| Title : Molecular modeling and enzymatic studies of the interaction of a choline analogue and acetylcholinesterase - Alcaro_2002_Bioorg.Med.Chem.Lett_12_2899 |
| Author(s) : Alcaro S , Scipione L , Ortuso F , Posca S , Rispoli V , Rotiroti D |
| Ref : Bioorganic & Medicinal Chemistry Lett , 12 :2899 , 2002 |
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Abstract :
Pivaloyl-choline iodide 1 interactions with acetylcholinesterase (AChE) have been studied by theoretical and enzymatic methods. An integrated computational approach has clearly shown a substrate rather than inhibitory profile for 1. Enzymatic experiments have also supported the same theoretical conclusion indicating that AChE was able to hydrolyze 1 to choline. |
| PubMedSearch : Alcaro_2002_Bioorg.Med.Chem.Lett_12_2899 |
| PubMedID: 12270172 |
Alcaro S, Scipione L, Ortuso F, Posca S, Rispoli V, Rotiroti D (2002)
Molecular modeling and enzymatic studies of the interaction of a choline analogue and acetylcholinesterase
Bioorganic & Medicinal Chemistry Lett
12 :2899
Alcaro S, Scipione L, Ortuso F, Posca S, Rispoli V, Rotiroti D (2002)
Bioorganic & Medicinal Chemistry Lett
12 :2899