F329C_human-BCHE

General

Gene Locus : human-BCHE

Mode of mutation : Site directed mutagenesis

Disease :

Summary : OP-resistance resistant to echothiophate Gnatt_1994_J.Neurochem_62_749 || Aging F329C increases half-life of aging by DFP 2 times Masson_1997_Biochem.J_327_601

AAA Change :

Allelic Variant :

Risk Factor :

Inhibitor :

Structure :

Disease by interaction :

Interact Gene Locus :

Xenobiotic sensitivity :

Modification : OP-resistance

Torpedo_number : 331

Kinetic Parameter : Butyrylthiocholine_F329C_human-BCHE, Echothiophate_F329C_human-BCHE, Iso-OMPA_F329C_human-BCHE, DFP_F329C_human-BCHE

News : No news

Comment :
p.F329C Phe329Cys (p.F357C Phe357Cys in primary sequence with 28 amino-acids signal peptide) F329C increases half-life of aging by DFP 2 times

References (2)

Title : Aging of di-isopropyl-phosphorylated human butyrylcholinesterase - Masson_1997_Biochem.J_327_601
Author(s) : Masson P , Fortier PL , Albaret C , Froment MT , Bartels CF , Lockridge O
Ref : Biochemical Journal , 327 ( Pt 2) :601 , 1997
Abstract :
PubMedSearch : Masson_1997_Biochem.J_327_601
PubMedID: 9359435

Title : Site-directed mutagenesis of active site residues reveals plasticity of human butyrylcholinesterase in substrate and inhibitor interactions - Gnatt_1994_J.Neurochem_62_749
Author(s) : Gnatt A , Loewenstein Y , Yaron A , Schwarz M , Soreq H
Ref : Journal of Neurochemistry , 62 :749 , 1994
Abstract :
PubMedSearch : Gnatt_1994_J.Neurochem_62_749
PubMedID: 8294937