Bajgar_2007_J.Appl.Toxicol_27_458

Reference

Title : Inhibition of blood cholinesterases following intoxication with VX and its derivatives - Bajgar_2007_J.Appl.Toxicol_27_458
Author(s) : Bajgar J , Kuca K , Fusek J , Karasova J , Kassa J , Cabal J , Jun D , Blaha V
Ref : J Appl Toxicol , 27 :458 , 2007
Abstract :

Nerve agents can be divided into G-agents (sarin, soman, tabun, cyclosarin etc.) and V-agents. The studies dealing with V-agents (O-alkyl S-2-dialkylaminoethyl methyl phosphonothiolates) are limited to one or two representatives only (VX, Russian VX). Anticholinesterase properties of 11 V-agents were studied in rats in vivo. Following intoxication with these agents in doses of 1 x LD(50) (intramuscular administration), activities of cholinesterases in the blood were continuously monitored and half-lives (t(0.5)) of inhibition were determined. These values varied from 3 min (VX and some other agents) to 10-14 min (derivatives substituted on the phosphorus head by O-ethyl- or O-isopropyl-, and by dimethyl-, diethyl- and dibutyl- on the nitrogen). Acetylcholinesterase activities in selected parts of the brain and diaphragm (30 min after the intoxication) were also detected. A correlation between toxicities and rates of inhibition of the blood enzymes was demonstrated. A similar relationship between acetylcholinesterase inhibition in vitro (from literature data) and half-lives of the blood cholinesterases was also observed. Though the chemical similarity of V compounds is evident, marked differences were observed among different derivatives; however, all agents examined had high inhibition potency corresponding to their toxicities.

PubMedSearch : Bajgar_2007_J.Appl.Toxicol_27_458
PubMedID: 17299830

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Citations formats

Bajgar J, Kuca K, Fusek J, Karasova J, Kassa J, Cabal J, Jun D, Blaha V (2007)
Inhibition of blood cholinesterases following intoxication with VX and its derivatives
J Appl Toxicol 27 :458

Bajgar J, Kuca K, Fusek J, Karasova J, Kassa J, Cabal J, Jun D, Blaha V (2007)
J Appl Toxicol 27 :458