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Mutation Report for: F368A_drome-ACHE

F368A_drome-ACHE
Gene_Locus|drome-ACHE
Mode of mutation|Natural mutant, Site directed mutagenesis
Amino Acid change|F368A
Torpedo number|290
Summary|
Comment|Point mutation responsible for the malathion resistance in the MH19 strain isolated by Morton and Singh 1982 Transformant with a minigenebearing this mutations give malathion resistance
Kinetic parameters|none


References:
    Title: Acetylcholinesterase engineering for detection of insecticide residues
    Boublik Y, Saint-Aguet P, Lougarre A, Arnaud M, Villatte F, Estrada-Mondaca S, Fournier D
    Ref: Protein Engineering, 15:43, 2002 : PubMed

            

    Title: Acetylcholinesterase. Two types of modifications confer resistance to insecticide
    Fournier D, Bride JM, Hoffmann F, Karch F
    Ref: Journal of Biological Chemistry, 267:14270, 1992 : PubMed

            

    Title: The association between malathion resistance and acetylcholinesterase in Drosophila melanogaster
    Morton RA, Singh RS
    Ref: Biochemical Genetics, 20:179, 1982 : PubMed

            




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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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