Segall Y

General

Full name : Segall Yoffi

First name : Yoffi

Mail : Dept. of Organic Chemistry, Israel Inst. for BioI. Res., P.O.B. 19, 70450 Ness-Ziona

Zip Code :

City :

Country : Israel

Email :

Phone : (972) 8 381549

Fax : (972) 8 401094

Website :

Directory :

References (31)

Title : Function-specific blockage of M(1) and M(3) muscarinic acetylcholine receptors by VX and echothiophate - Pittel_2006_Brain.Res_1085_102
Author(s) : Pittel Z , Barak D , Segall Y
Ref : Brain Research , 1085 :102 , 2006
PubMedID: 16580648

Title : The role of AChE active site gorge in determining stereoselectivity of charged and noncharged VX enantiomers - Ordentlich_2005_Chem.Biol.Interact_157-158_191
Author(s) : Ordentlich A , Barak D , Sod-Moriah G , Kaplan D , Mizrahi D , Segall Y , Kronman C , Karton Y , Lazar A , Marcus D , Velan B , Shafferman A
Ref : Chemico-Biological Interactions , 157-158 :191 , 2005
PubMedID: 16289014

Title : MALDI-TOF\/MS analysis of tabun-acetylcholinesterase conjugate. -
Author(s) : Elhanany E , Ordentlich A , Dgany OR , Kaplan D , Segall Y , Barak R , Velan B , Shafferman A
Ref : Cholinergic Mechanisms, CRC Press :563 , 2004
PubMedID:

Title : Stereoselectivity toward VX is determined by interactions with residues of the acyl pocket as well as of the peripheral anionic site of AChE - Ordentlich_2004_Biochemistry_43_11255
Author(s) : Ordentlich A , Barak D , Sod-Moriah G , Kaplan D , Mizrahi D , Segall Y , Kronman C , Karton Y , Lazar A , Marcus D , Velan B , Shafferman A
Ref : Biochemistry , 43 :11255 , 2004
PubMedID: 15366935

Title : Poster (23) Phosphorylation and aging of AChE - insights from mutagenesis, mass spectrometry and structural studies -
Author(s) : Barak D , Ordentlich A , Kaplan D , Elhanani E , Segall Y , Barak R , Velan B , Shafferman A
Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :332 , 2004
PubMedID:

Title : Arachidonylsulfonyl derivatives as cannabinoid CB1 receptor and fatty acid amide hydrolase inhibitors - Segall_2003_Bioorg.Med.Chem.Lett_13_3301
Author(s) : Segall Y , Quistad GB , Nomura DK , Casida JE
Ref : Bioorganic & Medicinal Chemistry Lett , 13 :3301 , 2003
PubMedID: 12951114

Title : Major intermediates in organophosphate synthesis (PCl3, POCl3, PSCl3, and their diethyl esters) are anticholinesterase agents directly or on activation - Segall_2003_Chem.Res.Toxicol_16_350
Author(s) : Segall Y , Quistad GB , Sparks SE , Casida JE
Ref : Chemical Research in Toxicology , 16 :350 , 2003
PubMedID: 12641435

Title : Toxicological and structural features of organophosphorus and organosulfur cannabinoid CB1 receptor ligands - Segall_2003_Toxicol.Sci_76_131
Author(s) : Segall Y , Quistad GB , Sparks SE , Nomura DK , Casida JE
Ref : Toxicol Sci , 76 :131 , 2003
PubMedID: 12944586

Title : Selective inhibitors of fatty acid amide hydrolase relative to neuropathy target esterase and acetylcholinesterase: toxicological implications - Quistad_2002_Toxicol.Appl.Pharmacol_179_57
Author(s) : Quistad GB , Sparks SE , Segall Y , Nomura DK , Casida JE
Ref : Toxicol Appl Pharmacol , 179 :57 , 2002
PubMedID: 11884237

Title : Cannabinoid CB1 receptor as a target for chlorpyrifos oxon and other organophosphorus pesticides - Quistad_2002_Toxicol.Lett_135_89
Author(s) : Quistad GB , Nomura DK , Sparks SE , Segall Y , Casida JE
Ref : Toxicol Lett , 135 :89 , 2002
PubMedID: 12243867

Title : Resolving pathways of interaction of covalent inhibitors with the active site of acetylcholinesterases: maldi-tof\/ms analysis of various nerve agent phosphyl adducts - Elhanany_2001_Chem.Res.Toxicol_14_912
Author(s) : Elhanany E , Ordentlich A , Dgany O , Kaplan D , Segall Y , Barak R , Velan B , Shafferman A
Ref : Chemical Research in Toxicology , 14 :912 , 2001
PubMedID: 11453739

Title : Evidence for P-N bond scission in phosphoroamidate nerve agent adducts of human acetylcholinesterase - Barak_2000_Biochemistry_39_1156
Author(s) : Barak D , Ordentlich A , Kaplan D , Barak R , Mizrahi D , Kronman C , Segall Y , Velan B , Shafferman A
Ref : Biochemistry , 39 :1156 , 2000
PubMedID: 10653663

Title : Crystal structures of aged phosphonylated acetylcholinesterase: nerve agent reaction products at the atomic level - Millard_1999_Biochemistry_38_7032
Author(s) : Millard CB , Kryger G , Ordentlich A , Greenblatt HM , Harel M , Raves ML , Segall Y , Barak D , Shafferman A , Silman I , Sussman JL
Ref : Biochemistry , 38 :7032 , 1999
PubMedID: 10353814
Gene_locus related to this paper: torca-ACHE

Title : Exploring the active center of human acetylcholinesterase with stereomers of an organophosphorus inhibitor with two chiral centers - Ordentlich_1999_Biochemistry_38_3055
Author(s) : Ordentlich A , Barak D , Kronman C , Benschop HP , De Jong LP , Ariel N , Barak R , Segall Y , Velan B , Shafferman A
Ref : Biochemistry , 38 :3055 , 1999
PubMedID: 10074358

Title : Crystal Structures of Aged Phosphorylated and Phosphonylated Torpedo Californica Acetylcholinesterase -
Author(s) : Millard CB , Kryger G , Ordentlich A , Harel M , Raves ML , Greenblatt HM , Segall Y , Barak D , Shafferman A , Silman I , Sussman JL
Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :425 , 1998
PubMedID:

Title : Crystal structure of Aged phosphorylated and phosphonylated Torpedo Californica Acetylcholinesterase -
Author(s) : Millard CB , Kryger G , Ordentlich A , Harel M , Raves ML , Greenblatt HM , Segall Y , Barak D , Shafferman A , Silman I , Sussman JL
Ref : In Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :425 , 1998
PubMedID:
Gene_locus related to this paper: torca-ACHE

Title : Crystal Structures of Aged Phosphorylated and Phosphonylated Torpedo Californica Acetylcholinesterase -
Author(s) : Millard CB , Kryger G , Ordentlich A , Harel M , Raves ML , Greenblatt HM , Segall Y , Barak D , Shafferman A , Silman I , Sussman JL
Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :454 , 1998
PubMedID:

Title : Functional characteristics of the oxyanion hole in human acetylcholinesterase - Ordentlich_1998_J.Biol.Chem_273_19509
Author(s) : Ordentlich A , Barak D , Kronman C , Ariel N , Segall Y , Velan B , Shafferman A
Ref : Journal of Biological Chemistry , 273 :19509 , 1998
PubMedID: 9677373

Title : The Aromatic Moiety at Position-86 of HuAChE Accelerate the Aging of Phosphonyl-AChE Conjugates through Cation- Interactions -
Author(s) : Barak D , Ordentlich A , Stein D , Segall Y , Velan B , Benschop HP , De Jong LP , Shafferman A
Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :246 , 1998
PubMedID:

Title : ESMS as a Unique Tool for the Molecular Monitoring of Reactions between HuAChE and Various OP-Agents -
Author(s) : Ordentlich A , Barak R , Barak D , Fischer M , Benschop HP , De Jong LP , Segall Y , Velan B , Shafferman A
Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :249 , 1998
PubMedID:

Title : Direct determination of the chemical composition of acetylcholinesterase phosphonylation products utilizing electrospray- ionization mass spectrometry - Barak_1997_FEBS.Lett_407_347
Author(s) : Barak R , Ordentlich A , Barak D , Fischer M , Benschop HP , De Jong LP , Segall Y , Velan B , Shafferman A
Ref : FEBS Letters , 407 :347 , 1997
PubMedID: 9175882

Title : The architecture of human acetylcholinesterase active center probed by interactions with selected organophosphate inhibitors - Ordentlich_1996_J.Biol.Chem_271_11953
Author(s) : Ordentlich A , Barak D , Kronman C , Ariel N , Segall Y , Velan B , Shafferman A
Ref : Journal of Biological Chemistry , 271 :11953 , 1996
PubMedID: 8662593

Title : Molecular Aspects of Catalysis and of Allosteric Regulation of Aceytlcholinesterases -
Author(s) : Shafferman A , Ordentlich A , Barak D , Kronman C , Ariel N , Leitner M , Segall Y , Bromberg A , Reuveny S , Marcus D , Bino T , Lazar A , Cohen S , Velan B
Ref : In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases , (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp. :189 , 1995
PubMedID:

Title : Contribution of aromatic moieties of tyrosine 133 and of the anionic subsite tryptophan 86 to catalytic efficiency and allosteric modulation of acetylcholinesterase - Ordentlich_1995_J.Biol.Chem_270_2082
Author(s) : Ordentlich A , Barak D , Kronman C , Ariel N , Segall Y , Velan B , Shafferman A
Ref : Journal of Biological Chemistry , 270 :2082 , 1995
PubMedID: 7836436

Title : Amino Acids Determining Specificity to OP-Agents and Facilitating the Aging Process in Human Acetylcholinesterase -
Author(s) : Ordentlich A , Kronman C , Stein D , Ariel N , Reuveny S , Marcus D , Segall Y , Barak D , Velan B , Shafferman A
Ref : In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases , (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp. :221 , 1995
PubMedID:

Title : Direct observation and elucidation of the structures of aged and nonaged phosphorylated cholinesterases by 31P NMR spectroscopy - Segall_1993_Biochemistry_32_13441
Author(s) : Segall Y , Waysbort D , Barak D , Ariel N , Doctor BP , Grunwald J , Ashani Y
Ref : Biochemistry , 32 :13441 , 1993
PubMedID: 8257680

Title : Dissection of the human acetylcholinesterase active center determinants of substrate specificity. Identification of residues constituting the anionic site, the hydrophobic site, and the acyl pocket - Ordentlich_1993_J.Biol.Chem_268_17083
Author(s) : Ordentlich A , Barak D , Kronman C , Flashner Y , Leitner M , Segall Y , Ariel N , Cohen S , Velan B , Shafferman A
Ref : Journal of Biological Chemistry , 268 :17083 , 1993
PubMedID: 8349597
Gene_locus related to this paper: human-ACHE , human-BCHE

Title : Progress in medicinal chemistry of novel selective muscarinic agonists - Fisher_1993_Drug.Des.Discov_9_221
Author(s) : Fisher A , Karton Y , Heldman E , Gurwitz D , Haring R , Meshulam H , Brandeis R , Pittel Z , Segall Y , Marciano D , et al.
Ref : Drug Des Discov , 9 :221 , 1993
PubMedID: 8400004

Title : Protection against tabun toxicity in mice by prophylaxis with an enzyme hydrolyzing organophosphate esters - Raveh_1992_Biochem.Pharmacol_44_397
Author(s) : Raveh L , Segall Y , Leader H , Rothschild N , Levanon D , Henis Y , Ashani Y
Ref : Biochemical Pharmacology , 44 :397 , 1992
PubMedID: 1322669

Title : Prophylaxis against organophosphate poisoning by an enzyme hydrolysing organophosphorus compounds in mice - Ashani_1991_Life.Sci_49_367
Author(s) : Ashani Y , Rothschild N , Segall Y , Levanon D , Raveh L
Ref : Life Sciences , 49 :367 , 1991
PubMedID: 1649941

Title : Conformational differences between aged and nonaged pyrenebutyl-containing organophosphoryl conjugates of chymotrypsin as detected by optical spectroscopy - Steinberg_1989_Biochemistry_28_1248
Author(s) : Steinberg N , van der Drift AC , Grunwald J , Segall Y , Shirin E , Haas E , Ashani Y , Silman I
Ref : Biochemistry , 28 :1248 , 1989
PubMedID: 2713362