S75N_human-CES1

General

Gene Locus : human-CES1

Mode of mutation : Natural mutant

Disease :

Summary : Natural mutant Wang_2017_Drug.Metab.Dispos_45_1149 || Expression Clopidogrel metabolism is impaired Xiao_2017_Sci.Rep_7_7244

AAA Change :

Allelic Variant :

Risk Factor :

Inhibitor :

Structure :

Disease by interaction :

Interact Gene Locus :

Xenobiotic sensitivity :

Modification : Natural mutation

Torpedo_number : 55

Kinetic Parameter : No kinetic parameter

News : No news

Comment :
p.Ser75Asn Nucleotide change G332A rs2307240 || p.Ser75ASn rs2307240 C>T

References (2)

Title : Effect of carboxylesterase 1 S75N on clopidogrel therapy among acute coronary syndrome patients - Xiao_2017_Sci.Rep_7_7244
Author(s) : Xiao FY , Luo JQ , Liu M , Chen BL , Cao S , Liu ZQ , Zhou HH , Zhou G , Zhang W
Ref : Sci Rep , 7 :7244 , 2017
Abstract :
PubMedSearch : Xiao_2017_Sci.Rep_7_7244
PubMedID: 28775293
Gene_locus related to this paper: human-CES1

Title : A Comprehensive Functional Assessment of Carboxylesterase 1 Nonsynonymous Polymorphisms - Wang_2017_Drug.Metab.Dispos_45_1149
Author(s) : Wang X , Rida N , Shi J , Wu AH , Bleske BE , Zhu HJ
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 45 :1149 , 2017
Abstract :
PubMedSearch : Wang_2017_Drug.Metab.Dispos_45_1149
PubMedID: 28838926
Gene_locus related to this paper: human-CES1