| Title : The identification of a potent, water soluble inhibitor of lipoprotein-associated phospholipase A2 - Boyd_2001_Bioorg.Med.Chem.Lett_11_701 |
| Author(s) : Boyd HF , Hammond B , Hickey DM , Ife RJ , Leach CA , Lewis VA , Macphee CH , Milliner KJ , Pinto IL , Smith SA , Stansfield IG , Theobald CJ , Whittaker CM |
| Ref : Bioorganic & Medicinal Chemistry Lett , 11 :701 , 2001 |
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Abstract :
Modification of the pyrimidone 5-substituent in a series of 1-((amidolinked)-alkyl)-pyrimidones, lipophilic inhibitors of lipoprotein-associated phospholipase A2, has given inhibitors of nanomolar potency and improved physicochemical properties. Compound 23 was identified as a potent, highly water soluble. CNS penetrant inhibitor suitable for intravenous administration. |
| PubMedSearch : Boyd_2001_Bioorg.Med.Chem.Lett_11_701 |
| PubMedID: 11266173 |
| Inhibitor | CHEMBL351434 |
Boyd HF, Hammond B, Hickey DM, Ife RJ, Leach CA, Lewis VA, Macphee CH, Milliner KJ, Pinto IL, Smith SA, Stansfield IG, Theobald CJ, Whittaker CM (2001)
The identification of a potent, water soluble inhibitor of lipoprotein-associated phospholipase A2
Bioorganic & Medicinal Chemistry Lett
11 :701
Boyd HF, Hammond B, Hickey DM, Ife RJ, Leach CA, Lewis VA, Macphee CH, Milliner KJ, Pinto IL, Smith SA, Stansfield IG, Theobald CJ, Whittaker CM (2001)
Bioorganic & Medicinal Chemistry Lett
11 :701