| Title : Active site-directed probes targeting dipeptidyl peptidases 8 and 9 - Espadinha_2024_Eur.J.Med.Chem_270_116389 |
| Author(s) : Espadinha M , De Loose J , Corthaut S , Thys S , Van Rymenant Y , Verhulst E , Benramdane S , Filippi N , Augustyns K , Van Wielendaele P , Pintelon I , De Meester I , Van der Veken P |
| Ref : Eur Journal of Medicinal Chemistry , 270 :116389 , 2024 |
| Abstract : |
| PubMedSearch : Espadinha_2024_Eur.J.Med.Chem_270_116389 |
| PubMedID: 38593588 |
| Gene_locus related to this paper: human-DPP8 , human-DPP9 |
| Title : An interdisciplinary approach provides insights into the pronounced selectivity of compound 42 for DPP9 - Beyens_2024_ChemMedChem__e202400700 |
| Author(s) : Beyens O , Corthaut S , Lambeir AM , Van der Veken P , Sterckx YG , De Meester I , De Winter H |
| Ref : ChemMedChem , :e202400700 , 2024 |
| Abstract : |
| PubMedSearch : Beyens_2024_ChemMedChem__e202400700 |
| PubMedID: 39552560 |
| Gene_locus related to this paper: human-DPP8 , human-DPP9 |
| Title : Cosolvent Molecular Dynamics Applied to DPP4, DPP8 and DPP9: Reproduction of Important Binding Features and Use in Inhibitor Design - Beyens_2024_J.Chem.Inf.Model_64_7650 |
| Author(s) : Beyens O , Corthaut S , Peeters S , Van der Veken P , De Meester I , De Winter H |
| Ref : J Chem Inf Model , 64 :7650 , 2024 |
| Abstract : |
| PubMedSearch : Beyens_2024_J.Chem.Inf.Model_64_7650 |
| PubMedID: 39332821 |
| Title : Highly Selective Inhibitors of Dipeptidyl Peptidase 9 (DPP9) Derived from the Clinically Used DPP4-Inhibitor Vildagliptin - Benramdane_2023_J.Med.Chem__ |
| Author(s) : Benramdane S , De Loose J , Filippi N , Espadinha M , Beyens O , Rymenant YV , Dirkx L , Bozdag M , Feijens PB , Augustyns K , Caljon G , De Winter H , De Meester I , Van der Veken P |
| Ref : Journal of Medicinal Chemistry , : , 2023 |
| Abstract : |
| PubMedSearch : Benramdane_2023_J.Med.Chem__ |
| PubMedID: 37721854 |
| Title : Vildagliptin-Derived Dipeptidyl Peptidase 9 (DPP9) Inhibitors: Identification of a DPP8\/9-Specific Lead - Benramdane_2022_ChemMedChem__e202200097 |
| Author(s) : Benramdane S , De Loose J , Beyens O , Van Rymenant Y , Vliegen G , Augustyns K , De Winter H , De Meester I , Van der Veken P |
| Ref : ChemMedChem , :e202200097 , 2022 |
| Abstract : |
| PubMedSearch : Benramdane_2022_ChemMedChem__e202200097 |
| PubMedID: 35760756 |
| Title : Targeting fibroblast activation protein (FAP): next generation PET radiotracers using squaramide coupled bifunctional DOTA and DATA(5m) chelators - Moon_2020_EJNMMI.Radiopharm.Chem_5_19 |
| Author(s) : Moon ES , Elvas F , Vliegen G , De Lombaerde S , Vangestel C , De Bruycker S , Bracke A , Eppard E , Greifenstein L , Klasen B , Kramer V , Staelens S , De Meester I , Van der Veken P , Rosch F |
| Ref : EJNMMI Radiopharm Chem , 5 :19 , 2020 |
| Abstract : |
| PubMedSearch : Moon_2020_EJNMMI.Radiopharm.Chem_5_19 |
| PubMedID: 32728930 |
| Title : The development and validation of a combined kinetic fluorometric activity assay for fibroblast activation protein alpha and prolyl oligopeptidase in plasma - Bracke_2019_Clin.Chim.Acta_495_154 |
| Author(s) : Bracke A , Van Elzen R , Van der Veken P , Augustyns K , De Meester I , Lambeir AM |
| Ref : Clinica Chimica Acta , 495 :154 , 2019 |
| Abstract : |
| PubMedSearch : Bracke_2019_Clin.Chim.Acta_495_154 |
| PubMedID: 30981844 |
| Gene_locus related to this paper: human-FAP , human-PREP |
| Title : DPP8\/DPP9 inhibition elicits canonical Nlrp1b inflammasome hallmarks in murine macrophages - de Vasconcelos_2019_Life.Sci.Alliance_2_ |
| Author(s) : de Vasconcelos NM , Vliegen G , Goncalves A , De Hert E , Martin-Perez R , Van Opdenbosch N , Jallapally A , Geiss-Friedlander R , Lambeir AM , Augustyns K , Van der Veken P , De Meester I , Lamkanfi M |
| Ref : Life Sciences Alliance , 2 : , 2019 |
| Abstract : |
| PubMedSearch : de Vasconcelos_2019_Life.Sci.Alliance_2_ |
| PubMedID: 30718379 |
| Gene_locus related to this paper: human-DPP8 , human-DPP9 |
| Title : Ligand-induced conformational changes in prolyl oligopeptidase: a kinetic approach - Van Elzen_2017_Protein.Eng.Des.Sel_30_217 |
| Author(s) : Van Elzen R , Schoenmakers E , Brandt I , Van der Veken P , Lambeir AM |
| Ref : Protein Engineering Des Sel , 30 :217 , 2017 |
| Abstract : |
| PubMedSearch : Van Elzen_2017_Protein.Eng.Des.Sel_30_217 |
| PubMedID: 28062644 |
| Title : Crystal structure of Porphyromonas gingivalis dipeptidyl peptidase 4 and structure-activity relationships based on inhibitor profiling - Rea_2017_Eur.J.Med.Chem_139_482 |
| Author(s) : Rea D , Van Elzen R , De Winter H , Van Goethem S , Landuyt B , Luyten W , Schoofs L , Van der Veken P , Augustyns K , De Meester I , Fulop V , Lambeir AM |
| Ref : Eur Journal of Medicinal Chemistry , 139 :482 , 2017 |
| Abstract : |
| PubMedSearch : Rea_2017_Eur.J.Med.Chem_139_482 |
| PubMedID: 28826083 |
| Gene_locus related to this paper: porgi-DPP |
| Title : Prolyl carboxypeptidase purified from human placenta: its characterization and identification as an apelin-cleaving enzyme - |
| Author(s) : Kehoe K , Van Elzen R , Verkerk R , Sim Y , Van der Veken P , Lambeir AM , De Meester I |
| Ref : Biochimica & Biophysica Acta , 1864 :1481 , 2016 |
| PubMedID: 27449720 |
| Gene_locus related to this paper: human-PRCP |
| Title : The Dipeptidyl Peptidases 4, 8, and 9 in Mouse Monocytes and Macrophages: DPP8\/9 Inhibition Attenuates M1 Macrophage Activation in Mice - Waumans_2016_Inflammation_39_413 |
| Author(s) : Waumans Y , Vliegen G , Maes L , Rombouts M , Declerck K , Van der Veken P , Vanden Berghe W , De Meyer GRY , Schrijvers D , De Meester I |
| Ref : Inflammation , 39 :413 , 2016 |
| Abstract : |
| PubMedSearch : Waumans_2016_Inflammation_39_413 |
| PubMedID: 26454447 |
| Title : Extended structure-activity relationship and pharmacokinetic investigation of (4-quinolinoyl)glycyl-2-cyanopyrrolidine inhibitors of fibroblast activation protein (FAP) - Jansen_2014_J.Med.Chem_57_3053 |
| Author(s) : Jansen K , Heirbaut L , Verkerk R , Cheng JD , Joossens J , Cos P , Maes L , Lambeir AM , De Meester I , Augustyns K , Van der Veken P |
| Ref : Journal of Medicinal Chemistry , 57 :3053 , 2014 |
| Abstract : |
| PubMedSearch : Jansen_2014_J.Med.Chem_57_3053 |
| PubMedID: 24617858 |
| Title : Selective Inhibitors of Fibroblast Activation Protein (FAP) with a (4-Quinolinoyl)-glycyl-2-cyanopyrrolidine Scaffold - Jansen_2013_ACS.Med.Chem.Lett_4_491 |
| Author(s) : Jansen K , Heirbaut L , Cheng JD , Joossens J , Ryabtsova O , Cos P , Maes L , Lambeir AM , De Meester I , Augustyns K , Van der Veken P |
| Ref : ACS Med Chem Lett , 4 :491 , 2013 |
| Abstract : |
| PubMedSearch : Jansen_2013_ACS.Med.Chem.Lett_4_491 |
| PubMedID: 24900696 |
| Title : Dipeptidyl peptidases in atherosclerosis: expression and role in macrophage differentiation, activation and apoptosis - Matheeussen_2013_Basic.Res.Cardiol_108_350 |
| Author(s) : Matheeussen V , Waumans Y , Martinet W , Van Goethem S , Van der Veken P , Scharpe S , Augustyns K , De Meyer GR , De Meester I |
| Ref : Basic Res Cardiol , 108 :350 , 2013 |
| Abstract : |
| PubMedSearch : Matheeussen_2013_Basic.Res.Cardiol_108_350 |
| PubMedID: 23608773 |
| Title : Validation of a specific prolylcarboxypeptidase activity assay and its suitability for plasma and serum measurements - Kehoe_2013_Anal.Biochem_443_232 |
| Author(s) : Kehoe K , Verkerk R , Sim Y , Waumans Y , Van der Veken P , Lambeir AM , De Meester I |
| Ref : Analytical Biochemistry , 443 :232 , 2013 |
| Abstract : |
| PubMedSearch : Kehoe_2013_Anal.Biochem_443_232 |
| PubMedID: 24036038 |
| Title : A prolyl oligopeptidase inhibitor, KYP-2047, reduces alpha-synuclein protein levels and aggregates in cellular and animal models of Parkinson's disease - Myohanen_2012_Br.J.Pharmacol_166_1097 |
| Author(s) : Myohanen TT , Hannula MJ , Van Elzen R , Gerard M , Van der Veken P , Garcia-Horsman JA , Baekelandt V , Mannisto PT , Lambeir AM |
| Ref : British Journal of Pharmacology , 166 :1097 , 2012 |
| Abstract : |
| PubMedSearch : Myohanen_2012_Br.J.Pharmacol_166_1097 |
| PubMedID: 22233220 |
| Title : Method comparison of dipeptidyl peptidase IV activity assays and their application in biological samples containing reversible inhibitors - Matheeussen_2012_Clin.Chim.Acta_413_456 |
| Author(s) : Matheeussen V , Lambeir AM , Jungraithmayr W , Gomez N , Mc Entee K , Van der Veken P , Scharpe S , De Meester I |
| Ref : Clinica Chimica Acta , 413 :456 , 2012 |
| Abstract : |
| PubMedSearch : Matheeussen_2012_Clin.Chim.Acta_413_456 |
| PubMedID: 22093941 |
| Title : P2-substituted N-acylprolylpyrrolidine inhibitors of prolyl oligopeptidase: biochemical evaluation, binding mode determination, and assessment in a cellular model of synucleinopathy - Van der Veken_2012_J.Med.Chem_55_9856 |
| Author(s) : Van der Veken P , Fulop V , Rea D , Gerard M , Van Elzen R , Joossens J , Cheng JD , Baekelandt V , De Meester I , Lambeir AM , Augustyns K |
| Ref : Journal of Medicinal Chemistry , 55 :9856 , 2012 |
| Abstract : |
| PubMedSearch : Van der Veken_2012_J.Med.Chem_55_9856 |
| PubMedID: 23121075 |
| Gene_locus related to this paper: pig-ppce |
| Title : Acylated Gly-(2-cyano)pyrrolidines as inhibitors of fibroblast activation protein (FAP) and the issue of FAP\/prolyl oligopeptidase (PREP)-selectivity - Ryabtsova_2012_Bioorg.Med.Chem.Lett_22_3412 |
| Author(s) : Ryabtsova O , Jansen K , Van Goethem S , Joossens J , Cheng JD , Lambeir AM , De Meester I , Augustyns K , Van der Veken P |
| Ref : Bioorganic & Medicinal Chemistry Lett , 22 :3412 , 2012 |
| Abstract : |
| PubMedSearch : Ryabtsova_2012_Bioorg.Med.Chem.Lett_22_3412 |
| PubMedID: 22525314 |
| Title : In situ prolyl oligopeptidase activity assay in neural cell cultures - Klimaviciusa_2012_J.Neurosci.Methods_204_104 |
| Author(s) : Klimaviciusa L , Jain RK , Jaako K , Van Elzen R , Gerard M , Van der Veken P , Lambeir AM , Zharkovsky A |
| Ref : Journal of Neuroscience Methods , 204 :104 , 2012 |
| Abstract : |
| PubMedSearch : Klimaviciusa_2012_J.Neurosci.Methods_204_104 |
| PubMedID: 22101193 |
| Title : Structure-activity relationship studies on isoindoline inhibitors of dipeptidyl peptidases 8 and 9 (DPP8, DPP9): is DPP8-selectivity an attainable goal? - Van Goethem_2011_J.Med.Chem_54_5737 |
| Author(s) : Van Goethem S , Matheeussen V , Joossens J , Lambeir AM , Chen X , De Meester I , Haemers A , Augustyns K , Van der Veken P |
| Ref : Journal of Medicinal Chemistry , 54 :5737 , 2011 |
| Abstract : |
| PubMedSearch : Van Goethem_2011_J.Med.Chem_54_5737 |
| PubMedID: 21711053 |
| Gene_locus related to this paper: human-DPP8 , human-DPP9 |
| Title : Expression and spatial heterogeneity of dipeptidyl peptidases in endothelial cells of conduct vessels and capillaries - Matheeussen_2011_Biol.Chem_392_189 |
| Author(s) : Matheeussen V , Baerts L , De Meyer G , De Keulenaer G , Van der Veken P , Augustyns K , Dubois V , Scharpe S , De Meester I |
| Ref : Biol Chem , 392 :189 , 2011 |
| Abstract : |
| PubMedSearch : Matheeussen_2011_Biol.Chem_392_189 |
| PubMedID: 21194356 |
| Title : Enzyme activity and immunohistochemical localization of dipeptidyl peptidase 8 and 9 in male reproductive tissues - Dubois_2009_J.Histochem.Cytochem_57_531 |
| Author(s) : Dubois V , Van Ginneken C , De Cock H , Lambeir AM , Van der Veken P , Augustyns K , Chen X , Scharpe S , De Meester I |
| Ref : Journal of Histochemistry & Cytochemistry , 57 :531 , 2009 |
| Abstract : |
| PubMedSearch : Dubois_2009_J.Histochem.Cytochem_57_531 |
| PubMedID: 19188489 |
| Gene_locus related to this paper: rat-dpp9 |
| Title : Inhibitors of dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Part 2: isoindoline containing inhibitors - Van Goethem_2008_Bioorg.Med.Chem.Lett_18_4159 |
| Author(s) : Van Goethem S , Van der Veken P , Dubois V , Soroka A , Lambeir AM , Chen X , Haemers A , Scharpe S , De Meester I , Augustyns K |
| Ref : Bioorganic & Medicinal Chemistry Lett , 18 :4159 , 2008 |
| Abstract : |
| PubMedSearch : Van Goethem_2008_Bioorg.Med.Chem.Lett_18_4159 |
| PubMedID: 18556198 |
| Title : Inhibitors of dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Part 1: identification of dipeptide derived leads - Van der Veken_2008_Bioorg.Med.Chem.Lett_18_4154 |
| Author(s) : Van der Veken P , De Meester I , Dubois V , Soroka A , Van Goethem S , Maes MB , Brandt I , Lambeir AM , Chen X , Haemers A , Scharpe S , Augustyns K |
| Ref : Bioorganic & Medicinal Chemistry Lett , 18 :4154 , 2008 |
| Abstract : |
| PubMedSearch : Van der Veken_2008_Bioorg.Med.Chem.Lett_18_4154 |
| PubMedID: 18556199 |
| Title : Purification and characterization of dipeptidyl peptidase IV-like enzymes from bovine testes - Dubois_2008_Front.Biosci_13_3558 |
| Author(s) : Dubois V , Lambeir AM , Van der Veken P , Augustyns K , Creemers J , Chen X , Scharpe S , De Meester I |
| Ref : Front Biosci , 13 :3558 , 2008 |
| Abstract : |
| PubMedSearch : Dubois_2008_Front.Biosci_13_3558 |
| PubMedID: 18508455 |
| Title : Dipeptidyl peptidase 8\/9-like activity in human leukocytes - Maes_2007_J.Leukoc.Biol_81_1252 |
| Author(s) : Maes MB , Dubois V , Brandt I , Lambeir AM , Van der Veken P , Augustyns K , Cheng JD , Chen X , Scharpe S , De Meester I |
| Ref : J Leukoc Biol , 81 :1252 , 2007 |
| Abstract : |
| PubMedSearch : Maes_2007_J.Leukoc.Biol_81_1252 |
| PubMedID: 17287297 |
| Title : Prolyl peptidases related to dipeptidyl peptidase IV: potential of specific inhibitors in drug discovery - Van der Veken_2007_Curr.Top.Med.Chem_7_621 |
| Author(s) : Van der Veken P , Haemers A , Augustyns K |
| Ref : Curr Top Med Chem , 7 :621 , 2007 |
| Abstract : |
| PubMedSearch : Van der Veken_2007_Curr.Top.Med.Chem_7_621 |
| PubMedID: 17352682 |
| Title : Irreversible inhibition of dipeptidyl peptidase 8 by dipeptide-derived diaryl phosphonates - Van der Veken_2007_J.Med.Chem_50_5568 |
| Author(s) : Van der Veken P , Soroka A , Brandt I , Chen YS , Maes MB , Lambeir AM , Chen X , Haemers A , Scharpe S , Augustyns K , De Meester I |
| Ref : Journal of Medicinal Chemistry , 50 :5568 , 2007 |
| Abstract : |
| PubMedSearch : Van der Veken_2007_J.Med.Chem_50_5568 |
| PubMedID: 17958345 |
| Title : In vivo effects of a potent, selective DPPII inhibitor: UAMC00039 is a possible tool for the elucidation of the physiological function of DPPII - |
| Author(s) : Maes MB , Lambeir AM , Van der Veken P , De Winter B , Augustyns K , Scharpe S , De Meester I |
| Ref : Advances in Experimental Medicine & Biology , 575 :73 , 2006 |
| PubMedID: 16700510 |
| Title : Synthesis and dipeptidyl peptidase inhibition of N-(4-substituted-2,4-diaminobutanoyl)piperidines - Soroka_2006_Bioorg.Med.Chem.Lett_16_4777 |
| Author(s) : Soroka A , Van der Veken P , De Meester I , Lambeir AM , Maes MB , Scharpe S , Haemers A , Augustyns K |
| Ref : Bioorganic & Medicinal Chemistry Lett , 16 :4777 , 2006 |
| Abstract : |
| PubMedSearch : Soroka_2006_Bioorg.Med.Chem.Lett_16_4777 |
| PubMedID: 16844373 |
| Title : Dipeptidyl peptidase II and leukocyte cell death - Maes_2006_Biochem.Pharmacol_72_70 |
| Author(s) : Maes MB , Martinet W , Schrijvers DM , Van der Veken P , De Meyer GR , Augustyns K , Lambeir AM , Scharpe S , De Meester I |
| Ref : Biochemical Pharmacology , 72 :70 , 2006 |
| Abstract : |
| PubMedSearch : Maes_2006_Biochem.Pharmacol_72_70 |
| PubMedID: 16725115 |
| Title : The therapeutic potential of inhibitors of dipeptidyl peptidase IV (DPP IV) and related proline-specific dipeptidyl aminopeptidases - Augustyns_2005_Curr.Med.Chem_12_971 |
| Author(s) : Augustyns K , Van der Veken P , Senten K , Haemers A |
| Ref : Curr Med Chem , 12 :971 , 2005 |
| Abstract : |
| PubMedSearch : Augustyns_2005_Curr.Med.Chem_12_971 |
| PubMedID: 15853709 |
| Title : Fluoro-olefins as peptidomimetic inhibitors of dipeptidyl peptidases - Van der Veken_2005_J.Med.Chem_48_1768 |
| Author(s) : Van der Veken P , Senten K , Kertesz I , De Meester I , Lambeir AM , Maes MB , Scharpe S , Haemers A , Augustyns K |
| Ref : Journal of Medicinal Chemistry , 48 :1768 , 2005 |
| Abstract : |
| PubMedSearch : Van der Veken_2005_J.Med.Chem_48_1768 |
| PubMedID: 15771423 |
| Title : Kinetic investigation of human dipeptidyl peptidase II (DPPII)-mediated hydrolysis of dipeptide derivatives and its identification as quiescent cell proline dipeptidase (QPP)\/dipeptidyl peptidase 7 (DPP7) - Maes_2005_Biochem.J_386_315 |
| Author(s) : Maes MB , Lambeir AM , Gilany K , Senten K , Van der Veken P , Leiting B , Augustyns K , Scharpe S , De Meester I |
| Ref : Biochemical Journal , 386 :315 , 2005 |
| Abstract : |
| PubMedSearch : Maes_2005_Biochem.J_386_315 |
| PubMedID: 15487984 |
| Gene_locus related to this paper: human-DPP7 |
| Title : Gamma-amino-substituted analogues of 1-[(S)-2,4-diaminobutanoyl]piperidine as highly potent and selective dipeptidyl peptidase II inhibitors - Senten_2004_J.Med.Chem_47_2906 |
| Author(s) : Senten K , Van der Veken P , De Meester I , Lambeir AM , Scharpe S , Haemers A , Augustyns K |
| Ref : Journal of Medicinal Chemistry , 47 :2906 , 2004 |
| Abstract : |
| PubMedSearch : Senten_2004_J.Med.Chem_47_2906 |
| PubMedID: 15139769 |
| Title : Design, synthesis, and SAR of potent and selective dipeptide-derived inhibitors for dipeptidyl peptidases - Senten_2003_J.Med.Chem_46_5005 |
| Author(s) : Senten K , Van der Veken P , De Meester I , Lambeir AM , Scharpe S , Haemers A , Augustyns K |
| Ref : Journal of Medicinal Chemistry , 46 :5005 , 2003 |
| Abstract : |
| PubMedSearch : Senten_2003_J.Med.Chem_46_5005 |
| PubMedID: 14584950 |
| Title : Rapid parallel synthesis of dipeptide diphenyl phosphonate esters as inhibitors of dipeptidyl peptidases - Senten_2003_J.Comb.Chem_5_336 |
| Author(s) : Senten K , Daniels L , Van der Veken P , De Meester I , Lambeir AM , Scharpe S , Haemers A , Augustyns K |
| Ref : J Comb Chem , 5 :336 , 2003 |
| Abstract : |
| PubMedSearch : Senten_2003_J.Comb.Chem_5_336 |
| PubMedID: 12739951 |
| Title : Prolylisoxazoles: potent inhibitors of prolyloligopeptidase with antitrypanosomal activity - Bal_2003_Bioorg.Med.Chem.Lett_13_2875 |
| Author(s) : Bal G , Van der Veken P , Antonov D , Lambeir AM , Grellier P , Croft SL , Augustyns K , Haemers A |
| Ref : Bioorganic & Medicinal Chemistry Lett , 13 :2875 , 2003 |
| Abstract : |
| PubMedSearch : Bal_2003_Bioorg.Med.Chem.Lett_13_2875 |
| PubMedID: 14611847 |