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Mutation Report for: S250T_musdo-EST23aes07

Mode of mutation|Natural mutant
Amino Acid change|S250T
Torpedo number|232
Comment|p.Ser250Thr n.T748A. For S250T W251S M303I L334L W378R S383T majority of female carried the homozygous susceptible allele in susceptible strain while males were primary heterozygous for these alleles. In resistant strains both male and females were homozygous for the mutation. S found also in some resistant strains Zhang et al. 2010 Claudianos 1999 finds reverse
Kinetic parameters|none

    Title: Multiple mutations and overexpression of the MdaE7 carboxylesterase gene associated with male-linked malathion resistance in housefly, Musca domestica (Diptera: Muscidae)
    Zhang Y, Li J, Ma Z, Shan C, Gao X
    Ref: Sci Rep, 8:224, 2018 : PubMed


    Title: Quantitative and qualitative changes of the carboxylesterase associated with beta-cypermethrin resistance in the housefly, Musca domestica (Diptera: Muscidae)
    Zhang L, Shi J, Shi X, Liang P, Gao J, Gao X
    Ref: Comparative Biochemistry & Physiology B Biochem Mol Biol, 156:6, 2010 : PubMed


    Title: The house fly aliesterase gene (MdalphaE7) is not associated with insecticide resistance or P450 expression in three strains of house fly
    Scott JG, Zhang L
    Ref: Insect Biochemistry & Molecular Biology, 33:139, 2003 : PubMed


    Title: The same amino acid substitution in orthologous esterases confers organophosphate resistance on the house fly and a blowfly
    Claudianos C, Russell RJ, Oakeshott JG
    Ref: Insect Biochemistry & Molecular Biology, 29:675, 1999 : PubMed


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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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