Azizi_2006_Cancer.Lett_241_235

Reference

Title : Mass spectrometric identification of serine hydrolase OVCA2 in the medulloblastoma cell line DAOY - Azizi_2006_Cancer.Lett_241_235
Author(s) : Azizi AA , Gelpi E , Yang JW , Rupp B , Godwin AK , Slater C , Slavc I , Lubec G
Ref : Cancer Letters , 241 :235 , 2006
Abstract :

OVCA2 is a putative serine-hydrolase. Performing protein profiling in human tumour cell lines, OVCA2 was detected in DAOY medulloblastoma cells as a high abundance protein. The protein was unambiguously identified by 2D gel-electrophoresis and MALDI-MS and MS/MS, its presence was confirmed by western blotting. Immunohistochemistry revealed expression in medulloblastoma and predominantly in oligodendrocytes. Computational approaches predicted functional motifs and domains, interaction with apoptosis-related protein BAG and 3D structure. In addition to the presence of OVCA2 in medulloblastoma, it was furthermore detectable in three out of 10 human tumour cell-lines as a high abundance protein probably suggesting a role in the tumour biology.

PubMedSearch : Azizi_2006_Cancer.Lett_241_235
PubMedID: 16368187
Gene_locus related to this paper: human-OVCA2

Related information

Gene_locus human-OVCA2
Family human-OVCA2    FSH1

Citations formats

Azizi AA, Gelpi E, Yang JW, Rupp B, Godwin AK, Slater C, Slavc I, Lubec G (2006)
Mass spectrometric identification of serine hydrolase OVCA2 in the medulloblastoma cell line DAOY
Cancer Letters 241 :235

Azizi AA, Gelpi E, Yang JW, Rupp B, Godwin AK, Slater C, Slavc I, Lubec G (2006)
Cancer Letters 241 :235