Homo sapiens (Human) Candidate tumor suppressor in ovarian cancer
human-OVCA2 Human Candidate tumor suppressor in ovarian cancer and yeast-FSH3 regulated by the Crt1 transcription factor, an effector of the DNA damage checkpoint pathway in Saccharomyces cerevisiae, may be involved in folate metabolism. OVCA2 has a strong preference for long-chain alkyl ester substrates (>10-carbons) and high selectivity against a variety of short, branched, and substituted esters Bun et al. 2020
Family : FSH1
Block : X
Position in NCBI Life Tree : Homo sapiens
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N EMAAQRPLRVL CLAGFRQSER GFREKTGALR KALRGRAELV CLSGPHPVPD PPGPEGARSD FGSCPPEEQP RGWWFSEQEA DVFSALEEPA VCRGLEESLG MVAQALNRLG PFDGLLGFSQ GAALAALVCA LGQAGDPRFP LPRFILLVSG FCPRGIGFKE SILQRPLSLP SLHVFGDTDK VIPSQESVQL ASQFPGAITL THSGGHFIPA AAPQRQAYLK FLDQFAE
| Title : Human OVCA2 and its homolog FSH3-induced apoptosis in Saccharomyces cerevisiae - Gowsalya_2021_Curr.Genet_67_631 |
| Author(s) : Gowsalya R , Ravi C , Nachiappan V |
| Ref : Curr Genet , 67 :631 , 2021 |
| Abstract : |
| PubMedSearch : Gowsalya_2021_Curr.Genet_67_631 |
| PubMedID: 33715035 |
| Gene_locus related to this paper: human-OVCA2 |
| Title : Comparative analysis of the human serine hydrolase OVCA2 to the model serine hydrolase homolog FSH1 from S. cerevisiae - Bun_2020_PLoS.One_15_e0230166 |
| Author(s) : Bun JS , Slack MD , Schemenauer DE , Johnson RJ |
| Ref : PLoS ONE , 15 :e0230166 , 2020 |
| Abstract : |
| PubMedSearch : Bun_2020_PLoS.One_15_e0230166 |
| PubMedID: 32182256 |
| Gene_locus related to this paper: human-OVCA2 , yeast-FSH1 |
| Title : Genome-Wide CRISPR Screening Identifies the Tumor Suppressor Candidate OVCA2 As a Determinant of Tolerance to Acetaldehyde - Sobh_2019_Toxicol.Sci_169_235 |
| Author(s) : Sobh A , Loguinov A , Stornetta A , Balbo S , Tagmount A , Zhang L , Vulpe CD |
| Ref : Toxicol Sci , 169 :235 , 2019 |
| Abstract : |
| PubMedSearch : Sobh_2019_Toxicol.Sci_169_235 |
| PubMedID: 31059574 |
| Gene_locus related to this paper: human-OVCA2 |
| Title : Minimal deletion regions in lung squamous cell carcinoma: association with abnormality of the DNA double-strand break repair genes and their applications on gene identification and prognostic biomarkers - Tseng_2008_Lung.Cancer_59_332 |
| Author(s) : Tseng RC , Hsieh FJ , Hsu HS , Wang YC |
| Ref : Lung Cancer , 59 :332 , 2008 |
| Abstract : |
| PubMedSearch : Tseng_2008_Lung.Cancer_59_332 |
| PubMedID: 17931740 |
| Gene_locus related to this paper: human-OVCA2 |
| Title : Mass spectrometric identification of serine hydrolase OVCA2 in the medulloblastoma cell line DAOY - Azizi_2006_Cancer.Lett_241_235 |
| Author(s) : Azizi AA , Gelpi E , Yang JW , Rupp B , Godwin AK , Slater C , Slavc I , Lubec G |
| Ref : Cancer Letters , 241 :235 , 2006 |
| Abstract : |
| PubMedSearch : Azizi_2006_Cancer.Lett_241_235 |
| PubMedID: 16368187 |
| Gene_locus related to this paper: human-OVCA2 |
| Title : Establishment and characterization of xenografts and cancer cell cultures derived from BRCA1 -\/- epithelial ovarian cancers - Indraccolo_2006_Eur.J.Cancer_42_1475 |
| Author(s) : Indraccolo S , Tisato V , Agata S , Moserle L , Ferrari S , Callegaro M , Persano L , Palma MD , Scaini MC , Esposito G , Fassina A , Nicoletto O , Plebani M , Chieco-Bianchi L , Amadori A , D'Andrea E , Montagna M |
| Ref : Eur J Cancer , 42 :1475 , 2006 |
| Abstract : |
| PubMedSearch : Indraccolo_2006_Eur.J.Cancer_42_1475 |
| PubMedID: 16759848 |
| Gene_locus related to this paper: human-OVCA2 |
| Title : OVCA2 is downregulated and degraded during retinoid-induced apoptosis - Prowse_2002_Int.J.Cancer_99_185 |
| Author(s) : Prowse AH , Vanderveer L , Milling SW , Pan ZZ , Dunbrack RL , Xu XX , Godwin AK |
| Ref : International Journal of Cancer , 99 :185 , 2002 |
| Abstract : |
| PubMedSearch : Prowse_2002_Int.J.Cancer_99_185 |
| PubMedID: 11979432 |
| Gene_locus related to this paper: human-OVCA2 |
| Title : Identification of two candidate tumor suppressor genes on chromosome 17p13.3 - Schultz_1996_Cancer.Res_56_1997 |
| Author(s) : Schultz DC , Vanderveer L , Berman DB , Hamilton TC , Wong AJ , Godwin AK |
| Ref : Cancer Research , 56 :1997 , 1996 |
| Abstract : |
| PubMedSearch : Schultz_1996_Cancer.Res_56_1997 |
| PubMedID: 8616839 |
| Gene_locus related to this paper: human-OVCA2 |