Gene Locus : human-ACHE
Mode of mutation : Site directed mutagenesis
Disease :
Summary : Choline binding site Catalysis\/Maintenance of Choline binding site 90 fold increase of Km for ATCh 760 fold red of kapp Ordentlich_1995_J.Biol.Chem_270_2082
AAA Change :
Allelic Variant :
Risk Factor :
Inhibitor :
Structure :
Disease by interaction :
Interact Gene Locus :
Xenobiotic sensitivity :
Modification : Choline binding site
Torpedo_number : 130
Kinetic Parameter : Acetylthiocholine_Y133A_human-ACHE, 3,3-dimethylbutylthioacetate_Y133A_human-ACHE, Edrophonium_Y133A_human-ACHE, Propidium_Y133A_human-ACHE, Decamethonium_Y133A_human-ACHE, Tacrine_Y133A_human-ACHE, HuperzineA_Y133A_human-ACHE
News : No news
Comment :
p.Y133A Tyr133Ala (p.Y164A Tyr164Ala in primary sequence with 31 amino-acids signal peptide) Choline binding site\;Catalysis\/Maintenance of Choline binding site 90 fold increase of Km for ATCh 760 fold red of kapp
| Title : The 'aromatic patch' of three proximal residues in the human acetylcholinesterase active centre allows for versatile interaction modes with inhibitors - Ariel_1998_Biochem.J_335_95 |
| Author(s) : Ariel N , Ordentlich A , Barak D , Bino T , Velan B , Shafferman A |
| Ref : Biochemical Journal , 335 :95 , 1998 |
| Abstract : |
| PubMedSearch : Ariel_1998_Biochem.J_335_95 |
| PubMedID: 9742217 |
| Title : Contribution of aromatic moieties of tyrosine 133 and of the anionic subsite tryptophan 86 to catalytic efficiency and allosteric modulation of acetylcholinesterase - Ordentlich_1995_J.Biol.Chem_270_2082 |
| Author(s) : Ordentlich A , Barak D , Kronman C , Ariel N , Segall Y , Velan B , Shafferman A |
| Ref : Journal of Biological Chemistry , 270 :2082 , 1995 |
| Abstract : |
| PubMedSearch : Ordentlich_1995_J.Biol.Chem_270_2082 |
| PubMedID: 7836436 |