Mutschler E

General

Full name : Mutschler Ernst

First name : Ernst

Mail : Department of Pharmacology, Biocentre Niederursel, University of Frankfurt, Marie-Curie-Strasse 9, Geb.N260, D-60439 Frankfurt\/M

Zip Code :

City :

Country : Germany

Email :

Phone :

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Website : \/\/de.wikipedia.org\/wiki\/Ernst_Mutschler

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References (131)

Title : Rate-limiting biotransformation of triamterene is mediated by CYP1A2 - Fuhr_2005_Int.J.Clin.Pharmacol.Ther_43_327
Author(s) : Fuhr U , Kober S , Zaigler M , Mutschler E , Spahn-Langguth H
Ref : Int J Clinical Pharmacology & Therapeutics , 43 :327 , 2005
PubMedID: 16035375

Title : Structure-activity relationships of dimethindene derivatives as new M2-selective muscarinic receptor antagonists - Bohme_2003_J.Med.Chem_46_856
Author(s) : Bohme TM , Keim C , Kreutzmann K , Linder M , Dingermann T , Dannhardt G , Mutschler E , Lambrecht G
Ref : Journal of Medicinal Chemistry , 46 :856 , 2003
PubMedID: 12593665

Title : Design and pharmacology of quinuclidine derivatives as M2-selective muscarinic receptor ligands - Bohme_2001_Bioorg.Med.Chem.Lett_11_1241
Author(s) : Bohme TM , Keim C , Dannhardt G , Mutschler E , Lambrecht G
Ref : Bioorganic & Medicinal Chemistry Lett , 11 :1241 , 2001
PubMedID: 11354386

Title : The novel pyridoxal-5'-phosphate derivative PPNDS potently antagonizes activation of P2X(1) receptors - Lambrecht_2000_Eur.J.Pharmacol_387_R19
Author(s) : Lambrecht G , Rettinger J , Baumert HG , Czeche S , Damer S , Ganso M , Hildebrandt C , Niebel B , Spatz-Kumbel G , Schmalzing G , Mutschler E
Ref : European Journal of Pharmacology , 387 :R19 , 2000
PubMedID: 10650184

Title : Muscarinic properties of compounds related to arecaidine propargyl ester - Tumiatti_2000_Arzneimittelforschung_50_11
Author(s) : Tumiatti V , Wehrle J , Hildebrandt C , Moser U , Dannhardt G , Mutschler E , Lambrecht G
Ref : Arzneimittelforschung , 50 :11 , 2000
PubMedID: 10683710

Title : Neuronal soma-dendritic and prejunctional M1-M4 receptors in gastrointestinal and genitourinary smooth muscle - Lambrecht_1999_Life.Sci_64(6-7)_403
Author(s) : Lambrecht G , Gross J , Mutschler E
Ref : Life Sciences , 64 :403 , 1999
PubMedID: 10069503

Title : Poster: Stereoselective interaction of trihexyphenidyl and related compounds with muscarinic receptors -
Author(s) : Gross J , Pfaff O , Rachel D , Tacke R , Leis A , Ruhlmann K , Waelbroeck M , Mutschler E , Lambrecht G
Ref : Life Sciences , 64 :593 , 1999
PubMedID:

Title : Poster: Binding affinities of new dimethindene analogues at five muscarinic receptor subtypes -
Author(s) : Keim C , Bohme T , Dannhardt G , Niebel B , Lambrecht G , Mutschler E
Ref : Life Sciences , 64 :556 , 1999
PubMedID:

Title : Poster: Facilitation of acetylcholine release from myenteric neurones by alpha,beta-methylene ATP causes a contraction of the guinea-pig ileum via postjunctional M3 receptors -
Author(s) : Czeche S , Niebel B , Mutschler E , Lambrecht G
Ref : Life Sciences , 64 :592 , 1999
PubMedID:

Title : NF279: a novel potent and selective antagonist of P2X receptor-mediated responses - Damer_1998_Eur.J.Pharmacol_350_R5
Author(s) : Damer S , Niebel B , Czeche S , Nickel P , Ardanuy U , Schmalzing G , Rettinger J , Mutschler E , Lambrecht G
Ref : European Journal of Pharmacology , 350 :R5 , 1998
PubMedID: 9683026

Title : Poster: Stereoselective interaction of p-fluoro-trihexyphenidyl and its methiodide with four muscarinic receptor subtypes -
Author(s) : Lambrecht G , Pfaff O , Aasen AJ , Sjo P , Mutschler E , Waelbroeck M
Ref : Life Sciences , 60 :1166 , 1997
PubMedID:

Title : Poster: Antimuscarinic properties of the stereoisomers of glycopyrronium bromide -
Author(s) : Czeche S , Elgert M , Noe C , Waelbroeck M , Mutschler E , Lambrecht G
Ref : Life Sciences , 60 :1167 , 1997
PubMedID:

Title : Poster: Functional characterisation of PD102807: A novel M4-selective muscarinic antagonist -
Author(s) : Gross J , Augelli-Szafran CE , Czeche S , Friebe T , Jaen JC , Penvose-Yi JR , Schwarz RD , Mutschler E , Lambrecht G
Ref : Life Sciences , 60 :1168 , 1997
PubMedID:

Title : Characterization of postjunctional muscarinic receptors mediating contraction in rat anococcygeus muscle - Weiser_1997_Naunyn.Schmiedebergs.Arch.Pharmacol_356_671
Author(s) : Weiser M , Mutschler E , Lambrecht G
Ref : Naunyn Schmiedebergs Arch Pharmacol , 356 :671 , 1997
PubMedID: 9402048

Title : Quantitative colorimetric and gas chromatographic determination of arecaidine propargyl ester - Langer_1997_J.Chromatogr.B.Biomed.Sci.Appl_692_345
Author(s) : Langer K , Lambrecht G , Moser U , Mutschler E , Kreuter J
Ref : Journal of Chromatography B Biomed Sci Appl , 692 :345 , 1997
PubMedID: 9188823

Title : Evidence for muscarinic M4 receptors mediating nonadrenergic noncholinergic relaxations in rabbit anococcygeus muscle - Gross_1997_Naunyn.Schmiedebergs.Arch.Pharmacol_356_505
Author(s) : Gross J , Mutschler E , Lambrecht G
Ref : Naunyn Schmiedebergs Arch Pharmacol , 356 :505 , 1997
PubMedID: 9349639

Title : Poster: Functional characterization of postjunctional muscarinic receptors in rat anococcygeus muscle -
Author(s) : Weiser M , Waelbroeck M , Lambrecht G , Mutschler E
Ref : Life Sciences , 60 :1192 , 1997
PubMedID:

Title : Stereoselective interaction of uncharged esters at four muscarinic receptor subtypes - Waelbroeck_1996_Eur.J.Pharmacol_303_221
Author(s) : Waelbroeck M , Hou X , Wehrle J , Mutschler E , Van Tilburg E , Menge W , Timmerman H , Lambrecht G
Ref : European Journal of Pharmacology , 303 :221 , 1996
PubMedID: 8813573

Title : Stereoselective recognition of the enantiomers of phenglutarimide and of six related compounds by four muscarinic receptor subtypes - Waelbroeck_1996_Br.J.Pharmacol_119_1319
Author(s) : Waelbroeck M , Lazareno S , Pfaff O , Friebe T , Tastenoy M , Mutschler E , Lambrecht G
Ref : British Journal of Pharmacology , 119 :1319 , 1996
PubMedID: 8968538

Title : Influence of monovalent cations on the binding of a charged and an uncharged ('carbo'-)muscarinic antagonist to muscarinic receptors - Hou_1996_Br.J.Pharmacol_117_955
Author(s) : Hou X , Wehrle J , Menge W , Ciccarelli E , Wess J , Mutschler E , Lambrecht G , Timmerman H , Waelbroeck M
Ref : British Journal of Pharmacology , 117 :955 , 1996
PubMedID: 8851517

Title : The renin-angiotensin-aldosterone system: focus on its distinct role in arterial hypertension and its various inhibitors as a therapeutic strategy to effectively lower blood pressure - Soldner_1996_Pharmazie_51_783
Author(s) : Soldner A , Spahn-Langguth H , Mutschler E
Ref : Pharmazie , 51 :783 , 1996
PubMedID: 8985974

Title : Aliphatic and heterocyclic analogues of arecaidine propargyl ester. Structure-activity relationships of mono- and bivalent ligands at muscarinic M1 (M4), M2 and M3 receptor subtypes - Moser_1995_Arzneimittelforschung_45_449
Author(s) : Moser U , Gubitz C , Galvan M , Immel-Sehr A , Lambrecht G , Mutschler E
Ref : Arzneimittelforschung , 45 :449 , 1995
PubMedID: 7779140

Title : Muscarinic receptor subtypes--pharmacological, molecular biological and therapeutical aspects -
Author(s) : Mutschler E , Moser U , Wess J , Lambrecht G
Ref : Pharm Acta Helv , 69 :243 , 1995
PubMedID: 7651968

Title : Regioisomeric 5(3)-aminomethyl-3(5)-phenylisoxazoles: synthesis, spectroscopic discrimination, and muscarinic activity - Dannhardt_1995_Arch.Pharm.(Weinheim)_328_437
Author(s) : Dannhardt G , Lambrecht G , Laufer S , Mutschler E , Schweiger J
Ref : Arch Pharm (Weinheim) , 328 :437 , 1995
PubMedID: 7611839

Title : The design and pharmacology of novel selective muscarinic agonists and antagonists - Lambrecht_1995_Life.Sci_56(11-12)_815
Author(s) : Lambrecht G , Gross J , Hacksell U , Hermanni U , Hildebrandt C , Hou X , Moser U , Nilsson BM , Pfaff O , Waelbroeck M , Wehrle J , Mutschler E
Ref : Life Sciences , 56(11-12) :815 , 1995
PubMedID: 10188780

Title : Poster: Functional characterization of muscarinic receptors in rat duodenum -
Author(s) : Pfaff O , Gross J , Waelbroeck M , Mutschler E , Lambrecht G
Ref : Life Sciences , 56(11-12) :1038 , 1995
PubMedID:

Title : Poster: Functional characterization of neuronal muscarinic receptors in rabbit anococcygeus muscle -
Author(s) : Gross J , Waelbroeck M , Mutschler E , Lambrecht G
Ref : Life Sciences , 56(11-12) :1038 , 1995
PubMedID:

Title : Muscarinic acetylcholine receptors: structural basis of ligand binding and G protein coupling - Wess_1995_Life.Sci_56(11-12)_915
Author(s) : Wess J , Blin N , Mutschler E , Bluml K
Ref : Life Sciences , 56(11-12) :915 , 1995
PubMedID: 10188793

Title : Inhibitory action of PPADS on relaxant responses to adenine nucleotides or electrical field stimulation in guinea-pig taenia coli and rat duodenum - Windscheif_1995_Br.J.Pharmacol_115_1509
Author(s) : Windscheif U , Pfaff O , Ziganshin AU , Hoyle CH , Baumert HG , Mutschler E , Burnstock G , Lambrecht G
Ref : British Journal of Pharmacology , 115 :1509 , 1995
PubMedID: 8564212

Title : Poster: Pharmacology of selective muscarinic ligands related to McN-A-343 -
Author(s) : Moser U , Wehrle J , Hacksell U , Nilsson BM , Tumiatti V , Lambrecht G , Mutschler E
Ref : Life Sciences , 56(11-12) :1006 , 1995
PubMedID:

Title : The (S)-(+)-enantiomer of dimethindene: a novel M2-selective muscarinic receptor antagonist - Pfaff_1995_Eur.J.Pharmacol_286_229
Author(s) : Pfaff O , Hildebrandt C , Waelbroeck M , Hou X , Moser U , Mutschler E , Lambrecht G
Ref : European Journal of Pharmacology , 286 :229 , 1995
PubMedID: 8608784

Title : Functional role in ligand binding and receptor activation of an asparagine residue present in the sixth transmembrane domain of all muscarinic acetylcholine receptors - Bluml_1994_J.Biol.Chem_269_18870
Author(s) : Bluml K , Mutschler E , Wess J
Ref : Journal of Biological Chemistry , 269 :18870 , 1994
PubMedID: 8034642

Title : Functional role of a cytoplasmic aromatic amino acid in muscarinic receptor-mediated activation of phospholipase C - Bluml_1994_J.Biol.Chem_269_11537
Author(s) : Bluml K , Mutschler E , Wess J
Ref : Journal of Biological Chemistry , 269 :11537 , 1994
PubMedID: 8157684

Title : Identification of an intracellular tyrosine residue critical for muscarinic receptor-mediated stimulation of phosphatidylinositol hydrolysis - Bluml_1994_J.Biol.Chem_269_402
Author(s) : Bluml K , Mutschler E , Wess J
Ref : Journal of Biological Chemistry , 269 :402 , 1994
PubMedID: 8276826

Title : Insertion mutagenesis as a tool to predict the secondary structure of a muscarinic receptor domain determining specificity of G-protein coupling - Bluml_1994_Proc.Natl.Acad.Sci.U.S.A_91_7980
Author(s) : Bluml K , Mutschler E , Wess J
Ref : Proc Natl Acad Sci U S A , 91 :7980 , 1994
PubMedID: 8058746

Title : Binding and functional properties of hexocyclium and sila-hexocyclium derivatives to muscarinic receptor subtypes - Waelbroeck_1994_Br.J.Pharmacol_112_505
Author(s) : Waelbroeck M , Camus J , Tastenoy M , Feifel R , Mutschler E , Tacke R , Strohmann C , Rafeiner K , Rodrigues de Miranda JF , Lambrecht G
Ref : British Journal of Pharmacology , 112 :505 , 1994
PubMedID: 8075869

Title : Synthesis and muscarinic activity of isoxazole-substituted 1,2,5,6-tetrahydropyridines -
Author(s) : Dannhardt G , Schweiger J , Lambrecht G , Mutschler E
Ref : Arch Pharm (Weinheim) , 327 :751 , 1994
PubMedID: 7840738

Title : Vasoconstrictor and vasodilator responses to various agonists in the rat perfused mesenteric arterial bed: selective inhibition by PPADS of contractions mediated via P2x-purinoceptors - Windscheif_1994_Br.J.Pharmacol_113_1015
Author(s) : Windscheif U , Ralevic V , Baumert HG , Mutschler E , Lambrecht G , Burnstock G
Ref : British Journal of Pharmacology , 113 :1015 , 1994
PubMedID: 7858843

Title : Investigation of the actions of PPADS, a novel P2x-purinoceptor antagonist, in the guinea-pig isolated vas deferens - McLaren_1994_Br.J.Pharmacol_111_913
Author(s) : McLaren GJ , Lambrecht G , Mutschler E , Baumert HG , Sneddon P , Kennedy C
Ref : British Journal of Pharmacology , 111 :913 , 1994
PubMedID: 8019769

Title : Pharmacokinetic and pharmacodynamic aspects of an ophthalmic pilocarpine nanoparticle-delivery-system - Zimmer_1994_Pharm.Res_11_1435
Author(s) : Zimmer A , Mutschler E , Lambrecht G , Mayer D , Kreuter J
Ref : Pharm Res , 11 :1435 , 1994
PubMedID: 7855048

Title : Characterization of the prejunctional muscarinic receptors mediating inhibition of evoked release of endogenous noradrenaline in rabbit isolated vas deferens - Grimm_1994_Naunyn.Schmiedebergs.Arch.Pharmacol_349_1
Author(s) : Grimm U , Fuder H , Moser U , Bumert HG , Mutschler E , Lambrecht G
Ref : Naunyn Schmiedebergs Arch Pharmacol , 349 :1 , 1994
PubMedID: 8139696

Title : Muscarinic receptors: focus on presynaptic mechanisms and recently developed novel agonists and antagonists -
Author(s) : Grimm U , Moser U , Mutschler E , Lambrecht G
Ref : Pharmazie , 49 :711 , 1994
PubMedID: 7816897

Title : Characterization of muscarinic receptors mediating vasodilation in rat perfused kidney - Eltze_1993_Eur.J.Pharmacol_238_343
Author(s) : Eltze M , Ullrich B , Mutschler E , Moser U , Bungardt E , Friebe T , Gubitz C , Tacke R , Lambrecht G
Ref : European Journal of Pharmacology , 238 :343 , 1993
PubMedID: 8405103

Title : New functionally selective muscarinic agonists - Lambrecht_1993_Life.Sci_52(5-6)_481
Author(s) : Lambrecht G , Moser U , Grimm U , Pfaff O , Hermanni U , Hildebrandt C , Waelbroeck M , Christophe J , Mutschler E
Ref : Life Sciences , 52 :481 , 1993
PubMedID: 7680092

Title : Poster: New functionally selective M1 agonists related to McN-A-343 -
Author(s) : Moser U , Lambrecht G , Mellin C , Mutschler E
Ref : Life Sciences , 52(5-6) :550 , 1993
PubMedID:

Title : Thermodynamics of antagonist binding to rat muscarinic M2 receptors: antimuscarinics of the pridinol, sila-pridinol, diphenidol and sila-diphenidol type - Waelbroeck_1993_Br.J.Pharmacol_109_360
Author(s) : Waelbroeck M , Camus J , Tastenoy M , Lambrecht G , Mutschler E , Kropfgans M , Sperlich J , Wiesenberger F , Tacke R , Christophe J
Ref : British Journal of Pharmacology , 109 :360 , 1993
PubMedID: 8102927

Title : Poster: Functional characterization of muscarinic receptors in rabbit peripheral lung -
Author(s) : Vockert E , Egerer HP , Tacke R , Lambrecht G , Mutschler E
Ref : Life Sciences , 52(5-6) :551 , 1993
PubMedID:

Title : WAL 2014--a muscarinic agonist with preferential neuron-stimulating properties - Ensinger_1993_Life.Sci_52(5-6)_473
Author(s) : Ensinger HA , Doods HN , Immel-Sehr AR , Kuhn FJ , Lambrecht G , Mendla KD , Muller RE , Mutschler E , Sagrada A , Walther G , Hammer R
Ref : Life Sciences , 52 :473 , 1993
PubMedID: 8441328

Title : Poster: Characterization of the vasodilatory muscarinic receptor in perfused rat kidney by the use of agonists and antagonists -
Author(s) : Eltze M , Mutschler E , Moser U , Friebe T , Gubitz C , Tacke R , Lambrecht G
Ref : Life Sciences , 52(5-6) :579 , 1993
PubMedID:

Title : PPADS selectively antagonizes P2X-purinoceptor-mediated responses in the rabbit urinary bladder - Ziganshin_1993_Br.J.Pharmacol_110_1491
Author(s) : Ziganshin AU , Hoyle CH , Bo X , Lambrecht G , Mutschler E , Baumert HG , Burnstock G
Ref : British Journal of Pharmacology , 110 :1491 , 1993
PubMedID: 8306091

Title : Poster: Muscarinic inhibition of noradrenaline release evoked by field stimulation on rabbit isolated vas deferens -
Author(s) : Grimm U , Fuder H , Mutschler E , Lambrecht G
Ref : Life Sciences , 52(5-6) :563 , 1993
PubMedID:

Title : Affinity profiles of pizotifen, ketotifen and other tricyclic antimuscarinics at muscarinic receptor subtypes M1, M2 and M3 - Eltze_1992_Eur.J.Pharmacol_211_283
Author(s) : Eltze M , Mutschler E , Lambrecht G
Ref : European Journal of Pharmacology , 211 :283 , 1992
PubMedID: 1377628

Title : Stereoselective interaction of procyclidine, hexahydro-difenidol, hexbutinol and oxyphencyclimine, and of related antagonists, with four muscarinic receptors - Waelbroeck_1992_Eur.J.Pharmacol_227_33
Author(s) : Waelbroeck M , Camus J , Tastenoy M , Mutschler E , Strohmann C , Tacke R , Schjelderup L , Aasen A , Lambrecht G , Christophe J
Ref : European Journal of Pharmacology , 227 :33 , 1992
PubMedID: 1426023

Title : Cryptolepis sanguinolenta: antimuscarinic properties of cryptolepine and the alkaloid fraction at M1, M2 and M3 receptors - Rauwald_1992_Planta.Med_58_486
Author(s) : Rauwald HW , Kober M , Mutschler E , Lambrecht G
Ref : Planta Med , 58 :486 , 1992
PubMedID: 1484884

Title : PPADS, a novel functionally selective antagonist of P2 purinoceptor-mediated responses - Lambrecht_1992_Eur.J.Pharmacol_217_217
Author(s) : Lambrecht G , Friebe T , Grimm U , Windscheif U , Bungardt E , Hildebrandt C , Baumert HG , Spatz-Kumbel G , Mutschler E
Ref : European Journal of Pharmacology , 217 :217 , 1992
PubMedID: 1330591

Title : Characterization of muscarinic receptors mediating vasodilation in guinea-pig ileum submucosal arterioles by the use of computer-assisted videomicroscopy - Bungardt_1992_Eur.J.Pharmacol_213_53
Author(s) : Bungardt E , Vockert E , Feifel R , Moser U , Tacke R , Mutschler E , Lambrecht G , Surprenant A
Ref : European Journal of Pharmacology , 213 :53 , 1992
PubMedID: 1499657

Title : Binding affinities of hexahydro-difenidol and hexahydro-sila-difenidol analogues at four muscarinic receptor subtypes: constitutional and stereochemical aspects - Waelbroeck_1991_Eur.J.Pharmacol_206_95
Author(s) : Waelbroeck M , Camus J , Tastenoy M , Mutschler E , Strohmann C , Tacke R , Lambrecht G , Christophe J
Ref : European Journal of Pharmacology , 206 :95 , 1991
PubMedID: 2065719

Title : Stereoselectivity of (R)- and (S)-hexahydro-difenidol binding to neuroblastoma M1, cardiac M2, pancreatic M3, and striatum M4 muscarinic receptors - Waelbroeck_1991_Chirality_3_118
Author(s) : Waelbroeck M , Camus J , Tastenoy M , Mutschler E , Strohmann C , Tacke R , Lambrecht G , Christophe J
Ref : Chirality , 3 :118 , 1991
PubMedID: 1863523

Title : Selective labelling of muscarinic M1 receptors in calf superior cervical ganglia by [3H](+\/-)-telenzepine - Feifel_1991_Eur.J.Pharmacol_195_115
Author(s) : Feifel R , Rodrigues de Miranda JF , Strohmann C , Tacke R , Aasen AJ , Mutschler E , Lambrecht G
Ref : European Journal of Pharmacology , 195 :115 , 1991
PubMedID: 2065706

Title : Selectivity profile of the novel muscarinic antagonist UH-AH 37 determined by the use of cloned receptors and isolated tissue preparations - Wess_1991_Br.J.Pharmacol_102_246
Author(s) : Wess J , Lambrecht G , Mutschler E , Brann MR , Dorje F
Ref : British Journal of Pharmacology , 102 :246 , 1991
PubMedID: 2043926

Title : Pharmacological characterization of the vascular muscarinic receptors mediating relaxation and contraction in rabbit aorta - Jaiswal_1991_J.Pharmacol.Exp.Ther_258_842
Author(s) : Jaiswal N , Lambrecht G , Mutschler E , Tacke R , Malik KU
Ref : Journal of Pharmacology & Experimental Therapeutics , 258 :842 , 1991
PubMedID: 1716312

Title : Effect of extracellular calcium concentration on potency of muscarinic agonists at M1 and M2 receptors in rabbit vas deferens - Dorje_1991_Eur.J.Pharmacol_203_417
Author(s) : Dorje F , Rettenmayr NM , Mutschler E , Lambrecht G
Ref : European Journal of Pharmacology , 203 :417 , 1991
PubMedID: 1723047

Title : Antagonist binding profiles of five cloned human muscarinic receptor subtypes - Dorje_1991_J.Pharmacol.Exp.Ther_256_727
Author(s) : Dorje F , Wess J , Lambrecht G , Tacke R , Mutschler E , Brann MR
Ref : Journal of Pharmacology & Experimental Therapeutics , 256 :727 , 1991
PubMedID: 1994002

Title : AF-DX 116, a cardioselective muscarinic antagonist in humans: pharmacodynamic and pharmacokinetic properties - Schulte_1991_Clin.Pharmacol.Ther_50_372
Author(s) : Schulte B , Volz-Zang C , Mutschler E , Horne C , Palm D , Wellstein A , Pitschner HF
Ref : Clinical Pharmacology & Therapeutics , 50 :372 , 1991
PubMedID: 1914372

Title : Stereoselectivity of procyclidine binding to muscarinic receptor subtypes M1, M2 and M4 - Waelbroeck_1990_Eur.J.Pharmacol_189_135
Author(s) : Waelbroeck M , Camus J , Tastenoy M , Lambrecht G , Mutschler E , Tacke R , Christophe J
Ref : European Journal of Pharmacology , 189 :135 , 1990
PubMedID: 2253700

Title : Stereoselective inhibition of muscarinic receptor subtypes by the enantiomers of hexahydro-difenidol and acetylenic analogues - Feifel_1990_Br.J.Pharmacol_99_455
Author(s) : Feifel R , Wagner-Roder M , Strohmann C , Tacke R , Waelbroeck M , Christophe J , Mutschler E , Lambrecht G
Ref : British Journal of Pharmacology , 99 :455 , 1990
PubMedID: 2331578

Title : Pharmacokinetic properties of the antimuscarinic drug [3H]-hexahydro-sila-difenidol in the rat - Rettenmayr_1990_Naunyn.Schmiedebergs.Arch.Pharmacol_342_146
Author(s) : Rettenmayr NM , Rodrigues de Miranda JF , Rijntjes NV , Russel FG , van Ginneken CA , Strohmann C , Tacke R , Lambrecht G , Mutschler E
Ref : Naunyn Schmiedebergs Arch Pharmacol , 342 :146 , 1990
PubMedID: 2234099

Title : Novel pharmacological profile of muscarinic receptors mediating contraction of the guinea-pig uterus - Dorje_1990_Naunyn.Schmiedebergs.Arch.Pharmacol_342_284
Author(s) : Dorje F , Friebe T , Tacke R , Mutschler E , Lambrecht G
Ref : Naunyn Schmiedebergs Arch Pharmacol , 342 :284 , 1990
PubMedID: 2280796

Title : Human gastric mucosa expresses glandular M3 subtype of muscarinic receptors - Pfeiffer_1990_Dig.Dis.Sci_35_1468
Author(s) : Pfeiffer A , Hanack C , Kopp R , Tacke R , Moser U , Mutschler E , Lambrecht G , Herawi M
Ref : Digestive Diseases & Sciences , 35 :1468 , 1990
PubMedID: 2253531

Title : Muscarinic receptors mediating acid secretion in isolated rat gastric parietal cells are of M3 type - Pfeiffer_1990_Gastroenterology_98_218
Author(s) : Pfeiffer A , Rochlitz H , Noelke B , Tacke R , Moser U , Mutschler E , Lambrecht G
Ref : Gastroenterology , 98 :218 , 1990
PubMedID: 2293581

Title : Muscarinic receptor subtypes in rat pancreatic islets: binding and functional studies - Verspohl_1990_Eur.J.Pharmacol_178_303
Author(s) : Verspohl EJ , Tacke R , Mutschler E , Lambrecht G
Ref : European Journal of Pharmacology , 178 :303 , 1990
PubMedID: 2187704

Title : Selective antagonists provide evidence that M1 muscarinic receptors may mediate carbachol-induced drinking in the rat - Polidori_1990_Eur.J.Pharmacol_179_159
Author(s) : Polidori C , Massi M , Lambrecht G , Mutschler E , Tacke R , Melchiorre C
Ref : European Journal of Pharmacology , 179 :159 , 1990
PubMedID: 2364977

Title : Cyproheptadine displays high affinity for muscarinic receptors but does not discriminate between receptor subtypes - Eltze_1989_Eur.J.Pharmacol_173_219
Author(s) : Eltze M , Lambrecht G , Mutschler E
Ref : European Journal of Pharmacology , 173 :219 , 1989
PubMedID: 2625138

Title : Poster: M1-Potencies of muscarinic agonists in rabbit isolated vas deferens -
Author(s) : Jokisch-Mehrling B , Feifel R , Eltze M , Rodrigues de Miranda JF , Lambrecht G , Mutschler E
Ref : Trends in Pharmacological Sciences , Suppl :109 , 1989
PubMedID:

Title : Poster: [3H]-(+\/-}-Telenzepine selectively labels muscarinic M1-receptors in calf superior cervical ganglia -
Author(s) : Feifel R , Rodrigues de Miranda JF , Strohmann C , Tacke R , Lambrecht G , Mutschler E
Ref : Trends in Pharmacological Sciences , Suppl :110 , 1989
PubMedID:

Title : Structure-activity relationships of new analogues of arecaidine propargyl ester at muscarinic M1 and M2 receptor subtypes - Moser_1989_Br.J.Pharmacol_96_319
Author(s) : Moser U , Lambrecht G , Wagner M , Wess J , Mutschler E
Ref : British Journal of Pharmacology , 96 :319 , 1989
PubMedID: 2924082

Title : Poster: Antimuscarinic potencies of olefinic analogues related to hexahydro-difenidol at three muscarinic receptor subtypes -
Author(s) : Choo LK , Wagner M , Unterhalt B , Middelberg C , Tacke R , Strohmann C , Tafel A , Mutschler E , Lambrecht G
Ref : Trends in Pharmacological Sciences , Suppl :113 , 1989
PubMedID:

Title : Poster: Pharmacophore model for antimuscarinic agents related to difenidol and siladifenidol - a molecular modeling study -
Author(s) : Bruggmann J , Holtje HD , Mutschler E , Lambrecht G , Tacke R
Ref : Trends in Pharmacological Sciences , Suppl :114 , 1989
PubMedID:

Title : Binding and functional properties of antimuscarinics of the hexocyclium\/sila-hexocyclium and hexahydro-diphenidol\/hexahydro-sila-diphenidol type to muscarinic receptor subtypes - Waelbroeck_1989_Br.J.Pharmacol_98_197
Author(s) : Waelbroeck M , Tastenoy M , Camus J , Christophe J , Strohmann C , Linoh H , Zilch H , Tacke R , Mutschler E , Lambrecht G
Ref : British Journal of Pharmacology , 98 :197 , 1989
PubMedID: 2804545

Title : Stereoselectivity at muscarinic receptor subtypes: observations with the enantiomers of phenglutarimide - Lambrecht_1989_Chirality_1_170
Author(s) : Lambrecht G , Feifel R , Mutschler E
Ref : Chirality , 1 :170 , 1989
PubMedID: 2642045

Title : Affinity profiles of hexahydro-sila-difenidol analogues at muscarinic receptor subtypes - Lambrecht_1989_Eur.J.Pharmacol_168_71
Author(s) : Lambrecht G , Feifel R , Wagner-Roder M , Strohmann C , Zilch H , Tacke R , Waelbroeck M , Christophe J , Boddeke HW , Mutschler E
Ref : European Journal of Pharmacology , 168 :71 , 1989
PubMedID: 2583233

Title : Effect of M2 muscarinic receptor antagonist 4-DAMP, on prostaglandin synthesis and mechanical function in the isolated rabbit heart - Jaiswal_1989_Gen.Pharmacol_20_497
Author(s) : Jaiswal N , Lambrecht G , Mutschler E , Malik KU
Ref : General Pharmacology , 20 :497 , 1989
PubMedID: 2753346

Title : Different muscarine receptors mediate the prejunctional inhibition of [3H]-noradrenaline release in rat or guinea-pig iris and the contraction of the rabbit iris sphincter muscle - Fuder_1989_Naunyn.Schmiedebergs.Arch.Pharmacol_340_597
Author(s) : Fuder H , Schopf J , Unckell J , Wesner MT , Melchiorre C , Tacke R , Mutschler E , Lambrecht G
Ref : Naunyn Schmiedebergs Arch Pharmacol , 340 :597 , 1989
PubMedID: 2615852

Title : Synthesis and muscarinic activity of a series of tertiary and quaternary N-substituted guvacine esters structurally related to arecoline and arecaidine propargyl ester - Wolf-Pflugmann_1989_Arzneimittelforschung_39_539
Author(s) : Wolf-Pflugmann M , Lambrecht G , Wess J , Mutschler E
Ref : Arzneimittelforschung , 39 :539 , 1989
PubMedID: 2757669

Title : Stereoselectivity of the interaction of muscarinic antagonists with their receptors - Waelbroeck_1989_Trends.Pharmacol.Sci_Suppl_65
Author(s) : Waelbroeck M , Tastenoy M , Camus J , Feifel R , Mutschler E , Strohmann C , Tacke R , Lambrecht G , Christophe J
Ref : Trends in Pharmacological Sciences , Suppl :65 , 1989
PubMedID: 2694526

Title : Human HT-29 colon carcinoma cells contain muscarinic M3 receptors coupled to phosphoinositide metabolism - Kopp_1989_Eur.J.Pharmacol_172_397
Author(s) : Kopp R , Lambrecht G , Mutschler E , Moser U , Tacke R , Pfeiffer A
Ref : European Journal of Pharmacology , 172 :397 , 1989
PubMedID: 2555210

Title : Poster: High affinity pirenzepine receptors in chicken atria are different from Ml type -
Author(s) : Tietz H , Lindmar R , Loffelholz K , Strohmann C , Tacke R , Lambrecht G , Mutschler E
Ref : Trends in Pharmacological Sciences , Suppl :107 , 1989
PubMedID:

Title : Affinity profiles of BTM-1086 and BTM-1041 at muscarinic receptor subtypes and at H1- and alpha 1-receptors - Eltze_1989_Eur.J.Pharmacol_170_225
Author(s) : Eltze M , Boer R , Mutschler E , Lambrecht G
Ref : European Journal of Pharmacology , 170 :225 , 1989
PubMedID: 2575995

Title : Poster: Presynaptic autoreceptors in chicken heart exhibit M1 characteristics -
Author(s) : Lindmar R , Loffelholz K , Lambrecht G , Mutschler E
Ref : Trends in Pharmacological Sciences , Suppl :108 , 1989
PubMedID:

Title : Different binding properties of muscarinic M2-receptor subtypes for agonists and antagonists in porcine gastric smooth muscle and mucosa - Herawi_1988_Gastroenterology_94_630
Author(s) : Herawi M , Lambrecht G , Mutschler E , Moser U , Pfeiffer A
Ref : Gastroenterology , 94 :630 , 1988
PubMedID: 3338633

Title : p-fluoro-hexahydro-sila-difenidol: the first M2 beta-selective muscarinic antagonist -
Author(s) : Lambrecht G , Feifel R , Forth B , Strohmann C , Tacke R , Mutschler E
Ref : European Journal of Pharmacology , 152 :193 , 1988
PubMedID: 3208832

Title : Stereoselectivity of the enantiomers of trihexyphenidyl and its methiodide at muscarinic receptor subtypes - Lambrecht_1988_Eur.J.Pharmacol_155_167
Author(s) : Lambrecht G , Feifel R , Moser U , Aasen AJ , Waelbroeck M , Christophe J , Mutschler E
Ref : European Journal of Pharmacology , 155 :167 , 1988
PubMedID: 3243330

Title : o-Methoxy-sila-hexocyclium: a new quaternary M1-selective muscarinic antagonist -
Author(s) : Lambrecht G , Gmelin G , Rafeiner K , Strohmann C , Tacke R , Mutschler E
Ref : European Journal of Pharmacology , 151 :155 , 1988
PubMedID: 3416923

Title : Methoctramine selectively blocks cardiac muscarinic M2 receptors in vivo - Wess_1988_Naunyn.Schmiedebergs.Arch.Pharmacol_338_246
Author(s) : Wess J , Angeli P , Melchiorre C , Moser U , Mutschler E , Lambrecht G
Ref : Naunyn Schmiedebergs Arch Pharmacol , 338 :246 , 1988
PubMedID: 3057387

Title : Contribution of M2 alpha and M2 beta muscarinic receptors to the action of cholinergic stimuli on prostaglandin synthesis and mechanical function in the isolated rabbit heart - Jaiswal_1988_J.Pharmacol.Exp.Ther_247_104
Author(s) : Jaiswal N , Lambrecht G , Mutschler E , Malik KU
Ref : Journal of Pharmacology & Experimental Therapeutics , 247 :104 , 1988
PubMedID: 3171970

Title : Presynaptic muscarinic receptors mediating inhibition of neurogenic contractions in rabbit vas deferens are of the ganglionic M1-type - Eltz_1988_Eur.J.Pharmacol_158_233
Author(s) : Eltz M , Gmelin G , Wess J , Strohmann C , Tacke R , Mutschler E , Lambrecht G
Ref : European Journal of Pharmacology , 158 :233 , 1988
PubMedID: 2472963

Title : Binding of the S(+)- and R(-)-enantiomers of bethanechol to muscarinic receptors in jejunal smooth muscle, nasal mucosa, atrial and ventricular myocardium of the rat - Buhl_1987_Eur.J.Pharmacol_140_221
Author(s) : Buhl T , Rodrigues de Miranda JF , Beld AJ , Lambrecht G , Mutschler E
Ref : European Journal of Pharmacology , 140 :221 , 1987
PubMedID: 3666019

Title : [The spasmolytic activity of propiverine and some of its structural analogs] - Riotte_1987_Arzneimittelforschung_37_300
Author(s) : Riotte J , Mutschler E
Ref : Arzneimittelforschung , 37 :300 , 1987
PubMedID: 2885006

Title : Antimuscarinic action of methoctramine, a new cardioselective M-2 muscarinic receptor antagonist, alone and in combination with atropine and gallamine - Melchiorre_1987_Eur.J.Pharmacol_144_117
Author(s) : Melchiorre C , Angeli P , Lambrecht G , Mutschler E , Picchio MT , Wess J
Ref : European Journal of Pharmacology , 144 :117 , 1987
PubMedID: 3436364

Title : Stimulation of ganglionic muscarinic M1 receptors by a series of tertiary arecaidine and isoarecaidine esters in the pithed rat - Wess_1987_Eur.J.Pharmacol_134_61
Author(s) : Wess J , Lambrecht G , Moser U , Mutschler E
Ref : European Journal of Pharmacology , 134 :61 , 1987
PubMedID: 3556399

Title : Selective blockade in vivo of cardiac muscarinic M2 receptors by a polymethylene tetramine, BHC-9C - Wess_1987_Eur.J.Pharmacol_142_475
Author(s) : Wess J , Lambrecht G , Mutschler E , Melchiorre C , Angeli P
Ref : European Journal of Pharmacology , 142 :475 , 1987
PubMedID: 3428357

Title : Lipophilisation of hydrophilic compounds. Consequences on transepidermal and intestinal transport of trospium chloride - Langguth_1987_Arzneimittelforschung_37_1362
Author(s) : Langguth P , Mutschler E
Ref : Arzneimittelforschung , 37 :1362 , 1987
PubMedID: 3449063

Title : Poster: Hexahydrosiladifenidol: a selective antagonist at muscarinic M2 receptor subtypes -
Author(s) : Lambrecht G , Moser U , Wess J , Riotte J , Fuder H , Kilbinger H , Milller H , Linoh H , Tacke R , Zilch H , Mutschler E
Ref : Trends in Pharmacological Sciences , Suppl :91 , 1986
PubMedID:

Title : Muscarinic ganglionic stimulants: conformationally restrained analogues related to [4-[[N-(3-chlorophenyl)carbamoyl]oxy]-2-butynyl]trimethylammonium chloride - Lambrecht_1986_J.Med.Chem_29_1309
Author(s) : Lambrecht G , Moser U , Mutschler E , Walther G , Wess J
Ref : Journal of Medicinal Chemistry , 29 :1309 , 1986
PubMedID: 3806582

Title : Determination of the bioavailability of the quaternary compound trospium chloride in man from urinary excretion data - Schladitz-Keil_1986_Arzneimittelforschung_36_984
Author(s) : Schladitz-Keil G , Spahn H , Mutschler E
Ref : Arzneimittelforschung , 36 :984 , 1986
PubMedID: 3741535

Title : Study of the contractile effect of 5-hydroxytryptamine (5-HT) in the isolated longitudinal muscle strip from guinea-pig ileum. Evidence for two distinct release mechanisms - Buchheit_1985_Naunyn.Schmiedebergs.Arch.Pharmacol_329_36
Author(s) : Buchheit KH , Engel G , Mutschler E , Richardson B
Ref : Naunyn Schmiedebergs Arch Pharmacol , 329 :36 , 1985
PubMedID: 2582276

Title : Fluorimetric determination of the quaternary compound trospium and its metabolite in biological material after derivatization with benoxaprofen chloride - Schladitz-Keil_1985_J.Chromatogr_345_99
Author(s) : Schladitz-Keil G , Spahn H , Mutschler E
Ref : Journal of Chromatography , 345 :99 , 1985
PubMedID: 4086592

Title : The effects of racemic bethanechol and its (R)- and (S)-enantiomers on pre- and postjunctional muscarine receptors in the guinea-pig ileum - Schworer_1985_Naunyn.Schmiedebergs.Arch.Pharmacol_331_307
Author(s) : Schworer H , Lambrecht G , Mutschler E , Kilbinger H
Ref : Naunyn Schmiedebergs Arch Pharmacol , 331 :307 , 1985
PubMedID: 2869412

Title : A comparison of the antimuscarinic effects of pirenzepine and N-methylatropine on ganglionic and vascular muscarinic receptors in the rat - Wess_1984_Life.Sci_35_553
Author(s) : Wess J , Lambrecht G , Moser U , Mutschler E
Ref : Life Sciences , 35 :553 , 1984
PubMedID: 6379356

Title : Selective muscarinic agonists and antagonists in functional tests -
Author(s) : Mutschler E , Lambrecht G
Ref : Trends in Pharmacological Sciences , Suppl :39 , 1984
PubMedID:

Title : [Structure- and conformation-activity relationships of heterocyclic acetylcholine analogues. 16. Conformational behaviour and cholinergic properties of isoarecaidine and sulfoisoarecaidine esters] - Holtje_1983_Arzneimittelforschung_33_190
Author(s) : Holtje HD , Lambrecht G , Moser U , Mutschler E
Ref : Arzneimittelforschung , 33 :190 , 1983
PubMedID: 6601954

Title : [Structure- and conformation-activity relationships of heterocyclic acetylcholine analogs, 18. Synthesis and muscarine-type activity of sulfoarecaidine and sulfoisoarecaidine esters] -
Author(s) : Moser U , Lambrecht G , Mutschler E , Sombroek J
Ref : Arch Pharm (Weinheim) , 316 :670 , 1983
PubMedID: 6625874

Title : [Structure- and conformation-activity relationships of heterocyclic acetylcholine analogs. 17. Conformational behavior and cholinergic properties of arecaidine and sulfoarecaidine esters] - Mutschler_1983_Arzneimittelforschung_33_806
Author(s) : Mutschler E , Holtje HD , Lambrecht G , Moser U
Ref : Arzneimittelforschung , 33 :806 , 1983
PubMedID: 6684432

Title : Muscarinic effects of various isoarecaidine esters in sympathetic ganglia - Porsius_1981_J.Auton.Pharmacol_1_119
Author(s) : Porsius AJ , Wilffert B , Lambrecht G , Moser U , Mutschler E
Ref : J Auton Pharmacol , 1 :119 , 1981
PubMedID: 7338525

Title : The central action of various arecaidine esters (arecoline derivatives) on blood pressure and heart rate in the cat. Comparison with the peripheral effects - Porsius_1978_Arzneimittelforschung_28_1373
Author(s) : Porsius AJ , Mutschler E , van Zwieten PA
Ref : Arzneimittelforschung , 28 :1373 , 1978
PubMedID: 582403

Title : Quaternary isoarecoline: a potent muscarine-like and nicotine-like acting agonist -
Author(s) : Lambrecht G , Mutschler E
Ref : Experientia , 31 :1317 , 1975
PubMedID: 1204788

Title : [Structure- and conformation-activity relationships of cyclic acetylcholine analogs of the piperidine and quinuclidine series] -
Author(s) : Lambrecht G , Mutschler E
Ref : Arzneimittelforschung , 24 :1725 , 1974
PubMedID: 4480042

Title : [Structure-activity relationships of unsaturated esters of arecaidine and dihydroarecaidine] -
Author(s) : Mutschler E , Hultzsch K
Ref : Arzneimittelforschung , 23 :732 , 1973
PubMedID: 4740217

Title : [Structure-activity relationships of isoarecaidine esters] -
Author(s) : Lambrecht G , Mutschler E
Ref : Arzneimittelforschung , 23 :1427 , 1973
PubMedID: 4801326

Title : [Basic substituted tryptamines and tryptophols. 3. Pharmacologic studies on 1- and 2-position of basic substituted derivatives] -
Author(s) : Eichele O , Mutschler E
Ref : Arch Pharm Ber Dtsch Pharm Ges , 303 :865 , 1970
PubMedID: 4396211

Title : [Structure-effect relations in cyclic acetylcholine analogues of the pilocarpine series] -
Author(s) : Mutschler E , Woog H
Ref : Arzneimittelforschung , 19 :217 , 1969
PubMedID: 4388761

Title : [On the structure-function relation of cyclic acetylcholine analogues of the aminophenol series. 2. Pharmacologic studies on isolated rat and guinea pig uterus, on isolated guinea pig uterus, on isolated guinea pig auricle and on blood pressure of the rat] -
Author(s) : Mutschler E , Woog H
Ref : Pharm Acta Helv , 43 :665 , 1968
PubMedID: 5693170

Title : [On the influence of cholinergic drugs on ulcer development and gastric juice secretion on the Shay rat] -
Author(s) : Blum H , Mutschler E , van Zwieten PA
Ref : Naunyn Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie , 256 :99 , 1967
PubMedID: 4231714

Title : [On the structure-effect-relations in cyclic acetylcholine analogues of the aminophenol-series] -
Author(s) : Mutschler E , Wassermann O , Woog H
Ref : Arzneimittelforschung , 17 :837 , 1967
PubMedID: 5632841

Title : [On cyclic acetylcholine analogs of the aminophenol series] -
Author(s) : Mutschler E , Woog H
Ref : Naunyn Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie , 257 :45 , 1967
PubMedID: 4231858

Title : Investigations on structure-activity relationships of arecaidine-derivatives on the guinea pig isolated atria -
Author(s) : Christiansen A , Lullmann H , Mutschler E
Ref : European Journal of Pharmacology , 1 :81 , 1967
PubMedID: 6060194

Title : [On the affinity of arecaidine derivatives for acetylcholinesterase of guinea pig erythrocytes] -
Author(s) : Konig E , Lullmann H , Mutschler E
Ref : Archives Internationales de Pharmacodynamie et de Therapie , 165 :142 , 1967
PubMedID: 6030234

Title : [On the effect of arecaidine esters on the blood pressure of the cat] -
Author(s) : Kummer B , Lullmann H , Mutschler E
Ref : Naunyn Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie , 254 :159 , 1966
PubMedID: 4228025

Title : [On the chemistry and pharmacology of the alkaloids damascenine and arecoline. 5. On structure-effect relations in cyclical acetylcholine derivatives of the arecoline and damascenine series] -
Author(s) : Mutschler E
Ref : Arzneimittelforschung , 16 :73 , 1966
PubMedID: 6013760

Title : The action of tertiary and quaternary arecaidine and dihydroarecaidine esters on the guinea pig isolated ileum -
Author(s) : Gloge H , Lullmann H , Mutschler E
Ref : British Journal of Pharmacology and Chemotherapy , 27 :185 , 1966
PubMedID: 5961464

Title : [On the presence of atropine in Sclerotinia minor Jagger and Corticium rolfsii Curzi] -
Author(s) : Mutschler E , Rochelmeyer H
Ref : Arch Pharm Ber Dtsch Pharm Ges , 293\/65 :662 , 1960
PubMedID: 13727173