Mutation

Kinetic parameters

Tree Display

AceDB Schema

XML Display

Feedback

Mutation Report for: S250T_musdo-EST23aes07

S250T_musdo-EST23aes07
Gene_Locus|musdo-EST23aes07
Mode of mutation|Natural mutant
Amino Acid change|S250T
Torpedo number|232
Summary|
Comment|p.Ser250Thr n.T748A. For S250T W251S M303I L334L W378R S383T majority of female carried the homozygous susceptible allele in susceptible strain while males were primary heterozygous for these alleles. In resistant strains both male and females were homozygous for the mutation. S found also in some resistant strains Zhang et al. 2010 Claudianos 1999 finds reverse
Kinetic parameters|none


References:
    Title: Multiple mutations and overexpression of the MdaE7 carboxylesterase gene associated with male-linked malathion resistance in housefly, Musca domestica (Diptera: Muscidae)
    Zhang Y, Li J, Ma Z, Shan C, Gao X
    Ref: Sci Rep, 8:224, 2018 : PubMed

            

    Title: Quantitative and qualitative changes of the carboxylesterase associated with beta-cypermethrin resistance in the housefly, Musca domestica (Diptera: Muscidae)
    Zhang L, Shi J, Shi X, Liang P, Gao J, Gao X
    Ref: Comparative Biochemistry & Physiology B Biochem Mol Biol, 156:6, 2010 : PubMed

            

    Title: The house fly aliesterase gene (MdalphaE7) is not associated with insecticide resistance or P450 expression in three strains of house fly
    Scott JG, Zhang L
    Ref: Insect Biochemistry & Molecular Biology, 33:139, 2003 : PubMed

            

    Title: The same amino acid substitution in orthologous esterases confers organophosphate resistance on the house fly and a blowfly
    Claudianos C, Russell RJ, Oakeshott JG
    Ref: Insect Biochemistry & Molecular Biology, 29:675, 1999 : PubMed

            




Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page
webmaster

Acknowledgements and disclaimer