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mouse-ACHE

Mus musculus (Mouse) acetylcholinesterase

Comment

Alternate Cterminus: T or H peptide

Relationship

Family : ACHE

Block : C

Position in NCBI Life Tree : Mus musculus

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Glires N E > Rodentia N E > Myomorpha N E > Muroidea N E > Muridae N E > Murinae N E > Mus [genus] N E > Mus [subgenus] N E > Mus musculus N E

Molecular evidence

1J06 - Crystal structure of mouse acetylcholinesterase 1J07 - Crystal structure of the mouse acetylcholinesterase-decidium complex 1KU6 - Fasciculin2 - Mouse Acetylcholinesterase Complex 1MAA - Mouse acetylcholinesterase 1MAH - Mouse acetylcholinesterase + fasciculin2 1N5M - Crystal structure of the mouse acetylcholinesterase-gallamine complex 1N5R - Crystal structure of the mouse acetylcholinesterase-propidium complex 1Q83 - Crystal structure of the mouse acetylcholinesterase-TZ2PA6 syn complex 1Q84 - Crystal structure of the mouse acetylcholinesterase-TZ2PA6 anti complex 2C0P - Mouse acetylcholinesterase aged Tabun inhibited 2C0Q - Mouse acetylcholinesterase nonaged Tabun inhibited 2GYU - Crystal structure of Mus musculus Acetylcholinesterase in complex with HI-6 2GYV - Crystal structure of Mus musculus Acetylcholinesterase in complex with Ortho-7 2GYW - Crystal Structure of Mus musculus Acetylcholinesterase in Complex with Obidoxime 2H9Y - Crystal structure of mouse acetylcholinesterase complexed with m-(N,N,N-trimethylammonio)trifluoroacetophenone 2HA0 - Crystal structure of mouse acetylcholinesterase complexed with 4-ketoamyltrimethylammonium 2HA2 - Crystal structure of mouse acetylcholinesterase complexed with succinylcholine 2HA3 - Crystal structure of mouse acetylcholinesterase complexed with choline 2HA4 - Crystal structure of mutant S203A of mouse acetylcholinesterase complexed with acetylcholine 2HA5 - Crystal structure of mutant S203A of acetylcholinesterase complexed with acetylthiocholine 2HA6 - Crystal structure of mutant S203A of mouse acetylcholinesterase complexed with succinylcholine 2HA7 - Crystal structure of mutant S203A of mouse acetylcholinesterase complexed with butyrylthiocholine 2JEY - Mus musculus acetylcholinesterase in complex with HLo-7 2JEZ - Mus musculus acetylcholinesterase in complex with tabun and HLo-7 2JF0 - Mus musculus acetylcholinesterase in complex with tabun and Ortho-7 2JGE - Crystal structure of mouse acetylcholinesterase inhibited by non-aged methamidophos 2JGF - Crystal structure of mouse acetylcholinesterase inhibited by non-aged fenamiphos 2JGI - Crystal structure of mouse acetylcholinesterase inhibited by non-aged diisopropyl fluorophosphate (DFP) 2JGJ - Crystal structure of mouse acetylcholinesterase inhibited by aged methamidophos 2JGK - Crystal structure of mouse acetylcholinesterase inhibited by aged fenamiphos 2JGL - Crystal structure of mouse acetylcholinesterase inhibited by aged VX and sarin 2JGM - Crystal structure of mouse acetylcholinesterase inhibited by aged diisopropyl fluorophosphate (DFP) 2WHP - Crystal structure of acetylcholinesterase, phosphonylated by sarin and in complex with HI-6 2WHQ - Crystal structure of acetylcholinesterase, phosphonylated by sarin (aged) in complex with HI-6 2WHR - Crystal structure of acetylcholinesterase in complex with K027 2WLS - Crystal structure of Mus musculus Acetylcholinesterase in complex with AMTS13 2WU3 - Crystal structure of mouse acetylcholinesterase in complex with fenamiphos and HI-6 2WU4 - Crystal structure of mouse acetylcholinesterase in complex with fenamiphos and ortho-7 2XUD - Crystal structure of the Y337A mutant of mouse acetylcholinesterase 2XUF - Crystal structure of mAChE-Y337A-TZ2PA6 ANTI complex (1 MTH) 2XUG - Crystal structure of mAChE-Y337A-TZ2PA6 anti complex (1 wk) 2XUH - Crystal structure of mAChE-Y337A-TZ2PA6 ANTI complex (10 MTH) 2XUI - Crystal structure of mAChE-Y337A-TZ2PA6 SYN complex (1 WK) 2XUJ - Crystal structure of mAChE-Y337A-TZ2PA6 SYN complex (1 MTH) 2XUK - Crystal structure of mAChE-Y337A-TZ2PA6 SYN complex (10 MTH) 2XUO - Crystal structure of mAChE-Y337A mutant in complex with soaked TZ2PA6 ANTI inhibitor 2XUP - Crystal structure of the mAChE-Y337A mutant in complex with soaked TZ2PA6 SYN inhibitor 2XUQ - Crystal structure of the mAChE-Y337A mutant in complex with soaked TZ2PA6 ANTI-SYN inhibitors 2Y2U - Nonaged form of Mouse Acetylcholinesterase inhibited by VX-Update (superseeds 2JGH) 2Y2V - Nonaged form of Mouse Acetylcholinesterase inhibited by Sarin-Update (superseeds 2JGG) 3DL4 - Nonaged Form of mouse Acetylcholinesterase Inhibited by Tabun - Update 3DL7 - Aged Form of mouse Acetylcholinesterase Inhibited by Tabun - Update 3ZLT - Crystal structure of acetylcholinesterase in complex with RVX (Russian-VX) 3ZLU - Crystal structure of mouse acetylcholinesterase in complex with cyclosarin 3ZLV - Crystal structure of mouse acetylcholinesterase in complex with tabun and HI-6 4A16 - Structure of mouse Acetylcholinesterase complex with Huprine derivative 4A23 - Mus musculus Acetylcholinesterase in complex with racemic C5685 4ARA - Mus musculus Acetylcholinesterase in complex with (R)-C5685 at 2.5 A resolution. 4ARB - Mus musculus Acetylcholinesterase in complex with (S)-C5685 at 2.25 A resolution. 4B7Z - Mus musculus Acetylcholinesterase in complex with N-(2-Diethylamino- ethyl)-C-p-tolyl-methanesulfonamide 4B80 - Mus musculus Acetylcholinesterase in complex with N-(2-Diethylamino- ethyl)-C-(4-fluoro-phenyl)-methanesulfonamide 4B81 - Mus musculus Acetylcholinesterase in complex with C-(4-Chloro-phenyl)- N-(2-diethylamino-ethyl)-methanesulfonamide 4B82 - Mus musculus Acetylcholinesterase in complex with N-(2-Diethylamino- ethyl)-2-fluoro-benzenesulfonamide 4B83 - Mus musculus Acetylcholinesterase in complex with N-(2-Diethylamino- ethyl)-3-methoxy-benzenesulfonamide 4B84 - Mus musculus Acetylcholinesterase in complex with N-(2-Diethylamino- ethyl)-3-trifluoromethyl-benzenesulfonamide 4B85 - Mus musculus Acetylcholinesterase in complex with 4-Chloro-N-(2- diethylamino-ethyl)-benzenesulfonamide 4BC0 - Structure of mouse acetylcholinesterase inhibited by CBDP (12-h soak) : Cresyl-phosphoserine adduct 4BC1 - Structure of mouse acetylcholinesterase inhibited by CBDP (30-min soak) : Cresyl-saligenin-phosphoserine adduct 4BTL - Aromatic interactions in acetylcholinesterase-inhibitor complexes 5DTG - Crystal structure of mouse acetylchoinesterase inhibited by DFP 5DTI - Crystal structure of mouse acetylcholinesterase 5DTJ - Crystal Structure of DFP-inhibited mouse acetylcholinesterase in complex with the reactivator SP-134 5EHN - mAChE-syn TZ2PA5 complex 5EHQ - mAChE-anti TZ2PA5 complex 5EHZ - mAChE-syn TZ2PA5 complex from an equimolar mixture of the syn\/anti isomers 5EIA - mACHE-anti TZ2PA5 complex from a 1:6 mixture of the syn\/anti isomers 5EIE - mAChE-TZ2 complex 5EIH - mAChE-TZ2\/PA5 complex 5FKJ - Crystal structure of mouse acetylcholinesterase in complex with C-547, an alkyl ammonium derivative of 6-methyl uracil 5FOQ - Acetylcholinesterase in complex with C7653 5FUM - Mus musculus acetylcholinesterase in complex with AL200 5HCU - Crystal structure of mouse acetylchoinesterase inhibited by DFP 5OV9 - Mus musculus acetylcholinesterase in complex with Crystal Violet 6FSD - Mus musculus acetylcholinesterase in complex with 2-(4-Biphenylyloxy)-N-[3-(1-piperidinyl)propyl]-acetamide hydrochloride (10) 6FSE - Mus musculus acetylcholinesterase in complex with 1-(4-(4-Ethylpiperazin-1-yl)piperidin-1-yl)-2-((4'-methoxy-[1,1'-biphenyl]-4-yl)oxy)ethanone dihydrochloride (15) 6TD2 - Mus musculus Acetylcholinesterase in complex with N-(2-(diethylamino)ethyl)-1-(4-(trifluoromethyl)phenyl)methanesulfonamide 7QAK - Mus musculus Acetylcholinesterase in complex with 7-[(4-{[benzyl(methyl)amino]methyl}benzyl)oxy]-4-(hydroxymethyl)-2H-chromen-2-one multitargeting inhibitor of AChE and MAO 7QB4 - Mus musculus Acetylcholinesterase in complex with 7-[(1-benzylpiperidin-3-yl)methoxy]-3,4-dimethyl-2H-chromen-2-one multitargeting inhibitor of AChE and MAO 7QYN - Mus musculus Acetylcholinesterase in complex with reactivator 4-methyl-3-nitrobenzamido-pentyl-PAM-7d 7R02 - Mus musculus Acetylcholinesterase in complex with inhibitor 4-methyl-3-nitrobenzamido-pentyl-1a 7R0A - Mus musculus Acetylcholinesterase inhibited by Sarin in complex with reactivator 4-methyl-3-nitrobenzamido-pentyl-PAM-7d 7R2F - Structure of tabun inhibited acetylcholinesterase in complex with 2-((hydroxyimino)methyl)-1-(5-(4-methyl-3-nitrobenzamido)pentyl)pyridinium 7R3C - Mus musculus Acetylcholinesterase inhibited by VX in complex with reactivator 4-methyl-3-nitrobenzamido-pentyl-PAM-7d 7R4E - Mus musculus Acetylcholinesterase inhibited by Russian-VX in complex with reactivator 4-methyl-3-nitrobenzamido-pentyl-PAM-7d 8ORC - Mus musculus Acetylcholinesterase in complex with AL237

9-Aminoacridine_WT_mouse-ACHE 9-Aminoacridine_Y337A_mouse-ACHE 9-Aminoacridine_Y337F_mouse-ACHE Acetylthiocholine_B5-174-A175-487-B488-575_mouse-chimerae-ACHE-BCHE Acetylthiocholine_B5-174-A175-575_mouse-chimerae-ACHE-BCHE Acetylthiocholine_D74N_mouse-ACHE Acetylthiocholine_F295A_mouse-ACHE Acetylthiocholine_F295L\/F297I_mouse-ACHE Acetylthiocholine_F295L_mouse-ACHE Acetylthiocholine_F295Y_mouse-ACHE Acetylthiocholine_F297A_mouse-ACHE Acetylthiocholine_F297I_mouse-ACHE Acetylthiocholine_F297Y_mouse-ACHE Acetylthiocholine_F338G_mouse-ACHE Acetylthiocholine_R296S_mouse-ACHE Acetylthiocholine_V300G_mouse-ACHE Acetylthiocholine_W286R_mouse-ACHE Acetylthiocholine_WT_mouse-ACHE Acetylthiocholine_Y124Q\/W286R_mouse-ACHE Acetylthiocholine_Y124Q_mouse-ACHE Acetylthiocholine_Y337A_mouse-ACHE Acetylthiocholine_Y337F_mouse-ACHE Acetylthiocholine_Y72N\/D74N\/Y124Q\/W286A_mouse-ACHE Acetylthiocholine_Y72N\/D74N\/Y124Q\/W286R_mouse-ACHE Acetylthiocholine_Y72N\/W286R_mouse-ACHE Acetylthiocholine_Y72N\/Y124Q\/W286A_mouse-ACHE Acetylthiocholine_Y72N\/Y124Q\/W286R_mouse-ACHE Acetylthiocholine_Y72N\/Y124Q_mouse-ACHE Acetylthiocholine_Y72N_mouse-ACHE Acridine_WT_mouse-ACHE Acridine_Y337A_mouse-ACHE Acridine_Y337F_mouse-ACHE BW284C51_D74N_mouse-ACHE BW284C51_W286R_mouse-ACHE BW284C51_WT_mouse-ACHE BW284C51_Y124Q\/W286R_mouse-ACHE BW284C51_Y124Q_mouse-ACHE BW284C51_Y72N\/D74N\/Y124Q\/W286A_mouse-ACHE BW284C51_Y72N\/D74N\/Y124Q\/W286R_mouse-ACHE BW284C51_Y72N\/W286R_mouse-ACHE BW284C51_Y72N\/Y124Q\/W286A_mouse-ACHE BW284C51_Y72N\/Y124Q\/W286R_mouse-ACHE BW284C51_Y72N\/Y124Q_mouse-ACHE BW284C51_Y72N_mouse-ACHE Benzoylthiocholine_F295A_mouse-ACHE Benzoylthiocholine_F295L_mouse-ACHE Benzoylthiocholine_F295Y_mouse-ACHE Benzoylthiocholine_F297A_mouse-ACHE Benzoylthiocholine_F297I_mouse-ACHE Benzoylthiocholine_F297Y_mouse-ACHE Benzoylthiocholine_WT_mouse-ACHE Butyrylthiocholine_F295A_mouse-ACHE Butyrylthiocholine_F295L_mouse-ACHE Butyrylthiocholine_F295Y_mouse-ACHE Butyrylthiocholine_F297A_mouse-ACHE Butyrylthiocholine_F297I_mouse-ACHE Butyrylthiocholine_F297Y_mouse-ACHE Butyrylthiocholine_WT_mouse-ACHE Chlorpromazine_WT_mouse-ACHE Chlorpromazine_Y337A_mouse-ACHE Chlorpromazine_Y337F_mouse-ACHE D45K-fasciculin2_WT_mouse-ACHE Decamethonium_D74N_mouse-ACHE Decamethonium_W286R_mouse-ACHE Decamethonium_WT_mouse-ACHE Decamethonium_Y124Q\/W286R_mouse-ACHE Decamethonium_Y124Q_mouse-ACHE Decamethonium_Y72N\/D74N\/Y124Q\/W286A_mouse-ACHE Decamethonium_Y72N\/D74N\/Y124Q\/W286R_mouse-ACHE Decamethonium_Y72N\/W286R_mouse-ACHE Decamethonium_Y72N\/Y124Q\/W286A_mouse-ACHE Decamethonium_Y72N\/Y124Q\/W286R_mouse-ACHE Decamethonium_Y72N\/Y124Q_mouse-ACHE Decamethonium_Y72N_mouse-ACHE Edrophonium_WT_mouse-ACHE Edrophonium_Y337A_mouse-ACHE Edrophonium_Y337F_mouse-ACHE Edrophonium_Y72N\/D74N\/Y124Q\/W286A_mouse-ACHE Edrophonium_Y72N\/D74N\/Y124Q\/W286R_mouse-ACHE Edrophonium_Y72N\/Y124Q\/W286A_mouse-ACHE Edrophonium_Y72N\/Y124Q\/W286R_mouse-ACHE Ethopropazine_WT_mouse-ACHE Ethopropazine_Y337A_mouse-ACHE Ethopropazine_Y337F_mouse-ACHE H29D-fasciculin2_WT_mouse-ACHE K25L-fasciculin2_WT_mouse-ACHE K32G-fasciculin2_WT_mouse-ACHE K51S-fasciculin2_WT_mouse-ACHE M33A-fasciculin2_WT_mouse-ACHE MEPQ_WT_mouse-ACHE N-Methyl-acridinium_WT_mouse-ACHE N-Methyl-acridinium_Y337A_mouse-ACHE N-Methyl-acridinium_Y337F_mouse-ACHE P30del-fasciculin2_WT_mouse-ACHE P31R-fasciculin2_WT_mouse-ACHE Promazine_WT_mouse-ACHE Promazine_Y337A_mouse-ACHE Promazine_Y337F_mouse-ACHE Promethazine_WT_mouse-ACHE Promethazine_Y337A_mouse-ACHE Promethazine_Y337F_mouse-ACHE Propidium_D74N_mouse-ACHE Propidium_W286R_mouse-ACHE Propidium_WT_mouse-ACHE Propidium_Y124Q\/W286R_mouse-ACHE Propidium_Y124Q_mouse-ACHE Propidium_Y72N\/D74N\/Y124Q\/W286A_mouse-ACHE Propidium_Y72N\/D74N\/Y124Q\/W286R_mouse-ACHE Propidium_Y72N\/W286R_mouse-ACHE Propidium_Y72N\/Y124Q\/W286A_mouse-ACHE Propidium_Y72N\/Y124Q\/W286R_mouse-ACHE Propidium_Y72N\/Y124Q_mouse-ACHE Propidium_Y72N_mouse-ACHE R11Q-fasciculin2_WT_mouse-ACHE R24T-fasciculin2_WT_mouse-ACHE R27W-fasciculin2_WT_mouse-ACHE R28D-fasciculin2_WT_mouse-ACHE T8A,T9A-fasciculin2_WT_mouse-ACHE T8A\/T9A-fasciculin2_WT_mouse-ACHE Tacrine_WT_mouse-ACHE Tacrine_Y337A_mouse-ACHE Tacrine_Y337F_mouse-ACHE V34A,L35A-fasciculin2_WT_mouse-ACHE V34A\/L35A-fasciculin2_WT_mouse-ACHE WT-fasciculin2_D74N_mouse-ACHE WT-fasciculin2_F295L_mouse-ACHE WT-fasciculin2_F297I_mouse-ACHE WT-fasciculin2_F297Y_mouse-ACHE WT-fasciculin2_F338G_mouse-ACHE WT-fasciculin2_W286R_mouse-ACHE WT-fasciculin2_WT_mouse-ACHE WT-fasciculin2_Y124Q\/W286R_mouse-ACHE WT-fasciculin2_Y124Q_mouse-ACHE WT-fasciculin2_Y337A_mouse-ACHE WT-fasciculin2_Y72N\/W286R_mouse-ACHE WT-fasciculin2_Y72N\/Y124Q\/W286R_mouse-ACHE WT-fasciculin2_Y72N\/Y124Q_mouse-ACHE WT-fasciculin2_Y72N_mouse-ACHE

No disease

Database

Sequence

Peptide

MRPPWYPLHT PSLAFPLLFL LLSLLGGGAR AEGREDPQLL VRVRGGQLRG IRLKAPGGPV SAFLGIPFAE PPVGSRRFMP PEPKRPWSGV LDATTFQNVC YQYVDTLYPG FEGTEMWNPN RELSEDCLYL NVWTPYPRPA SPTPVLIWIY GGGFYSGAAS LDVYDGRFLA QVEGAVLVSM NYRVGTFGFL ALPGSREAPG NVGLLDQRLA LQWVQENIAA FGGDPMSVTL FGESAGAASV GMHILSLPSR SLFHRAVLQS GTPNGPWATV SAGEARRRAT LLARLVGCPP GGAGGNDTEL IACLRTRPAQ DLVDHEWHVL PQESIFRFSF VPVVDGDFLS DTPEALINTG DFQDLQVLVG VVKDEGSYFL VYGVPGFSKD NESLISRAQF LAGVRIGVPQ ASDLAAEAVV LHYTDWLHPE DPTHLRDAMS AVVGDHNVVC PVAQLAGRLA AQGARVYAYI FEHRASTLTW PLWMGVPHGY EIEFIFGLPL DPSLNYTTEE RIFAQRLMKY WTNFARTGDP NDPRDSKSPQ WPPYTTAAQQ YVSLNLKPLE VRRGLRAQTC AFWNRFLPKL LSATDTLDEA ERQWKAEFHR WSSYMVHWKN QFDHYSKQER CSDL

References (35)

Title : Enzyme Dynamics Determine the Potency and Selectivity of Inhibitors Targeting Disease-Transmitting Mosquitoes - Kumari_2024_ACS.Infect.Dis__
Author(s) : Kumari R , Lindgren C , Kumar R , Forsgren N , Andersson CD , Ekstrom F , Linusson A
Ref : ACS Infect Dis , : , 2024
Abstract :
PubMedSearch : Kumari_2024_ACS.Infect.Dis__
PubMedID: 39291389
Gene_locus related to this paper: anoga-ACHE1 , mouse-ACHE

Title : Dual Reversible Coumarin Inhibitors Mutually Bound to Monoamine Oxidase B and Acetylcholinesterase Crystal Structures - Ekstrom_2022_ACS.Med.Chem.Lett_13_499
Author(s) : Ekstrom F , Gottinger A , Forsgren N , Catto M , Iacovino LG , Pisani P , Binda C
Ref : ACS Med Chem Lett , 13 :499 , 2022
Abstract :
PubMedSearch : Ekstrom_2022_ACS.Med.Chem.Lett_13_499
PubMedID: 35300078
Gene_locus related to this paper: mouse-ACHE

Title : Broad-spectrum antidote discovery by untangling the reactivation mechanism of nerve agent inhibited acetylcholinesterase - Lindgren_2022_Chemistry_28_e202200678
Author(s) : Lindgren C , Forsgren N , Hoster N , Akfur C , Artursson E , Edvinsson L , Svensson R , Worek F , Ekstrom , Linusson A
Ref : Chemistry , 28 :e202200678 , 2022
Abstract :
PubMedSearch : Lindgren_2022_Chemistry_28_e202200678
PubMedID: 35420233
Gene_locus related to this paper: mouse-ACHE

Title : Physical Mechanisms Governing Substituent Effects on Arene-Arene Interactions in a Protein Milieu - Andersson_2020_J.Phys.Chem.B_124_6529
Author(s) : Andersson CD , Mishra BK , Forsgren N , Ekstrom F , Linusson A
Ref : J Phys Chem B , 124 :6529 , 2020
Abstract :
PubMedSearch : Andersson_2020_J.Phys.Chem.B_124_6529
PubMedID: 32610016
Gene_locus related to this paper: mouse-ACHE

Title : Noncovalent Inhibitors of Mosquito Acetylcholinesterase 1 with Resistance-Breaking Potency - Knutsson_2018_J.Med.Chem_61_10545
Author(s) : Knutsson S , Engdahl C , Kumari R , Forsgren N , Lindgren C , Kindahl T , Kitur S , Wachira L , Kamau L , Ekstrom F , Linusson A
Ref : Journal of Medicinal Chemistry , 61 :10545 , 2018
Abstract :
PubMedSearch : Knutsson_2018_J.Med.Chem_61_10545
PubMedID: 30339371
Gene_locus related to this paper: mouse-ACHE

Title : An Unusual Dimeric Inhibitor of Acetylcholinesterase: Cooperative Binding of Crystal Violet - Allgardsson_2017_Molecules_22_
Author(s) : Allgardsson A , David Andersson C , Akfur C , Worek F , Linusson A , Ekstrom F
Ref : Molecules , 22 : , 2017
Abstract :
PubMedSearch : Allgardsson_2017_Molecules_22_
PubMedID: 28867801
Gene_locus related to this paper: mouse-ACHE

Title : The Nature of Activated Non-classical Hydrogen Bonds: A Case Study on Acetylcholinesterase-Ligand Complexes - Berg_2016_Chemistry_22_2672
Author(s) : Berg L , Mishra BK , Andersson CD , Ekstrom F , Linusson A
Ref : Chemistry , 22 :2672 , 2016
Abstract :
PubMedSearch : Berg_2016_Chemistry_22_2672
PubMedID: 26751405
Gene_locus related to this paper: mouse-ACHE

Title : Slow-binding inhibition of acetylcholinesterase by an alkylammonium derivative of 6-methyluracil: mechanism and possible advantages for myasthenia gravis treatment - Kharlamova_2016_Biochem.J_473_1225
Author(s) : Kharlamova AD , Lushchekina SV , Petrov KA , Kots ED , Nachon F , Villard-Wandhammer M , Zueva IV , Krejci E , Reznik VS , Zobov VV , Nikolsky EE , Masson P
Ref : Biochemical Journal , 473 :1225 , 2016
Abstract :
PubMedSearch : Kharlamova_2016_Biochem.J_473_1225
PubMedID: 26929400
Gene_locus related to this paper: mouse-ACHE

Title : Discovery of Selective Inhibitors Targeting Acetylcholinesterase 1 from Disease-Transmitting Mosquitoes - Engdahl_2016_J.Med.Chem_59_9409
Author(s) : Engdahl C , Knutsson S , Ekstrom F , Linusson A
Ref : Journal of Medicinal Chemistry , 59 :9409 , 2016
Abstract :
PubMedSearch : Engdahl_2016_J.Med.Chem_59_9409
PubMedID: 27598521
Gene_locus related to this paper: anoga-ACHE1 , mouse-ACHE

Title : Steric and Dynamic Parameters Influencing In Situ Cycloadditions to Form Triazole Inhibitors with Crystalline Acetylcholinesterase - Bourne_2016_J.Am.Chem.Soc_138_1611
Author(s) : Bourne Y , Sharpless KB , Taylor P , Marchot P
Ref : Journal of the American Chemical Society , 138 :1611 , 2016
Abstract :
PubMedSearch : Bourne_2016_J.Am.Chem.Soc_138_1611
PubMedID: 26731630
Gene_locus related to this paper: mouse-ACHE

Title : Discovery of New Classes of Compounds that Reactivate Acetylcholinesterase Inhibited by Organophosphates - Katz_2015_Chembiochem_16_2205
Author(s) : Katz FS , Pecic S , Tran TH , Trakht I , Schneider L , Zhu Z , Ton-That L , Luzac M , Zlatanic V , Damera S , MacDonald J , Landry DW , Tong L , Stojanovic MN
Ref : Chembiochem , 16 :2205 , 2015
Abstract :
PubMedSearch : Katz_2015_Chembiochem_16_2205
PubMedID: 26350723
Gene_locus related to this paper: mouse-ACHE

Title : Divergent Structure-Activity Relationships of Structurally Similar Acetylcholinesterase Inhibitors - Andersson_2013_J.Med.Chem_56_7615
Author(s) : Andersson CD , Forsgren N , Akfur C , Allgardsson A , Berg L , Engdahl C , Qian W , Ekstrom F , Linusson A
Ref : Journal of Medicinal Chemistry , 56 :7615 , 2013
Abstract :
PubMedSearch : Andersson_2013_J.Med.Chem_56_7615
PubMedID: 23984975
Gene_locus related to this paper: mouse-ACHE

Title : Catalytic-site conformational equilibrium in nerve-agent adducts of acetylcholinesterase: possible implications for the HI-6 antidote substrate specificity - Artursson_2013_Biochem.Pharmacol_85_1389
Author(s) : Artursson E , Andersson PO , Akfur C , Linusson A , Borjegren S , Ekstrom F
Ref : Biochemical Pharmacology , 85 :1389 , 2013
Abstract :
PubMedSearch : Artursson_2013_Biochem.Pharmacol_85_1389
PubMedID: 23376121
Gene_locus related to this paper: mouse-ACHE

Title : Inhibition pathways of the potent organophosphate CBDP with cholinesterases revealed by X-ray crystallographic snapshots and mass spectrometry - Carletti_2013_Chem.Res.Toxicol_26_280
Author(s) : Carletti E , Colletier JP , Schopfer LM , Santoni G , Masson P , Lockridge O , Nachon F , Weik M
Ref : Chemical Research in Toxicology , 26 :280 , 2013
Abstract :
PubMedSearch : Carletti_2013_Chem.Res.Toxicol_26_280
PubMedID: 23339663
Gene_locus related to this paper: human-BCHE , mouse-ACHE

Title : Huprine derivatives as sub-nanomolar human acetylcholinesterase inhibitors: from rational design to validation by X-ray crystallography - Ronco_2012_ChemMedChem_7_400
Author(s) : Ronco C , Carletti E , Colletier JP , Weik M , Nachon F , Jean L , Renard PY
Ref : ChemMedChem , 7 :400 , 2012
Abstract :
PubMedSearch : Ronco_2012_ChemMedChem_7_400
PubMedID: 22052791
Gene_locus related to this paper: mouse-ACHE

Title : Similar but different: thermodynamic and structural characterization of a pair of enantiomers binding to acetylcholinesterase - Berg_2012_Angew.Chem.Int.Ed.Engl_51_12716
Author(s) : Berg L , Niemiec MS , Qian W , Andersson CD , Wittung-Stafshede P , Ekstrom F , Linusson A
Ref : Angew Chem Int Ed Engl , 51 :12716 , 2012
Abstract :
PubMedSearch : Berg_2012_Angew.Chem.Int.Ed.Engl_51_12716
PubMedID: 23161758
Gene_locus related to this paper: mouse-ACHE

Title : Targeting acetylcholinesterase: identification of chemical leads by high throughput screening, structure determination and molecular modeling - Berg_2011_PLoS.One_6_e26039
Author(s) : Berg L , Andersson CD , Artursson E , Hornberg A , Tunemalm AK , Linusson A , Ekstrom F
Ref : PLoS ONE , 6 :e26039 , 2011
Abstract :
PubMedSearch : Berg_2011_PLoS.One_6_e26039
PubMedID: 22140425
Gene_locus related to this paper: mouse-ACHE

Title : Conformational remodeling of femtomolar inhibitor-acetylcholinesterase complexes in the crystalline state - Bourne_2010_J.Am.Chem.Soc_132_18292
Author(s) : Bourne Y , Radic Z , Taylor P , Marchot P
Ref : Journal of the American Chemical Society , 132 :18292 , 2010
Abstract :
PubMedSearch : Bourne_2010_J.Am.Chem.Soc_132_18292
PubMedID: 21090615
Gene_locus related to this paper: mouse-ACHE

Title : Crystal structures of oxime-bound fenamiphos-acetylcholinesterases: reactivation involving flipping of the His447 ring to form a reactive Glu334-His447-oxime triad - Hornberg_2010_Biochem.Pharmacol_79_507
Author(s) : Hornberg A , Artursson E , Warme R , Pang YP , Ekstrom F
Ref : Biochemical Pharmacology , 79 :507 , 2010
Abstract :
PubMedSearch : Hornberg_2010_Biochem.Pharmacol_79_507
PubMedID: 19732756
Gene_locus related to this paper: mouse-ACHE

Title : Selective and irreversible inhibitors of mosquito acetylcholinesterases for controlling malaria and other mosquito-borne diseases - Pang_2009_PLoS.One_4_e6851
Author(s) : Pang YP , Ekstrom F , Polsinelli GA , Gao Y , Rana S , Hua DH , Andersson B , Andersson PO , Peng L , Singh SK , Mishra RK , Zhu KY , Fallon AM , Ragsdale DW , Brimijoin S
Ref : PLoS ONE , 4 :e6851 , 2009
Abstract :
PubMedSearch : Pang_2009_PLoS.One_4_e6851
PubMedID: 19714254
Gene_locus related to this paper: mouse-ACHE , mouse-acnt1

Title : Structure of HI-6*sarin-acetylcholinesterase determined by X-ray crystallography and molecular dynamics simulation: reactivator mechanism and design - Ekstrom_2009_PLoS.One_4_e5957
Author(s) : Ekstrom F , Hornberg A , Artursson E , Hammarstrom LG , Schneider G , Pang YP
Ref : PLoS ONE , 4 :e5957 , 2009
Abstract :
PubMedSearch : Ekstrom_2009_PLoS.One_4_e5957
PubMedID: 19536291
Gene_locus related to this paper: mouse-ACHE

Title : Aging of cholinesterases phosphylated by tabun proceeds through O-dealkylation - Carletti_2008_J.Am.Chem.Soc_130_16011
Author(s) : Carletti E , Li H , Li B , Ekstrom F , Nicolet Y , Loiodice M , Gillon E , Froment MT , Lockridge O , Schopfer LM , Masson P , Nachon F
Ref : Journal of the American Chemical Society , 130 :16011 , 2008
Abstract :
PubMedSearch : Carletti_2008_J.Am.Chem.Soc_130_16011
PubMedID: 18975951
Gene_locus related to this paper: human-BCHE , mouse-ACHE

Title : Novel nerve-agent antidote design based on crystallographic and mass spectrometric analyses of tabun-conjugated acetylcholinesterase in complex with antidotes - Ekstrom_2007_Clin.Pharmacol.Ther_82_282
Author(s) : Ekstrom F , Astot C , Pang YP
Ref : Clinical Pharmacology & Therapeutics , 82 :282 , 2007
Abstract :
PubMedSearch : Ekstrom_2007_Clin.Pharmacol.Ther_82_282
PubMedID: 17443135
Gene_locus related to this paper: mouse-ACHE

Title : Crystal structures of acetylcholinesterase in complex with organophosphorus compounds suggest that the acyl pocket modulates the aging reaction by precluding the formation of the trigonal bipyramidal transition state - Hornberg_2007_Biochemistry_46_4815
Author(s) : Hornberg A , Tunemalm AK , Ekstrom F
Ref : Biochemistry , 46 :4815 , 2007
Abstract :
PubMedSearch : Hornberg_2007_Biochemistry_46_4815
PubMedID: 17402711
Gene_locus related to this paper: mouse-ACHE

Title : Substrate and product trafficking through the active center gorge of acetylcholinesterase analyzed by crystallography and equilibrium binding - Bourne_2006_J.Biol.Chem_281_29256
Author(s) : Bourne Y , Radic Z , Sulzenbacher G , Kim E , Taylor P , Marchot P
Ref : Journal of Biological Chemistry , 281 :29256 , 2006
Abstract :
PubMedSearch : Bourne_2006_J.Biol.Chem_281_29256
PubMedID: 16837465
Gene_locus related to this paper: mouse-ACHE

Title : Crystal structures of acetylcholinesterase in complex with HI-6, Ortho-7 and obidoxime: structural basis for differences in the ability to reactivate tabun conjugates - Ekstrom_2006_Biochem.Pharmacol_72_597
Author(s) : Ekstrom F , Pang YP , Boman M , Artursson E , Akfur C , Borjegren S
Ref : Biochemical Pharmacology , 72 :597 , 2006
Abstract :
PubMedSearch : Ekstrom_2006_Biochem.Pharmacol_72_597
PubMedID: 16876764
Gene_locus related to this paper: mouse-ACHE

Title : Structural changes of phenylalanine 338 and histidine 447 revealed by the crystal structures of tabun-inhibited murine acetylcholinesterase - Ekstrom_2006_Biochemistry_45_74
Author(s) : Ekstrom F , Akfur C , Tunemalm AK , Lundberg S
Ref : Biochemistry , 45 :74 , 2006
Abstract :
PubMedSearch : Ekstrom_2006_Biochemistry_45_74
PubMedID: 16388582
Gene_locus related to this paper: mouse-ACHE

Title : Freeze-frame inhibitor captures acetylcholinesterase in a unique conformation - Bourne_2004_Proc.Natl.Acad.Sci.U.S.A_101_1449
Author(s) : Bourne Y , Kolb HC , Radic Z , Sharpless KB , Taylor P , Marchot P
Ref : Proc Natl Acad Sci U S A , 101 :1449 , 2004
Abstract :
PubMedSearch : Bourne_2004_Proc.Natl.Acad.Sci.U.S.A_101_1449
PubMedID: 14757816
Gene_locus related to this paper: mouse-ACHE

Title : Structural insights into ligand interactions at the acetylcholinesterase peripheral anionic site - Bourne_2003_Embo.J_22_1
Author(s) : Bourne Y , Taylor P , Radic Z , Marchot P
Ref : EMBO Journal , 22 :1 , 2003
Abstract :
PubMedSearch : Bourne_2003_Embo.J_22_1
PubMedID: 12505979
Gene_locus related to this paper: mouse-ACHE

Title : Comparative analysis of the gene-dense ACHE\/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5 - Wilson_2001_Nucleic.Acids.Res_29_1352
Author(s) : Wilson MD , Riemer C , Martindale DW , Schnupf P , Boright AP , Cheung TL , Hardy DM , Schwartz S , Scherer SW , Tsui LC , Miller W , Koop BF
Ref : Nucleic Acids Research , 29 :1352 , 2001
Abstract :
PubMedSearch : Wilson_2001_Nucleic.Acids.Res_29_1352
PubMedID: 11239002
Gene_locus related to this paper: human-ACHE , mouse-ACHE

Title : Postnatal developmental delay and supersensitivity to organophosphate in gene-targeted mice lacking acetylcholinesterase - Xie_2000_J.Pharmacol.Exp.Ther_293_896
Author(s) : Xie W , Stribley JA , Chatonnet A , Wilder PJ , Rizzino A , McComb RD , Taylor P , Hinrichs SH , Lockridge O
Ref : Journal of Pharmacology & Experimental Therapeutics , 293 :896 , 2000
Abstract :
PubMedSearch : Xie_2000_J.Pharmacol.Exp.Ther_293_896
PubMedID: 10869390
Gene_locus related to this paper: mouse-ACHE

Title : Crystal structure of mouse acetylcholinesterase. A peripheral site- occluding loop in a tetrameric assembly - Bourne_1999_J.Biol.Chem_274_2963
Author(s) : Bourne Y , Taylor P , Bougis PE , Marchot P
Ref : Journal of Biological Chemistry , 274 :2963 , 1999
Abstract :
PubMedSearch : Bourne_1999_J.Biol.Chem_274_2963
PubMedID: 9915834
Gene_locus related to this paper: mouse-ACHE

Title : Soluble monomeric acetylcholinesterase from mouse: expression, purification, and crystallization in complex with fasciculin - Marchot_1996_Prot.Sci_5_672
Author(s) : Marchot P , Ravelli RB , Raves ML , Bourne Y , Vellom DC , Kanter J , Camp S , Sussman JL , Taylor P
Ref : Protein Science , 5 :672 , 1996
Abstract :
PubMedSearch : Marchot_1996_Prot.Sci_5_672
PubMedID: 8845756
Gene_locus related to this paper: mouse-ACHE

Title : Acetylcholinesterase inhibition by fasciculin: crystal structure of the complex - Bourne_1995_Cell_83_503
Author(s) : Bourne Y , Taylor P , Marchot P
Ref : Cell , 83 :503 , 1995
Abstract :
PubMedSearch : Bourne_1995_Cell_83_503
PubMedID: 8521480
Gene_locus related to this paper: mouse-ACHE

Title : Molecular cloning of mouse acetylcholinesterase: tissue distribution of alternatively spliced mRNA species - Rachinsky_1990_Neuron_5_317
Author(s) : Rachinsky TL , Camp S , Li Y , Ekstrom TJ , Newton M , Taylor P
Ref : Neuron , 5 :317 , 1990
Abstract :
PubMedSearch : Rachinsky_1990_Neuron_5_317
PubMedID: 2400605
Gene_locus related to this paper: mouse-ACHE , mouse-BCHE