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Mutation Report for: L125V_human-BCHE

L125V_human-BCHE
Gene_Locus|human-BCHE
Mode of mutation|Site directed mutagenesis
Amino Acid change|L125V
Torpedo number|127
Summary|
Comment|p.L125V Leu125Val (p.L153V Leu153Val in primary sequence with 28 amino-acids signal peptide) Not as strong resistance as G117H
Kinetic parameters|none


References:
    Title: Identification of Human Butyrylcholinesterase Organophosphate-Resistant Variants through a Novel Mammalian Enzyme Functional Screen
    Zhang J, Chen S, Ralph EC, Dwyer MA, Cashman JR
    Ref: Journal of Pharmacology & Experimental Therapeutics, 343:673, 2012 : PubMed

            




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Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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