| Title : Similar but different: thermodynamic and structural characterization of a pair of enantiomers binding to acetylcholinesterase - Berg_2012_Angew.Chem.Int.Ed.Engl_51_12716 |
| Author(s) : Berg L , Niemiec MS , Qian W , Andersson CD , Wittung-Stafshede P , Ekstrom F , Linusson A |
| Ref : Angew Chem Int Ed Engl , 51 :12716 , 2012 |
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Abstract :
Take a closer look: Unexpectedly, a pair of enantiomeric ligands proved to have similar binding affinities for acetylcholinesterase. Further studies indicated that the enantiomers exhibit different thermodynamic profiles. Analyses of the noncovalent interactions in the protein-ligand complexes revealed that these differences are partly due to nonclassical hydrogen bonds between the ligands and aromatic side chains of the protein. |
| PubMedSearch : Berg_2012_Angew.Chem.Int.Ed.Engl_51_12716 |
| PubMedID: 23161758 |
| Gene_locus related to this paper: mouse-ACHE |
| Inhibitor | C5685 |
| Gene_locus | mouse-ACHE |
| Structure | 4ARA 4ARB |
Berg L, Niemiec MS, Qian W, Andersson CD, Wittung-Stafshede P, Ekstrom F, Linusson A (2012)
Similar but different: thermodynamic and structural characterization of a pair of enantiomers binding to acetylcholinesterase
Angew Chem Int Ed Engl
51 :12716
Berg L, Niemiec MS, Qian W, Andersson CD, Wittung-Stafshede P, Ekstrom F, Linusson A (2012)
Angew Chem Int Ed Engl
51 :12716