| Title : In silico studies and in vitro evaluation of isatin-pyridine oxime hybrids as novel reactivators of acetylcholinesterase inhibited by an A-230 surrogate - Bernardo_2025_Arch.Toxicol__ |
| Author(s) : Bernardo LB , Vieira LA , Borges CVN , Buitrago PAG , Kuca K , Franca TCC , Cavalcante SFA , Sousa RB , Lima ALS , Kitagawa DAS |
| Ref : Archives of Toxicology , : , 2025 |
|
Abstract :
Recent events involving nerve agents of the A-Series, a once elusive class of chemical warfare agents, have provoked a great concern in the international community. In this paper, continuing our research efforts in Medicinal Chemistry at the Brazilian Institute of Chemical, Biological, Radiological and Nuclear Defense (IDQBRN) (an OPCW-designated Laboratory for environmental samples), we explore ANMP, an A-230 surrogate, in the search for new treatment options for intoxications caused by these chemicals. Five isatin-pyridine oxime hybrids were evaluated as acetylcholinesterase (AChE) reactivators using a modified Ellman's assay. Our results indicate that monocationic hybrids with five methylene units, as well as its oxa-analog, are promising compounds for the design of new AChE reactivators. |
| PubMedSearch : Bernardo_2025_Arch.Toxicol__ |
| PubMedID: 40035846 |
| Inhibitor | ANMP |
Bernardo LB, Vieira LA, Borges CVN, Buitrago PAG, Kuca K, Franca TCC, Cavalcante SFA, Sousa RB, Lima ALS, Kitagawa DAS (2025)
In silico studies and in vitro evaluation of isatin-pyridine oxime hybrids as novel reactivators of acetylcholinesterase inhibited by an A-230 surrogate
Archives of Toxicology
:
Bernardo LB, Vieira LA, Borges CVN, Buitrago PAG, Kuca K, Franca TCC, Cavalcante SFA, Sousa RB, Lima ALS, Kitagawa DAS (2025)
Archives of Toxicology
: