Leach CA

References (7)

Title : Novel Brain-Penetrating Oxime Acetylcholinesterase Reactivators Attenuate Organophosphate-Induced Neuropathology in the Rat Hippocampus - Dail_2019_Toxicol.Sci_169_465
Author(s) : Dail MB , Leach CA , Meek EC , Olivier AK , Pringle RB , Green CE , Chambers JE
Ref : Toxicol Sci , 169 :465 , 2019
PubMedID: 30835286

Title : Novel substituted phenoxyalkyl pyridinium oximes enhance survival and attenuate seizure-like behavior of rats receiving lethal levels of nerve agent surrogates - Chambers_2015_Toxicology_339_51
Author(s) : Chambers JE , Meek EC , Bennett JP , Bennett WS , Chambers HW , Leach CA , Pringle RB , Wills RW
Ref : Toxicology , 339 :51 , 2015
PubMedID: 26705700

Title : The identification of clinical candidate SB-480848: a potent inhibitor of lipoprotein-associated phospholipase A2 - Blackie_2003_Bioorg.Med.Chem.Lett_13_1067
Author(s) : Blackie JA , Bloomer JC , Brown MJ , Cheng HY , Hammond B , Hickey DM , Ife RJ , Leach CA , Lewis VA , Macphee CH , Milliner KJ , Moores KE , Pinto IL , Smith SA , Stansfield IG , Stanway SJ , Taylor MA , Theobald CJ
Ref : Bioorganic & Medicinal Chemistry Lett , 13 :1067 , 2003
PubMedID: 12643913

Title : The identification of a potent, water soluble inhibitor of lipoprotein-associated phospholipase A2 - Boyd_2001_Bioorg.Med.Chem.Lett_11_701
Author(s) : Boyd HF , Hammond B , Hickey DM , Ife RJ , Leach CA , Lewis VA , Macphee CH , Milliner KJ , Pinto IL , Smith SA , Stansfield IG , Theobald CJ , Whittaker CM
Ref : Bioorganic & Medicinal Chemistry Lett , 11 :701 , 2001
PubMedID: 11266173

Title : 2-(Alkylthio)pyrimidin-4-ones as novel, reversible inhibitors of lipoprotein-associated phospholipase A2 - Boyd_2000_Bioorg.Med.Chem.Lett_10_395
Author(s) : Boyd HF , Flynn ST , Hickey DM , Ife RJ , Jones M , Leach CA , Macphee CH , Milliner KJ , Rawlings DA , Slingsby BP , Smith SA , Stansfield IG , Tew DG , Theobald CJ
Ref : Bioorganic & Medicinal Chemistry Lett , 10 :395 , 2000
PubMedID: 10714508

Title : Lipoprotein-associated phospholipase A2, platelet-activating factor acetylhydrolase, generates two bioactive products during the oxidation of low-density lipoprotein: use of a novel inhibitor - MacPhee_1999_Biochem.J_338 ( Pt 2)_479
Author(s) : Macphee CH , Moores KE , Boyd HF , Dhanak D , Ife RJ , Leach CA , Leake DS , Milliner KJ , Patterson RA , Suckling KE , Tew DG , Hickey DM
Ref : Biochemical Journal , 338 ( Pt 2) :479 , 1999
PubMedID: 10024526

Title : Mechanism of inhibition of LDL phospholipase A2 by monocyclic-beta-lactams. Burst kinetics and the effect of stereochemistry - Tew_1998_Biochemistry_37_10087
Author(s) : Tew DG , Boyd HF , Ashman S , Theobald C , Leach CA
Ref : Biochemistry , 37 :10087 , 1998
PubMedID: 9665713