Jun D

General

Full name : Jun Daniel

First name : Daniel

Mail : Faculty of Military Health Sciences\; University of Defence\; Brno

Zip Code :

City :

Country : Czech Republic

Email : daniel.jun@unob.cz

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References (179)

Title : Carltonine-Derived Compounds for Targeted Butyrylcholinesterase Inhibition - Pidany_2024_RSC.Med.Chem__
Author(s) : Pidany F , Kroustkova J , Jenco J , Breiterova K , Muckovab L , Novakova L , Kunes J , Fibigar J , Kucera T , Novak M , Sorf A , Hrabinova M , Pulkrabkova L , Janousek J , Soukup O , Jun D , Korabecny J , Cahlikova L
Ref : RSC Med Chem , : , 2024
PubMedID:

Title : Uncharged mono- and bisoximes: In search of a zwitterion to countermeasure organophosphorus intoxication - Gorecki_2024_Chem.Biol.Interact__110941
Author(s) : Gorecki L , Markova A , Hepnarova V , Zivna N , Junova L , Hrabinova M , Janousek J , Kobrlova T , Prchal L , Jun D , Soukup O , Horn G , Worek F , Marek J , Korabecny J
Ref : Chemico-Biological Interactions , :110941 , 2024
PubMedID: 38493910

Title : A-series agent A-234: initial in vitro and in vivo characterization - Hrabinova_2024_Arch.Toxicol__
Author(s) : Hrabinova M , Pejchal J , Hepnarova V , Muckova L , Junova L , Opravil J , Zdarova Karasova J , Rozsypal T , Dlabkova A , Rehulkova H , Kucera T , Vecera Z , Caisberger F , Schmidt M , Soukup O , Jun D
Ref : Archives of Toxicology , : , 2024
PubMedID: 38446233

Title : Sustainable ionic liquids-based molecular platforms for designing acetylcholinesterase reactivators - Kapitanov_2023_Chem.Biol.Interact_14ChEPon_110735
Author(s) : Kapitanov IV , Spulak M , Pour M , Soukup O , Marek J , Jun D , Novak M , Diz de Almeida JSF , Costa Franca TC , Gathergood N , Kuca K , Karpichev Y
Ref : Chemico-Biological Interactions , :110735 , 2023
PubMedID: 37802409

Title : Highly selective butyrylcholinesterase inhibitors related to Amaryllidaceae alkaloids - Design, synthesis, and biological evaluation - Pidany_2023_Eur.J.Med.Chem_252_115301
Author(s) : Pidany F , Kroustkova J , Al Mamun A , Suchankova D , Brazzolotto X , Nachon F , Chantegreil F , Dolezal R , Pulkrabkova L , Muckova L , Hrabinova M , Finger V , Kufa M , Soukup O , Jun D , Jenco J , Kunes J , Novakova L , Korabecny J , Cahlikova L
Ref : Eur Journal of Medicinal Chemistry , 252 :115301 , 2023
PubMedID: 36996715
Gene_locus related to this paper: human-BCHE

Title : Differentiated SH-SY5Y neuroblastoma cells as a model for evaluation of nerve agent-associated neurotoxicity - Pulkrabkova_2023_Arch.Toxicol__
Author(s) : Pulkrabkova L , Muckova L , Hrabinova M , Sorf A , Kobrlova T , Jost P , Bezdekova D , Korabecny J , Jun D , Soukup O
Ref : Archives of Toxicology , : , 2023
PubMedID: 37221426

Title : A-agents, misleadingly known as Novichoks: a narrative review - Opravil_2023_Arch.Toxicol__
Author(s) : Opravil J , Pejchal J , Finger V , Korabecny J , Rozsypal T , Hrabinova M , Muckova L , Hepnarova V , Konecny J , Soukup O , Jun D
Ref : Archives of Toxicology , : , 2023
PubMedID: 37612377

Title : N-substituted arylhydroxamic acids as acetylcholinesterase reactivators - Bondar_2022_Chem.Biol.Interact__110078
Author(s) : Bondar D , Kapitanov I , Pulkrabkova L , Soukup O , Jun D , Diniz FB , Franca TCC , Kuca K , Karpichev Y
Ref : Chemico-Biological Interactions , :110078 , 2022
PubMedID: 35940282

Title : Non-covalent acetylcholinesterase inhibitors: In vitro screening and molecular modeling for novel selective insecticides - Hepnarova_2022_Toxicol.In.Vitro__105463
Author(s) : Hepnarova V , Hrabinova M , Muckova L , Kucera T , Schmidt M , Dolezal R , Gorecki L , Hrabcova V , Korabecny J , Mezeiova E , Jun D , Pejchal J
Ref : Toxicol In Vitro , :105463 , 2022
PubMedID: 36041654

Title : Amaryllidaceae Alkaloids of Norbelladine-Type as Inspiration for Development of Highly Selective Butyrylcholinesterase Inhibitors: Synthesis, Biological Activity Evaluation, and Docking Studies - Al Mamun_2021_Int.J.Mol.Sci_22_
Author(s) : Al Mamun A , Pidany F , Hulcova D , Marikova J , Kucera T , Schmidt M , Catapano MC , Hrabinova M , Jun D , Muckova L , Kunes J , Janousek J , Andrys R , Novakova L , Perinova R , Maafi N , Soukup O , Korabecny J , Cahlikova L
Ref : Int J Mol Sci , 22 : , 2021
PubMedID: 34361074

Title : Design and synthesis of novel tacrine-indole hybrids as potential multitarget-directed ligands for the treatment of Alzheimer's disease - Hamulakova_2021_Future.Med.Chem__
Author(s) : Hamulakova S , Kudlickova Z , Janovec L , Mezencev R , Deckner ZJ , Chernoff YO , Janockova J , Ihnatova V , Bzonek P , Novakova N , Hepnarova V , Hrabinova M , Jun D , Korabecny J , Soukup O , Kuca K
Ref : Future Med Chem , : , 2021
PubMedID: 33829876

Title : Synthesis and Decontamination Effect on Chemical and Biological Agents of Benzoxonium-Like Salts - Markova_2021_Toxics_9_
Author(s) : Markova A , Hympanova M , Matula M , Prchal L , Sleha R , Benkova M , Pulkrabkova L , Soukup O , Krocova Z , Jun D , Marek J
Ref : Toxics , 9 : , 2021
PubMedID: 34564373

Title : Huprine Y - tryptophan heterodimers with potential implication to Alzheimer's disease treatment - Mezeiova_2021_Bioorg.Med.Chem.Lett__128100
Author(s) : Mezeiova E , Hrabinova M , Hepnarova V , Jun D , Janockova J , Muckova L , Prchal L , Kristofikova Z , Kucera T , Gorecki L , Chalupova K , Kunes J , Hroudova J , Soukup O , Korabecny J
Ref : Bioorganic & Medicinal Chemistry Lett , :128100 , 2021
PubMedID: 33984470

Title : Monoterpene indole alkaloids from Vinca minor L. (Apocynaceae): Identification of new structural scaffold for treatment of Alzheimer's disease - Vrabec_2021_Phytochemistry_194_113017
Author(s) : Vrabec R , Marikova J , Locarek M , Korabecny J , Hulcova D , Hosalkova A , Kunes J , Chlebek J , Kucera T , Hrabinova M , Jun D , Soukup O , Andrisano V , Jenco J , Safratova M , Novakova L , Opletal L , Cahlikova L
Ref : Phytochemistry , 194 :113017 , 2021
PubMedID: 34798410

Title : (+\/-)-BIGI-3h: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3beta Inhibition with Calcium Channel Antagonism and Antiaggregating Properties for Alzheimer's Disease - Ismaili_2021_ACS.Chem.Neurosci__
Author(s) : Ismaili L , Monnin J , Etievant A , Arribas RL , Viejo L , Refouvelet B , Soukup O , Janockova J , Hepnarova V , Korabecny J , Kucera T , Jun D , Andrys R , Musilek K , Baguet A , Garcia-Frutos EM , De Simone A , Andrisano V , Bartolini M , de los Rios C , Marco-Contelles J , Haffen E
Ref : ACS Chem Neurosci , : , 2021
PubMedID: 33797877

Title : Synthesis of New Biscoumarin Derivatives, In Vitro Cholinesterase Inhibition, Molecular Modelling and Antiproliferative Effect in A549 Human Lung Carcinoma Cells - Hudacova_2021_Int.J.Mol.Sci_22_
Author(s) : Hudacova M , Hamuakova S , Konkoova E , Jendzelovsky R , Vargova J , Sevc J , Fedorocko P , Soukup O , Janockova J , Ihnatova V , Kucera T , Bzonek P , Novakova N , Jun D , Junova L , Korabecny J , Kuca K , Kozurkova M
Ref : Int J Mol Sci , 22 : , 2021
PubMedID: 33917200

Title : Development of versatile and potent monoquaternary reactivators of acetylcholinesterase - Gorecki_2021_Arch.Toxicol__
Author(s) : Gorecki L , Hepnarova V , Karasova JZ , Hrabinova M , Courageux C , Dias J , Kucera T , Kobrlova T , Muckova L , Prchal L , Malinak D , Jun D , Musilek K , Worek F , Nachon F , Soukup O , Korabecny J
Ref : Archives of Toxicology , : , 2021
PubMedID: 33517499

Title : Alkaloids of Zephyranthes citrina (Amaryllidaceae) and their implication to Alzheimer's disease: Isolation, structural elucidation and biological activity - Kohelova_2020_Bioorg.Chem_107_104567
Author(s) : Kohelova E , Marikova J , Korabecny J , Hulcova D , Kucera T , Jun D , Chlebek J , Jenco J , Safratova M , Hrabinova M , Ritomska A , Malanik M , Perinova R , Breiterova K , Kunes J , Novakova L , Opletal L , Cahlikova L
Ref : Bioorg Chem , 107 :104567 , 2020
PubMedID: 33387730

Title : Donepezil and Rivastigmine: Pharmacokinetic Profile and Brain-targeting After Intramuscular Administration in Rats - Karasova_2020_Iran.J.Pharm.Res_19_95
Author(s) : Karasova JZ , Hrabinova M , Krejciova M , Jun D , Kuca K
Ref : Iran J Pharm Res , 19 :95 , 2020
PubMedID: 33680013

Title : Cysteine-Targeted Insecticides against A. gambiae Acetylcholinesterase Are Neither Selective nor Reversible Inhibitors - Gorecki_2020_ACS.Med.Chem.Lett_11_65
Author(s) : Gorecki L , Andrys R , Schmidt M , Kucera T , Psotka M , Svobodova B , Hrabcova V , Hepnarova V , Bzonek P , Jun D , Kuca K , Korabecny J , Musilek K
Ref : ACS Med Chem Lett , 11 :65 , 2020
PubMedID: 31938465

Title : Synthesis, in vitro screening and molecular docking of isoquinolinium-5-carbaldoximes as acetylcholinesterase and butyrylcholinesterase reactivators - Malinak_2020_J.Enzyme.Inhib.Med.Chem_35_478
Author(s) : Malinak D , Dolezal R , Hepnarova V , Hozova M , Andrys R , Bzonek P , Racakova V , Korabecny J , Gorecki L , Mezeiova E , Psotka M , Jun D , Kuca K , Musilek K
Ref : J Enzyme Inhib Med Chem , 35 :478 , 2020
PubMedID: 31910701

Title : Encapsulation of oxime K027 into cucurbit[7]uril: In vivo evaluation of safety, absorption, brain distribution and reactivation effectiveness - Karasova_2020_Toxicol.Lett_320_64
Author(s) : Karasova JZ , Hepnarova V , Andrys R , Lisa M , Jost P , Muckova L , Pejchal J , Herman D , Jun D , Kassa J , Kuca K
Ref : Toxicol Lett , 320 :64 , 2020
PubMedID: 31794810

Title : Tacrine - Benzothiazoles: Novel class of potential multitarget anti-Alzheimes drugs dealing with cholinergic, amyloid and mitochondrial systems - Nepovimova_2020_Bioorg.Chem_107_104596
Author(s) : Nepovimova E , Svobodova L , Dolezal R , Hepnarova V , Junova L , Jun D , Korabecny J , Kucera T , Gazova Z , Motykova K , Kubackova J , Bednarikova Z , Janockova J , Jesus C , Cortes L , Pina J , Rostohar D , Serpa C , Soukup O , Aitken L , Hughes RE , Musilek K , Muckova L , Jost P , Chvojkova M , Vales K , Valis M , Chrienova Z , Chalupova K , Kuca K
Ref : Bioorg Chem , 107 :104596 , 2020
PubMedID: 33421953

Title : Discovery of novel berberine derivatives with balanced cholinesterase and prolyl oligopeptidase inhibition profile - Sobolova_2020_Eur.J.Med.Chem_203_112593
Author(s) : Sobolova K , Hrabinova M , Hepnarova V , Kucera T , Kobrlova T , Benkova M , Janockova J , Dolezal R , Prchal L , Benek O , Mezeiova E , Jun D , Soukup O , Korabecny J
Ref : Eur Journal of Medicinal Chemistry , 203 :112593 , 2020
PubMedID: 32688201

Title : Pursuing the Complexity of Alzheimer's Disease: Discovery of Fluoren-9-Amines as Selective Butyrylcholinesterase Inhibitors and N-Methyl-d-Aspartate Receptor Antagonists - Konecny_2020_Biomolecules_11_
Author(s) : Konecny J , Misiachna A , Hrabinova M , Pulkrabkova L , Benkova M , Prchal L , Kucera T , Kobrlova T , Finger V , Kolcheva M , Kortus S , Jun D , Valko M , Horak M , Soukup O , Korabecny J
Ref : Biomolecules , 11 : , 2020
PubMedID: 33375115

Title : Functionalized aromatic esters of the Amaryllidaceae alkaloid haemanthamine and their in vitro and in silico biological activity connected to Alzheimer's disease - Perinova_2020_Bioorg.Chem_100_103928
Author(s) : Perinova R , Maafi N , Korabecny J , Kohelova E , De Simone A , Al Mamun A , Hulcova D , Markova J , Kucera T , Jun D , Safratova M , Marikova J , Andrisano V , Jenco J , Kunes J , Martinez A , Novakova L , Cahlikova L
Ref : Bioorg Chem , 100 :103928 , 2020
PubMedID: 32450384

Title : In Vitro and In Silico Acetylcholinesterase Inhibitory Activity of Thalictricavine and Canadine and Their Predicted Penetration across the Blood-Brain Barrier - Chlebek_2019_Molecules_24_
Author(s) : Chlebek J , Korabecny J , Dolezal R , Stepankova S , Perez DI , Hostalkova A , Opletal L , Cahlikova L , Macakova K , Kucera T , Hrabinova M , Jun D
Ref : Molecules , 24 : , 2019
PubMedID: 30959739

Title : Oxidative stress induced by oxime reactivators of acetylcholinesterase in vitro - Muckova_2019_Toxicol.In.Vitro_56_110
Author(s) : Muckova L , Vanova N , Misik J , Herman D , Pejchal J , Jun D
Ref : Toxicol In Vitro , 56 :110 , 2019
PubMedID: 30682493

Title : Synthesis and biological assessment of KojoTacrines as new agents for Alzheimer's disease therapy - Dgachi_2019_J.Enzyme.Inhib.Med.Chem_34_163
Author(s) : Dgachi Y , Martin H , Malek R , Jun D , Janockova J , Sepsova V , Soukup O , Iriepa I , Moraleda I , Maalej E , Carreiras MC , Refouvelet B , Chabchoub F , Marco-Contelles J , Ismaili L
Ref : J Enzyme Inhib Med Chem , 34 :163 , 2019
PubMedID: 30482062

Title : Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease - Chalupova_2019_Eur.J.Med.Chem_168_491
Author(s) : Chalupova K , Korabecny J , Bartolini M , Monti B , Lamba D , Caliandro R , Pesaresi A , Brazzolotto X , Gastellier AJ , Nachon F , Pejchal J , Jarosova M , Hepnarova V , Jun D , Hrabinova M , Dolezal R , Karasova JZ , Mzik M , Kristofikova Z , Misik J , Muckova L , Jost P , Soukup O , Benkova M , Setnicka V , Habartova L , Chvojkova M , Kleteckova L , Vales K , Mezeiova E , Uliassi E , Valis M , Nepovimova E , Bolognesi ML , Kuca K
Ref : Eur Journal of Medicinal Chemistry , 168 :491 , 2019
PubMedID: 30851693
Gene_locus related to this paper: torca-ACHE

Title : Exploring Structure-Activity Relationship in Tacrine-Squaramide Derivatives as Potent Cholinesterase Inhibitors - Svobodova_2019_Biomolecules_9_
Author(s) : Svobodova B , Mezeiova E , Hepnarova V , Hrabinova M , Muckova L , Kobrlova T , Jun D , Soukup O , Jimeno ML , Marco-Contelles J , Korabecny J
Ref : Biomolecules , 9 : , 2019
PubMedID: 31430943

Title : N-alkylated Tacrine Derivatives as Potential Agents in Alzheimer's Disease Therapy - Nepovimova_2019_Curr.Alzheimer.Res_16_333
Author(s) : Nepovimova E , Korabecny J , Hepnarova V , Jun D , Dolezal R , Muckova L , Jost P , Soukup O , Janockova J , Pham NL , Nguyen TD , Valis M , Kuca K
Ref : Curr Alzheimer Res , 16 :333 , 2019
PubMedID: 30873921

Title : Isoquinoline Alkaloids from Berberis vulgaris as Potential Lead Compounds for the Treatment of Alzheimer's Disease - Hostalkova_2019_J.Nat.Prod_82_239
Author(s) : Hostalkova A , Marikova J , Opletal L , Korabecny J , Hulcova D , Kunes J , Novakova L , Perez DI , Jun D , Kucera T , Andrisano V , Siatka T , Cahlikova L
Ref : Journal of Natural Products , 82 :239 , 2019
PubMedID: 30701972

Title : Amaryllidaceae alkaloids from Narcissus pseudonarcissus L. cv. Dutch Master as potential drugs in treatment of Alzheimer's disease - Hulcova_2019_Phytochemistry_165_112055
Author(s) : Hulcova D , Marikova J , Korabecny J , Hostalkova A , Jun D , Kunes J , Chlebek J , Opletal L , De Simone A , Novakova L , Andrisano V , Ruzicka A , Cahlikova L
Ref : Phytochemistry , 165 :112055 , 2019
PubMedID: 31261031

Title : Pharmacological and toxicological in vitro and in vivo effect of higher doses of oxime reactivators - Hepnarova_2019_Toxicol.Appl.Pharmacol__114776
Author(s) : Hepnarova V , Muckova L , Ring A , Pejchal J , Herman D , Misik J , Hrabinova M , Jun D , Soukup O
Ref : Toxicol Appl Pharmacol , :114776 , 2019
PubMedID: 31629733

Title : Oxime K203: a drug candidate for the treatment of tabun intoxication - Gorecki_2019_Arch.Toxicol_93_673
Author(s) : Gorecki L , Soukup O , Kucera T , Malinak D , Jun D , Kuca K , Musilek K , Korabecny J
Ref : Archives of Toxicology , 93 :673 , 2019
PubMedID: 30564897

Title : Some Possibilities to Study New Prophylactics against Nerve Agents - Bajgar_2019_Mini.Rev.Med.Chem_19_970
Author(s) : Bajgar J , Kassa J , Kucera T , Musilek K , Jun D , Kuca K
Ref : Mini Rev Med Chem , 19 :970 , 2019
PubMedID: 30827238

Title : Surface screening, molecular modeling and in vitro studies on the interactions of aflatoxin M1 and human enzymes acetyl- and butyrylcholinesterase - de Almeida_2019_Chem.Biol.Interact_13ChEPon_308_113
Author(s) : de Almeida JSFD , Cavalcante SFA , Dolezal R , Kuca K , Musilek K , Jun D , Franca TCC
Ref : Chemico-Biological Interactions , 308 :113 , 2019
PubMedID: 31100275

Title : The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease - Hepnarova_2018_Eur.J.Med.Chem_150_292
Author(s) : Hepnarova V , Korabecny J , Matouskova L , Jost P , Muckova L , Hrabinova M , Vykoukalova N , Kerhartova M , Kucera T , Dolezal R , Nepovimova E , Spilovska K , Mezeiova E , Pham NL , Jun D , Staud F , Kaping D , Kuca K , Soukup O
Ref : Eur Journal of Medicinal Chemistry , 150 :292 , 2018
PubMedID: 29533874

Title : A newly developed oxime K203 is the most effective reactivator of tabun-inhibited acetylcholinesterase - Kuca_2018_BMC.Pharmacol.Toxicol_19_8
Author(s) : Kuca K , Musilek K , Jun D , Karasova JZ , Nepovimova E , Soukup O , Hrabinova M , Mikler J , Franca TCC , da Cunha EFF , de Castro AA , Valis M , Ramalho TC
Ref : BMC Pharmacol Toxicol , 19 :8 , 2018
PubMedID: 29467029

Title : Development of small bisquaternary cholinesterase inhibitors as drugs for pre-treatment of nerve agent poisonings - Kuca_2018_Drug.Des.Devel.Ther_12_505
Author(s) : Kuca K , Karasova JZ , Soukup O , Kassa J , Novotna E , Sepsova V , Horova A , Pejchal J , Hrabinova M , Vodakova E , Jun D , Nepovimova E , Valis M , Musilek K
Ref : Drug Des Devel Ther , 12 :505 , 2018
PubMedID: 29563775

Title : Synthesis, Biological Evaluation, and Docking Studies of Novel Bisquaternary Aldoxime Reactivators on Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon - Kuca_2018_Molecules_23_
Author(s) : Kuca K , Jun D , Junova L , Musilek K , Hrabinova M , da Silva JAV , Ramalho TC , Valko M , Wu Q , Nepovimova E , Franca TCC
Ref : Molecules , 23 : , 2018
PubMedID: 29735900

Title : In vitro and in silico Evaluation of Non-Quaternary Reactivators of AChE as Antidotes of Organophosphorus Poisoning - a New Hope or a Blind Alley? - Soukup_2018_Med.Chem_14_281
Author(s) : Soukup O , Korabecny J , Malinak D , Nepovimova E , Pham NL , Musilek K , Hrabinova M , Hepnarova V , Dolezal R , Pavek P , Jost P , Kobrlova T , Jankockova J , Gorecki L , Psotka M , Nguyen TD , Box K , Outhwaite B , Ceckova M , Sorf A , Jun D , Kuca K
Ref : Med Chem , 14 :281 , 2018
PubMedID: 29332594

Title : Profiling donepezil template into multipotent hybrids with antioxidant properties - Mezeiova_2018_J.Enzyme.Inhib.Med.Chem_33_583
Author(s) : Mezeiova E , Spilovska K , Nepovimova E , Gorecki L , Soukup O , Dolezal R , Malinak D , Janockova J , Jun D , Kuca K , Korabecny J
Ref : J Enzyme Inhib Med Chem , 33 :583 , 2018
PubMedID: 29529892

Title : Novel Group of AChE Reactivators-Synthesis, In Vitro Reactivation and Molecular Docking Study - Malinak_2018_Molecules_23_
Author(s) : Malinak D , Nepovimova E , Jun D , Musilek K , Kuca K
Ref : Molecules , 23 : , 2018
PubMedID: 30205495

Title : Cytotoxicity of acetylcholinesterase reactivators evaluated in vitro and its relation to their structure - Muckova_2018_Drug.Chem.Toxicol__1
Author(s) : Muckova L , Pejchal J , Jost P , Vanova N , Herman D , Jun D
Ref : Drug & Chemical Toxicology , :1 , 2018
PubMedID: 29421945

Title : Tacrine-coumarin and Tacrine-7-chloroquinoline Hybrids with Thiourea Linkers: Cholinesterase Inhibition Properties, Kinetic Study, Molecular Docking and Permeability Assay for Blood-brain Barrier - Hamulakova_2018_Curr.Alzheimer.Res_15_1096
Author(s) : Hamulakova S , Janovec L , Soukup O , Jun D , Janockova J , Hrabinova M , Sepsova V , Kuca K
Ref : Curr Alzheimer Res , 15 :1096 , 2018
PubMedID: 29992880

Title : Alkaloids from Narcissus poeticus cv. Pink Parasol of various structural types and their biological activity - Safratova_2018_Arch.Pharm.Res_41_208
Author(s) : Safratova M , Hostalkova A , Hulcova D , Breiterova K , Hrabcova V , Machado M , Fontinha D , Prudencio M , Kunes J , Chlebek J , Jun D , Hrabinova M , Novakova L , Havelek R , Seifrtova M , Opletal L , Cahlikova L
Ref : Arch Pharm Res , 41 :208 , 2018
PubMedID: 29243039

Title : Oxidative stress in organophosphate poisoning: role of standard antidotal therapy - Vanova_2018_J.Appl.Toxicol_38_1058
Author(s) : Vanova N , Pejchal J , Herman D , Dlabkova A , Jun D
Ref : J Appl Toxicol , 38 :1058 , 2018
PubMedID: 29516527

Title : Molecular modeling studies on the interactions of aflatoxin B1 and its metabolites with the peripheral anionic site (PAS) of human acetylcholinesterase - de Almeida_2018_J.Biomol.Struct.Dyn__1
Author(s) : de Almeida JSFD , Cavalcante SFA , Dolezal R , Kuca K , Musilek K , Jun D , Franca TCC
Ref : J Biomol Struct Dyn , :1 , 2018
PubMedID: 29749305

Title : Molecular Modeling Studies on the Interactions of Aflatoxin B1 and Its Metabolites with Human Acetylcholinesterase. Part II: Interactions with the Catalytic Anionic Site (CAS) - de Almeida_2018_Toxins.(Basel)_10_
Author(s) : de Almeida JSFD , Dolezal R , Krejcar O , Kuca K , Musilek K , Jun D , Franca TCC
Ref : Toxins (Basel) , 10 : , 2018
PubMedID: 30257474

Title : Acetylcholinesterase Inhibitors and Drugs Acting on Muscarinic Receptors- Potential Crosstalk of Cholinergic Mechanisms During Pharmacological Treatment - Soukup_2017_Curr.Neuropharmacol_15_637
Author(s) : Soukup O , Winder M , Killi UK , Wsol V , Jun D , Kuca K , Tobin G
Ref : Curr Neuropharmacol , 15 :637 , 2017
PubMedID: 27281175

Title : HLo-7 - A review of acetylcholinesterase reactivator against organophosphorus intoxication - Psotka_2017_Mil.Med.Sci.Lett_86_70
Author(s) : Psotka M , Malinak D , Gorecki L , Nguyen TD , Soukup O , Jun D , Kuca K , Musilek K , Korabecny J
Ref : Military Medical Science Letters , 86 :70 , 2017
PubMedID:

Title : Prolyl oligopeptidase and its role in the organism: attention to the most promising and clinically relevant inhibitors - Babkova_2017_Future.Med.Chem_9_1015
Author(s) : Babkova K , Korabecny J , Soukup O , Nepovimova E , Jun D , Kuca K
Ref : Future Med Chem , 9 :1015 , 2017
PubMedID: 28632451

Title : Progress in acetylcholinesterase reactivators and in the treatment of organophosphorus intoxication: a patent review (2006-2016) - Gorecki_2017_Expert.Opin.Ther.Pat_27_971
Author(s) : Gorecki L , Korabecny J , Musilek K , Nepovimova E , Malinak D , Kucera T , Dolezal R , Jun D , Soukup O , Kuca K
Ref : Expert Opin Ther Pat , 27 :971 , 2017
PubMedID: 28569609

Title : Novel Tacrine-Scutellarin Hybrids as Multipotent Anti-Alzheimer's Agents: Design, Synthesis and Biological Evaluation - Spilovska_2017_Molecules_22_
Author(s) : Spilovska K , Korabecny J , Sepsova V , Jun D , Hrabinova M , Jost P , Muckova L , Soukup O , Janockova J , Kucera T , Dolezal R , Mezeiova E , Kaping D , Kuca K
Ref : Molecules , 22 : , 2017
PubMedID: 28621747

Title : Synthesis, in vitro acetylcholinesterase inhibitory activity and molecular docking of new acridine-coumarin hybrids - Hamulakova_2017_Int.J.Biol.Macromol_104_333
Author(s) : Hamulakova S , Janovec L , Soukup O , Jun D , Kuca K
Ref : Int J Biol Macromol , 104 :333 , 2017
PubMedID: 28601645

Title : Development of 2-Methoxyhuprine as Novel Lead for Alzheimer's Disease Therapy - Mezeiova_2017_Molecules_22_
Author(s) : Mezeiova E , Korabecny J , Sepsova V , Hrabinova M , Jost P , Muckova L , Kucera T , Dolezal R , Misik J , Spilovska K , Pham NL , Pokrievkova L , Roh J , Jun D , Soukup O , Kaping D , Kuca K
Ref : Molecules , 22 : , 2017
PubMedID: 28788095

Title : Cholinesterase and Prolyl Oligopeptidase Inhibitory Activities of Alkaloids from Argemone platyceras (Papaveraceae) - Siatka_2017_Molecules_22_
Author(s) : Siatka T , Adamcova M , Opletal L , Cahlikova L , Jun D , Hrabinova M , Kunes J , Chlebek J
Ref : Molecules , 22 : , 2017
PubMedID: 28708094

Title : Activity of cholinesterases in a young and healthy middle-European population: Relevance for toxicology, pharmacology and clinical praxis - Karasova_2017_Toxicol.Lett_277_24
Author(s) : Karasova JZ , Maderycova Z , Tumova M , Jun D , Rehacek V , Kuca K , Misik J
Ref : Toxicol Lett , 277 :24 , 2017
PubMedID: 28465191

Title : Targeting copper(II)-induced oxidative stress and the acetylcholinesterase system in Alzheimer's disease using multifunctional tacrine-coumarin hybrid molecules - Hamulakova_2016_J.Inorg.Biochem_161_52
Author(s) : Hamulakova S , Poprac P , Jomova K , Brezova V , Lauro P , Drostinova L , Jun D , Sepsova V , Hrabinova M , Soukup O , Kristian P , Gazova Z , Bednarikova Z , Kuca K , Valko M
Ref : J Inorg Biochem , 161 :52 , 2016
PubMedID: 27230386

Title : SAR study to find optimal cholinesterase reactivator against organophosphorous nerve agents and pesticides - Gorecki_2016_Arch.Toxicol_90_2831
Author(s) : Gorecki L , Korabecny J , Musilek K , Malinak D , Nepovimova E , Dolezal R , Jun D , Soukup O , Kuca K
Ref : Archives of Toxicology , 90 :2831 , 2016
PubMedID: 27582056

Title : Isoquinoline Alkaloids from Fumaria officinalis L. and Their Biological Activities Related to Alzheimer's Disease - Chlebek_2016_Chem.Biodivers_13_91
Author(s) : Chlebek J , Novak Z , Kassemova D , Safratova M , Kostelnik J , Maly L , Locarek M , Opletal L , Host'alkova A , Hrabinova M , Kunes J , Novotna P , Urbanova M , Novakova L , Macakova K , Hulcova D , Solich P , Perez Martin C , Jun D , Cahlikova L
Ref : Chem Biodivers , 13 :91 , 2016
PubMedID: 26765356

Title : Design, Synthesis and in vitro Evaluation of Indolotacrine Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease - Benek_2016_ChemMedChem_11_1264
Author(s) : Benek O , Soukup O , Pasdiorova M , Hroch L , Sepsova V , Jost P , Hrabinova M , Jun D , Kuca K , Zala D , Ramsay RR , Marco-Contelles J , Musilek K
Ref : ChemMedChem , 11 :1264 , 2016
PubMedID: 26427608

Title : A 7-methoxytacrine-4-pyridinealdoxime hybrid as a novel prophylactic agent with reactivation properties in organophosphate intoxication - Nepovimova_2016_Toxicol.Res.(Camb)_5_1012
Author(s) : Nepovimova E , Korabecny J , Dolezal R , Nguyen TD , Jun D , Soukup O , Pasdiorova M , Jost P , Muckova L , Malinak D , Gorecki L , Musilek K , Kuca K
Ref : Toxicol Res (Camb) , 5 :1012 , 2016
PubMedID: 30090408

Title : The Antioxidant Additive Approach for Alzheimer's Disease Therapy: New Ferulic (Lipoic) Acid Plus Melatonin Modified Tacrines as Cholinesterases Inhibitors, Direct Antioxidants, and Nuclear Factor (Erythroid-Derived 2)-Like 2 Activators - Benchekroun_2016_J.Med.Chem_59_9967
Author(s) : Benchekroun M , Romero A , Egea J , Leon R , Michalska P , Buendia I , Jimeno ML , Jun D , Janockova J , Sepsova V , Soukup O , Bautista-Aguilera OM , Refouvelet B , Ouari O , Marco-Contelles J , Ismaili L
Ref : Journal of Medicinal Chemistry , 59 :9967 , 2016
PubMedID: 27736061

Title : Impact of tacrine and 7-methoxytacrine on gastric myoelectrical activity assessed using electrogastrography in experimental pigs - Bures_2015_Neuro.Endocrinol.Lett_36_
Author(s) : Bures J , Jun D , Hrabinova M , Tacheci I , Kvetina J , Pavlik M , Rejchrt S , Douda T , Kunes M , Kuca K , Kopacova M
Ref : Neuro Endocrinol Lett , 36 : , 2015
PubMedID: 26757120

Title : Universality of Oxime K203 for Reactivation of Nerve Agent-Inhibited AChE - Kuca_2015_Med.Chem_11_683
Author(s) : Kuca K , Hrabinova M , Jun D , Musilek K , Penhaker M , Krejcar O , Soukup O
Ref : Med Chem , 11 :683 , 2015
PubMedID: 25845909

Title : Tacrine-Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity - Nepovimova_2015_J.Med.Chem_58_8985
Author(s) : Nepovimova E , Korabecny J , Dolezal R , Babkova K , Ondrejicek A , Jun D , Sepsova V , Horova A , Hrabinova M , Soukup O , Bukum N , Jost P , Muckova L , Kassa J , Malinak D , Andrs M , Kuca K
Ref : Journal of Medicinal Chemistry , 58 :8985 , 2015
PubMedID: 26503905

Title : Cholinergic properties of new 7-methoxytacrine-donepezil derivatives - Sepsova_2015_Gen.Physiol.Biophys_34_189
Author(s) : Sepsova V , Karasova JZ , Tobin G , Jun D , Korabecny J , Cabelova P , Janska K , Krusek J , Skrenkova K , Kuca K , Soukup O
Ref : Gen Physiol Biophys , 34 :189 , 2015
PubMedID: 25504063

Title : 7-Methoxytacrine-p-Anisidine Hybrids as Novel Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer's Disease Treatment - Korabecny_2015_Molecules_20_22084
Author(s) : Korabecny J , Andrs M , Nepovimova E , Dolezal R , Babkova K , Horova A , Malinak D , Mezeiova E , Gorecki L , Sepsova V , Hrabinova M , Soukup O , Jun D , Kuca K
Ref : Molecules , 20 :22084 , 2015
PubMedID: 26690394

Title : Revised NMR data for 9-O-demethylgalanthine: an alkaloid from Zephyranthes robusta (Amaryllidaceae) and its biological activity - Safratova_2014_Nat.Prod.Commun_9_787
Author(s) : Safratova M , Novak Z , Kulhankova A , Kunes J , Hrabinova M , Jun D , Macakova K , Opletal L , Cahlikova L
Ref : Nat Prod Commun , 9 :787 , 2014
PubMedID: 25115079

Title : From Pyridinium-based to Centrally Active Acetylcholinesterase Reactivators - Korabecny_2014_Mini.Rev.Med.Chem_14_215
Author(s) : Korabecny J , Soukup O , Dolezal R , Spilovska K , Nepovimova E , Andrs M , Nguyen TD , Jun D , Musilek K , Kucerova-Chlupacova M , Kuca K
Ref : Mini Rev Med Chem , 14 :215 , 2014
PubMedID: 24552265

Title : Chemical composition of bioactive alkaloid extracts from some Narcissus species and varieties and their biological activity - Havlasova_2014_Nat.Prod.Commun_9_1151
Author(s) : Havlasova J , Safratova M , Siatka T , Stepankova S , Novak Z , Locarek M , Opletal L , Hrabinova M , Jun D , Benesova N , Kunes J , Cahlikova L
Ref : Nat Prod Commun , 9 :1151 , 2014
PubMedID: 25233595

Title : Structure-activity relationship for the reactivators of acetylcholinesterase inhibited by nerve agent VX - Kuca_2013_Med.Chem_9_689
Author(s) : Kuca K , Musilek K , Jun D , Karasova J , Soukup O , Pejchal J , Hrabinova M
Ref : Med Chem , 9 :689 , 2013
PubMedID: 22779796

Title : Preparation, in vitro evaluation and molecular modelling of pyridinium-quinolinium\/isoquinolinium non-symmetrical bisquaternary cholinesterase inhibitors - Komloova_2013_Bioorg.Med.Chem.Lett_23_6663
Author(s) : Komloova M , Horova A , Hrabinova M , Jun D , Dolezal M , Vinsova J , Kuca K , Musilek K
Ref : Bioorganic & Medicinal Chemistry Lett , 23 :6663 , 2013
PubMedID: 24220173

Title : Prophylaxis and Post-exposure Treatment of Intoxications Caused by Nerve Agents and Organophosphorus Pesticides - Kuca_2013_Mini.Rev.Med.Chem_13_2102
Author(s) : Kuca K , Jun D , Musilek K , Pohanka M , Karasova JZ , Soukup O
Ref : Mini Rev Med Chem , 13 :2102 , 2013
PubMedID: 24195661

Title : Alkaloids from Chlidanthus fragrans and their acetylcholinesterase, butyrylcholinesterase and prolyl oligopeptidase activities - Cahlikova_2013_Nat.Prod.Commun_8_1541
Author(s) : Cahlikova L , Hrabinova M , Kulhankova A , Benesova N , Chlebek J , Jun D , Novak Z , Macakova K , Kunes J , Kuca K , Opletal L
Ref : Nat Prod Commun , 8 :1541 , 2013
PubMedID: 24427936

Title : Impact of paraoxon followed by acetylcholinesterase reactivator HI-6 on gastric myoelectric activity in experimental pigs - Bures_2013_Neuro.Endocrinol.Lett_34_79
Author(s) : Bures J , Kvetina J , Pavlik M , Kunes M , Kopacova M , Rejchrt S , Jun D , Hrabinova M , Kuca K , Tacheci I
Ref : Neuro Endocrinol Lett , 34 :79 , 2013
PubMedID: 24362097

Title : Intravenous application of HI-6 salts (dichloride and dimethansulphonate) in pigs: comparison with pharmacokinetics profile after intramuscular administration - Karasova_2013_Neuro.Endocrinol.Lett_34_74
Author(s) : Karasova JZ , Zemek F , Kunes M , Kvetina J , Chladek J , Jun D , Bures J , Tacheci I , Kuca K
Ref : Neuro Endocrinol Lett , 34 :74 , 2013
PubMedID: 24362096

Title : A Resurrection of 7-MEOTA: A Comparison with Tacrine - Soukup_2013_Curr.Alzheimer.Res_10_893
Author(s) : Soukup O , Jun D , Karasova JZ , Patocka J , Musilek K , Korabecny J , Krusek J , Kaniakova M , Sepsova V , Mandikova J , Trejtnar F , Pohanka M , Drtinova L , Pavlik M , Tobin G , Kuca K
Ref : Curr Alzheimer Res , 10 :893 , 2013
PubMedID: 24093535

Title : The summary on non-reactivation cholinergic properties of oxime reactivators: the interaction with muscarinic and nicotinic receptors - Soukup_2013_Arch.Toxicol_87_711
Author(s) : Soukup O , Jun D , Tobin G , Kuca K
Ref : Archives of Toxicology , 87 :711 , 2013
PubMedID: 23179755

Title : selective monitoring of enzymatic activity of acetylcholinesterase by flow injection analysis with mass spectrometric detection - Dohnal_2013_Mil.Med.Sci.Lett_82_120
Author(s) : Dohnal V , Dohnalova L , Jun D , Kuca K
Ref : Military Medical Science Letters , 82 :120 , 2013
PubMedID:

Title : The interaction of standard oxime reactivators with hemicholinium-3 sensitive choline carriers - Soukup_2012_Toxicol.Lett_212_315
Author(s) : Soukup O , Kristofikova Z , Jun D , Tambor V , Ripova D , Kuca K
Ref : Toxicol Lett , 212 :315 , 2012
PubMedID: 22683831

Title : On the universality of oxime Hl-7 - antidote for case of the nerve agent poisoning - Kuca_2011_Mil.Med.Sci.Lett_80_80
Author(s) : Kuca K , Musilek K , Karasova J , Jun D , Soukup O , Pohanka M , Ghosh KK , Hrabinova M
Ref : Military Medical Science Letters , 80 :80 , 2011
PubMedID:

Title : Human serum butyrylcholinesterase as a prophylaxis against russian VX - Karasova_2011_Mil.Med.Sci.Lett_80_97
Author(s) : Karasova JZ , Kuca K , Jun D , Bajgar J
Ref : Military Medical Science Letters , 80 :97 , 2011
PubMedID:

Title : In vitro ability of currently available oximes to reactivate organophosphate pesticide-inhibited human acetylcholinesterase and butyrylcholinesterase - Jun_2011_Int.J.Mol.Sci_12_2077
Author(s) : Jun D , Musilova L , Musilek K , Kuca K
Ref : Int J Mol Sci , 12 :2077 , 2011
PubMedID: 21673941

Title : Organophosphate hydrolases as catalytic bioscavengers of organophosphorus nerve agents - Trovaslet-Leroy_2011_Toxicol.Lett_206_14
Author(s) : Trovaslet-Leroy M , Musilova L , Renault F , Brazzolotto X , Misik J , Novotny L , Froment MT , Gillon E , Loiodice M , Verdier L , Masson P , Rochu D , Jun D , Nachon F
Ref : Toxicol Lett , 206 :14 , 2011
PubMedID: 21683774

Title : The effect of oxime reactivators on muscarinic receptors: functional and binding examinations - Soukup_2011_Environ.Toxicol.Pharmacol_31_364
Author(s) : Soukup O , Kumar UK , Proska J , Bratova L , Adem A , Jun D , Fusek J , Kuca K , Tobin G
Ref : Environ Toxicol Pharmacol , 31 :364 , 2011
PubMedID: 21787706

Title : Oxime reactivators and their in vivo and in vitro effects on nicotinic receptors - Soukup_2011_Physiol.Res_60_679
Author(s) : Soukup O , Krusek J , Kaniakova M , Kumar UK , Oz M , Jun D , Fusek J , Kuca K , Tobin G
Ref : Physiol Res , 60 :679 , 2011
PubMedID: 21574759

Title : Why acetylcholinesterase reactivators do not work in butyrylcholinesterase - Wiesner_2010_J.Enzyme.Inhib.Med.Chem_25_318
Author(s) : Wiesner J , Kriz Z , Kuca K , Jun D , Koca J
Ref : J Enzyme Inhib Med Chem , 25 :318 , 2010
PubMedID: 19874115

Title : High-performance liquid chromatography analysis of by-products and intermediates arising during the synthesis of the acetylcholinesterase reactivator HI-6 - Jun_2010_J.Chromatogr.Sci_48_694
Author(s) : Jun D , Stodulka P , Kuca K , Dolezal B
Ref : Journal of Chromatography Sci , 48 :694 , 2010
PubMedID: 20819302

Title : Preparation and characterization of methoxy polyethylene glycol-conjugated phosphotriesterase as a potential catalytic bioscavenger against organophosphate poisoning - Jun_2010_Chem.Biol.Interact_187_380
Author(s) : Jun D , Musilova L , Link M , Loiodice M , Nachon F , Rochu D , Renault F , Masson P
Ref : Chemico-Biological Interactions , 187 :380 , 2010
PubMedID: 20230809

Title : Influence of the acetylcholinesterase active site protonation on omega loop and active site dynamics - Wiesner_2010_J.Biomol.Struct.Dyn_28_393
Author(s) : Wiesner J , Kriz Z , Kuca K , Jun D , Koca J
Ref : J Biomol Struct Dyn , 28 :393 , 2010
PubMedID: 20919754

Title : Synthesis and in vitro evaluation of N-(Bromobut-3-en-2-yl)-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine as a cholinesterase inhibitor with regard to Alzheimer's disease treatment - Korabecny_2010_Molecules_15_8804
Author(s) : Korabecny J , Musilek K , Holas O , Nepovimova E , Jun D , Zemek F , Opletalova V , Patocka J , Dohnal V , Nachon F , Hroudova J , Fisar Z , Kuca K
Ref : Molecules , 15 :8804 , 2010
PubMedID: 21127466

Title : Pseudo-catalytic scavenging: searching for a suitable reactivator of phosphorylated butyrylcholinesterase - Kovarik_2010_Chem.Biol.Interact_187_167
Author(s) : Kovarik Z , Katalinic M , Sinko G , Binder J , Holas O , Jung YS , Musilova L , Jun D , Kuca K
Ref : Chemico-Biological Interactions , 187 :167 , 2010
PubMedID: 20206154

Title : Oxime K027: novel low-toxic candidate for the universal reactivator of nerve agent- and pesticide-inhibited acetylcholinesterase - Kuca_2010_J.Enzyme.Inhib.Med.Chem_25_509
Author(s) : Kuca K , Musilek K , Jun D , Pohanka M , Ghosh KK , Hrabinova M
Ref : J Enzyme Inhib Med Chem , 25 :509 , 2010
PubMedID: 20192902

Title : Novel acetylcholinesterase reactivator K112 and its cholinergic properties - Soukup_2010_Biomed.Pharmacother_64_541
Author(s) : Soukup O , Kristofikova Z , Proska J , Tobin G , Patocka J , Marek J , Jun D , Fusek J , Ripova D , Kuca K
Ref : Biomed Pharmacother , 64 :541 , 2010
PubMedID: 20634031

Title : Interaction of nerve agent antidotes with cholinergic systems - Soukup_2010_Curr.Med.Chem_17_1708
Author(s) : Soukup O , Tobin G , Kumar UK , Binder J , Proska J , Jun D , Fusek J , Kuca K
Ref : Curr Med Chem , 17 :1708 , 2010
PubMedID: 20345348

Title : A comparison of tabun-inhibited rat brain acetylcholinesterase reactivation by three oximes (HI-6, obidoxime, and K048) in vivo detected by biochemical and histochemical techniques - Bajgar_2010_J.Enzyme.Inhib.Med.Chem_25_790
Author(s) : Bajgar J , Hajek P , Karasova JZ , Kassa J , Paseka A , Slizova D , Krs O , Kuca K , Jun D , Fusek J , Capek L
Ref : J Enzyme Inhib Med Chem , 25 :790 , 2010
PubMedID: 21054236

Title : Characterization of the anticholinergic properties of obidoxime\; functional examinations of the rat atria and the urinary bladder - Soukup_2010_Toxicol.Mech.Methods_20_428
Author(s) : Soukup O , Tobin G , Kumar UK , Jun D , Fusek J , Kuca K
Ref : Toxicol Mech Methods , 20 :428 , 2010
PubMedID: 20602545

Title : Time-course changes of acetylcholinesterase activity in blood and some tissues in rats after intoxication by Russian VX - Karasova_2009_Neurotox.Res_16_356
Author(s) : Karasova JZ , Bajgar J , Jun D , Pavlikova R , Kuca K
Ref : Neurotox Res , 16 :356 , 2009
PubMedID: 19728005

Title : Chemical aspects of pharmacological prophylaxis against nerve agent poisoning - Bajgar_2009_Curr.Med.Chem_16_2977
Author(s) : Bajgar J , Fusek J , Kassa J , Kuca K , Jun D
Ref : Curr Med Chem , 16 :2977 , 2009
PubMedID: 19689278

Title : Reactivation of human brain homogenate cholinesterases inhibited by Tabun using newly developed oximes K117 and K127 - Kuca_2009_Basic.Clin.Pharmacol.Toxicol_105_207
Author(s) : Kuca K , Cabal J , Jung YS , Musilek K , Soukup O , Jun D , Pohanka M , Musilova L , Karasova J , Novotny L , Hrabinova M
Ref : Basic Clin Pharmacol Toxicol , 105 :207 , 2009
PubMedID: 19473310

Title : Novel bisquaternary oximes--reactivation of acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon - Kuca_2009_Molecules_14_4915
Author(s) : Kuca K , Musilova L , Palecek J , Cirkva V , Paar M , Musilek K , Hrabinova M , Pohanka M , Karasova JZ , Jun D
Ref : Molecules , 14 :4915 , 2009
PubMedID: 20032868

Title : In vitro reactivation of trichlorfon-inhibited butyrylcholinesterase using HI-6, obidoxime, pralidoxime and K048 - Pohanka_2009_J.Enzyme.Inhib.Med.Chem_24_680
Author(s) : Pohanka M , Jun D , Kuca K
Ref : J Enzyme Inhib Med Chem , 24 :680 , 2009
PubMedID: 18825528

Title : Effect of acetylcholinesterase oxime-type reactivators K-48 and HI-6 on human liver microsomal cytochromes P450 in vitro - Veinlichova_2009_Chem.Biol.Interact_180_449
Author(s) : Veinlichova A , Jancova P , Siller M , Anzenbacher P , Kuca K , Jun D , Fusek J , Anzenbacherova E
Ref : Chemico-Biological Interactions , 180 :449 , 2009
PubMedID: 19539805

Title : Cholinesterase biosensor construction - a review - Pohanka_2008_Protein.Pept.Lett_15_795
Author(s) : Pohanka M , Jun D , Kalasz H , Kuca K
Ref : Protein Pept Lett , 15 :795 , 2008
PubMedID: 18855751

Title : Possible role of hydroxylated metabolites of tacrine in drug toxicity and therapy of Alzheimer's disease - Patocka_2008_Curr.Drug.Metab_9_332
Author(s) : Patocka J , Jun D , Kuca K
Ref : Curr Drug Metab , 9 :332 , 2008
PubMedID: 18473751

Title : Amperometric Biosensors for Real Time Assays of Organophosphates - Pohanka_2008_Sensors.(Basel)_8_5303
Author(s) : Pohanka M , Jun D , Kuca K
Ref : Sensors (Basel) , 8 :5303 , 2008
PubMedID: 27873815

Title : A comparison of reactivating efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in soman, cyclosarin and tabun-poisoned rats - Kassa_2008_Chem.Biol.Interact_175_425
Author(s) : Kassa J , Jun D , Karasova J , Bajgar J , Kuca K
Ref : Chemico-Biological Interactions , 175 :425 , 2008
PubMedID: 18547554

Title : Photometric microplate assay for estimation of the efficacy of paraoxon-inhibited acetylcholinesterase reactivation - Pohanka_2008_J.Enzyme.Inhib.Med.Chem_23_781
Author(s) : Pohanka M , Jun D , Kuca K
Ref : J Enzyme Inhib Med Chem , 23 :781 , 2008
PubMedID: 18615283

Title : Potency of several oximes to reactivate human acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon in vitro - Jun_2008_Chem.Biol.Interact_175_421
Author(s) : Jun D , Musilova L , Kuca K , Kassa J , Bajgar J
Ref : Chemico-Biological Interactions , 175 :421 , 2008
PubMedID: 18617161

Title : RP-HPLC determination of the lipophilicity of bispyridinium reactivators of acetylcholinesterase bearing a but-2-ene connecting linker - Musilek_2008_Anal.Bioanal.Chem_391_367
Author(s) : Musilek K , Jampilek J , Dohnal J , Jun D , Gunn-Moore F , Dolezal M , Kuca K
Ref : Anal Bioanal Chem , 391 :367 , 2008
PubMedID: 18369602

Title : Monoquaternary pyridinium salts with modified side chain-synthesis and evaluation on model of tabun- and paraoxon-inhibited acetylcholinesterase - Musilek_2008_Bioorg.Med.Chem_16_8218
Author(s) : Musilek K , Kucera J , Jun D , Dohnal V , Opletalova V , Kuca K
Ref : Bioorganic & Medicinal Chemistry , 16 :8218 , 2008
PubMedID: 18676153

Title : The effect of HI-6 on cholinesterases and on the cholinergic system of the rat bladder - Soukup_2008_Neuro.Endocrinol.Lett_29_759
Author(s) : Soukup O , Pohanka M , Tobin G , Jun D , Fusek J , Musilek K , Marek J , Kassa J , Kuca K
Ref : Neuro Endocrinol Lett , 29 :759 , 2008
PubMedID: 18987577

Title : Potency of novel oximes to reactivate sarin inhibited human cholinesterases - Jun_2008_Drug.Chem.Toxicol_31_1
Author(s) : Jun D , Kuca K , Picha J , Koleckar V , Marek J
Ref : Drug & Chemical Toxicology , 31 :1 , 2008
PubMedID: 18161504

Title : TLC analysis of intermediates arising during the preparation of oxime HI-6 dimethanesulfonate - Jun_2008_J.Chromatogr.Sci_46_316
Author(s) : Jun D , Stodulka P , Kuca K , Koleckar V , Dolezal B , Simon P , Veverka M
Ref : Journal of Chromatography Sci , 46 :316 , 2008
PubMedID: 18402722

Title : Synthesis of monooxime-monocarbamoyl bispyridinium compounds bearing (E)-but-2-ene linker and evaluation of their reactivation activity against tabun- and paraoxon-inhibited acetylcholinesterase - Musilek_2008_J.Enzyme.Inhib.Med.Chem_23_70
Author(s) : Musilek K , Holas O , Kuca K , Jun D , Dohnal V , Opletalova V , Dolezal M
Ref : J Enzyme Inhib Med Chem , 23 :70 , 2008
PubMedID: 18341256

Title : An attempt to assess functionally minimal acetylcholinesterase activity necessary for survival of rats intoxicated with nerve agents - Bajgar_2008_Chem.Biol.Interact_175_281
Author(s) : Bajgar J , Fusek J , Kassa J , Jun D , Kuca K , Hajek P
Ref : Chemico-Biological Interactions , 175 :281 , 2008
PubMedID: 18579126

Title : Reactivation of DFP- and paraoxon-inhibited acetylcholinesterases by pyridinium oximes - Oh_2008_Chem.Biol.Interact_175_365
Author(s) : Oh KA , Park NJ , Park NS , Kuca K , Jun D , Jung YS
Ref : Chemico-Biological Interactions , 175 :365 , 2008
PubMedID: 18565503

Title : Structural factors influencing potency of currently used acetylcholinesterase reactivators for treatment of cyclosarin intoxications - Kuca_2007_Curr.Pharm.Des_13_3445
Author(s) : Kuca K , Jun D , Bajgar J
Ref : Curr Pharm Des , 13 :3445 , 2007
PubMedID: 18045198

Title : Targeted synthesis of 1-(4-hydroxyiminomethylpyridinium)-3-pyridiniumpropane dibromide--a new nerve agent reactivator - Kuca_2007_Molecules_12_1964
Author(s) : Kuca K , Musilek K , Paar M , Jun D , Stodulka P , Hrabinova M , Marek J
Ref : Molecules , 12 :1964 , 2007
PubMedID: 17960099

Title : Design of a potent reactivator of tabun-inhibited acetylcholinesterase--synthesis and evaluation of (E)-1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide (K203) - Musilek_2007_J.Med.Chem_50_5514
Author(s) : Musilek K , Jun D , Cabal J , Kassa J , Gunn-Moore F , Kuca K
Ref : Journal of Medicinal Chemistry , 50 :5514 , 2007
PubMedID: 17924614

Title : Amperometric biosensor for pesticide methamidophos assay - Pohanka_2007_Acta.Medica.(Hradec.Kralove)_50_239
Author(s) : Pohanka M , Kuca K , Jun D
Ref : Acta Medica (Hradec Kralove) , 50 :239 , 2007
PubMedID: 18290547

Title : Cholinesterase reactivators: the fate and effects in the organism poisoned with organophosphates\/nerve agents - Bajgar_2007_Curr.Drug.Metab_8_803
Author(s) : Bajgar J , Kuca K , Jun D , Bartosova L , Fusek J
Ref : Curr Drug Metab , 8 :803 , 2007
PubMedID: 18220560

Title : Monooxime reactivators of acetylcholinesterase with (E)-but-2-ene linker: preparation and reactivation of tabun- and paraoxon-inhibited acetylcholinesterase - Musilek_2007_Bioorg.Med.Chem_15_6733
Author(s) : Musilek K , Holas O , Jun D , Dohnal V , Gunn-Moore F , Opletalova V , Dolezal M , Kuca K
Ref : Bioorganic & Medicinal Chemistry , 15 :6733 , 2007
PubMedID: 17764957

Title : Potency of five structurally different acetylcholinesterase reactivators to reactivate human brain cholinesterases inhibited by cyclosarin - Kuca_2007_Clin.Toxicol.(Phila)_45_512
Author(s) : Kuca K , Cabal J , Jun D , Hrabinova M
Ref : Clinical Toxicology (Phila) , 45 :512 , 2007
PubMedID: 17503257

Title : A comparison of reactivating efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in cyclosarin-and tabun-poisoned rats - Kassa_2007_J.Enzyme.Inhib.Med.Chem_22_297
Author(s) : Kassa J , Jun D , Kuca K
Ref : J Enzyme Inhib Med Chem , 22 :297 , 2007
PubMedID: 17674811

Title : Evaluation of potency of known oximes (pralidoxime, trimedoxime, HI-6, methoxime, obidoxime) to in vitro reactivate acetylcholinesterase inhibited by pesticides (chlorpyrifos and methylchlorpyrifos) and nerve agent (Russian VX) - Musilek_2007_Acta.Medica.(Hradec.Kralove)_50_203
Author(s) : Musilek K , Kuca K , Jun D
Ref : Acta Medica (Hradec Kralove) , 50 :203 , 2007
PubMedID: 18254274

Title : A Comparison of Newly Synthesized Oximes (K074, K075) and Oximes Introduced into the Czech Army (Obidoxime, HI-6) to Reactivate Tabun or Soman-Inhibited Acetylcholinesterase in Rat's Blood and Brain - Kassa_2007_Mil.Med.Sci.Lett_76_27
Author(s) : Kassa J , Jun D
Ref : Military Medical Science Letters , 76 :27 , 2007
PubMedID:

Title : In vitro reactivation potency of acetylcholinesterase reactivators--K074 and K075--to reactivate tabun-inhibited human brain cholinesterases - Kuca_2007_Neurotox.Res_11_101
Author(s) : Kuca K , Cabal J , Jun D , Musilek K
Ref : Neurotox Res , 11 :101 , 2007
PubMedID: 17449453

Title : Acetylcholinesterases--the structural similarities and differences - Wiesner_2007_J.Enzyme.Inhib.Med.Chem_22_417
Author(s) : Wiesner J , Kriz Z , Kuca K , Jun D , Koca J
Ref : J Enzyme Inhib Med Chem , 22 :417 , 2007
PubMedID: 17847707

Title : Treatment of organophosphate intoxication using cholinesterase reactivators: facts and fiction - Bajgar_2007_Mini.Rev.Med.Chem_7_461
Author(s) : Bajgar J , Fusek J , Kuca K , Bartosova L , Jun D
Ref : Mini Rev Med Chem , 7 :461 , 2007
PubMedID: 17504181

Title : Novel series of bispyridinium compounds bearing a (Z)-but-2-ene linker--synthesis and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase - Musilek_2007_Bioorg.Med.Chem.Lett_17_3172
Author(s) : Musilek K , Holas O , Kuca K , Jun D , Dohnal V , Opletalova V , Dolezal M
Ref : Bioorganic & Medicinal Chemistry Lett , 17 :3172 , 2007
PubMedID: 17383875

Title : Inhibition of blood cholinesterases following intoxication with VX and its derivatives - Bajgar_2007_J.Appl.Toxicol_27_458
Author(s) : Bajgar J , Kuca K , Fusek J , Karasova J , Kassa J , Cabal J , Jun D , Blaha V
Ref : J Appl Toxicol , 27 :458 , 2007
PubMedID: 17299830

Title : Comparison of reactivating and therapeutic efficacy of two salts of the oxime HI-6 against tabun, soman and cyclosarin in rats - Kassa_2007_Basic.Clin.Pharmacol.Toxicol_101_328
Author(s) : Kassa J , Jun D , Kuca K , Bajgar J
Ref : Basic Clin Pharmacol Toxicol , 101 :328 , 2007
PubMedID: 17910616

Title : Changes of cholinesterase activities in the rat blood and brain after sarin intoxication pretreated with butyrylcholinesterase - Bajgar_2007_Drug.Chem.Toxicol_30_351
Author(s) : Bajgar J , Bartosova L , Kuca K , Jun D , Fusek J
Ref : Drug & Chemical Toxicology , 30 :351 , 2007
PubMedID: 17934924

Title : Changes of acetylcholinesterase activity in different rat brain areas following intoxication with nerve agents: biochemical and histochemical study - Bajgar_2007_Chem.Biol.Interact_165_14
Author(s) : Bajgar J , Hajek P , Slizova D , Krs O , Fusek J , Kuca K , Jun D , Bartosova L , Blaha V
Ref : Chemico-Biological Interactions , 165 :14 , 2007
PubMedID: 17145052

Title : Differential effects of statins and alendronate on cholinesterases in serum and brain of rats - Cibickova_2007_Physiol.Res_56_765
Author(s) : Cibickova L , Palicka V , Cibicek N , Cermakova E , Micuda S , Bartosova L , Jun D
Ref : Physiol Res , 56 :765 , 2007
PubMedID: 17087598

Title : Currently used cholinesterase reactivators against nerve agent intoxication: comparison of their effectivity in vitro - Kuca_2007_Drug.Chem.Toxicol_30_31
Author(s) : Kuca K , Jun D , Bajgar J
Ref : Drug & Chemical Toxicology , 30 :31 , 2007
PubMedID: 17364862

Title : Synthesis of a novel series of non-symmetrical bispyridinium compounds bearing a xylene linker and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase - Musilek_2007_J.Enzyme.Inhib.Med.Chem_22_425
Author(s) : Musilek K , Holas O , Kuca K , Jun D , Dohnal V , Dolezal M
Ref : J Enzyme Inhib Med Chem , 22 :425 , 2007
PubMedID: 17847708

Title : Two step synthesis of a non-symmetric acetylcholinesterase reactivator - Musilek_2007_Molecules_12_1755
Author(s) : Musilek K , Kuca K , Dohnal V , Jun D , Marek J , Koleckar V
Ref : Molecules , 12 :1755 , 2007
PubMedID: 17960085

Title : Structural requirements of acetylcholinesterase reactivators - Kuca_2006_Mini.Rev.Med.Chem_6_269
Author(s) : Kuca K , Jun D , Musilek K
Ref : Mini Rev Med Chem , 6 :269 , 2006
PubMedID: 16515465

Title : New group of xylene linker-containing acetylcholinesterase reactivators as antidotes against the nerve agent cyclosarin - Hrabinova_2006_J.Enzyme.Inhib.Med.Chem_21_515
Author(s) : Hrabinova M , Musilek K , Jun D , Kuca K
Ref : J Enzyme Inhib Med Chem , 21 :515 , 2006
PubMedID: 17194020

Title : Synthesis of asymmetrical bispyridinium compounds bearing cyano-moiety and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase - Musilek_2006_Bioorg.Med.Chem.Lett_16_5673
Author(s) : Musilek K , Holas O , Kuca K , Jun D , Dohnal V , Dolezal M
Ref : Bioorganic & Medicinal Chemistry Lett , 16 :5673 , 2006
PubMedID: 16934462

Title : Evaluation of reactivation test in anaesthetized dogs with experimental intoxication with nerve agents - Bajgar_2006_J.Appl.Toxicol_26_439
Author(s) : Bajgar J , Fusek J , Bartosova L , Jun D , Kuca K
Ref : J Appl Toxicol , 26 :439 , 2006
PubMedID: 16915560

Title : The Reactivating and Therapeutic Efficacy of Oximes to Counteract Russian VX Poisonings - Kassa_2006_Int.J.Toxicol_25_397
Author(s) : Kassa J , Jun D , Kuca K
Ref : Int J Toxicol , 25 :397 , 2006
PubMedID: 16940011

Title : Russian VX: inhibition and reactivation of acetylcholinesterase compared with VX agent - Kuca_2006_Basic.Clin.Pharmacol.Toxicol_98_389
Author(s) : Kuca K , Jun D , Cabal J , Hrabinova M , Bartosova L , Opletalova V
Ref : Basic Clin Pharmacol Toxicol , 98 :389 , 2006
PubMedID: 16623863

Title : Influence of Length and Shape of the Connecting Chain of Bisquaternary Acetylcholinesterase Reactivators on Their Potency to Reactivate Enzyme Inhibited by Sarin - Kuca_2006_Mil.Med.Sci.Lett_75_37
Author(s) : Kuca K , Jun D , Musilek K
Ref : Military Medical Science Letters , 75 :37 , 2006
PubMedID:

Title : Equine butyrylcholinesterase protects rats against inhalation exposure to sublethal sarin concentrations - Bajgar_2006_Arh.Hig.Rada.Toksikol_57_391
Author(s) : Bajgar J , Bartosova L , Fusek J , Jun D , Kuca K
Ref : Arh Hig Rada Toksikol , 57 :391 , 2006
PubMedID: 17265678

Title : Synthesis of the novel series of bispyridinium compounds bearing (E)-but-2-ene linker and evaluation of their reactivation activity against chlorpyrifos-inhibited acetylcholinesterase - Musilek_2006_Bioorg.Med.Chem.Lett_16_622
Author(s) : Musilek K , Kuca K , Jun D , Dohnal V , Dolezal M
Ref : Bioorganic & Medicinal Chemistry Lett , 16 :622 , 2006
PubMedID: 16288867

Title : In vitro and in vivo evaluation of pyridinium oximes: mode of interaction with acetylcholinesterase, effect on tabun- and soman-poisoned mice and their cytotoxicity - Calic_2006_Toxicology_219_85
Author(s) : Calic M , Vrdoljak AL , Radic B , Jelic D , Jun D , Kuca K , Kovarik Z
Ref : Toxicology , 219 :85 , 2006
PubMedID: 16332406

Title : In vitro evaluation of acetylcholinesterase reactivators as potential antidotes against tabun nerve agent poisonings - Kuca_2006_Drug.Chem.Toxicol_29_443
Author(s) : Kuca K , Cabal J , Jun D , Hrabinova M
Ref : Drug & Chemical Toxicology , 29 :443 , 2006
PubMedID: 16931445

Title : Effect of some acetylcholinesterase reactivators on human platelet aggregation in vitro - Jun_2006_J.Appl.Toxicol_26_258
Author(s) : Jun D , Kuca K , Hronek M , Opletal L
Ref : J Appl Toxicol , 26 :258 , 2006
PubMedID: 16307468

Title : The acute toxicity of acetylcholinesterase reactivators in mice in relation to their structure - Bartosova_2006_Neurotox.Res_9_291
Author(s) : Bartosova L , Kuca K , Kunesova G , Jun D
Ref : Neurotox Res , 9 :291 , 2006
PubMedID: 16782588

Title : Potency of new structurally different oximes to reactivate cyclosarin-inhibited human brain acetylcholinesterases - Kuca_2006_J.Enzyme.Inhib.Med.Chem_21_663
Author(s) : Kuca K , Cabal J , Jun D , Bajgar J , Hrabinova M
Ref : J Enzyme Inhib Med Chem , 21 :663 , 2006
PubMedID: 17252938

Title : Reactivation of sarin-inhibited pig brain acetylcholinesterase using oxime antidotes - Kuca_2006_J.Med.Toxicol_2_141
Author(s) : Kuca K , Jun D
Ref : J Med Toxicol , 2 :141 , 2006
PubMedID: 18072133

Title : Pretreatment with pyridinium oximes improves antidotal therapy against tabun poisoning - Lucic_2006_Toxicology_228_41
Author(s) : Lucic Vrdoljak A , Calic M , Radic B , Zunec S , Jun D , Kuca K , Kovarik Z
Ref : Toxicology , 228 :41 , 2006
PubMedID: 16982122

Title : In vitro potency of H oximes (HI-6, HLo-7), the oxime BI-6, and currently used oximes (pralidoxime, obidoxime, trimedoxime) to reactivate nerve agent-inhibited rat brain acetylcholinesterase - Kuca_2006_J.Toxicol.Environ.Health.A_69_1431
Author(s) : Kuca K , Cabal J , Kassa J , Jun D , Hrabinova M
Ref : J Toxicol Environ Health A , 69 :1431 , 2006
PubMedID: 16766478

Title : Substituted monoquaternary oximes as reactivators of cyclosarin--and chlorpyrifos--inhibited acetylcholinesterase - Racakova_2006_Arh.Hig.Rada.Toksikol_57_387
Author(s) : Racakova V , Hrabinova M , Jun D , Kuca K
Ref : Arh Hig Rada Toksikol , 57 :387 , 2006
PubMedID: 17265677

Title : Reactivation potency of new group of acetylcholinesterase reactivators and their comparison with currently available oximes - Kuca_2006_Acta.Medica.(Hradec.Kralove)_49_233
Author(s) : Kuca K , Picha J , Jun D
Ref : Acta Medica (Hradec Kralove) , 49 :233 , 2006
PubMedID: 17438836

Title : [Synthesis of reactivators of phosphorylated acetylcholinesterase of bis-pyridiniumdialdoxime type with a 3-oxapentane connecting chain and their testing in vitro on a model of the enzyme inhibited by chlorpyrifos and methylchlorpyrifos] - Musilek_2006_Ceska.Slov.Farm_55_115
Author(s) : Musilek K , Kuca K , Jun D , Dohnal V , Kim TH , Jung YS , Dolezal M
Ref : Ceska a Slovenska Farmacie , 55 :115 , 2006
PubMedID: 16838488

Title : A comparison of the potency of the oxime HLo-7 and currently used oximes (HI-6, pralidoxime, obidoxime) to reactivate nerve agent-inhibited rat brain acetylcholinesterase by in vitro methods - Kuca_2005_Acta.Medica.(Hradec.Kralove)_48_81
Author(s) : Kuca K , Cabal J , Kassa J , Jun D , Hrabinova M
Ref : Acta Medica (Hradec Kralove) , 48 :81 , 2005
PubMedID: 16259317

Title : Bispyridinium oximes as antidotal treatment of cyclosarin poisoning-in vitro and in vivo testing - Bartosova_2005_Int.J.Toxicol_24_399
Author(s) : Bartosova L , Kuca K , Jun D , Kunesova G
Ref : Int J Toxicol , 24 :399 , 2005
PubMedID: 16393932

Title : Computer Modeling and Simulation - New Technologies in Development of Means against Combat Chemical Substances - Wiesner_2005_Mil.Med.Sci.Lett_74_165
Author(s) : Wiesner J , Kriz Z , Kuca K , Jun D , Koca J
Ref : Military Medical Science Letters , 74 :165 , 2005
PubMedID:

Title : New quaternary pyridine aldoximes as casual antidotes against nerve agents intoxications - Kuca_2005_Biomed.Pap.Med.Fac.Univ.Palacky.Olomouc.Czech.Repub_149_75
Author(s) : Kuca K , Bartosova L , Jun D , Patocka J , Cabal J , Kassa J , Kunesova G
Ref : Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub , 149 :75 , 2005
PubMedID: 16170392

Title : In vitro reactivation potency of some acetylcholinesterase reactivators against sarin- and cyclosarin-induced inhibitions - Kuca_2005_J.Appl.Toxicol_25_296
Author(s) : Kuca K , Cabal J , Jun D , Kassa J , Bartosova L , Kunesova G
Ref : J Appl Toxicol , 25 :296 , 2005
PubMedID: 16025528

Title : Effective bisquaternary reactivators of tabun-inhibited AChE - Kuca_2005_J.Appl.Toxicol_25_491
Author(s) : Kuca K , Cabal J , Musilek K , Jun D , Bajgar J
Ref : J Appl Toxicol , 25 :491 , 2005
PubMedID: 16092078

Title : Design and synthesis of new bis-pyridinium oxime reactivators for acetylcholinesterase inhibited by organophosphorous nerve agents - Kim_2005_Bioorg.Med.Chem.Lett_15_2914
Author(s) : Kim TH , Kuca K , Jun D , Jung YS
Ref : Bioorganic & Medicinal Chemistry Lett , 15 :2914 , 2005
PubMedID: 15911280

Title : In vitro inactivation of rat brain acetylcholinesterase by DSP-4 and its derivatives OS-21 and OS-23 and protective activity of tacrine (9-amino-1,2,3,4-tetrahydroacridine) - Patocka_2005_Acta.Medica.(Hradec.Kralove)_48_145
Author(s) : Patocka J , Jun D , Kuca K
Ref : Acta Medica (Hradec Kralove) , 48 :145 , 2005
PubMedID: 16640027

Title : Comparison of the potency of newly developed and currently available oximes to reactivate nerve agent-inhibited acetylcholinesterase in vitro and in vivo - Kuca_2005_Chem.Biol.Interact_157-158_367
Author(s) : Kuca K , Bartosova L , Kassa J , Cabal J , Bajgar J , Kunesova G , Jun D
Ref : Chemico-Biological Interactions , 157-158 :367 , 2005
PubMedID: 16429489

Title : Strategy for the development of new acetylcholinesterase reactivators - antidotes used for treatment of nerve agent poisonings - Kuca_2005_Biomed.Pap.Med.Fac.Univ.Palacky.Olomouc.Czech.Repub_149_429
Author(s) : Kuca K , Cabal J , Jun D , Kassa J , Bartosova L , Kunesova G , Dohnal V
Ref : Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub , 149 :429 , 2005
PubMedID: 16601804

Title : [A comparison of the efficacy of the reactivators of acetylcholinesterase inhibited with tabun] - Cabal_2005_Ceska.Slov.Farm_54_192
Author(s) : Cabal J , Kuca K , Jun D , Bajgar J , Hrabinova M
Ref : Ceska a Slovenska Farmacie , 54 :192 , 2005
PubMedID: 16124202

Title : Comparison of in vitro potency of oximes (pralidoxime, obidoxime, HI-6) to reactivate sarin-inhibited acetylcholinesterase in various parts of pig brain - Kuca_2005_J.Appl.Toxicol_25_271
Author(s) : Kuca K , Cabal J , Kassa J , Jun D , Hrabinova M
Ref : J Appl Toxicol , 25 :271 , 2005
PubMedID: 16021679

Title : Comparison of ability of some oximes to reactivate sarin-inhibited brain acetylcholinesterase from different species - Jun_2005_Chem.Biol.Interact_157-158_385
Author(s) : Jun D , Kuca K , Cabal J , Bartosova L , Kunesova G , Kassa J
Ref : Chemico-Biological Interactions , 157-158 :385 , 2005
PubMedID: 16429518

Title : Synthesis of a novel series of bispyridinium compounds bearing a xylene linker and evaluation of their reactivation activity against chlorpyrifos-inhibited acetylcholinesterase - Musilek_2005_J.Enzyme.Inhib.Med.Chem_20_409
Author(s) : Musilek K , Kuca K , Jun D , Dohnal V , Dolezal M
Ref : J Enzyme Inhib Med Chem , 20 :409 , 2005
PubMedID: 16335048

Title : Acetylcholinesterase and butyrylcholinesterase--important enzymes of human body - Patocka_2004_Acta.Medica.(Hradec.Kralove)_47_215
Author(s) : Patocka J , Kuca K , Jun D
Ref : Acta Medica (Hradec Kralove) , 47 :215 , 2004
PubMedID: 15841900

Title : Reactivation of organophosphate-inhibited acetylcholinesterase by quaternary pyridinium aldoximes - Kuca_2004_Neurotox.Res_6_565
Author(s) : Kuca K , Patocka J , Cabal J , Jun D
Ref : Neurotox Res , 6 :565 , 2004
PubMedID: 15639788