |
| Ref : Biochemistry , 31 :9760 , 1992 |
| Abstract : |
| PubMedSearch : Radic_1992_Biochemistry_31_9760 |
| PubMedID: 1356436 |
| Title : Mechanism of Substrate Inhibition of Acetylcholinesterase - |
| Author(s) : Reiner E , Aldridge WN , Simeon-Rudolf V , Radic Z , Taylor P |
| Ref : In: Cholinesterases: Structure, Function, Mechanism, Genetics, and Cell Biology , (Massoulie J, Barnard EA, Chatonnet A, Bacou F, Doctor BP, Quinn DM) American Chemical Society, Washington, DC :227 , 1991 |
| PubMedID: |
| Title : Poster: Pyrydinium oximes: reaction with cholinesterase substrates - |
| Author(s) : Skrinjaric-Spoljar M , Radic Z , Simeon-Rudolf V |
| Ref : In: Cholinesterases: Structure, Function, Mechanism, Genetics, and Cell Biology , (Massoulie J, Barnard EA, Chatonnet A, Bacou F, Doctor BP, Quinn DM) American Chemical Society, Washington, DC :305 , 1991 |
| PubMedID: |
| Title : Dialkylphosphorus metabolites in the urine and activities of esterases in the serum as biochemical indices for human absorption of organophosphorus pesticides - Drevenkar_1991_Arch.Environ.Contam.Toxicol_20_417 |
| Author(s) : Drevenkar V , Radic Z , Vasilic Z , Reiner E |
| Ref : Archives of Environmental Contamination & Toxicology , 20 :417 , 1991 |
| Abstract : |
| PubMedSearch : Drevenkar_1991_Arch.Environ.Contam.Toxicol_20_417 |
| PubMedID: 1650168 |
| Title : Poster: Onchidal: a naturally occurring irreversible inhibitor of acetylcholinesterase with a novel mechanism of action - |
| Author(s) : Abramson SN , Radic Z , Manker D , Faulkner DJ , Taylor P |
| Ref : In: Cholinesterases: Structure, Function, Mechanism, Genetics, and Cell Biology , (Massoulie J, Barnard EA, Chatonnet A, Bacou F, Doctor BP, Quinn DM) American Chemical Society, Washington, DC :296 , 1991 |
| PubMedID: |
| Title : Poster: Human serum esterases: differentiation of EDTA-insensitive enzymes - |
| Author(s) : Radic Z , Pavkovic E , Reiner E |
| Ref : In: Cholinesterases: Structure, Function, Mechanism, Genetics, and Cell Biology , (Massoulie J, Barnard EA, Chatonnet A, Bacou F, Doctor BP, Quinn DM) American Chemical Society, Washington, DC :288 , 1991 |
| PubMedID: |
| Title : Role of the peripheral anionic site on acetylcholinesterase: inhibition by substrates and coumarin derivatives - Radic_1991_Mol.Pharmacol_39_98 |
| Author(s) : Radic Z , Reiner E , Taylor P |
| Ref : Molecular Pharmacology , 39 :98 , 1991 |
| Abstract : |
| PubMedSearch : Radic_1991_Mol.Pharmacol_39_98 |
| PubMedID: 1987454 |
| Title : Inhibition of serum cholinesterase by trialkylphosphorothiolates - Franciskovic_1989_Arch.Toxicol_63_489 |
| Author(s) : Franciskovic L , Radic Z , Reiner E |
| Ref : Archives of Toxicology , 63 :489 , 1989 |
| Abstract : |
| PubMedSearch : Franciskovic_1989_Arch.Toxicol_63_489 |
| PubMedID: 2619563 |
| Title : Onchidal: a naturally occurring irreversible inhibitor of acetylcholinesterase with a novel mechanism of action - Abramson_1989_Mol.Pharmacol_36_349 |
| Author(s) : Abramson SN , Radic Z , Manker D , Faulkner DJ , Taylor P |
| Ref : Molecular Pharmacology , 36 :349 , 1989 |
| Abstract : |
| PubMedSearch : Abramson_1989_Mol.Pharmacol_36_349 |
| PubMedID: 2779521 |
| Title : An enzyme test for determining isomalathion impurities in water-dispersible powders of malathion - Reiner_1986_Bull.World.Health.Organ_64_397 |
| Author(s) : Reiner E , Radic Z |
| Ref : Bulletin of the World Health Organization , 64 :397 , 1986 |
| Abstract : |
| PubMedSearch : Reiner_1986_Bull.World.Health.Organ_64_397 |
| PubMedID: 3490319 |
| Title : Binding sites on acetylcholinesterase for reversible ligands and phosphorylating agents. A theoretical model tested on haloxon and phosphostigmine - Radic_1984_Biochem.Pharmacol_33_671 |
| Author(s) : Radic Z , Reiner E , Simeon-Rudolf V |
| Ref : Biochemical Pharmacology , 33 :671 , 1984 |
| Abstract : |
| PubMedSearch : Radic_1984_Biochem.Pharmacol_33_671 |
| PubMedID: 6704184 |