Boyd_2001_Bioorg.Med.Chem.Lett_11_701

Reference

Title : The identification of a potent, water soluble inhibitor of lipoprotein-associated phospholipase A2 - Boyd_2001_Bioorg.Med.Chem.Lett_11_701
Author(s) : Boyd HF , Hammond B , Hickey DM , Ife RJ , Leach CA , Lewis VA , Macphee CH , Milliner KJ , Pinto IL , Smith SA , Stansfield IG , Theobald CJ , Whittaker CM
Ref : Bioorganic & Medicinal Chemistry Lett , 11 :701 , 2001
Abstract :

Modification of the pyrimidone 5-substituent in a series of 1-((amidolinked)-alkyl)-pyrimidones, lipophilic inhibitors of lipoprotein-associated phospholipase A2, has given inhibitors of nanomolar potency and improved physicochemical properties. Compound 23 was identified as a potent, highly water soluble. CNS penetrant inhibitor suitable for intravenous administration.

PubMedSearch : Boyd_2001_Bioorg.Med.Chem.Lett_11_701
PubMedID: 11266173

Related information

Inhibitor CHEMBL351434

Citations formats

Boyd HF, Hammond B, Hickey DM, Ife RJ, Leach CA, Lewis VA, Macphee CH, Milliner KJ, Pinto IL, Smith SA, Stansfield IG, Theobald CJ, Whittaker CM (2001)
The identification of a potent, water soluble inhibitor of lipoprotein-associated phospholipase A2
Bioorganic & Medicinal Chemistry Lett 11 :701

Boyd HF, Hammond B, Hickey DM, Ife RJ, Leach CA, Lewis VA, Macphee CH, Milliner KJ, Pinto IL, Smith SA, Stansfield IG, Theobald CJ, Whittaker CM (2001)
Bioorganic & Medicinal Chemistry Lett 11 :701