| Title : Structure-activity relationship studies on isoindoline inhibitors of dipeptidyl peptidases 8 and 9 (DPP8, DPP9): is DPP8-selectivity an attainable goal? - Van Goethem_2011_J.Med.Chem_54_5737 |
| Author(s) : Van Goethem S , Matheeussen V , Joossens J , Lambeir AM , Chen X , De Meester I , Haemers A , Augustyns K , Van der Veken P |
| Ref : Journal of Medicinal Chemistry , 54 :5737 , 2011 |
| Abstract : |
| PubMedSearch : Van Goethem_2011_J.Med.Chem_54_5737 |
| PubMedID: 21711053 |
| Gene_locus related to this paper: human-DPP8 , human-DPP9 |
| Title : Inhibitors of dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Part 2: isoindoline containing inhibitors - Van Goethem_2008_Bioorg.Med.Chem.Lett_18_4159 |
| Author(s) : Van Goethem S , Van der Veken P , Dubois V , Soroka A , Lambeir AM , Chen X , Haemers A , Scharpe S , De Meester I , Augustyns K |
| Ref : Bioorganic & Medicinal Chemistry Lett , 18 :4159 , 2008 |
| Abstract : |
| PubMedSearch : Van Goethem_2008_Bioorg.Med.Chem.Lett_18_4159 |
| PubMedID: 18556198 |
| Title : Inhibitors of dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Part 1: identification of dipeptide derived leads - Van der Veken_2008_Bioorg.Med.Chem.Lett_18_4154 |
| Author(s) : Van der Veken P , De Meester I , Dubois V , Soroka A , Van Goethem S , Maes MB , Brandt I , Lambeir AM , Chen X , Haemers A , Scharpe S , Augustyns K |
| Ref : Bioorganic & Medicinal Chemistry Lett , 18 :4154 , 2008 |
| Abstract : |
| PubMedSearch : Van der Veken_2008_Bioorg.Med.Chem.Lett_18_4154 |
| PubMedID: 18556199 |
| Title : Prolyl peptidases related to dipeptidyl peptidase IV: potential of specific inhibitors in drug discovery - Van der Veken_2007_Curr.Top.Med.Chem_7_621 |
| Author(s) : Van der Veken P , Haemers A , Augustyns K |
| Ref : Curr Top Med Chem , 7 :621 , 2007 |
| Abstract : |
| PubMedSearch : Van der Veken_2007_Curr.Top.Med.Chem_7_621 |
| PubMedID: 17352682 |
| Title : Irreversible inhibition of dipeptidyl peptidase 8 by dipeptide-derived diaryl phosphonates - Van der Veken_2007_J.Med.Chem_50_5568 |
| Author(s) : Van der Veken P , Soroka A , Brandt I , Chen YS , Maes MB , Lambeir AM , Chen X , Haemers A , Scharpe S , Augustyns K , De Meester I |
| Ref : Journal of Medicinal Chemistry , 50 :5568 , 2007 |
| Abstract : |
| PubMedSearch : Van der Veken_2007_J.Med.Chem_50_5568 |
| PubMedID: 17958345 |
| Title : Synthesis and dipeptidyl peptidase inhibition of N-(4-substituted-2,4-diaminobutanoyl)piperidines - Soroka_2006_Bioorg.Med.Chem.Lett_16_4777 |
| Author(s) : Soroka A , Van der Veken P , De Meester I , Lambeir AM , Maes MB , Scharpe S , Haemers A , Augustyns K |
| Ref : Bioorganic & Medicinal Chemistry Lett , 16 :4777 , 2006 |
| Abstract : |
| PubMedSearch : Soroka_2006_Bioorg.Med.Chem.Lett_16_4777 |
| PubMedID: 16844373 |
| Title : The therapeutic potential of inhibitors of dipeptidyl peptidase IV (DPP IV) and related proline-specific dipeptidyl aminopeptidases - Augustyns_2005_Curr.Med.Chem_12_971 |
| Author(s) : Augustyns K , Van der Veken P , Senten K , Haemers A |
| Ref : Curr Med Chem , 12 :971 , 2005 |
| Abstract : |
| PubMedSearch : Augustyns_2005_Curr.Med.Chem_12_971 |
| PubMedID: 15853709 |
| Title : Fluoro-olefins as peptidomimetic inhibitors of dipeptidyl peptidases - Van der Veken_2005_J.Med.Chem_48_1768 |
| Author(s) : Van der Veken P , Senten K , Kertesz I , De Meester I , Lambeir AM , Maes MB , Scharpe S , Haemers A , Augustyns K |
| Ref : Journal of Medicinal Chemistry , 48 :1768 , 2005 |
| Abstract : |
| PubMedSearch : Van der Veken_2005_J.Med.Chem_48_1768 |
| PubMedID: 15771423 |
| Title : Gamma-amino-substituted analogues of 1-[(S)-2,4-diaminobutanoyl]piperidine as highly potent and selective dipeptidyl peptidase II inhibitors - Senten_2004_J.Med.Chem_47_2906 |
| Author(s) : Senten K , Van der Veken P , De Meester I , Lambeir AM , Scharpe S , Haemers A , Augustyns K |
| Ref : Journal of Medicinal Chemistry , 47 :2906 , 2004 |
| Abstract : |
| PubMedSearch : Senten_2004_J.Med.Chem_47_2906 |
| PubMedID: 15139769 |
| Title : Exploration of the active site of dipeptidyl peptidase IV from Porphyromonas gingivalis. Comparison with the human enzyme - |
| Author(s) : Lambeir AM , Rea D , Fulop V , Kumagai Y , Augustyns K , De Meester I , Haemers A , Scharpe S |
| Ref : Advances in Experimental Medicine & Biology , 524 :29 , 2003 |
| PubMedID: 12675220 |
| Title : Rapid parallel synthesis of dipeptide diphenyl phosphonate esters as inhibitors of dipeptidyl peptidases - Senten_2003_J.Comb.Chem_5_336 |
| Author(s) : Senten K , Daniels L , Van der Veken P , De Meester I , Lambeir AM , Scharpe S , Haemers A , Augustyns K |
| Ref : J Comb Chem , 5 :336 , 2003 |
| Abstract : |
| PubMedSearch : Senten_2003_J.Comb.Chem_5_336 |
| PubMedID: 12739951 |
| Title : Design, synthesis, and SAR of potent and selective dipeptide-derived inhibitors for dipeptidyl peptidases - Senten_2003_J.Med.Chem_46_5005 |
| Author(s) : Senten K , Van der Veken P , De Meester I , Lambeir AM , Scharpe S , Haemers A , Augustyns K |
| Ref : Journal of Medicinal Chemistry , 46 :5005 , 2003 |
| Abstract : |
| PubMedSearch : Senten_2003_J.Med.Chem_46_5005 |
| PubMedID: 14584950 |
| Title : Prolylisoxazoles: potent inhibitors of prolyloligopeptidase with antitrypanosomal activity - Bal_2003_Bioorg.Med.Chem.Lett_13_2875 |
| Author(s) : Bal G , Van der Veken P , Antonov D , Lambeir AM , Grellier P , Croft SL , Augustyns K , Haemers A |
| Ref : Bioorganic & Medicinal Chemistry Lett , 13 :2875 , 2003 |
| Abstract : |
| PubMedSearch : Bal_2003_Bioorg.Med.Chem.Lett_13_2875 |
| PubMedID: 14611847 |
| Title : Molecular characterization of dipeptidyl peptidase activity in serum: soluble CD26\/dipeptidyl peptidase IV is responsible for the release of X-Pro dipeptides - Durinx_2000_Eur.J.Biochem_267_5608 |
| Author(s) : Durinx C , Lambeir AM , Bosmans E , Falmagne JB , Berghmans R , Haemers A , Scharpe S , De Meester I |
| Ref : European Journal of Biochemistry , 267 :5608 , 2000 |
| Abstract : |
| PubMedSearch : Durinx_2000_Eur.J.Biochem_267_5608 |
| PubMedID: 10951221 |
| Title : The unique properties of dipeptidyl-peptidase IV (DPP IV \/ CD26) and the therapeutic potential of DPP IV inhibitors - Augustyns_1999_Curr.Med.Chem_6_311 |
| Author(s) : Augustyns K , Bal G , Thonus G , Belyaev A , Zhang XM , Bollaert W , Lambeir AM , Durinx C , Goossens F , Haemers A |
| Ref : Curr Med Chem , 6 :311 , 1999 |
| Abstract : |
| PubMedSearch : Augustyns_1999_Curr.Med.Chem_6_311 |
| PubMedID: 10101215 |
| Title : Structure-activity relationship of diaryl phosphonate esters as potent irreversible dipeptidyl peptidase IV inhibitors - Belyaev_1999_J.Med.Chem_42_1041 |
| Author(s) : Belyaev A , Zhang X , Augustyns K , Lambeir AM , De Meester I , Vedernikova I , Scharpe S , Haemers A |
| Ref : Journal of Medicinal Chemistry , 42 :1041 , 1999 |
| Abstract : |
| PubMedSearch : Belyaev_1999_J.Med.Chem_42_1041 |
| PubMedID: 10090787 |
| Title : In vivo inhibition of dipeptidyl peptidase IV activity by pro-pro-diphenyl-phosphonate (Prodipine) - De Meester_1997_Biochem.Pharmacol_54_173 |
| Author(s) : De Meester I , Belyaev A , Lambeir AM , De Meyer GR , Van Osselaer N , Haemers A , Scharpe S |
| Ref : Biochemical Pharmacology , 54 :173 , 1997 |
| Abstract : |
| PubMedSearch : De Meester_1997_Biochem.Pharmacol_54_173 |
| PubMedID: 9296364 |
| Title : Development and evaluation of peptide-based prolyl oligopeptidase inhibitors--introduction of N-benzyloxycarbonyl-prolyl-3- fluoropyrrolidine as a lead in inhibitor design - Goossens_1997_Eur.J.Biochem_250_177 |
| Author(s) : Goossens F , Vanhoof G , De Meester I , Augustyns K , Borloo M , Tourwe D , Haemers A , Scharpe S |
| Ref : European Journal of Biochemistry , 250 :177 , 1997 |
| Abstract : |
| PubMedSearch : Goossens_1997_Eur.J.Biochem_250_177 |
| PubMedID: 9432007 |
| Title : Dipeptide-derived diphenyl phosphonate esters: mechanism-based inhibitors of dipeptidyl peptidase IV - Lambeir_1996_Biochim.Biophys.Acta_1290_76 |
| Author(s) : Lambeir AM , Borloo M , De Meester I , Belyaev A , Augustyns K , Hendriks D , Scharpe S , Haemers A |
| Ref : Biochimica & Biophysica Acta , 1290 :76 , 1996 |
| Abstract : |
| PubMedSearch : Lambeir_1996_Biochim.Biophys.Acta_1290_76 |
| PubMedID: 8645710 |