| Title : Prolylisoxazoles: potent inhibitors of prolyloligopeptidase with antitrypanosomal activity - Bal_2003_Bioorg.Med.Chem.Lett_13_2875 |
| Author(s) : Bal G , Van der Veken P , Antonov D , Lambeir AM , Grellier P , Croft SL , Augustyns K , Haemers A |
| Ref : Bioorganic & Medicinal Chemistry Lett , 13 :2875 , 2003 |
|
Abstract :
Prolylprolylisoxazoles and prolylprolylisoxazolines were synthesized through a 1,3-dipolar cycloaddition reaction. These compounds are potent inhibitors of human and trypanosomal prolyloligopeptidase. They were shown to inhibit Trypanosoma cruzi and Trypanosoma b. brucei in in vitro systems with ED(50)'s in the lower microM range. |
| PubMedSearch : Bal_2003_Bioorg.Med.Chem.Lett_13_2875 |
| PubMedID: 14611847 |
Bal G, Van der Veken P, Antonov D, Lambeir AM, Grellier P, Croft SL, Augustyns K, Haemers A (2003)
Prolylisoxazoles: potent inhibitors of prolyloligopeptidase with antitrypanosomal activity
Bioorganic & Medicinal Chemistry Lett
13 :2875
Bal G, Van der Veken P, Antonov D, Lambeir AM, Grellier P, Croft SL, Augustyns K, Haemers A (2003)
Bioorganic & Medicinal Chemistry Lett
13 :2875