Gene Locus : pluxy-ACHE1
Mode of mutation : Natural mutant
Disease :
Summary : OP-resistance G227A A201S A441G (G324A,A298S,A324G) found together in resistant strains but G227A likely to be important (also numbered G324A in Lee et al.) Baek_2005_Pestic.Biochem.Physiol_81_164 || OP-resistance D131G A201S A441G (D229G, A298S,A324G) found together in resistant strains but G227A likely to be important Lee_2007_Biochem.Biophys.Res.Commun_353_591 || OP-resistance G227A A201S (G324A,A298S) found together in resistant strains but A201S likely to be important Kim_2012_J.Asia.Pac.Entomol_15_401 || OP-resistance A298S and G324A mutations showed no correlation with levels of resistance to acephate Sonoda_2014_Insect.Biochem.Mol.Biol_48_83
AAA Change :
Allelic Variant :
Risk Factor :
Inhibitor :
Structure :
Disease by interaction :
Interact Gene Locus :
Xenobiotic sensitivity :
Modification : OP-resistance
Torpedo_number : 227
Kinetic Parameter : No kinetic parameter
News : MAY-03-2005
Comment :
Gly227Ala G227A (G324A) also found in drome and musdo -ACHE (ace2 othologues of pluxy-ACHE and not pluxy-ACHE1) is likely to give resistance to OP || G324A in the Plutella xylostella (L.) ACHE1. a highly resistant strain has the two mutations, a low resistant strain has only G227A Kim et al 2012. There is a rade-off between thermal tolerance and insecticide resistance Zhang et al.2015. G892T, G971C, T1156T\/G leading to A298S, G324A, and F386F\/V
| Title : Resistance Mechanism of Plutella xylostella (L.) Associated with Amino Acid Substitutions in Acetylcholinesterase-1: Insights from Homology Modeling, Docking and Molecular Dynamic Simulation - Zolfaghari_2024_Insects_15_144 |
| Author(s) : Zolfaghari M , Xiao Y , Safiul Azam FM , Yin F , Peng ZK , Li ZY |
| Ref : Insects , 15 :144 , 2024 |
| Abstract : |
| PubMedSearch : Zolfaghari_2024_Insects_15_144 |
| PubMedID: 38535339 |
| Gene_locus related to this paper: pluxy-ACHE , pluxy-ACHE1 |
| Title : Frequencies of insecticide resistance mutations detected by the amplicon sequencing in Plutella xylostella (Lepidoptera: Plutellidae) and Spodoptera exigua (Lepidoptera: Noctuidae) from China - Liu_2024_J.Econ.Entomol__ |
| Author(s) : Liu Z , Ma H , Li K , Liu J , Zhu H , Zhou Y , Man Y , Zhou X |
| Ref : J Econ Entomol , : , 2024 |
| Abstract : |
| PubMedSearch : Liu_2024_J.Econ.Entomol__ |
| PubMedID: 38748551 |
| Title : Insecticide-resistance mechanism of Plutella xylostella (L.) associated with amino acid substitutions in acetylcholinesterase-1: A molecular docking and molecular dynamics investigation - Sindhu_2018_Comput.Biol.Chem_77_240 |
| Author(s) : Sindhu T , Venkatesan T , Prabhu D , Jeyakanthan J , Gracy GR , Jalali SK , Rai A |
| Ref : Comput Biol Chem , 77 :240 , 2018 |
| Abstract : |
| PubMedSearch : Sindhu_2018_Comput.Biol.Chem_77_240 |
| PubMedID: 30368112 |
| Title : Inheritance and stability of mevinphos-resistance in Plutella xylostella (L.), with special reference to mutations of acetylcholinesterase 1 - Lin_2017_Pestic.Biochem.Physiol_141_65 |
| Author(s) : Lin CL , Yeh SC , Feng HT , Dai SM |
| Ref : Pestic Biochem Physiol , 141 :65 , 2017 |
| Abstract : |
| PubMedSearch : Lin_2017_Pestic.Biochem.Physiol_141_65 |
| PubMedID: 28911742 |
| Title : Trade-off between thermal tolerance and insecticide resistance in Plutella xylostella - Zhang_2015_Ecol.Evol_5_515 |
| Author(s) : Zhang LJ , Wu ZL , Wang KF , Liu Q , Zhuang HM , Wu G |
| Ref : Ecol Evol , 5 :515 , 2015 |
| Abstract : |
| PubMedSearch : Zhang_2015_Ecol.Evol_5_515 |
| PubMedID: 25691976 |
| Gene_locus related to this paper: pluxy-ACHE1 |
| Title : Amino acid substitutions and intron polymorphism of acetylcholinesterase1 associated with mevinphos resistance in diamondback moth, Plutella xylostella (L.) - Yeh_2014_Pestic.Biochem.Physiol_112_7 |
| Author(s) : Yeh SC , Lin CL , Chang C , Feng HT , Dai SM |
| Ref : Pestic Biochem Physiol , 112 :7 , 2014 |
| Abstract : |
| PubMedSearch : Yeh_2014_Pestic.Biochem.Physiol_112_7 |
| PubMedID: 24974111 |
| Title : Duplication of acetylcholinesterase gene in diamondback moth strains with different sensitivities to acephate - Sonoda_2014_Insect.Biochem.Mol.Biol_48_83 |
| Author(s) : Sonoda S , Shi X , Song D , Liang P , Gao X , Zhang Y , Li J , Liu Y , Li M , Matsumura M , Sanada-Morimura S , Minakuchi C , Tanaka T , Miyata T |
| Ref : Insect Biochemistry & Molecular Biology , 48 :83 , 2014 |
| Abstract : |
| PubMedSearch : Sonoda_2014_Insect.Biochem.Mol.Biol_48_83 |
| PubMedID: 24632376 |
| Title : Mutation in ace1 associated with an insecticide resistant population of Plutella xylostella - Kim_2012_J.Asia.Pac.Entomol_15_401 |
| Author(s) : Kim JI , Joo YR , Kwon M , Kim GH , Lee SH |
| Ref : Journal of Asia-Pacific Entomology , 15 :401 , 2012 |
| Abstract : |
| PubMedSearch : Kim_2012_J.Asia.Pac.Entomol_15_401 |
| PubMedID: |
| Title : Mutations of acetylcholinesterase1 contribute to prothiofos-resistance in Plutella xylostella (L.) - Lee_2007_Biochem.Biophys.Res.Commun_353_591 |
| Author(s) : Lee DW , Choi JY , Kim WT , Je YH , Song JT , Chung BK , Boo KS , Koh YH |
| Ref : Biochemical & Biophysical Research Communications , 353 :591 , 2007 |
| Abstract : |
| PubMedSearch : Lee_2007_Biochem.Biophys.Res.Commun_353_591 |
| PubMedID: 17196934 |
| Gene_locus related to this paper: pluxy-ACHE , pluxy-ACHE1 |
| Title : Identification and characterization of ace1-type acetylcholinesterase likely associated with organophosphate resistance in Plutella xylostella - Baek_2005_Pestic.Biochem.Physiol_81_164 |
| Author(s) : Baek JH , Kim JI , Lee DW , Chung BK , Miyata T , Lee SH |
| Ref : Pesticide Biochemistry and Physiology , 81 :164 , 2005 |
| Abstract : |
| PubMedSearch : Baek_2005_Pestic.Biochem.Physiol_81_164 |
| PubMedID: |
| Gene_locus related to this paper: pluxy-ACHE1 |