F297Y_mouse-ACHE

General

Gene Locus : mouse-ACHE

Mode of mutation : Site directed mutagenesis

Disease :

Summary : Acyl specificity Acyl pocket, increase km decrease kcat ATC Radic_1993_Biochemistry_32_12074 Radic_1994_J.Biol.Chem_269_11233 Pickering_1995_5th.ChE.Meeting.Madras__227 || Substrate inhibition high Radic_1993_Biochemistry_32_12074 Radic_1994_J.Biol.Chem_269_11233 Pickering_1995_5th.ChE.Meeting.Madras__227

AAA Change :

Allelic Variant :

Risk Factor :

Inhibitor :

Structure :

Disease by interaction :

Interact Gene Locus :

Xenobiotic sensitivity :

Modification : Acyl specificity || Substrate inhibition

Torpedo_number : 290

Kinetic Parameter : Acetylthiocholine_F297Y_mouse-ACHE, WT-fasciculin2_F297Y_mouse-ACHE, Butyrylthiocholine_F297Y_mouse-ACHE, Benzoylthiocholine_F297Y_mouse-ACHE

News : No news

Comment :
p.Phe297Tyr

References (4)

Title : Organophosphate Specificity of Acyl Pocket Cholinesterase Mutants -
Author(s) : Pickering NA , Taylor P , Berman HA
Ref : In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases , (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp. :227 , 1995
PubMedID:

Title : Specificity and orientation of trigonal carboxyl esters and tetrahedral alkylphosphonyl esters in cholinesterases - Hosea_1995_Biochemistry_34_11528
Author(s) : Hosea NA , Berman HA , Taylor P
Ref : Biochemistry , 34 :11528 , 1995
Abstract :
PubMedSearch : Hosea_1995_Biochemistry_34_11528
PubMedID: 7547883

Title : Site of fasciculin interaction with acetylcholinesterase - Radic_1994_J.Biol.Chem_269_11233
Author(s) : Radic Z , Duran R , Vellom DC , Li Y , Cervenansky C , Taylor P
Ref : Journal of Biological Chemistry , 269 :11233 , 1994
Abstract :
PubMedSearch : Radic_1994_J.Biol.Chem_269_11233
PubMedID: 8157652

Title : Three distinct domains in the cholinesterase molecule confer selectivity for acetyl- and butyrylcholinesterase inhibitors - Radic_1993_Biochemistry_32_12074
Author(s) : Radic Z , Pickering NA , Vellom DC , Camp S , Taylor P
Ref : Biochemistry , 32 :12074 , 1993
Abstract :
PubMedSearch : Radic_1993_Biochemistry_32_12074
PubMedID: 8218285