FSH1

Relationship

Family: FSH1

Block: X

Parent Family: No family

Comment

Family of serine hydrolase 1(FSH1). Previously: Domain of unknown function (DUF341). Contains human-OVCA2 Human Candidate tumor suppressor in ovarian cancer and yeast-FSH3 regulated by the Crt1 transcription factor, an effector of the DNA damage checkpoint pathway in Saccharomyces cerevisiae, may be involved in folate metabolism. Contains also the gene (dfr1) encoding FSH1 linked to a domain corresponding to dihydrofolate reductase (DHFR) in Schizosaccharomyces pombe. Fsh1p was identified as a lysophospholipase that specifically acts on lysophosphatidylserine (LPS) and impacts the lipid homeostasis in S. cerevisiae. Contains also Aspergillus terreus esterase LovG, which catalyzes the release of covalently bound dihydromonacolin L from LovB during lovastatin biosynthesis. OVCA2 has a strong preference for long-chain alkyl ester substrates (>10-carbons) and high selectivity against a variety of short, branched, and substituted esters

Database

Interpro : IPR005645 Serine hydrolase FSH FSH_dom

PIRSF : No PIRSF

Pdoc : No Pdoc

Pfam : PF03959 FSH1

Prints : No Print

EC Number : No EC Number

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

Structures (1)

Genes Proteins in FSH1 family (123)

Fragments of genes in FSH1 family (19)

Structures in FSH1 family (1)

Substrates in FSH1 family (1)

Inhibitors in FSH1 family (1)

References (11)

Title : FSH1 encodes lysophospholipase activity in Saccharomyces cerevisiae - Ramachandran_2021_Biotechnol.Lett_43_279
Author(s) : Ramachandran G , Chidambaram R , Nachiappan V
Ref : Biotechnol Lett , 43 :279 , 2021
PubMedID: 32920715
Gene_locus related to this paper: yeast-FSH1

Title : Comparative analysis of the human serine hydrolase OVCA2 to the model serine hydrolase homolog FSH1 from S. cerevisiae - Bun_2020_PLoS.One_15_e0230166
Author(s) : Bun JS , Slack MD , Schemenauer DE , Johnson RJ
Ref : PLoS ONE , 15 :e0230166 , 2020
PubMedID: 32182256
Gene_locus related to this paper: human-OVCA2 , yeast-FSH1

Title : FSH1 overexpression triggers apoptosis in Saccharomyces cerevisiae - Gowsalya_2019_Antonie.Van.Leeuwenhoek_112_1775
Author(s) : Gowsalya R , Ravi C , Arul M , Nachiappan V
Ref : Antonie Van Leeuwenhoek , 112 :1775 , 2019
PubMedID: 31363875
Gene_locus related to this paper: yeast-FSH1

Title : FSH3 mediated cell death is dependent on NUC1 in Saccharomyces cerevisiae - Gowsalya_2019_FEMS.Yeast.Res_19_
Author(s) : Gowsalya R , Ravi C , Kannan M , Nachiappan V
Ref : FEMS Yeast Res , 19 : , 2019
PubMedID: 30776074
Gene_locus related to this paper: yeast-FSH3

Title : FSH1 regulates the phenotype and pathogenicity of the pathogenic dermatophyte Microsporum canis - Zhang_2019_Int.J.Mol.Med_44_2047
Author(s) : Zhang F , Tan C , Xu Y , Yang G
Ref : Int J Mol Med , 44 :2047 , 2019
PubMedID: 31573050
Gene_locus related to this paper: artot-a0a516ux40

Title : LovG: the thioesterase required for dihydromonacolin L release and lovastatin nonaketide synthase turnover in lovastatin biosynthesis -
Author(s) : Xu W , Chooi YH , Choi JW , Li S , Vederas JC , Da Silva NA , Tang Y
Ref : Angew Chem Int Ed Engl , 52 :6472 , 2013
PubMedID: 23653178
Gene_locus related to this paper: asptn-LOVG

Title : Mass spectrometric identification of serine hydrolase OVCA2 in the medulloblastoma cell line DAOY - Azizi_2006_Cancer.Lett_241_235
Author(s) : Azizi AA , Gelpi E , Yang JW , Rupp B , Godwin AK , Slater C , Slavc I , Lubec G
Ref : Cancer Letters , 241 :235 , 2006
PubMedID: 16368187
Gene_locus related to this paper: human-OVCA2

Title : Crystal structure of yeast YHR049W\/FSH1, a member of the serine hydrolase family - Quevillon-Cheruel_2005_Protein.Sci_14_1350
Author(s) : Quevillon-Cheruel S , Leulliot N , Graille M , Hervouet N , Coste F , Benedetti H , Zelwer C , Janin J , van Tilbeurgh H
Ref : Protein Science , 14 :1350 , 2005
PubMedID: 15802654
Gene_locus related to this paper: yeast-FSH1

Title : Identification of new genes regulated by the Crt1 transcription factor, an effector of the DNA damage checkpoint pathway in Saccharomyces cerevisiae - Zaim_2005_J.Biol.Chem_280_28
Author(s) : Zaim J , Speina E , Kierzek AM
Ref : Journal of Biological Chemistry , 280 :28 , 2005
PubMedID: 15494396
Gene_locus related to this paper: yeast-FSH3

Title : OVCA2 is downregulated and degraded during retinoid-induced apoptosis - Prowse_2002_Int.J.Cancer_99_185
Author(s) : Prowse AH , Vanderveer L , Milling SW , Pan ZZ , Dunbrack RL , Xu XX , Godwin AK
Ref : International Journal of Cancer , 99 :185 , 2002
PubMedID: 11979432
Gene_locus related to this paper: human-OVCA2

Title : Identification of two candidate tumor suppressor genes on chromosome 17p13.3 - Schultz_1996_Cancer.Res_56_1997
Author(s) : Schultz DC , Vanderveer L , Berman DB , Hamilton TC , Wong AJ , Godwin AK
Ref : Cancer Research , 56 :1997 , 1996
PubMedID: 8616839
Gene_locus related to this paper: human-OVCA2