S203C_human-ACHE

General

Gene Locus : human-ACHE

Mode of mutation : Site directed mutagenesis

Disease :

Summary : Catalysis 1\% activity cmp WT Shafferman_1992_J.Biol.Chem_267_17640 || Catalytic triad 1\% activity cmp WT Shafferman_1992_J.Biol.Chem_267_17640

AAA Change :

Allelic Variant :

Risk Factor :

Inhibitor :

Structure :

Disease by interaction :

Interact Gene Locus :

Xenobiotic sensitivity :

Modification : Catalytic triad || Catalysis

Torpedo_number : 200

Kinetic Parameter : No kinetic parameter

News : No news

Comment :
p.S203C Ser203Cys (p.S234C Ser234Cys in primary sequence with 31 amino-acids signal peptide)Catalytic triad S Catalysis 1\% activity compared to WT

References (1)

Title : Mutagenesis of human acetylcholinesterase. Identification of residues involved in catalytic activity and in polypeptide folding - Shafferman_1992_J.Biol.Chem_267_17640
Author(s) : Shafferman A , Kronman C , Flashner Y , Leitner M , Grosfeld H , Ordentlich A , Gozes Y , Cohen S , Ariel N , Barak D , Harel M , Silman I , Sussman JL , Velan B
Ref : Journal of Biological Chemistry , 267 :17640 , 1992
PubMedID: 1517212