Gene Locus : human-BCHE
Mode of mutation : Site directed mutagenesis
Disease :
Summary : OP-resistance resistant to echothiophate Gnatt_1994_J.Neurochem_62_749 || Aging F329C increases half-life of aging by DFP 2 times Masson_1997_Biochem.J_327_601
AAA Change :
Allelic Variant :
Risk Factor :
Inhibitor :
Structure :
Disease by interaction :
Interact Gene Locus :
Xenobiotic sensitivity :
Modification : OP-resistance
Torpedo_number : 331
Kinetic Parameter : Butyrylthiocholine_F329C_human-BCHE, Echothiophate_F329C_human-BCHE, Iso-OMPA_F329C_human-BCHE, DFP_F329C_human-BCHE
News : No news
Comment :
p.F329C Phe329Cys (p.F357C Phe357Cys in primary sequence with 28 amino-acids signal peptide) F329C increases half-life of aging by DFP 2 times
| Title : Aging of di-isopropyl-phosphorylated human butyrylcholinesterase - Masson_1997_Biochem.J_327_601 |
| Author(s) : Masson P , Fortier PL , Albaret C , Froment MT , Bartels CF , Lockridge O |
| Ref : Biochemical Journal , 327 ( Pt 2) :601 , 1997 |
| Abstract : |
| PubMedSearch : Masson_1997_Biochem.J_327_601 |
| PubMedID: 9359435 |
| Title : Site-directed mutagenesis of active site residues reveals plasticity of human butyrylcholinesterase in substrate and inhibitor interactions - Gnatt_1994_J.Neurochem_62_749 |
| Author(s) : Gnatt A , Loewenstein Y , Yaron A , Schwarz M , Soreq H |
| Ref : Journal of Neurochemistry , 62 :749 , 1994 |
| Abstract : |
| PubMedSearch : Gnatt_1994_J.Neurochem_62_749 |
| PubMedID: 8294937 |