| Title : Design and pharmacology of quinuclidine derivatives as M2-selective muscarinic receptor ligands - Bohme_2001_Bioorg.Med.Chem.Lett_11_1241 |
| Author(s) : Bohme TM , Keim C , Dannhardt G , Mutschler E , Lambrecht G |
| Ref : Bioorganic & Medicinal Chemistry Lett , 11 :1241 , 2001 |
|
Abstract :
In our search for M2-selective muscarinic receptor antagonists, we synthesized 1,3-disubstituted indenes. The effects of different basic moieties with regard to binding and selectivity towards the five distinct muscarinic receptor subtypes were investigated. The results show that the quinuclidine series afforded the most promising compounds in terms of both receptor affinity and M2-subtype selectivity. |
| PubMedSearch : Bohme_2001_Bioorg.Med.Chem.Lett_11_1241 |
| PubMedID: 11354386 |
Bohme TM, Keim C, Dannhardt G, Mutschler E, Lambrecht G (2001)
Design and pharmacology of quinuclidine derivatives as M2-selective muscarinic receptor ligands
Bioorganic & Medicinal Chemistry Lett
11 :1241
Bohme TM, Keim C, Dannhardt G, Mutschler E, Lambrecht G (2001)
Bioorganic & Medicinal Chemistry Lett
11 :1241