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Mutation Report for: W378R_musdo-EST23aes07

W378R_musdo-EST23aes07
Gene_Locus|musdo-EST23aes07
Mode of mutation|Natural mutant
Amino Acid change|W378R
Torpedo number|353
Summary|
Comment|p.Trp378Arg n.T1132C. For S250T W251S M303I L334L W378R S383T majority of female carried the homozygous susceptible allele in susceptible strain while males were primary heterozygous for these alleles. In resistant strains both male and females were homozygous for the mutation. W found in Rutgers resistant strain Claudianos 1999
Kinetic parameters|none


References:
    Title: Multiple mutations and overexpression of the MdaE7 carboxylesterase gene associated with male-linked malathion resistance in housefly, Musca domestica (Diptera: Muscidae)
    Zhang Y, Li J, Ma Z, Shan C, Gao X
    Ref: Sci Rep, 8:224, 2018 : PubMed

            

    Title: Quantitative and qualitative changes of the carboxylesterase associated with beta-cypermethrin resistance in the housefly, Musca domestica (Diptera: Muscidae)
    Zhang L, Shi J, Shi X, Liang P, Gao J, Gao X
    Ref: Comparative Biochemistry & Physiology B Biochem Mol Biol, 156:6, 2010 : PubMed

            




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